Evaluation of laser Doppler imaging to measure blood flow in knee ligaments of adult rabbits.

Abstract:

:Laser Doppler imaging (LDI) is investigated as a novel method for in vivo ligament tissue blood flow determination. LDI output signal is obtained from surgically exposed rabbit medial collateral ligaments (MCL). The LDI signal is compared with simultaneously determined, coloured microsphere (CM)-derived standardised MCL blood flow. Correlation of LDI output with the CM flow data and a linear regression of 17 data points in nine rabbits (joint injured to provoke an acute vascular response in the tissues) indicate that LDI provides a reasonable estimate of MCL blood flow, at least over the ranges assessed. If properly calibrated, and given enough tissue-specific data points, LDI may have advantages over conventional, but more invasive, techniques. The potential clinical application of LDI technology to joint injury and arthritis research is discussed.

journal_name

Med Biol Eng Comput

authors

Bray R,Forrester K,McDougall JJ,Damji A,Ferrell WR

doi

10.1007/BF02520078

subject

Has Abstract

pub_date

1996-05-01 00:00:00

pages

227-31

issue

3

eissn

0140-0118

issn

1741-0444

journal_volume

34

pub_type

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