C4.4A gene ablation is compatible with normal epidermal development and causes modest overt phenotypes.


:C4.4A is a modular glycolipid-anchored Ly6/uPAR/α-neurotoxin multidomain protein that exhibits a prominent membrane-associated expression in stratified squamous epithelia. C4.4A is also expressed in various solid cancer lesions, where high expression levels often are correlated to poor prognosis. Circumstantial evidence suggests a role for C4.4A in cell adhesion, migration, and invasion, but a well-defined biological function is currently unknown. In the present study, we have generated and characterized the first C4.4A-deficient mouse line to gain insight into the functional significance of C4.4A in normal physiology and cancer progression. The unchallenged C4.4A-deficient mice were viable, fertile, born in a normal Mendelian distribution and, surprisingly, displayed normal development of squamous epithelia. The C4.4A-deficient mice were, nonetheless, significantly lighter than littermate controls predominantly due to differences in fat mass. Congenital C4.4A deficiency delayed migration of keratinocytes enclosing incisional skin wounds in male mice. In chemically induced bladder carcinomas, C4.4A deficiency attenuated the incidence of invasive lesions despite having no effect on total tumour burden. This new C4.4A-deficient mouse line provides a useful platform for future studies on functional aspects of C4.4A in tumour cell invasion in vivo.


Sci Rep


Scientific reports


Kriegbaum MC,Jacobsen B,Füchtbauer A,Hansen GH,Christensen IJ,Rundsten CF,Persson M,Engelholm LH,Madsen AN,Di Meo I,Lund IK,Holst B,Kjaer A,Lærum OD,Füchtbauer EM,Ploug M




Has Abstract


2016-05-12 00:00:00










  • A clinicohaematological prognostic model for nasal-type natural killer/T-cell lymphoma: A multicenter study.

    abstract::Extranodal NK/T-cell lymphoma, nasal type (NKTL) is an aggressive type of non-Hodgkin lymphoma closely associated with Epstein-Barr virus and characterized by varying degrees of systemic inflammation. We aim to examine the prognostic significance of peripheral blood neutrophil-lymphocyte ratio (NLR) in patients with N...

    journal_title:Scientific reports

    pub_type: 杂志文章,多中心研究


    authors: Tan KM,Chia B,Lim JQ,Khoo LP,Cheng CL,Tan L,Poon E,Somasundaram N,Farid M,Tang TPL,Tao M,Cheah DMZ,Laurensia Y,Pang JWL,Song T,Tan J,Huang D,Kim SJ,Kim WS,Ong CK,Lim ST,Chan JY

    更新日期:2019-10-18 00:00:00

  • Recent Arctic tundra fire initiates widespread thermokarst development.

    abstract::Fire-induced permafrost degradation is well documented in boreal forests, but the role of fires in initiating thermokarst development in Arctic tundra is less well understood. Here we show that Arctic tundra fires may induce widespread thaw subsidence of permafrost terrain in the first seven years following the distur...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Jones BM,Grosse G,Arp CD,Miller E,Liu L,Hayes DJ,Larsen CF

    更新日期:2015-10-29 00:00:00

  • UPLC-Q-TOF/MS-based metabonomic studies on the intervention effects of aspirin eugenol ester in atherosclerosis hamsters.

    abstract::Based on the pro-drug principle, aspirin and eugenol were used to synthesize aspirin eugenol ester (AEE) by esterification reaction. In present study, the anti-atherosclerosis effects of AEE were investigated in hamsters with the utilization of metabonomic approach based on UPLC-Q-TOF/MS. Biochemical parameters and hi...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Ma N,Yang Y,Liu X,Kong X,Li S,Qin Z,Jiao Z,Li J

    更新日期:2017-09-05 00:00:00

  • Passive acoustic listening stations (PALS) show rapid onset of ecological effects of harmful algal blooms in real time.

    abstract::Monitoring ecological changes in marine ecosystems is expensive and time-consuming. Passive acoustic methods provide continuous monitoring of soniferous species, are relatively inexpensive, and can be integrated into a larger network to provide enhanced spatial and temporal coverage of ecological events. We demonstrat...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Rycyk AM,Tyson Moore RB,Wells RS,McHugh KA,Berens McCabe EJ,Mann DA

    更新日期:2020-10-20 00:00:00

  • An improved scheme on decoy-state method for measurement-device-independent quantum key distribution.

    abstract::Quantum key distribution involving decoy-states is a significant application of quantum information. By using three-intensity decoy-states of single-photon-added coherent sources, we propose a practically realizable scheme on quantum key distribution which approaches very closely the ideal asymptotic case of an infini...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Wang D,Li M,Guo GC,Wang Q

