Multiplane spectroscopic whole-body photoacoustic imaging of small animals in vivo.

Abstract:

:We have successfully developed a multiscale acoustic-resolution photoacoustic tomography system in a single imaging platform. By switching between ultrasound transducers (center frequencies 5 and 40 MHz) and optical condensers, we have photoacoustically imaged microvasculatures of small animals in vivo at different scales. Further, we have extended the field of view of our imaging system to entire bodies of small animals. At different imaging planes, we have noninvasively imaged the major blood vessels (e.g., descending aorta, intercostal vessels, cephalic vessels, brachial vessels, femoral vessels, popliteal vessels, lateral marginal vessels, cranial mesenteric vessels, mammalian vessels, carotid artery, jugular vein, subclavian vessels, iliac vessels, and caudal vessels) as well as intact internal organs (e.g., spleen, liver, kidney, intestine, cecum, and spinal cord) of the animals in vivo. The spectroscopic whole-body photoacoustic imaging clearly reveals the spectral responses of the internal structures. Similar to other existing preclinical whole-body imaging systems, this whole-body photoacoustic tomography can be a useful tool for small-animal research.

journal_name

Med Biol Eng Comput

authors

Jeon M,Kim J,Kim C

doi

10.1007/s11517-014-1182-6

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

283-94

issue

2-3

eissn

0140-0118

issn

1741-0444

pii

10.1007/s11517-014-1182-6

journal_volume

54

pub_type

杂志文章
  • Quantitative measurement of Parkinsonian gait from walking in monocular image sequences using a centroid tracking algorithm.

    abstract::Parkinson's disease (PD) is a neurodegenerative disease of the central nervous system that results from the degeneration of dopaminergic neurons in the substantia nigra. Abnormal gait begins in the early stage and becomes severe as the disease progresses; therefore, the assessment of gait becomes an important issue in...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-015-1335-2

    authors: Lin SH,Chen SW,Lo YC,Lai HY,Yang CH,Chen SY,Chang YJ,Chen CH,Huang WT,Jaw FS,Chen YY,Tsang S,Liao LD

    更新日期:2016-03-01 00:00:00

  • Detection of very low-frequency oscillations of cerebral haemodynamics is influenced by data detrending.

    abstract::Recent studies were investigated that report spontaneous oscillations of cerebral perfusion in the very low-frequency range (0.01-0.04 Hz), emphasising details of spectral estimation. The effects of different spectral estimation procedures were compared, using simulated and clinical data. It was shown that data detren...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/BF02343541

    authors: Müller T,Reinhard M,Oehm E,Hetzel A,Timmer J

    更新日期:2003-01-01 00:00:00

  • Silicone rubber encapsulation for an endoscopically implantable gastrostimulator.

    abstract::Gastrointestinal stimulator implants have recently shown positive results in treating obesity. However, the implantation currently requires an invasive surgical procedure. Endoscopy could be used to place the gastric stimulator in the stomach, hence avoiding the riskier surgery. The implant then needs to go through th...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-014-1236-9

    authors: Lonys L,Vanhoestenberghe A,Julémont N,Godet S,Delplancke MP,Mathys P,Nonclercq A

    更新日期:2015-04-01 00:00:00

  • Application of genetic algorithms to parameter estimation of bioprocesses.

    abstract::The paper explains the application of a genetic algorithm (GA) to the problem of estimating parameters for a kinetic model of a biologically reacting system. It is demonstrated that the GA is a powerful tool for quantifying the kinetic parameters using kinetic data. As the operation of the GA does not depend on the fo...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/BF02510391

    authors: Park LJ,Park CH,Park C,Lee T

    更新日期:1997-01-01 00:00:00

  • Interpreting magnetic fields of the brain: minimum norm estimates.

    abstract::The authors have applied estimation theory to the problem of determining primary current distributions from measured neuromagnetic fields. In this procedure, essentially nothing is assumed about the source currents, except that they are spatially restricted to a certain region. Simulation experiments show that the res...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/BF02512476

    authors: Hämäläinen MS,Ilmoniemi RJ

    更新日期:1994-01-01 00:00:00

  • "Wave" as defined by wave intensity analysis.

