Identifying Life-Threatening Admissions for Drug Dependence or Abuse (ILIADDA): Derivation and Validation of a Model.

abstract：:Obstructive sleep apnea (OSA) is associated with increasing risk of recurrent stroke and mortality. Nasogastric tubes used by dysphagic stroke patients may interfere with nasal continuous positive airway pressure (CPAP) due to air leakage. This study was evaluated the effects and short-term tolerability of high-flow n...

journal_title：Scientific reports

authors： Ho CH,Chen CL,Yu CC,Yang YH,Chen CY

更新日期：2020-05-22 00:00:00

abstract：:While the feasibility of transpapillary drug delivery has previously been established, localized transport via the mammary ducts may be improved with tailored drug delivery formulations. The objective of this study was to investigate the impact of nanoemulsion encapsulation on transpapillary delivery in vitro. Nanoemu...

journal_title：Scientific reports

authors： Kurtz SL,Lawson LB

更新日期：2019-08-14 00:00:00

abstract：:Activation of the inflammasome is involved in the progression of retinal degenerative diseases, in particular, in the pathogenesis of Age-Related Macular Degeneration (AMD), with NLRP3 activation the focus of many investigations. In this study, we used genetic and pharmacological approaches to explore the role of the ...

journal_title：Scientific reports

authors： Wooff Y,Fernando N,Wong JHC,Dietrich C,Aggio-Bruce R,Chu-Tan JA,Robertson AAB,Doyle SL,Man SM,Natoli R

更新日期：2020-02-10 00:00:00

abstract：:Melamine detection has attracted much attention since the discovery of the damage of melamine to human health. Herein, we have developed a sensitive homogeneous electroanalytical platform for melamine detection, which is relied on the formation of triplex molecular beacon integrated with exonuclease III (Exo III)-medi...

journal_title：Scientific reports

authors： Liu X,Song M,Li F

更新日期：2017-07-03 00:00:00

abstract：:The development of human induced pluripotent stem cell (iPSC) technology has revolutionized the regenerative medicine field. This technology provides a powerful tool for disease modeling and drug screening approaches. To circumvent the risk of random integration into the host genome caused by retroviruses, non-integra...

journal_title：Scientific reports

authors： Diecke S,Lu J,Lee J,Termglinchan V,Kooreman NG,Burridge PW,Ebert AD,Churko JM,Sharma A,Kay MA,Wu JC

更新日期：2015-01-28 00:00:00

abstract：:Spermatogenesis is a highly regulated process during which haploid sperm cells are generated. Although autophagy is involved in the spermatogenesis process, the molecular pathways and regulations of autophagy in germ cell development remain elusive. Here, we showed that Ppp1r36, a regulatory subunit of protein phospha...

journal_title：Scientific reports

authors： Zhang Q,Gao M,Zhang Y,Song Y,Cheng H,Zhou R

更新日期：2016-04-21 00:00:00

abstract：:The relationship between the cuprate pseudogap (Δ(p)) and superconducting gap (Δ(s)) remains an unsolved mystery. Here, we present a temperature- and doping-dependent tunneling study of submicron Bi(2)Sr(2)CaCu(2)O(8+δ) intrinsic Josephson junctions, which provides a clear evidence that Δ(s) closes at a temperature T(...

journal_title：Scientific reports

authors： Ren JK,Zhu XB,Yu HF,Tian Y,Yang HF,Gu CZ,Wang NL,Ren YF,Zhao SP

更新日期：2012-01-01 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML version of this paper. The error has not been fixed in the paper. ...

journal_title：Scientific reports

authors： Sanchez-Alvarez M,Del Pozo MA,Bakal C

更新日期：2018-04-19 00:00:00

abstract：:Several studies have shown that the mu opioid receptor (MOR) located in the peripheral nerves can be activated after nerve injury and that it attenuates peripheral nociceptive signals to the spinal dorsal horn. Various cytokines and phosphorylated-p38 (p-p38) activation in the dorsal horn also play an important role i...

journal_title：Scientific reports

authors： Liao MF,Yeh SR,Lo AL,Chao PK,Lee YL,Hung YH,Lu KT,Ro LS

更新日期：2016-05-16 00:00:00

abstract：:Oysters are unusual among bivalves in that they possess chambers, often filled with soft, chalky calcite, that are irregularly scattered throughout the shell. Because the function of these so-called chalky deposits is still unclear, evaluating the growth and distribution of chalk is important for elucidating the ecolo...

journal_title：Scientific reports

authors： Banker RMW,Sumner DY

更新日期：2020-07-21 00:00:00

abstract：:Alternate bearing (AB) refers to the tendency of trees to have an irregular crop load from 1 year (ON) to the next year (OFF). Despite its economic importance, it is not fully understood how gene networks and their related metabolic pathways may influence the irregular bearing in olive trees. To unravel molecular mech...

journal_title：Scientific reports

authors： Dastkar E,Soleimani A,Jafary H,de Dios Alche J,Bahari A,Zeinalabedini M,Salami SA