    更新日期:2015-10-14 00:00:00

  • Serum Autotaxin Is a Useful Disease Progression Marker in Patients with Primary Biliary Cholangitis.

    abstract::Autotaxin (ATX) is a secreted enzyme metabolized by liver sinusoidal endothelial cells that has been associated with liver fibrosis. We evaluated serum ATX values in 128 treatment-naïve, histologically assessed primary biliary cholangitis (PBC) patients and 80 healthy controls for comparisons of clinical parameters in...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Joshita S,Umemura T,Usami Y,Yamashita Y,Norman GL,Sugiura A,Yamazaki T,Fujimori N,Kimura T,Matsumoto A,Igarashi K,Yoshizawa K,Ota M,Tanaka E

    更新日期:2018-05-25 00:00:00

  • SOX9-regulated cell plasticity in colorectal metastasis is attenuated by rapamycin.

    abstract::The cancer stem cell (CSC) hypothesis proposes a hierarchical organization of tumors, in which stem-like cells sustain tumors and drive metastasis. The molecular mechanisms underlying the acquisition of CSCs and metastatic traits are not well understood. SOX9 is a transcription factor linked to stem cell maintenance a...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Carrasco-Garcia E,Lopez L,Aldaz P,Arevalo S,Aldaregia J,Egaña L,Bujanda L,Cheung M,Sampron N,Garcia I,Matheu A

    更新日期:2016-08-30 00:00:00

  • Rating knockdown of flour beetles after exposure to two insecticides as an indicator of mortality.

    abstract::Knockdown and mortality of adults of the red flour beetle, Tribolium castaneum (Herbst) and the confused flour beetle, Tribolium confusum Jacquelin du Val, were assessed after exposure to two contact insecticides, chlorfenapyr and cyfluthrin, on a concrete surface. Individuals were rated on a scale for knockdown of ex...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Athanassiou CG,Kavallieratos NG,Arthur FH,Nakas CT

    更新日期:2021-01-13 00:00:00

  • Association of self-regulation with white matter correlates in boys with and without autism spectrum disorder.

    abstract::Previous studies demonstrated distinct neural correlates underpinning impaired self-regulation (dysregulation) between individuals with autism spectrum disorder (ASD) and typically developing controls (TDC). However, the impacts of dysregulation on white matter (WM) microstructural property in ASD and TDC remain uncle...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Ni HC,Lin HY,Tseng WI,Gau SS

    更新日期:2020-08-14 00:00:00

  • Evaluating and forecasting movement patterns of magnetically driven microbeads in complex geometries.

    abstract::The manipulation of superparamagnetic microbeads for lab-on-a-chip applications relies on the steering of microbeads across an altering stray field landscape on top of soft magnetic parent structures. Using ab initio principles, we show three-dimensional simulations forecasting the controlled movement of microbeads. S...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Klingbeil F,Block F,Sajjad U,Holländer RB,Deshpande S,McCord J

    更新日期:2020-05-29 00:00:00

  • Determination of the concentration of impurities in GaN from photoluminescence and secondary-ion mass spectrometry.

    abstract::Photoluminescence (PL) was used to estimate the concentration of carbon in GaN grown by hydride vapor phase epitaxy (HVPE). The PL data were compared with profiles of the impurities obtained from secondary ion mass spectrometry (SIMS) measurements. Comparison of PL and SIMS data has revealed that apparently high conce...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Reshchikov MA,Vorobiov M,Andrieiev O,Ding K,Izyumskaya N,Avrutin V,Usikov A,Helava H,Makarov Y

    更新日期:2020-02-10 00:00:00

  • Resistance Switching and Memristive Hysteresis in Visible-Light-Activated Adsorbed ZnO Thin Films.

    abstract::The discovery of resistance switching memristors marks a paradigm shift in the search for alternative non-volatile memory components in the semiconductor industry. Normally a dielectric in these bistable memory cells changes its resistance with an applied electric field or current, albeit retaining the resistive state...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Barnes BK,Das KS

    更新日期:2018-02-01 00:00:00

  • Sensitive detection of extremely small iron oxide nanoparticles in living mice using MP2RAGE with advanced image co-registration.

    abstract::Magnetic resonance imaging (MRI) is a widely used non-invasive methodology for both preclinical and clinical studies. However, MRI lacks molecular specificity. Molecular contrast agents for MRI would be highly beneficial for detecting specific pathological lesions and quantitatively evaluating therapeutic efficacy in ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Kim JH,Dodd S,Ye FQ,Knutsen AK,Nguyen D,Wu H,Su S,Mastrogiacomo S,Esparza TJ,Swenson RE,Brody DL

