Biochemical markers of muscle damage and high serum concentration of creatine kinase in patients on statin therapy.

abstract：:Cardiovascular disease refers to different diseases involving the heart and/or the arteries and/or the veins. Cardiovascular disease, overall considered, is a notable source of morbidity and mortality worldwide. Therefore, several research studies are dedicated to explore, by means of biomarkers, the possiblity to cal...

journal_title：Biomarkers in medicine

authors： Serra R,Ielapi N,Barbetta A,Andreucci M,de Franciscis S

更新日期：2018-09-01 00:00:00

abstract：:Aim: This study sought to investigate the relationship between galectin-3 (Gal-3), myocardial fibrosis (MF) and outcomes in acute heart failure. Materials & methods: The single-nucleotide polymorphisms (SNPs) of LGALS3 at rs4644 and rs4652, plasma Gal-3 level, MF and major adverse events (MAEs) were obtained. Results:...

journal_title：Biomarkers in medicine

authors： Fu H,Nie S,Luo P,Ruan Y,Zhang Z,Miao H,Li X,Wen S,Bai R

更新日期：2020-07-01 00:00:00

abstract：AIM:To investigate the role of gelsolin-like actin-capping protein (CapG) in prostate cancer (PCa). MATERIALS & METHODS:CapG expression and its correlation with clinicopathological characters and patient prognosis were analyzed in 76 cases of PCa by immunohistochemistry and qRT-PCR. Then, the influence of CapG downreg...

journal_title：Biomarkers in medicine

authors： Li T,Hong X,Zhao J,Teng Y,Zheng J,Chen H,Chen H,Li H

更新日期：2016-12-01 00:00:00

abstract：AIM:To investigate the prognostic performance of complement components in septic patients, complement 3, membrane attack complex (MAC) and mannose-binding lectin were measured and compared among adult patients with sepsis, severe sepsis and septic shock, as well as between in-hospital nonsurvivors and survivors. METHO...

journal_title：Biomarkers in medicine

authors： Zhao X,Chen YX,Li CS

更新日期：2015-01-01 00:00:00

abstract：AIM:Specific miRNA profiles have been identified for several samples from patients with bladder cancer. The results are not always congruent and partly contradictory. A comparison of published data was performed to select potential markers. MATERIALS & METHODS:A literature search in PubMed identified 79 articles publi...

journal_title：Biomarkers in medicine

authors： Tölle A,Ratert N,Jung K

更新日期：2014-01-01 00:00:00

abstract：:Impression cytology (IC) is a technique which permits the retrieval of the outermost layer of ocular surface cells via the use of various types of filters. It is a minimally invasive method of evaluating human conjunctival epithelial cell morphology in the diagnosis of dry eye disease, a common and distressing disorde...

journal_title：Biomarkers in medicine

authors： Hagan S

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Autism spectrum disorder (ASD) represents a wide range of neurodevelopmental disorders characterized by impairments in social interaction, language, communication and range of interests. Autism is usually diagnosed in children 3-5 years of age using behavioral characteristics; thus, diagnosis shortly after b...

journal_title：Biomarkers in medicine

authors： Mizejewski GJ,Lindau-Shepard B,Pass KA

更新日期：2013-04-01 00:00:00

abstract：AIM:To investigate the role of MMP-9 (-1562 C:T) polymorphism as a biomarker for susceptibility to pre-eclampsia. PATIENTS & METHODS:MMP-9 variants were detected in 160 women with mild and severe pre-eclampsia and 112 healthy pregnant women. RESULTS:A significantly higher frequency of MMP-9 CT genotype was observed i...

journal_title：Biomarkers in medicine

authors： Rahimi Z,Rahimi Z,Shahsavandi MO,Bidoki K,Rezaei M

更新日期：2013-02-01 00:00:00

abstract：:Coronary heart disease (CHD) is the main cause of death in post-menopausal women (PMW). Beyond the 'traditional' cardiovascular risk factors of CHD, newer biomarkers, reflecting inflammation, endothelial function and oxidative stress, have received growing consideration. We systematically reviewed the literature on th...

journal_title：Biomarkers in medicine

authors： Spoletini I,Vitale C,Rosano GM

更新日期：2011-08-01 00:00:00

abstract：AIM:This study aimed to assess the urinary concentrations of epidermal growth factor (EGF) and kidney injury molecule 1 (KIM-1) in patients with hydronephrosis. METHODS:Neonates with a history of prenatal hydronephrosis were enrolled in three groups. Group 1 included neonates with severe obstruction; group 2 included ...

journal_title：Biomarkers in medicine

authors： Mohammadjafari H,Rafiei A,Kosaryan M,Yeganeh Y,Hosseinimehr SJ

更新日期：2014-01-01 00:00:00

abstract：:The application of genomic medicine to the treatment of nicotine dependence holds great promise for revitalizing the steady decline in smoking rates witnessed in the USA over the past several decades. This paper examines the current knowledge base concerning the use of biomarkers to guide the selection of nicotine dep...

journal_title：Biomarkers in medicine

authors： Schnoll RA,Leone FT

更新日期：2011-12-01 00:00:00

abstract：:The uPA system mainly comprises the urokinase-type plasminogen activator uPA, the cell-surface receptor uPA receptor and the inhibitor PAI-1. Its clinical and prognostic impact especially in breast cancer is well investigated. In this short report, we summarize the published data describing expression of uPA, PAI-1 an...

journal_title：Biomarkers in medicine

authors： Taubert H,Magdolen V,Kotzsch M

更新日期：2013-06-01 00:00:00

abstract：:Like all human cancers, colorectal cancer is a complicated disease. While a mature body of research involving colorectal cancer has implicated the putative sequence of genetic alterations that trigger the disease and sustain its progression, there is a surprising paucity of well-validated, clinically useful diagnostic...

