Abstract:
:A three-element cardiac muscle fibre model, utilising Huxley's sliding filament theory for the contractile element and coupled with parallel and series elastic components, was simulated to see if it were possible to predict the cardiac Fenn effect. The force/length energy (FLE) was computed in both isometric and isotonic contractions, as a function of muscle fibre length (preload) in the isometric case and afterload in the isotonic contraction case. Simulation results demonstrated that isotonic contractions produced a greater FLE than isometric contractions at every corresponding afterload, with the difference being equal to the work produced in the isotonic case, which is characteristic of the Fenn effect. The maximum energy utilisation was observed at maximum force isometric contractions, as has been experimentally observed in cardiac muscle. Changing the stiffness of the series elastic component did not change the Fenn-effect behaviour. Fenn-effect plots using crossbridge energy predictions showed behaviour similar to the FLE plots, but the FLE: crossbridge energy ratio declined with decreasing force even though the efficiency has been experimentally found to be constant.
journal_name
Med Biol Eng Computjournal_title
Medical & biological engineering & computingauthors
Taylor TW,Goto Y,Suga Hdoi
10.1007/BF02446691subject
Has Abstractpub_date
1993-07-01 00:00:00pages
377-83issue
4eissn
0140-0118issn
1741-0444journal_volume
31pub_type
杂志文章abstract::Laser Doppler imaging (LDI) is investigated as a novel method for in vivo ligament tissue blood flow determination. LDI output signal is obtained from surgically exposed rabbit medial collateral ligaments (MCL). The LDI signal is compared with simultaneously determined, coloured microsphere (CM)-derived standardised M...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02520078
更新日期:1996-05-01 00:00:00
abstract::To evaluate the possibility of respiratory-volume measurement using photoplethysmography (PPG), PPG signals from 16 normal volunteers are collected, and the respiratory-induced intensity variations (RIIV) are digitally extracted. The RIIV signals are studied while respiratory volume is varied. Furthermore, respiratory...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02513264
更新日期:1999-01-01 00:00:00
abstract::A computer-assisted human peripheral blood leukocyte image classification method based on Siamese network is proposed. Firstly, a Siamese network with two identical convolutional neural network (CNN) sub-networks and a logistic regression for leukocyte five classification is designed, which can learn not only distingu...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-020-02180-2
更新日期:2020-07-01 00:00:00
abstract::A building block-based software framework was developed to simulate electrophysiological networks. The synaptic potentials generated during neurotransmission were simulated in an existing discrete bidomain model of smooth muscle, using cubic, three-dimensional grids of varying sizes. The model is automatically derived...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02345322
更新日期:2003-09-01 00:00:00
abstract::An automatic power-generating system (AGS) which converts kinetic energy into electric energy for quartz watches was tested as a power source for implantable cardiac pacemakers. An automatic power-generating mechanism and a capacitor (0.33 F) were removed from a quartz watch (SEIKO) and encapsulated in a polyvinyl cas...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02513315
更新日期:1999-05-01 00:00:00
abstract::The paper describes an investigation in which it is shown that small positive voltage pulses applied to an external conductor placed against the photocathode of a photomultiplier tube can be used to switch the photocathode completely off for the duration of the pulses. This suggests that a photomultiplier tube with a ...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02441486
更新日期:1989-05-01 00:00:00
abstract::A method is presented for automatic analysis of the P-wave, based on lead II of a 12-lead standard ECG, in resting conditions during a routine examination for the detection of patients prone to atrial fibrillation (AF), one of the most prevalent arrhythmias. First, the P-wave was delineated, and this was achieved in t...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02347697
更新日期:2002-01-01 00:00:00
abstract::A biphasic continuum model for the flow of intraocular fluid, the aqueous humour, in the trabecular meshwork is proposed in the paper. The model considers the meshwork as a circular ring with uniform thickness of homogeneous, isotropic, viscoelastic material swollen with continuously percolating aqueous humour. The mo...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02446710
更新日期:1991-05-01 00:00:00
abstract::Cerebral autoregulation controls cerebral blood flow under changing cerebral perfusion pressure. Standards for measurement and analysis of dynamic cerebral autoregulation (dCA) are lacking. In this study, dCA reproducibility, quantified by intraclass correlation coefficient, is evaluated for different methodological a...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-010-0706-y
更新日期:2010-12-01 00:00:00
abstract::The paper deals with the influence of mains interference on time coherent averaging using an internal trigger. The general distribution of the time jitter is derived and applied to a simplified signal. The authors prove that no amount of averaging can do away with this type of interference. Finally, the deformation th...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02457827
更新日期:1992-09-01 00:00:00
abstract::The performance of the stimulation coil in a magnetic nerve stimulator can be improved by attaching a ferromagnetic structure to the coil. This reduces heat generation at the coil and increases magnetic field strength for a given unit of current. Some technical aspects of the design of a stimulation coil with a ferrom...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02345312
更新日期:2003-09-01 00:00:00
abstract::Thousands of patients receive human tissue grafts every year. Developments in cell and tissue engineering have also increased considerably the number of available products of human origin. France has very strict regulations, in part stimulated by problems of public health and ethics that have emerged in recent years a...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02344783
更新日期:2000-03-01 00:00:00
abstract::We have successfully developed a multiscale acoustic-resolution photoacoustic tomography system in a single imaging platform. By switching between ultrasound transducers (center frequencies 5 and 40 MHz) and optical condensers, we have photoacoustically imaged microvasculatures of small animals in vivo at different sc...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-014-1182-6
更新日期:2016-03-01 00:00:00
