Abstract:
:High-frequency nanosecond-pulsed electric fields were recently introduced for tumor or abnormal tissue ablation to solve some problems of conventional electroporation. However, it is necessary to study the thermal effects of high-field-intensity nanosecond pulses inside tissues. The multi-parametric analysis performed here is based on a finite element model of liver tissue with a tumor that has been punctured by a pair of needle electrodes. The pulse voltage used in this study ranges from 1 to 4 kV, the pulse width ranges from 50 to 500 ns, and the repetition frequency is between 100 kHz and 1 MHz. The total pulse length is 100 μs, and the pulse burst repetition frequency is 1 Hz. Blood flow and metabolic heat generation have also been considered. Results indicate that the maximum instantaneous temperature at 100 µs can reach 49 °C, with a maximum instantaneous temperature at 1 s of 40 °C, and will not cause thermal damage during single pulse bursts. By parameter fitting, we can obtain maximum instantaneous temperature at 100 µs and 1 s for any parameter values. However, higher temperatures will be achieved and may cause thermal damage when multiple pulse bursts are applied. These results provide theoretical basis of pulse parameter selection for future experimental researches.
journal_name
Med Biol Eng Computjournal_title
Medical & biological engineering & computingauthors
Mi Y,Rui S,Li C,Yao C,Xu J,Bian C,Tang Xdoi
10.1007/s11517-016-1589-3subject
Has Abstractpub_date
2017-07-01 00:00:00pages
1109-1122issue
7eissn
0140-0118issn
1741-0444pii
10.1007/s11517-016-1589-3journal_volume
55pub_type
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