Abstract：
:The relation is investigated between stimulus frequency, stimulus pulse amplitude and the neural damage induced by continuous stimulation of the cat's sciatic nerve. The chronically implanted electrodes were pulsed continuously and the effects of the electrical stimulation were quantified as the amount of early axonal degeneration (EAD) present in the nerves seven days after the continuous stimulation. The primary effect of stimulating at 100 Hz rather than 50 Hz was to cause an increase in the slope of the plot of the amount of EAD versus stimulus amplitude, but the threshold stimulus for the induction of EAD also was slightly lower. There was a small amount of EAD in three of the nerves stimulated at 20 Hz, but there was no detectable correlation between the amount of EAD and the stimulus amplitude. This suggests that continuous electrical stimulation of peripheral nerves at a low frequency induce little or no neural damage, even if the stimulus amplitude is very high. A preliminary presentation of the results has been made elsewhere (Agnew et al., 1993).
journal_name
Med Biol Eng Computjournal_title
Medical & biological engineering & computingauthors
McCreery DB,Agnew WF,Yuen TG,Bullara LAdoi
10.1007/BF02510526subject
Has Abstractpub_date
1995-05-01 00:00:00pages
426-9issue
3 Spec Noeissn
0140-0118issn
1741-0444journal_volume
33pub_type
杂志文章abstract：:The reconstruction of bioluminescence tomography (BLT) is severely ill-posed due to the insufficient measurements and diffuses nature of the light propagation. Predefined permissible source region (PSR) combined with regularization terms is one common strategy to reduce such ill-posedness. However, the region of PSR i...
journal_title：Medical & biological engineering & computing
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journal_title：Medical & biological engineering & computing
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journal_title：Medical & biological engineering & computing
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