Abstract:
BACKGROUND:Autism spectrum disorder (ASD) represents a wide range of neurodevelopmental disorders characterized by impairments in social interaction, language, communication and range of interests. Autism is usually diagnosed in children 3-5 years of age using behavioral characteristics; thus, diagnosis shortly after birth would be beneficial for early initiation of treatment. AIM:This retrospective study sought to identify newborns at risk for ASD utilizing bloodspot specimens in an immunoassay. MATERIALS & METHODS:The present study utilized stored frozen specimens from ASD children already diagnosed at 15-36 months of age. The newborn specimens and controls were analyzed by immunoassay in a multiplex system that included 90 serum biomarkers and subjected to statisical analysis. RESULTS:Three sets of five biomarkers associated with ASD were found that differed from control groups. The 15 candidate biomarkers were then discussed regarding their association with ASD. CONCLUSION:This study determined that a statistically selected panel of 15 biomarkers successfully discriminated presumptive newborns at risk for ASD from those of nonaffected controls.
journal_name
Biomark Medjournal_title
Biomarkers in medicineauthors
Mizejewski GJ,Lindau-Shepard B,Pass KAdoi
10.2217/bmm.12.108subject
Has Abstractpub_date
2013-04-01 00:00:00pages
247-60issue
2eissn
1752-0363issn
1752-0371journal_volume
7pub_type
杂志文章abstract:AIM:We aimed to investigate whether baseline monocyte to high-density lipoprotein cholesterol ratio (MHR), an easily available inflammatory and oxidative stress marker, is associated with SYNTAX score. PATIENTS & METHODS:In this cross-sectional study, n = 1229 consecutive patients with coronary artery disease were cla...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2015-0050
更新日期:2016-01-01 00:00:00
abstract::Currently, decision-making for breast cancer treatment in the clinical setting is mainly based on clinical data, histomorphological features of the tumor tissue and a few cancer biomarkers such as steroid hormone receptor status (estrogen and progesterone receptors) and oncoprotein HER2 status. Although various therap...
journal_title:Biomarkers in medicine
pub_type: 杂志文章,评审
doi:10.2217/bmm.10.73
更新日期:2010-08-01 00:00:00
abstract:AIM:To assess the possible relationship between coronary atherosclerosis markers, pericardial fat volume (PFV) and coronary artery calcification, with ECG markers of index of the cardiac electrophysiological balance (iCEB) and transmural dispersion of the repolarization in patients with suspected coronary artery diseas...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2017-0187
更新日期:2018-04-01 00:00:00
abstract::It has become increasingly clear that the development of cancer, a multifactorial disease, cannot be explained by a single molecule or gene mutation. As a new discipline, metabolomics focuses on the body's metabolite changes, and attempts to find differences to explain the development of cancer; it has proven to be ef...
journal_title:Biomarkers in medicine
pub_type: 杂志文章,评审
doi:10.2217/bmm-2018-0229
更新日期:2018-12-01 00:00:00
abstract::Aim: Natural killer cell receptor group 2D (NKG2D) plays an important role in the immune regulation of tumors. We speculate that DNA methylation are involved in the regulation of NKG2D gene. Methods: We investigated the methylation status of the NKG2D promoter in peripheral blood mononuclear cells of hepatocellular ca...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2019-0102
更新日期:2019-09-01 00:00:00
abstract::Letter in regards to: Akboga MK, Balci KG, Maden O et al. Usefulness of monocyte to HDL-cholesterol ratio to predict high SYNTAX score in patients with stable coronary artery disease. Biomark. Med. 10(4), 375-383 (2016). ...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2016-0326
更新日期:2017-08-01 00:00:00
abstract::Aim: Some patients experience statin-associated muscle symptoms (SAMS) and elevated serum concentrations of CK. The relationship between SAMS and biomarkers of muscle damage was examined. Methods: We analyzed 359 consecutive patients taking statins with high CK values. Muscle-related symptoms and biochemical variables...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2018-0379
更新日期:2019-06-01 00:00:00
abstract:AIM:To explore the role of an adipokine-termed fatty acid-binding protein 4 (FABP4) in osteoarthritis (OA). METHODS:Patients with primary knee OA and non-OA controls were included. Paired tissues including plasma, synovial fluid (SF), subcutaneous fat and infrapatellar fat pad (IPFP) were harvested during surgery. FAB...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2017-0207
更新日期:2018-02-01 00:00:00
abstract::Epilepsy and seizures are very common in the early years of life and are often associated with significant morbidity and mortality. Identification of biomarkers for the early detection of epileptogenicity, epileptogenesis, comorbidities, disease progression and treatment implementation will be very important in implem...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm.11.71
更新日期:2011-10-01 00:00:00
abstract::Alzheimer's disease will reach epidemic proportions within the next 20-30 years if left unchecked. Currently, there are no treatments that prevent or slow Alzheimer's disease but many are being developed. Parallel efforts to develop biomarkers to aid in disease diagnosis and prognosis, and assess disease risk are curr...
