Evaluation of the relation between cardiac biomarkers and thorax computerized tomography findings in COVID-19 patients.

Abstract:

:Background: Troponin levels may be elevated in COVID-19 infection. The aim of this study was to the explore relation between troponin levels and COVID-19 severity. Materials & methods/Results: One hundred and forty consecutive patients with COVID-19 pneumonia were included. Diagnosis of COVID-19 pneumonia was based on positive chest computed tomography (CT) findings. Quantitative PCR test was performed in all patients. Only 74 patients were quantitative PCR-positive. Twenty four patients had severe CT findings and 27 patients had progressive disease. These patients had significantly lower albumin and higher ferritin, D-dimer, lactate dehydrogenase, C-reactive protein, and high-sensitivity cardiac troponin I (hs-cTnI). Conclusion: COVID-19 patients with severe CT findings and progressive disease had higher hs-cTnI levels suggesting the use of hs-cTnI in risk stratification.

journal_name

Biomark Med

journal_title

Biomarkers in medicine

authors

Ileri C,Dogan Z,Ozben B,Karaoglu C,Gunay N,Tigen K,Basat S,Uyan C

doi

10.2217/bmm-2020-0388

subject

Has Abstract

pub_date

2021-01-27 00:00:00

eissn

1752-0363

issn

1752-0371

pub_type

杂志文章
  • Identifying network-based biomarkers of complex diseases from high-throughput data.

    abstract::In this work, we review the main available computational methods of identifying biomarkers of complex diseases from high-throughput data. The emerging omics techniques provide powerful alternatives to measure thousands of molecules in cells in parallel manners. The generated genomic, transcriptomic, proteomic, metabol...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm-2015-0035

    authors: Liu ZP

    更新日期:2016-06-01 00:00:00

  • Correlation of peripheral arterial blood flow with plasma chemerin and VEGF in diabetic peripheral vascular disease.

    abstract:AIMS:Progressive vasodegeneration in microvascular beds is the major underlying factor in initiation and progression of diabetic complications. Chemerin shows a strong correlation with various facets of the metabolic syndrome, which is associated with dysregulated angiogenesis. VEGF is shown to have an angiogenic role ...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm.11.85

    authors: Zakareia FA

    更新日期:2012-02-01 00:00:00

  • FABP4 as a biomarker for knee osteoarthritis.

    abstract:AIM:To explore the role of an adipokine-termed fatty acid-binding protein 4 (FABP4) in osteoarthritis (OA). METHODS:Patients with primary knee OA and non-OA controls were included. Paired tissues including plasma, synovial fluid (SF), subcutaneous fat and infrapatellar fat pad (IPFP) were harvested during surgery. FAB...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2017-0207

    authors: Zhang C,Li T,Chiu KY,Wen C,Xu A,Yan CH

    更新日期:2018-02-01 00:00:00

  • Cardiotrophin-1 is associated with increased risk of arterial stiffness.

    abstract:AIM:Cardiotrophin-1 null mice presented decreased arterial stiffness. The aim of this study is to investigate the relationship between cardiotrophin-1 and arterial stiffness, assessed by brachial-ankle pulse-wave velocity (baPWV). METHODS:We enrolled 300 subjects, 200 with baPWV >1400 and 100 with baPWV ≤1400 cm/s. R...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm.14.87

    authors: Hung HC,Lu FH,Ou HY,Wu HT,Wu JS,Yang YC,Chang CJ

    更新日期:2015-01-01 00:00:00

  • Changing concept in treatment of asymptomatic severe aortic stenosis and normal ejection fraction: time for biomarkers reappraisal.

    abstract::The uncertainty of whether/how to treat asymptomatic patients with isolated severe aortic stenosis and normal left ventricular ejection fraction is one of the most topical in cardiovascular medicine. Recently, the AVATAR trial: first ever randomized trial in the setting of aortic stenosis has been started in an attemp...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2016-0369

    authors: Banovic MD

    更新日期:2017-04-01 00:00:00

  • Index of cardiac electrophysiological balance and transmural dispersion of the repolarization index relationships with pericardial fat volume and coronary calcification.