    更新日期:2021-01-08 00:00:00

  • Tailoring Thermal Transport Properties of Graphene Paper by Structural Engineering.

    abstract::As a two-dimensional material, graphene has attracted increasing attention as heat dissipation material owing to its excellent thermal transport property. In this work, we fabricated sisal nanocrystalline cellulose/functionalized graphene papers (NPGs) with high thermal conductivity by vacuum-assisted self-assembly me...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Ren L,Wang M,Lu S,Pan L,Xiong Z,Zhang Z,Peng Q,Li Y,Yu J

    更新日期:2019-03-14 00:00:00

  • Author Correction: DRP-1-mediated apoptosis induces muscle degeneration in dystrophin mutants.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误


    authors: Scholtes C,Bellemin S,Martin E,Carre-Pierrat M,Mollereau B,Gieseler K,Walter L

    更新日期:2020-07-10 00:00:00

  • Aquaponics using a fish farm effluent shifts bacterial communities profile in halophytes rhizosphere and endosphere.

    abstract::The intensification of marine aquaculture raises multiple sustainability issues, namely the handling of nutrient-rich effluents that can adversely impact ecosystems. As integrated multi-trophic aquaculture (IMTA) gains momentum, the use of halophyte plants to phytoremediate aquaculture effluents has received growing a...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Oliveira V,Martins P,Marques B,Cleary DFR,Lillebø AI,Calado R

    更新日期:2020-06-22 00:00:00

  • Provitamin D3 modulation through prebiotics supplementation: simulation based assessment.

    abstract::Vitamin D is important in multiple health conditions. Vitamin D deficiency is prevalent globally even with exposure to adequate sunlight. Reduction in provitamin D3 (7-dehydrocholesterol, 7-DHC) is an important cause of vitamin D3 deficiency. Vitamin supplementation, food fortification, and use of probiotics are some ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Gokhale S,Bhaduri A

    更新日期:2019-12-17 00:00:00

  • Modeling dynamic interactions between pre-exposure prophylaxis interventions & treatment programs: predicting HIV transmission & resistance.

    abstract::Clinical trials have recently demonstrated the effectiveness of Pre-Exposure Prophylaxis (PrEP) in preventing HIV infection. Consequently, PrEP may soon be used for epidemic control. We model the dynamic interactions that will occur between treatment programs and potential PrEP interventions in resource-constrained co...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Supervie V,Barrett M,Kahn JS,Musuka G,Moeti TL,Busang L,Blower S

    更新日期:2011-01-01 00:00:00

  • Low blood cell counts in wild Japanese monkeys after the Fukushima Daiichi nuclear disaster.

    abstract::In April 2012 we carried out a 1-year hematological study on a population of wild Japanese monkeys inhabiting the forest area of Fukushima City. This area is located 70 km from the Fukushima Daiichi Nuclear Power Plant (NPP), which released a large amount of radioactive material into the environment following the Grea...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Ochiai K,Hayama S,Nakiri S,Nakanishi S,Ishii N,Uno T,Kato T,Konno F,Kawamoto Y,Tsuchida S,Omi T

    更新日期:2014-07-24 00:00:00

  • Vacancy-induced brittle to ductile transition of W-M co-doped Al3Ti (M=Si, Ge, Sn and Pb).

    abstract::We investigated the effect of vacancy formation on brittle (D022) to ductile (L12-like) transition in Al3Ti using DFT calculations. The well-known pseudogap on the density of states of Al3Ti migrates towards its Fermi level from far above, via a W - M co-doping strategy, where M is Si, Ge, Sn or Pb respectively. In pa...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Zhu M,Wu P,Li Q,Xu B

    更新日期:2017-10-25 00:00:00

  • Enhanced absorption in all-dielectric metasurfaces due to magnetic dipole excitation.

    abstract::All-dielectric nanophotonics lies at a forefront of nanoscience and technology as it allows to control light at the nanoscale using its electric and magnetic components. Bulk silicon does not experience any magnetic response, nevertheless, we demonstrate that the metasurface made of silicon parallelepipeds allows to e...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Terekhov PD,Baryshnikova KV,Greenberg Y,Fu YH,Evlyukhin AB,Shalin AS,Karabchevsky A

    更新日期:2019-03-05 00:00:00

  • 2H-NbS2 film as a novel counter electrode for meso-structured perovskite solar cells.

    abstract::We report the use of 2H-NbS2 film as a novel counter electrode in perovskite solar cells fabricated with a cold isostatic pressing method. The 2H-NbS2 film, which was prepared through an exfoliation method followed by restacking from LixNbS2 powder, shows high electrical conductivity of 8.7 × 103 S cm-1 and work funct...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Shao F,Tian Z,Qin P,Bu K,Zhao W,Xu L,Wang D,Huang F