    abstract::The propagation of waves in the arteries is generally described using Fourier analysis in terms of periodic wavetrains formed by the superposition of a mean value and sinusoidal waves at the fundamental frequency (defined by the heart rate) and its harmonics. There is, however, an alternative way to describe waves in ...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-008-0403-2

    authors: Wang JJ,Shrive NG,Parker KH,Tyberg JV

    更新日期:2009-02-01 00:00:00

  • Elastic porous tube model of reactive hyperaemia.

    abstract::Reactive hyperaemia is the term given to the temporary increase in blood flow that follows release of an occlusion of the arterial supply. Measurement of reactive hyperaemia in the leg below the knee is useful in assessment of the vascular system, as resting flows remain unaffected even in the presence of quite severe...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/BF02515312

    authors: Smye SW,Bloor MI

    更新日期:1994-09-01 00:00:00

  • The formation of extracellular potentials over the innervation zone: Are these potentials affected by changes in fibre membrane properties?

    abstract::Widespread misconceptions still exist regarding the formation of extracellular potentials over the innervation zone: the assumption (1) that the first phase of these potentials mainly reflects the process of initiation of the intracellular action potential (IAP) at the neuromuscular junction and that (2) these potenti...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-016-1487-8

    authors: Rodriguez-Falces J

    更新日期:2016-12-01 00:00:00

  • Spatio-spectral filters for low-density surface electromyographic signal classification.

    abstract::In this paper, we proposed to utilize a novel spatio-spectral filter, common spatio-spectral pattern (CSSP), to improve the classification accuracy in identifying intended motions based on low-density surface electromyography (EMG). Five able-bodied subjects and a transradial amputee participated in an experiment of e...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-012-1024-3

    authors: Huang G,Zhang Z,Zhang D,Zhu X

    更新日期:2013-05-01 00:00:00

  • Hypothetical neural control of human bipedal walking with voluntary modulation.

    abstract::A hypothetical neuromusculoskeletal model is developed to simulate human normal walking and its modulated behaviors. A small set of neural periodic patterns drive spinal muscle synergies which in turn lead to specific pattern of muscle activation and supraspinal feedback systems maintain postural balance during walkin...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-007-0277-8

    authors: Jo S

    更新日期:2008-02-01 00:00:00

  • The effects of femoral neck cut, cable tension, and muscles forces on the greater trochanter fixation.

    abstract::Greater trochanter (GT) stabilization techniques following a fracture or an osteotomy are still showing high levels of postoperative complications. Understanding the effect of femoral neck cut placement, cable tension and muscles forces on GT fragment displacements could help surgeons optimize their techniques. A 3D f...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-012-0892-x

    authors: Petit Y,Cloutier LP,Duke K,Laflamme GY

    更新日期:2012-04-01 00:00:00

  • Chaotic behavior of the coronary circulation.

    abstract::The regulation of the coronary circulation is a complex paradigm in which many inputs that influence vasomotor tone have to be integrated to provide the coronary vasomotor adjustments to cardiac metabolism and to perfusion pressure. We hypothesized that the integration of many disparate signals that influence membrane...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-008-0329-8

    authors: Trzeciakowski J,Chilian WM

    更新日期:2008-05-01 00:00:00

  • Direct nanodrug delivery for tumor targeting subject to shear-augmented diffusion in blood flow.

    abstract::The advent of multifunctional nanoparticle has enabled numerous innovative strategies in diagnostics, imaging, and cancer therapy. Despite the intense research efforts in developing new nanoparticles and surface bonding ligands, one major obstacle in achieving highly effective treatment, including minimizing detriment...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-018-1818-z

    authors: Xu Z,Kleinstreuer C

    更新日期:2018-11-01 00:00:00

  • Opportunities for the cellular approach in biomedical engineering.

    abstract::This review is a commentary on recent, altered perspectives about biomedical engineering and its role in medicine. It is argued that, rather than being a peripheral specialty, medical engineering and engineering principles in general have a direct application to biochemical medicine and cell biology. A brief descripti...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章,评审

    doi:10.1007/BF02446170

    authors: Vadgama P

    更新日期:1992-07-01 00:00:00

  • Space-time network connectivity and cortical activations preceding spike wave discharges in human absence epilepsy: a MEG study.