    abstract:AIM:To assess the possible relationship between coronary atherosclerosis markers, pericardial fat volume (PFV) and coronary artery calcification, with ECG markers of index of the cardiac electrophysiological balance (iCEB) and transmural dispersion of the repolarization in patients with suspected coronary artery diseas...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2017-0187

    authors: Nafakhi H,Al-Mosawi AA,Alareedh M,Al-Nafakh HA

    更新日期:2018-04-01 00:00:00

  • Cerebrospinal fluid biomarkers of Alzheimer's disease.

    abstract::Alzheimer's disease will reach epidemic proportions within the next 20-30 years if left unchecked. Currently, there are no treatments that prevent or slow Alzheimer's disease but many are being developed. Parallel efforts to develop biomarkers to aid in disease diagnosis and prognosis, and assess disease risk are curr...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/BMM.09.83

    authors: Fagan AM,Holtzman DM

    更新日期:2010-02-01 00:00:00

  • Discovering biomarkers in bladder cancer by metabolomics.

    abstract::It has become increasingly clear that the development of cancer, a multifactorial disease, cannot be explained by a single molecule or gene mutation. As a new discipline, metabolomics focuses on the body's metabolite changes, and attempts to find differences to explain the development of cancer; it has proven to be ef...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm-2018-0229

    authors: Zhang WT,Zhang ZW,Guo YD,Wang LS,Mao SY,Zhang JF,Liu MN,Yao XD

    更新日期:2018-12-01 00:00:00

  • Proteomic profiling identifies N-acetylmuramoyl-l-alanine amidase as a novel biomarker of sepsis.

    abstract:AIM:Sepsis is a critical condition that leads to high mortality and is the most common cause of death in intensive care units. Despite exhaustive efforts by the scientific community, a reliable biomarker for diagnosis, evolution and prognosis of sepsis is still lacking. Results & methodology: Here, using high-throughpu...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2016-0184

    authors: Pinheiro da Silva F,Cataldi TR,de Lima TM,Starzynski PN,Barbeiro HV,Labate MT,CéMachado MC,de Souza HP,Labate CA

    更新日期:2016-12-01 00:00:00

  • Genetic polymorphisms associated with overweight and obesity in uncontrolled Type 2 diabetes mellitus.

    abstract::Generally, obese and overweight individuals display higher free fatty acid levels, which stimulate insulin resistance. The combination of overweight or obesity with insulin resistance can trigger Type 2 diabetes mellitus (T2DM) and are primary contributing factors to the development of uncontrolled T2DM. Genetic polym...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm-2015-0037

    authors: Kasim NB,Huri HZ,Vethakkan SR,Ibrahim L,Abdullah BM

    更新日期:2016-01-01 00:00:00

  • Galectin-3 and acute heart failure: genetic polymorphisms, plasma level, myocardial fibrosis and 1-year outcomes.

    abstract::Aim: This study sought to investigate the relationship between galectin-3 (Gal-3), myocardial fibrosis (MF) and outcomes in acute heart failure. Materials & methods: The single-nucleotide polymorphisms (SNPs) of LGALS3 at rs4644 and rs4652, plasma Gal-3 level, MF and major adverse events (MAEs) were obtained. Results:...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2020-0269

    authors: Fu H,Nie S,Luo P,Ruan Y,Zhang Z,Miao H,Li X,Wen S,Bai R

    更新日期:2020-07-01 00:00:00

  • US FDA draft Guidance Standard for Clinical Trial Imaging Endpoints: more than just imaging?

    abstract::The current cost of developing a successful drug is typically over a billion dollars, with the registration trial(s) determining the success or failure of the entire development program. Often the primary endpoint of these trials is a subjective assessment. For registration trials with subjective endpoints, a regulato...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.12.74

    authors: Walovitch RC,Chokron P,Agarwal S

    更新日期:2012-12-01 00:00:00

  • Urinary biomarkers of bladder cancer: an update and future perspectives.

    abstract::Bladder cancer is one of the most prevalent cancers worldwide. Early detection of bladder tumors is critical for improved patient outcomes. The standard method for detection and surveillance of bladder tumors is cystoscopy with urinary cytology. Limitations of cystoscopy and urinary cytology have brought to light the ...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.13.73

    authors: Rosser CJ,Urquidi V,Goodison S

    更新日期:2013-10-01 00:00:00

  • Analytical aspects of molecular Alzheimer's disease biomarkers.