journal_title:Biomarkers in medicine
pub_type: 杂志文章,评审
doi:10.2217/BMM.09.83
更新日期:2010-02-01 00:00:00
abstract:AIM:LncRNAs may act as promising biomarkers in esophageal cancer (EC). Here, we illustrate the LncRNA profile and their clinical relevance in EC. PATIENTS & METHODS:In this study, we utilized the Cancer Genome Atlas RNA-sequencing and clinical data from 186 patients and 13 normal samples. Various statistical and gene ...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2018-0032
更新日期:2018-10-01 00:00:00
abstract::In general, a biomarker has multiple uses such as a diagnostic tool and a method to monitor therapy. The quality of a biomarker depends on how big the difference is between, for example, patients and healthy controls, but also on the capacity of the method used to measure it (the uncertainty in the method should be mu...
journal_title:Biomarkers in medicine
pub_type: 杂志文章,评审
doi:10.2217/bmm.12.44
更新日期:2012-08-01 00:00:00
abstract::Coronary heart disease (CHD) is the main cause of death in post-menopausal women (PMW). Beyond the 'traditional' cardiovascular risk factors of CHD, newer biomarkers, reflecting inflammation, endothelial function and oxidative stress, have received growing consideration. We systematically reviewed the literature on th...
journal_title:Biomarkers in medicine
pub_type: 杂志文章,meta分析,评审
doi:10.2217/bmm.11.51
更新日期:2011-08-01 00:00:00
abstract:AIM:Childhood cancer remains one of the main cause of death in the pediatric population. Amino acids (AAs) level alterations in plasma are considered to play a role in carcinogenesis and further course of the disease. METHODS:Seventy-seven children with cancer, including 47 with hematological and 30 with solid tumors ...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2017-0102
更新日期:2017-08-01 00:00:00
abstract::The aim of this meta-analysis was to review the available evidence regarding the blood concentrations of the oxidative stress marker malondialdehyde (MDA) in chronic obstructive pulmonary disease (COPD) patients in comparison to healthy individuals. 14 studies were included in the meta-analysis (from inception to Octo...
journal_title:Biomarkers in medicine
pub_type: 杂志文章,meta分析
doi:10.2217/bmm-2017-0420
更新日期:2018-07-01 00:00:00
abstract::With increasing knowledge of the regulatory mechanisms of G-protein-coupled receptor signaling in heart physiology, many studies have focused on the role of this system in cardiovascular disease. In recent years, scientists have moved their attention from the receptors to their regulatory proteins: the G-protein-coupl...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm.09.50
更新日期:2009-10-01 00:00:00
abstract:AIM:This study aimed to assess the urinary concentrations of epidermal growth factor (EGF) and kidney injury molecule 1 (KIM-1) in patients with hydronephrosis. METHODS:Neonates with a history of prenatal hydronephrosis were enrolled in three groups. Group 1 included neonates with severe obstruction; group 2 included ...
journal_title:Biomarkers in medicine
pub_type: 临床试验,杂志文章
doi:10.2217/bmm.14.79
更新日期:2014-01-01 00:00:00
abstract::Interferons (IFNs) comprise type I, II and III families with multiple subtypes. Via transcription of IFN-stimulated genes (ISGs), IFNs can exert multiple biological effects on the cell. In infectious and chronic inflammatory diseases, the IFNs and their ISG sets can be potentially utilized as biomarkers of disease out...
journal_title:Biomarkers in medicine
pub_type: 杂志文章,评审
doi:10.2217/bmm.12.10
更新日期:2012-04-01 00:00:00
abstract::Dr Jake Micallef speaks to Hannah L Wilson, Commissioning Editor: Dr Micallef has 20 years of experience in research and development and in the management of early-stage biotechnical companies, including the manufacture of biotechnology products and the establishment of manufacturing operations. Dr Micallef gained thi...