    abstract::To describe the spatial and temporal profiles of connectivity networks and sources preceding generalized spike-and-wave discharges (SWDs) in human absence epilepsy. Nonlinear associations of MEG signals and cluster indices obtained within the framework of graph theory were determined, while source localization in the ...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-011-0778-3

    authors: Gupta D,Ossenblok P,van Luijtelaar G

    更新日期:2011-05-01 00:00:00

  • Contact mechanics of a thin-walled capsule adhered onto a rigid planar substrate.

    abstract::A thin-walled capsule, modelled as an incompressible liquid droplet contained in a thin flexible membrane, was allowed to adhere onto a rigid substrate. The contact mechanics were formulated, based on linear elasticity, to portray quantitatively the relationships between osmotic inflation, contact area and angle, memb...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/BF02345154

    authors: Wan KT,Liu KK

    更新日期:2001-09-01 00:00:00

  • Heart rate and body temperature sensitive diaphragm pacing.

    abstract::Two ways of rate control for diaphragm pacing are proposed. One is rate control using only the patients' body temperature (method I). The other is rate control by both the patients' heart rate and body temperature (method II). To test the effectiveness of these methods, a diaphragm pacemaker which can be controlled by...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/BF02446125

    authors: Kimura M,Sugiura T,Fukui Y,Kimura T,Harada Y

    更新日期:1992-03-01 00:00:00

  • Experimental and numerical investigation on soft tissue dynamic response due to turbulence-induced arterial vibration.

    abstract::Peripheral arterial occlusive disease is a serious cardiovascular disorder. The arterial occlusion leads to turbulent flow and arterial sound generation on the inner vessel wall. Stenosis-induced vibro-acoustic waves propagate through the surrounding soft tissues and reach the skin surface. In this study, the feasibil...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-019-01995-y

    authors: Salman HE,Yazicioglu Y

    更新日期:2019-08-01 00:00:00

  • Biphasic model of the trabecular meshwork in the eye.

    abstract::A biphasic continuum model for the flow of intraocular fluid, the aqueous humour, in the trabecular meshwork is proposed in the paper. The model considers the meshwork as a circular ring with uniform thickness of homogeneous, isotropic, viscoelastic material swollen with continuously percolating aqueous humour. The mo...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/BF02446710

    authors: Tandon PN,Autar R

    更新日期:1991-05-01 00:00:00

  • Non-contact diagnostic system for sleep apnea-hypopnea syndrome based on amplitude and phase analysis of thoracic and abdominal Doppler radars.

    abstract::Full-night polysomnography (PSG) has been recognized as the gold standard test for sleep apnea-hypopnea syndrome (SAHS). However, PSG examinees are physically restrained for the full night by many contact sensors and obtrusive connecting cables, inducing mental stress. We developed a non-contact SAHS diagnostic system...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-015-1370-z

    authors: Kagawa M,Tojima H,Matsui T

    更新日期:2016-05-01 00:00:00

  • PC/VAX or standalone PC-based general purpose biological data collection system.

    abstract::A system, to collect, analyse and display biological data, is developed using IBM PC AT compatibles (PCs) or CED1401/1609 devices networked to a VAX environment. It can be operated in three separate modes: using the CED/IEEE/VAX network; using the PC/Ethernet/VAX network; as a standalone PC. The original system compri...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/BF02446881

    authors: Marlow SP,Mackenzie DA,Tomlinson JB

    更新日期:1993-01-01 00:00:00

  • Decreased global field synchronization of multichannel frontal EEG measurements in obsessive-compulsive disorders.

    abstract::Global field synchronization (GFS) quantifies the synchronization level of brain oscillations. The GFS method has been introduced to measure functional synchronization of EEG data in the frequency domain. GFS also detects phase interactions between EEG signals acquired from all of the electrodes. If a considerable amo...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-017-1689-8

    authors: Özçoban MA,Tan O,Aydin S,Akan A

    更新日期:2018-02-01 00:00:00

  • Measurement of the local aortic stiffness by a non-invasive bioelectrical impedance technique.