    abstract::In general, a biomarker has multiple uses such as a diagnostic tool and a method to monitor therapy. The quality of a biomarker depends on how big the difference is between, for example, patients and healthy controls, but also on the capacity of the method used to measure it (the uncertainty in the method should be mu...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.12.44

    authors: Andreasson U,Vanmechelen E,Shaw LM,Zetterberg H,Vanderstichele H

    更新日期:2012-08-01 00:00:00

  • Aptamers generated by Cell SELEX for biomarker discovery.

    abstract::Biomarker discovery is essential to the advancement of our knowledge about diseases and to the development of new strategies for treatment and therapy. Among the newest technologies in this rapidly growing field is a process termed Cell SELEX by which a panel of aptamers can be generated to specifically target disease...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm.09.5

    authors: Kim Y,Liu C,Tan W

    更新日期:2009-04-01 00:00:00

  • Plasma albumin levels predict risk for nonsurvivors in critically ill patients with COVID-19.

    abstract::Aim: We aimed to explore the biomarkers for disease progression or the risk of nonsurvivors. Materials & methods: This study included 134 hospitalized patients with confirmed COVID-19 infection. The outcome of moderate versus severe versus critically ill patients and survivors versus nonsurvivors were compared. Result...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2020-0254

    authors: Li J,Li M,Zheng S,Li M,Zhang M,Sun M,Li X,Deng A,Cai Y,Zhang H

    更新日期:2020-07-01 00:00:00

  • B-type natriuretic peptides in heart failure: update on clinical applications and limitations.

    abstract::Heart failure remains an important clinical and public health problem with significant mortality, morbidity and economic consequences. The identification of natriuretic peptides and the large number of investigations that followed have led to a better understanding of the neurohormonal pathophysiology of heart failure...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/17520363.1.4.503

    authors: Miller WL,Targonski PV,Jaffe AS

    更新日期:2007-12-01 00:00:00

  • The application of biomarkers in clinical trials for motor neuron disease.

    abstract::The interest and research into disease-related biomarkers has greatly accelerated over the last 10 years. The potential clinical benefits for disease-specific biomarkers include a more rapid and accurate disease diagnosis, and potential reduction in size and duration of clinical drug trials, which would speed up drug ...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.09.71

    authors: Ganesalingam J,Bowser R

    更新日期:2010-04-01 00:00:00

  • Human tissue biobanks as instruments for drug discovery and development: impact on personalized medicine.

    abstract::In recent years, biobanks of human tissues have evolved from small-scale collections of pathological materials into structured resource centers for acquisition, storage, processing and usage of high-quality biospecimens for research. This evolution goes hand in hand with the development of highly sensitive, high-throu...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm.10.104

    authors: Zatloukal K,Hainaut P

    更新日期:2010-12-01 00:00:00

  • Impact of expression of the uPA system in sarcomas.

    abstract::The uPA system mainly comprises the urokinase-type plasminogen activator uPA, the cell-surface receptor uPA receptor and the inhibitor PAI-1. Its clinical and prognostic impact especially in breast cancer is well investigated. In this short report, we summarize the published data describing expression of uPA, PAI-1 an...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.12.105

    authors: Taubert H,Magdolen V,Kotzsch M

    更新日期:2013-06-01 00:00:00

  • Serum YKL-40 for monitoring myocardial ischemia after revascularization in patients with stable coronary artery disease.

    abstract:AIM:The aim was to investigate the inflammatory biomarker YKL-40 as a monitor of myocardial ischemia in patients with coronary artery disease (CAD). METHODS:A total of 311 patients with stable CAD were included. Blood samples were taken at baseline, the day after coronary angiography and/or after percutaneous coronary...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm.14.20

    authors: Harutyunyan M,Johansen JS,Mygind ND,Reuter SB,Kastrup J

    更新日期:2014-01-01 00:00:00

  • Endostatin: a promising biomarker in the cardiovascular continuum?

    abstract::The current review article aims to provide an up-to-date summary of previous studies in humans that have reported the association between circulating endostatin levels and different cardiovascular phenotypes. We also aim to provide suggestions for future directions of future research evaluating endostatin as a clinica...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm-2017-0025

    authors: Ruge T,Carlsson AC,Larsson A,Ärnlöv J

    更新日期:2017-10-01 00:00:00

  • Interferons as biomarkers and effectors: lessons learned from animal models.