更新日期：2020-09-25 00:00:00

abstract：:C4.4A is a modular glycolipid-anchored Ly6/uPAR/α-neurotoxin multidomain protein that exhibits a prominent membrane-associated expression in stratified squamous epithelia. C4.4A is also expressed in various solid cancer lesions, where high expression levels often are correlated to poor prognosis. Circumstantial eviden...

journal_title：Scientific reports

authors： Kriegbaum MC,Jacobsen B,Füchtbauer A,Hansen GH,Christensen IJ,Rundsten CF,Persson M,Engelholm LH,Madsen AN,Di Meo I,Lund IK,Holst B,Kjaer A,Lærum OD,Füchtbauer EM,Ploug M

更新日期：2016-05-12 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is closely associated with obesity, metabolic syndrome, and type II diabetes mellitus. Recently, circulating microRNAs (miRNAs) have been proposed as useful disease biomarkers. We examined whether circulating miRNAs, such as miR-20a, miR-27a, and miR-126, were useful biomarker...

journal_title：Scientific reports

authors： Ando Y,Yamazaki M,Yamada H,Munetsuna E,Fujii R,Mizuno G,Ichino N,Osakabe K,Sugimoto K,Ishikawa H,Ohashi K,Teradaira R,Ohta Y,Hamajima N,Hashimoto S,Suzuki K

更新日期：2019-12-11 00:00:00

abstract：:Regulation of the chromatin state is crucial for biological processes such as the regulation of transcription, DNA replication, and DNA damage repair. Here we show that knockdown of the BRD8 bromodomain protein - a subunit of the p400/Tip60 complex - leads to p21 induction, and concomitant cell cycle arrest in G1/S. W...

journal_title：Scientific reports

authors： Lashgari A,Fauteux M,Maréchal A,Gaudreau L

更新日期：2018-09-20 00:00:00

abstract：:Bioactive gibberellins (GAs) are essential phytohormones involved in the regulation of many aspects of plant development. GA receptors are crucial in GA signal transduction in plants. The GA receptor GoGID1 promotes plant elongation and improves biomass production when ectopically expressed in tobacco. Here, we discov...

journal_title：Scientific reports

authors： Wang X,Li J,Ban L,Wu Y,Wu X,Wang Y,Wen H,Chapurin V,Dzyubenko N,Li Z,Wang Z,Gao H

更新日期：2017-01-27 00:00:00

abstract：:The increasing demand for healthy baked goods boosted studies on sourdough microbiota with beneficial metabolic traits, to be used as potential functional starters. Here, 139 yeasts isolated from cereal-based fermented foods were in vitro characterized for their phytase and antioxidant activities. The molecular charac...

journal_title：Scientific reports

authors： Palla M,Blandino M,Grassi A,Giordano D,Sgherri C,Quartacci MF,Reyneri A,Agnolucci M,Giovannetti M

更新日期：2020-07-30 00:00:00

abstract：:CRISPR-Cas9/gRNA exhibits therapeutic efficacy against latent human immunodeficiency virus (HIV) genome but the delivery of this therapeutic cargo to the brain remains as a challenge. In this research, for the first time, we demonstrated magnetically guided non-invasive delivery of a nano-formulation (NF), composed of...

journal_title：Scientific reports

authors： Kaushik A,Yndart A,Atluri V,Tiwari S,Tomitaka A,Gupta P,Jayant RD,Alvarez-Carbonell D,Khalili K,Nair M

更新日期：2019-03-08 00:00:00

abstract：:Serious cutaneous adverse drug reactions [i.e., SJS/TEN with severe ocular complications (SOC)] associated with cold medicine (CM) were reported in several studies. To assess the risks of CM-induced SJS/TEN with SOC, systematic review and meta-analysis were employed. Studies investigating associations between HLA geno...

journal_title：Scientific reports

authors： Tangamornsuksan W,Chanprasert S,Nadee P,Rungruang S,Meesilsat N,Ueta M,Lohitnavy M

更新日期：2020-06-29 00:00:00

abstract：:Epididymal Cysteine Rich Secretory Proteins 1 and 4 (CRISP1 and CRISP4) associate with sperm during maturation and play different roles in fertilization. However, males lacking each of these molecules individually are fertile, suggesting compensatory mechanisms between these homologous proteins. Based on this, in the ...

journal_title：Scientific reports

authors： Carvajal G,Brukman NG,Weigel Muñoz M,Battistone MA,Guazzone VA,Ikawa M,Haruhiko M,Lustig L,Breton S,Cuasnicu PS

更新日期：2018-12-03 00:00:00

abstract：:It has previously been shown that the consumption of probiotics may have beneficial effects not only on peripheral tissues but also on the central nervous system and behavior via the microbiota-gut-brain axis, raising the possibility that treatment with probiotics could be an effective therapeutic strategy for managin...

journal_title：Scientific reports

authors： Kobayashi Y,Sugahara H,Shimada K,Mitsuyama E,Kuhara T,Yasuoka A,Kondo T,Abe K,Xiao JZ