    abstract::Aortic stiffness measurement is well recognized as an independent predictor of cardiovascular mortality and morbidity. Recently, a simple method has been proposed for the evaluation of the local aortic stiffness (AoStiff) using a non-invasive bioelectrical impedance (BI) technique. This approach relies on a novel inte...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-011-0741-3

    authors: Collette M,Lalande A,Willoteaux S,Leftheriotis G,Humeau A

    更新日期:2011-04-01 00:00:00

  • Time-frequency analysis of heart murmurs. Part I: Parametric modelling and numerical simulations.

    abstract::The object of this study is to compare the performance of two new bilinear time-frequency representation techniques with the spectrogram to characterise the behaviour of heart murmurs produced by bioprosthetic heart valves implanted in the mitral or aortic position. The murmurs are those of mitral stenosis, mitral reg...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/BF02525526

    authors: Debiais F,Durand LG,Pibarot P,Guardo R

    更新日期:1997-09-01 00:00:00

  • Arterial reservoir-excess pressure and ventricular work.

    abstract::This study is based on the hypothesis that the pressure within the arterial network can be usefully decomposed as the sum of a reservoir pressure and an excess pressure. The reservoir pressure waveform is defined to be the same in each vessel but delayed by the wave travel time from the root of the aorta. Using calcul...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-012-0872-1

    authors: Parker KH,Alastruey J,Stan GB

    更新日期:2012-04-01 00:00:00

  • Using a numerical method to precisely evaluate the alpha angle in a hip image.

    abstract::The alpha angle is a parameter extensively used to assess for cam-type femoroacetabular impingement (FAI) in a 2D image of the hip. As this angle requires estimation of the axis of the femoral neck, the drawing of this axis often results in measurement errors due to subjective judgment, influencing inter-rater and int...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-019-01973-4

    authors: Lai CL,Chi WM,Ho YJ,Lin CC,Lin HC,Kuo CL,Chen JH

    更新日期:2019-07-01 00:00:00

  • Physiological quality assessment of stored whole blood by means of electrical measurements.

    abstract::The physiological parameters of blood such as extracellular Na(+), K(+), Cl(-), pH, 2,3-DPG and ATP and the complex electrical impedance were measured using whole blood samples from 31 male donors (21 donors form the training set and ten donors were used for testing), on the 0th, 10th and 21st day of blood bank storag...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-007-0206-x

    authors: Ulgen Y,Sezdi M

    更新日期:2007-07-01 00:00:00

  • Selective laser sintering in biomedical engineering.

    abstract::Selective laser sintering (SLS) is a solid freeform fabrication technique, developed by Carl Deckard for his master's thesis at the University of Texas, patented in 1989. SLS manufacturing is a technique that produces physical models through a selective solidification of a variety of fine powders. SLS technology is ge...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章,评审

    doi:10.1007/s11517-012-1001-x

    authors: Mazzoli A

    更新日期:2013-03-01 00:00:00

  • Multi-parametric study of temperature and thermal damage of tumor exposed to high-frequency nanosecond-pulsed electric fields based on finite element simulation.

    abstract::High-frequency nanosecond-pulsed electric fields were recently introduced for tumor or abnormal tissue ablation to solve some problems of conventional electroporation. However, it is necessary to study the thermal effects of high-field-intensity nanosecond pulses inside tissues. The multi-parametric analysis performed...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-016-1589-3

    authors: Mi Y,Rui S,Li C,Yao C,Xu J,Bian C,Tang X

    更新日期:2017-07-01 00:00:00

  • A computer-assisted human peripheral blood leukocyte image classification method based on Siamese network.

    abstract::A computer-assisted human peripheral blood leukocyte image classification method based on Siamese network is proposed. Firstly, a Siamese network with two identical convolutional neural network (CNN) sub-networks and a logistic regression for leukocyte five classification is designed, which can learn not only distingu...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-020-02180-2

    authors: Wang Y,Cao Y

    更新日期:2020-07-01 00:00:00