    abstract::Interferons (IFNs) comprise type I, II and III families with multiple subtypes. Via transcription of IFN-stimulated genes (ISGs), IFNs can exert multiple biological effects on the cell. In infectious and chronic inflammatory diseases, the IFNs and their ISG sets can be potentially utilized as biomarkers of disease out...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.12.10

    authors: Berry CM,Hertzog PJ,Mangan NE

    更新日期:2012-04-01 00:00:00

  • Prognostic utility of the combination of pretreatment monocyte-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in patients with NMIBC after transurethral resection.

    abstract::Aim: To investigate and validate predictive value of combination of pretreatment monocyte-to-lymphocyte ratio (MLR) and neutrophil-to-lymphocyte ratio (NLR) for disease free survival (DFS) and overall survival (OS) in nonmuscle invasive bladder cancer after transurethral resection. Materials & methods: Total 358 patie...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2019-0398

    authors: Wang Q,Huang T,Ji J,Wang H,Guo C,Sun X,Zheng K,Dong Z,Cao Y

    更新日期:2019-12-01 00:00:00

  • Predictive biomarkers for immunotherapy efficacy in non-small-cell lung cancer: current status and future perspectives.

    abstract::In recent years, immune checkpoint inhibitors have rapidly changed treatment paradigms and have been pivotal for the treatment of advanced NSCLC patients. However, many patients don't respond to immunotherapy, and toxicities are a concern. Mounting evidence suggests that PD-L1 expression and tumor mutational burden ar...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2020-0310

    authors: C Guven D,Sahin TK,Dizdar O,Kilickap S

    更新日期:2020-10-01 00:00:00

  • Biomarkers of inflammation and oxidative stress in atherosclerosis.

    abstract::Increasing evidence has highlighted the roles of oxidative stress and inflammation in the promotion of atherosclerotic cardiovascular disease. Recent pathological studies have elucidated specific mediators that appear to link these pathways to the progression and rupture of atherosclerotic plaque in the artery wall. T...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.10.57

    authors: Uno K,Nicholls SJ

    更新日期:2010-06-01 00:00:00

  • The 44th Congress of the International Society of Oncology and Biomarkers: Rio de Janeiro, Brazil, 7-10 September 2017.

    abstract::The 44th Congress of the International Society of Oncology and Biomarkers: Rio de Janeiro, Brazil, 7-10 September 2017 The 44th congress followed the previous one of  International Society of Oncology and Biomarkers (ISOBM) that took place in Chicago (USA) in 2016. The title of the 44th Annual congress was: 'Biomarker...

    journal_title:Biomarkers in medicine

    pub_type:

    doi:10.2217/bmm-2017-0402

    authors: Kinkorová J

    更新日期:2018-02-01 00:00:00

  • Determination of the severity of ureteropelvic junction obstruction using urinary epidermal growth factor and kidney injury molecule 1 levels.

    abstract:AIM:This study aimed to assess the urinary concentrations of epidermal growth factor (EGF) and kidney injury molecule 1 (KIM-1) in patients with hydronephrosis. METHODS:Neonates with a history of prenatal hydronephrosis were enrolled in three groups. Group 1 included neonates with severe obstruction; group 2 included ...

    journal_title:Biomarkers in medicine

    pub_type: 临床试验,杂志文章

    doi:10.2217/bmm.14.79

    authors: Mohammadjafari H,Rafiei A,Kosaryan M,Yeganeh Y,Hosseinimehr SJ

    更新日期:2014-01-01 00:00:00

  • Association between Lp (a) and atherosclerosis in menopausal women without metabolic syndrome.

    abstract:AIM:The association between Lipoprotein (a) (Lp [a]) and common carotid intima media thickness (IMT) has been evaluated in 222 menopausal women. MATERIAL & METHODS:Lp (a) and IMT were measured, carotid ultrasound examination (B-Mode imaging) was performed and mean max IMT was calculated. RESULTS:Lp (a) was significan...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm.16.4

    authors: Gentile M,Iannuzzo G,Mattiello A,Marotta G,Iannuzzi A,Panico S,Rubba P

    更新日期:2016-01-01 00:00:00

  • Drug exposure: still an excellent biomarker.

    abstract::Relationships between plasma drug concentrations and clinical outcome have been defined for various chemotherapeutic agents, showing that drug exposure may be a marker of toxicity, mainly hematological and gastrointestinal toxicity, as well as efficacy, expressed as tumor response and survival. Biomarkers provide info...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm.09.58

    authors: Meza-Junco J,Sawyer MB

    更新日期:2009-12-01 00:00:00