Abstract：
:C4.4A is a modular glycolipid-anchored Ly6/uPAR/α-neurotoxin multidomain protein that exhibits a prominent membrane-associated expression in stratified squamous epithelia. C4.4A is also expressed in various solid cancer lesions, where high expression levels often are correlated to poor prognosis. Circumstantial evidence suggests a role for C4.4A in cell adhesion, migration, and invasion, but a well-defined biological function is currently unknown. In the present study, we have generated and characterized the first C4.4A-deficient mouse line to gain insight into the functional significance of C4.4A in normal physiology and cancer progression. The unchallenged C4.4A-deficient mice were viable, fertile, born in a normal Mendelian distribution and, surprisingly, displayed normal development of squamous epithelia. The C4.4A-deficient mice were, nonetheless, significantly lighter than littermate controls predominantly due to differences in fat mass. Congenital C4.4A deficiency delayed migration of keratinocytes enclosing incisional skin wounds in male mice. In chemically induced bladder carcinomas, C4.4A deficiency attenuated the incidence of invasive lesions despite having no effect on total tumour burden. This new C4.4A-deficient mouse line provides a useful platform for future studies on functional aspects of C4.4A in tumour cell invasion in vivo.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Kriegbaum MC,Jacobsen B,Füchtbauer A,Hansen GH,Christensen IJ,Rundsten CF,Persson M,Engelholm LH,Madsen AN,Di Meo I,Lund IK,Holst B,Kjaer A,Lærum OD,Füchtbauer EM,Ploug Mdoi
10.1038/srep25833subject
Has Abstractpub_date
2016-05-12 00:00:00pages
25833issn
2045-2322pii
srep25833journal_volume
6pub_type
杂志文章abstract：:Src family of kinases (SFKs) has been found to play an important role in the regulation of nociception. However, how each member of this family acts in the central nervous system (CNS) structures involved in the relay and/or modulation of nociceptive signals, and thereby contributes to the formation and maintenance of...
journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2019-03-07 00:00:00
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pub_type： 杂志文章
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更新日期：2017-03-23 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-02-06 00:00:00
abstract：:The gut of Drosophila melanogaster includes a proximal acidic region (~pH 2), however the genome lacks the H(+)/K(+) ATPase characteristic of the mammalian gastric parietal cell, and the molecular mechanisms of acid generation are poorly understood. Here, we show that maintenance of the low pH of the acidic region is ...
journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-06-02 00:00:00
abstract：:We previously demonstrated that ABCD4 does not localize to peroxisomes but rather, the endoplasmic reticulum (ER), because it lacks the NH2-terminal hydrophilic region required for peroxisomal targeting. It was recently reported that mutations in ABCD4 result in a failure to release vitamin B12 from lysosomes. A simil...
journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-07-26 00:00:00
abstract：:A long-standing debate regarding the configuration of Pangea during the Late Paleozoic has been going on among the paleomagnetic community concerning the validity of one of two significantly different Pangea reconstructions (Pangea A vs Pangea B) since the proposal of Pangea B. Although, Pangea B avoids any continenta...
journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-05-31 00:00:00
abstract：:A method for defect characterization is presented that allows to measure the activation energy, capture cross-section, and defect density in dielectric materials. This is exemplarily performed on aluminum oxide thin films deposited on hydrogen-terminated diamond. During the measurement, samples were illuminated using ...
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pub_type： 杂志文章
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abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2020-09-14 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2019-03-07 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-08-03 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-08-16 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-12-23 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-08-14 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-02-23 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-08-11 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2021-01-15 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25205
更新日期：2016-04-26 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-05-27 00:00:00
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journal_title：Scientific reports
pub_type： 临床试验,杂志文章,多中心研究
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2019-04-04 00:00:00
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更新日期：2020-02-28 00:00:00
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pub_type： 杂志文章
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更新日期：2020-02-06 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2019-02-20 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-09-21 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2015-11-19 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2015-12-04 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2013-01-01 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09462
更新日期：2015-03-25 00:00:00