abstract::A system, to collect, analyse and display biological data, is developed using IBM PC AT compatibles (PCs) or CED1401/1609 devices networked to a VAX environment. It can be operated in three separate modes: using the CED/IEEE/VAX network; using the PC/Ethernet/VAX network; as a standalone PC. The original system compri...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02446881
更新日期:1993-01-01 00:00:00
abstract::The paper describes a method of quantifying Duchenne muscular dystrophy which is examiner independent and uses surface electromyographic signals (EMG). A standardised protocol is proposed. Spectral parameters are first computed from digitised EMG, then a polynomial model is deduced from the evolution of each parameter...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02446966
更新日期:1992-05-01 00:00:00
abstract::We present a novel method to iteratively calculate discrete Fourier transforms for discrete time signals with sample time intervals that may be widely nonuniform. The proposed recursive Fourier transform (RFT) does not require interpolation of the samples to uniform time intervals, and each iterative transform update ...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-009-0461-0
更新日期:2009-07-01 00:00:00
abstract::To study the effects of the geometrical characteristics of a framing coil on aneurysm thromboembolization efficacy, the hemodynamics in lateral aneurysms filled with coils having a different shape, orientation, and thickness were analyzed using computational fluid dynamics. The aneurysms packed with vortex and cage-sh...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-013-1073-2
更新日期:2013-09-01 00:00:00
abstract::To describe the spatial and temporal profiles of connectivity networks and sources preceding generalized spike-and-wave discharges (SWDs) in human absence epilepsy. Nonlinear associations of MEG signals and cluster indices obtained within the framework of graph theory were determined, while source localization in the ...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-011-0778-3
更新日期:2011-05-01 00:00:00
abstract::In this paper, we proposed to utilize a novel spatio-spectral filter, common spatio-spectral pattern (CSSP), to improve the classification accuracy in identifying intended motions based on low-density surface electromyography (EMG). Five able-bodied subjects and a transradial amputee participated in an experiment of e...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-012-1024-3
更新日期:2013-05-01 00:00:00
abstract::Obstructive sleep apnea syndrome (OSAS) is a major public health problem. The golden reference for diagnosing OSAS is the sleep-laboratory based polysomnography (PSG). However, screening of population for OSAS may be practical and cost efficient only through ambulatory home recordings. In this work we aimed to design,...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-008-0418-8
更新日期:2009-01-01 00:00:00
abstract::A hydrodynamic model for the part of the human arterial network below the renal arteries has been constructed using specially fabricated distensible tubes and a pulsatile pump to simulate an aortoiliac bypass. The experiments and the computer model indicated that no 'steal' occurred due to the insertion of the bypass ...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02441802
更新日期:1993-11-01 00:00:00
abstract::Measurements of the dielectric properties of healthy and atherosclerotic human artery tissues were made in the frequency range of 100 Hz-100 kHz and temperatures from 22 to 260 degrees C. The temperature dependencies of the dielectric parameters for healthy tissues reveal distinctively the temperature ranges correspon...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-007-0181-2
更新日期:2007-06-01 00:00:00
abstract::Two ways of rate control for diaphragm pacing are proposed. One is rate control using only the patients' body temperature (method I). The other is rate control by both the patients' heart rate and body temperature (method II). To test the effectiveness of these methods, a diaphragm pacemaker which can be controlled by...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02446125
更新日期:1992-03-01 00:00:00
abstract::Axial head rotation prior to low speed automotive rear impacts has been clinically identified to increase morbidity and symptom duration. The present study was conducted to determine the effect of axial head rotation on facet joint capsule strains during simulated rear impacts. The study was conducted using a validate...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-010-0682-2
更新日期:2011-02-01 00:00:00
abstract::The relation is investigated between stimulus frequency, stimulus pulse amplitude and the neural damage induced by continuous stimulation of the cat's sciatic nerve. The chronically implanted electrodes were pulsed continuously and the effects of the electrical stimulation were quantified as the amount of early axonal...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02510526
更新日期:1995-05-01 00:00:00
abstract::The aim of the study was to investigate the effect of signal length on the performance of a signal source separation method, independent component analysis (ICA), when extracting the visual evoked potential (EP) lambda wave from saccade-related electro-encephalogram (EEG) waveforms. A method was devised that enabled t...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02348134
更新日期:2002-03-01 00:00:00
abstract::The management of postprandial glucose excursions in type 1 diabetes has a major impact on overall glycaemic control. In this work, we propose and evaluate various mechanistic models to characterize the disposal of meal-attributable glucose. Sixteen young volunteers with type 1 diabetes were subject to a variable-targ...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-016-1509-6
更新日期:2017-02-01 00:00:00
abstract::The first in vivo evaluation of a pO2 sensor constructed with a novel copolymer is described. The performance of the sensor is assessed under dynamic conditions in vitro and in vivo. This sensor is more stable and reliable than the control sensor with a heparin-treated polyethylene membrane. ...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02511245
更新日期:1996-07-01 00:00:00
abstract::Proper alignment of acetabular implantation is necessary for good patient outcomes and preventing complications or additional surgeries in total hip arthroplasty (THA). Rotation of the pelvis in lateral decubitus (LD) is typically not accounted for as surgeons use the surgery table as a reference plane to align implan...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-020-02235-4
更新日期:2020-10-01 00:00:00
abstract::Calcific aortic valve disease (CAVD) is characterized by calcification accumulation and thickening of the aortic valve cusps, leading to stenosis. The importance of fluid flow shear stress in the initiation and regulation of CAVD progression is well known and has been studied recently using fluid-structure interaction...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-016-1458-0
更新日期:2016-11-01 00:00:00