Synergistic effects of local temperature enhancements on cellular responses in the context of high-intensity, ultrashort electric pulses.

Abstract:

:Results of self-consistent analyses of cells show the possibility of temperature increases at membranes in response to a single nanosecond, high-voltage pulse, at least over small sections of the membrane. Molecular Dynamics simulations indicate that such a temperature increase could facilitate poration, which is one example of a bio-process at the plasma membrane. Our study thus suggests that the use of repetitive high-intensity voltage pulses could open up possibilities for a host of synergistic bio-responses involving both thermal and electrically driven phenomena.

journal_name

Med Biol Eng Comput

authors

Song J,Joshi RP,Schoenbach KH

doi

10.1007/s11517-011-0745-z

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

713-8

issue

6

eissn

0140-0118

issn

1741-0444

journal_volume

49

pub_type

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