更新日期：2017-10-18 00:00:00

abstract：:Pregnancy-associated malaria (PAM) is associated with poor pregnancy outcomes. Hemoglobin S (HbS) and hemoglobin C (HbC) mutations are frequently encountered in malaria-endemic areas of Africa, where they protect children from severe and uncomplicated Plasmodium falciparum malaria. However, scant epidemiological data ...

journal_title：Scientific reports

authors： Tétard M,Milet J,Dechavanne S,Fievet N,Dorin-Semblat D,Elion J,Fairhurst RM,Deloron P,Tuikue-Ndam N,Gamain B

更新日期：2017-05-03 00:00:00

abstract：:As critical primary producers and recyclers of organic matter, the diversity of marine protists has been extensively explored by high-throughput barcode sequencing. However, classification of short metabarcoding sequences into traditional taxonomic units is not trivial, especially for lineages mainly known by their ge...

journal_title：Scientific reports

authors： Cai R,Kayal E,Alves-de-Souza C,Bigeard E,Corre E,Jeanthon C,Marie D,Porcel BM,Siano R,Szymczak J,Wolf M,Guillou L

更新日期：2020-02-13 00:00:00

abstract：:Near infrared (NIR) fluorophores like Pt-porphyrin along with analyte specific enzymes require co-encapsulation in biocompatible and biodegradable carriers in order to be transformed into implantable biosensors for efficient and continuous monitoring of analytes in patients. The main objective of this research is to d...

journal_title：Scientific reports

authors： Pandey G,Chaudhari R,Joshi B,Choudhary S,Kaur J,Joshi A

更新日期：2019-03-22 00:00:00

abstract：:Constrained by the diffraction limit, a lens can only resolve features larger than half of the incident wavelength owing to the decaying nature of evanescent waves. Several novel devices have been proposed, for example, superlenses and hyperlenses to break this limit. In this work, we present a flat hyperlens composed...

journal_title：Scientific reports

authors： Tao CW,Yen TJ,Huang TY

更新日期：2020-03-24 00:00:00

abstract：:The aim of this study was to identify novel genetic markers related to coronary artery disease (CAD) using a whole-exome sequencing (WES) approach and determine any associations between the selected gene polymorphisms and CAD prevalence. CUBN, HNF1A and LIPC gene polymorphisms related to CAD susceptibility were identi...

journal_title：Scientific reports

authors： Park HS,Kim IJ,Kim EG,Ryu CS,Lee JY,Ko EJ,Park HW,Sung JH,Kim NK

更新日期：2020-10-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Ravaioli M,De Pace V,Angeletti A,Comai G,Vasuri F,Baldassarre M,Maroni L,Odaldi F,Fallani G,Caraceni P,Germinario G,Donadei C,Malvi D,Del Gaudio M,Bertuzzo VR,Siniscalchi A,Ranieri VM,D'Errico A,Pasquinelli G,Morell

更新日期：2020-09-01 00:00:00

abstract：:Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases, yet current therapeutic treatments are inadequate due to a complex disease pathogenesis. The plant polyphenol apigenin has been shown to have anti-inflammatory and neuroprotective properties in a number of cell and animal models; however...

journal_title：Scientific reports

authors： Balez R,Steiner N,Engel M,Muñoz SS,Lum JS,Wu Y,Wang D,Vallotton P,Sachdev P,O'Connor M,Sidhu K,Münch G,Ooi L

更新日期：2016-08-12 00:00:00

abstract：:A central goal of electronics based on correlated materials or 'Mottronics' is the ability to switch between distinct collective states with a control voltage. Small changes in structure and charge density near a transition can tip the balance between competing phases, leading to dramatic changes in electronic and mag...

journal_title：Scientific reports

authors： Liu M,Hoffman J,Wang J,Zhang J,Nelson-Cheeseman B,Bhattacharya A

更新日期：2013-01-01 00:00:00

abstract：:Insect pheromones offer potential for managing pests of crop plants. Volatility and instability are problems for deployment in agriculture but could be solved by expressing genes for the biosynthesis of pheromones in the crop plants. This has now been achieved by genetically engineering a hexaploid variety of wheat to...

journal_title：Scientific reports

authors： Bruce TJA,Aradottir GI,Smart LE,Martin JL,Caulfield JC,Doherty A,Sparks CA,Woodcock CM,Birkett MA,Napier JA,Jones HD,Pickett JA

更新日期：2015-06-25 00:00:00

abstract：:Pathologic diagnoses mainly depend on visual scoring by pathologists, a process that can be time-consuming, laborious, and susceptible to inter- and/or intra-observer variations. This study proposes a novel method to enhance pathologic scoring of renal allograft rejection. A fully automated system using a convolutiona...

journal_title：Scientific reports

authors： Kim YG,Choi G,Go H,Cho Y,Lee H,Lee AR,Park B,Kim N

更新日期：2019-03-26 00:00:00