    更新日期:2018-05-04 00:00:00

  • Light guiding and switching using eccentric core-shell geometries.

    abstract::High Refractive Index (HRI) dielectric nanoparticles have been proposed as an alternative to metallic ones due to their low absorption and magnetodielectric response in the VIS and NIR ranges. For the latter, important scattering directionality effects can be obtained. Also, systems constituted by dimers of HRI dielec...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Barreda ÁI,Gutiérrez Y,Sanz JM,González F,Moreno F

    更新日期:2017-09-11 00:00:00

  • Cortico-subcortical metabolic correlates of olfactory processing in healthy resting subjects.

    abstract::A wide network of interconnected areas was previously found in neuroimaging studies involving normal as well as pathological subjects; however literature seems to suffer from a lack of investigation in glucose metabolism behaviour under olfactory condition. Thus, the present work describe for the first time a pure olf...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Alessandrini M,Micarelli A,Chiaravalloti A,Candidi M,Bruno E,Di Pietro B,Schillaci O,Pagani M

    更新日期:2014-06-03 00:00:00

  • Stable carbon isotope as a signal index for monitoring grassland degradation.

    abstract::Grassland degradation due to overgrazing is common in many areas of the world. This study analyzed the potential of the stable carbon isotope (δ(13)C) value as a structural microcosmic index to monitor processes of grassland degradation. The δ(13)C values of plant leaves, roots and soils in non-grazed (NG) and over-gr...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Yao H,Wilkes A,Zhu G,Zhang H,Liu X,Dan Ding,Zhai X,Tang S,Chen Q,Zhang Y,Huang D,Wang C

    更新日期:2016-08-16 00:00:00

  • Association between anemia and bronchopulmonary dysplasia in preterm infants.

    abstract::Anemia is commonly seen in preterm infants. It may reduce the capacity of hemoglobin to transport oxygen throughout the body and may result in tissue and organ dysfunction. This study aimed to investigate the effect of anemia on the development of bronchopulmonary dysplasia (BPD) in preterm infants. 243 infants who we...

    journal_title:Scientific reports

    pub_type: 临床试验,杂志文章


    authors: Duan J,Kong X,Li Q,Hua S,Zhang S,Zhang X,Feng Z

    更新日期:2016-03-03 00:00:00

  • Coexisting and mixing phenomena of thermoacoustic and magnetoacoustic waves in water.

    abstract::Concurrent generation and mixing phenomenon of thermoacoustic (TA) and magnetoacoustic (MA) waves in water are predicted and observed. A theory unifying TA and MA is further put forward to analyze it. By scaling down the radio frequency in thermoacoustics to the low mega Hertz range and by incorporating appropriately ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Feng X,Gao F,Kishor R,Zheng Y

    更新日期:2015-06-26 00:00:00

  • Intradermal immunization by Ebola virus GP subunit vaccines using microneedle patches protects mice against lethal EBOV challenge.

    abstract::Development of a safe and efficacious filovirus vaccine is of high importance to public health. In this study, we compared immune responses induced by Ebola virus (EBOV) glycoprotein (GP) subunit vaccines via intradermal immunization with microneedle (MN) patches and the conventional intramuscular (IM) injection in mi...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Liu Y,Ye L,Lin F,Gomaa Y,Flyer D,Carrion R Jr,Patterson JL,Prausnitz MR,Smith G,Glenn G,Wu H,Compans RW,Yang C

    更新日期:2018-07-25 00:00:00

  • Bacterial community structure and function shift along a successional series of tidal flats in the Yellow River Delta.

    abstract::Coastal ecosystems play significant ecological and economic roles but are threatened and facing decline. Microbes drive various biogeochemical processes in coastal ecosystems. Tidal flats are critical components of coastal ecosystems; however, the structure and function of microbial communities in tidal flats are poor...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Lv X,Ma B,Yu J,Chang SX,Xu J,Li Y,Wang G,Han G,Bo G,Chu X

    更新日期:2016-11-08 00:00:00

  • Structural and mechanistic divergence of the small (p)ppGpp synthetases RelP and RelQ.

    abstract::The nutritional alarmones ppGpp and pppGpp (collectively: (p)ppGpp) are nucleotide-based second messengers enabling bacteria to respond to environmental and stress conditions. Several bacterial species contain two highly homologous (p)ppGpp synthetases named RelP (SAS2, YwaC) and RelQ (SAS1, YjbM). It is established t...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Steinchen W,Vogt MS,Altegoer F,Giammarinaro PI,Horvatek P,Wolz C,Bange G

    更新日期:2018-02-01 00:00:00