journal_title:Biomarkers in medicine
pub_type: 传,历史文章,面试
doi:10.2217/bmm.14.47
更新日期:2014-01-01 00:00:00
abstract:AIM:This meta-analysis was designed to analyze and evaluate the prognostic role of preoperative or pretreatment platelet-to-lymphocyte ratio (PLR) in patients with colorectal cancer (CRC). METHOD:We searched PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Chinese Biomedical L...
journal_title:Biomarkers in medicine
pub_type: 杂志文章,meta分析
doi:10.2217/bmm-2016-0181
更新日期:2017-01-01 00:00:00
abstract::Aim: The diagnostic and prognostic role of procalcitonin (PCT) and mid-regional-pro-adrenomedullin (MR-proADM) were investigated in patients with pneumonia. Material & methods: A total of 168 and 77 patients with pneumonia enrolled in two different hospital settings, an internal medicine unit and an emergency unit wer...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2019-0414
更新日期:2020-05-01 00:00:00
abstract:AIM:Predicting a poor treatment outcome would offer significant benefits for patient care and for new drug development. Materials, methods & results: Urine samples from tuberculosis-positive patients with a successful and unsuccessful treatment outcome were collected at baseline and analyzed. The identified metabolites...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2017-0133
更新日期:2017-12-01 00:00:00
abstract::Aim: To evaluate an 8.7-kb mitochondrial DNA (mtDNA) deletion as a potential biomarker of endometriosis. Materials & methods: We tested the diagnostic accuracy of the 8.7-kb deletion real-time PCR assay using 182 prospectively collected blood samples from females presenting with symptoms of endometriosis in a case-con...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2019-0451
更新日期:2020-02-01 00:00:00
abstract::Background: The Tp-e/QT (peak to end of T-wave duration/QT interval) ratio is a promising marker of myocardial repolarization and ventricular arrhythmogenesis. Its elevation is associated with sudden cardiac death in different clinical conditions. This study was designed to assess the possible association between incr...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2020-0230
更新日期:2020-12-01 00:00:00
abstract:AIM:The aim of the present study was to investigate the association of circulating miRNAs with white-coat hypertension (WCH) and further analyze whether miRNAs could be as potential biomarkers for WCH. METHOD:Quantitative reverse transcriptase PCR (qRT-PCR) was used to evaluate the expression of selected miRNAs. The a...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2016-0215
更新日期:2016-12-01 00:00:00
abstract:AIM:To investigate the expression of FLNA and its potential prognostic significance in cervical cancer. PATIENTS & METHODS:Real-time PCR was performed to evaluate the expression levels of FLNA in 44 pairs of cervical cancer and matched normal adjacent tissues. Kaplan-Meier analysis and Cox proportional hazards model w...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2016-0056
更新日期:2016-07-01 00:00:00
abstract::Aim: To develop robust and accurate prognostic biomarkers to help clinicians optimize therapeutic strategies. Materials & methods: Differentially prognosis-related autophagy genes were identified by bioinformatics analysis method. Results: Seven prognosis-related autophagy genes were more significantly related to the ...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2020-0170
更新日期:2020-09-01 00:00:00
abstract::Aim: To investigate and validate predictive value of combination of pretreatment monocyte-to-lymphocyte ratio (MLR) and neutrophil-to-lymphocyte ratio (NLR) for disease free survival (DFS) and overall survival (OS) in nonmuscle invasive bladder cancer after transurethral resection. Materials & methods: Total 358 patie...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2019-0398
更新日期:2019-12-01 00:00:00
abstract::Cardiac troponin is the standard biomarker for the diagnosis of acute myocardial infarction (AMI) and risk stratification for short-term adverse cardiac events (death, AMI or need for revascularization). Unfortunately, the concentration of troponin in blood is normal in AMI patients who present early after the onset o...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/17520363.1.1.45
更新日期:2007-06-01 00:00:00
abstract:AIM:The purpose of this study was to establish the influence of centrifugation and protease activity on the cerebrospinal fluid (CSF) concentrations of DJ-1 and hemoglobin. MATERIALS & METHODS:The concentrations of DJ-1 and hemoglobin were determined in 12 (DJ-1) and six (hemoglobin) pairs of CSF samples, with one sam...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm.13.125
更新日期:2014-01-01 00:00:00