Correlations between lncRNA-SOX2OT polymorphism and susceptibility to breast cancer in a Chinese population.

Abstract:

AIM:We evaluated the effect of lncRNA SOX2OT expression and its SNP in tumorigenesis and development of breast cancer (BC) in a case-control study. METHODS:A total of 1106 individuals, 505 newly diagnosed BC patients and 601 age-matched controls (±2 years) were testified. Real-time PCR was adopted for testing tissues' SOX2OT expression. Genotyping of rs9839776 were conducted by using SNaPshot assays. RESULTS:SOX2OT were overexpressed in BC tissues (p < 0.001). SOX2OT SNP rs9839776 was strongly associated with the higher expression of SOX2OT and an increased risk of BC in Chinese women (odds ratio: 1.42; 95% CI: 1.06-1.90; p = 0.018). CONCLUSION:These results confirmed that BC was conspicuously associated with higher SOX2OT expression. SOX2OT SNP rs9839776 was significantly associated with the onset of BC possibly via influencing the expression of SOX2OT.

journal_name

Biomark Med

journal_title

Biomarkers in medicine

authors

Tang X,Gao Y,Yu L,Lu Y,Zhou G,Cheng L,Sun K,Zhu B,Xu M,Liu J

doi

10.2217/bmm-2016-0238

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

277-284

issue

3

eissn

1752-0363

issn

1752-0371

journal_volume

11

pub_type

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