journal_title：Biomarkers in medicine

authors： Nibbe RK,Chance MR

更新日期：2009-08-01 00:00:00

abstract：:Aim: To develop robust and accurate prognostic biomarkers to help clinicians optimize therapeutic strategies. Materials & methods: Differentially prognosis-related autophagy genes were identified by bioinformatics analysis method. Results: Seven prognosis-related autophagy genes were more significantly related to the ...

journal_title：Biomarkers in medicine

authors： Wang J,Miao Y,Ran J,Yang Y,Guan Q,Mi D

更新日期：2020-09-01 00:00:00

abstract：:Systemic sclerosis is an autoimmune inflammatory disorder of unknown etiologycharacterized b y pronounced fibroproliferative alterations in the microvasculature, and frequent cellular and humoral immunity abnormalities, culminating in a severe and often progressive fibrotic process. Numerous biomarkers reflecting the ...

journal_title：Biomarkers in medicine

authors： Castro SV,Jimenez SA

更新日期：2010-02-01 00:00:00

abstract：:Dr Jake Micallef speaks to Hannah L Wilson, Commissioning Editor: Dr Micallef has 20 years of experience in research and development and in the management of early-stage biotechnical companies, including the manufacture of biotechnology products and the establishment of manufacturing operations. Dr Micallef gained thi...

journal_title：Biomarkers in medicine

authors： Micallef J,Wilson HL

更新日期：2014-01-01 00:00:00

abstract：AIM:The role of octamer-binding transcription factor 4 (Oct4) in gastric cancer (GC) progression is still under debate and reported results are inconsistent. Therefore, we conducted a meta-analysis to evaluate the clinicopathological and prognostic significance of Oct4 expression in patients with GC. MATERIALS & METHO...

journal_title：Biomarkers in medicine

authors： Wei Y,Liu H,Wang C,Zhang W,Wen X,Long H,Xu Z,Guo H,Liu Y,Wei D,Qiu C,Li G,Sun Z

更新日期：2019-02-01 00:00:00

abstract：AIM:LncRNAs may act as promising biomarkers in esophageal cancer (EC). Here, we illustrate the LncRNA profile and their clinical relevance in EC. PATIENTS & METHODS:In this study, we utilized the Cancer Genome Atlas RNA-sequencing and clinical data from 186 patients and 13 normal samples. Various statistical and gene ...

journal_title：Biomarkers in medicine

authors： Khadirnaikar S,Narayanan SP,Shukla SK

更新日期：2018-10-01 00:00:00

abstract：AIM:To assess the possible relationship between coronary atherosclerosis markers, pericardial fat volume (PFV) and coronary artery calcification, with ECG markers of index of the cardiac electrophysiological balance (iCEB) and transmural dispersion of the repolarization in patients with suspected coronary artery diseas...

journal_title：Biomarkers in medicine

authors： Nafakhi H,Al-Mosawi AA,Alareedh M,Al-Nafakh HA

更新日期：2018-04-01 00:00:00

abstract：AIMS:Progressive vasodegeneration in microvascular beds is the major underlying factor in initiation and progression of diabetic complications. Chemerin shows a strong correlation with various facets of the metabolic syndrome, which is associated with dysregulated angiogenesis. VEGF is shown to have an angiogenic role ...

journal_title：Biomarkers in medicine

authors： Zakareia FA

更新日期：2012-02-01 00:00:00

abstract：AIM:Because of the delayed rise of serum creatinine concentrations, novel biomarkers such as NGAL, GST and KIM-1 are proposed to detect acute kidney injury (AKI). In this study we evaluated these biomarkers. MATERIALS & METHODS:Twenty-six consecutive adult liver transplantations were evaluated. Markers were measured a...

journal_title：Biomarkers in medicine

authors： Dedeoglu B,de Geus HR,Fortrie G,Betjes MG

更新日期：2013-12-01 00:00:00

abstract：:The field of immuno-oncology has witnessed unprecedented success in recent years, with several PD=1 and PD-L1 inhibitors obtaining US FDA registration and breakthrough drug therapy designation in multiple tumor types. Despite its clear efficacy in certain cancers, treatment with these agents carries a risk of immune-r...

journal_title：Biomarkers in medicine

authors： Lim JS,Sundar R,Chénard-Poirier M,Lopez J,Yap TA

更新日期：2017-01-01 00:00:00

abstract：:The uncertainty of whether/how to treat asymptomatic patients with isolated severe aortic stenosis and normal left ventricular ejection fraction is one of the most topical in cardiovascular medicine. Recently, the AVATAR trial: first ever randomized trial in the setting of aortic stenosis has been started in an attemp...

journal_title：Biomarkers in medicine

authors： Banovic MD

更新日期：2017-04-01 00:00:00

abstract：:Interferons (IFNs) comprise type I, II and III families with multiple subtypes. Via transcription of IFN-stimulated genes (ISGs), IFNs can exert multiple biological effects on the cell. In infectious and chronic inflammatory diseases, the IFNs and their ISG sets can be potentially utilized as biomarkers of disease out...

journal_title：Biomarkers in medicine

authors： Berry CM,Hertzog PJ,Mangan NE

更新日期：2012-04-01 00:00:00

abstract：AIM:The aim was to investigate the inflammatory biomarker YKL-40 as a monitor of myocardial ischemia in patients with coronary artery disease (CAD). METHODS:A total of 311 patients with stable CAD were included. Blood samples were taken at baseline, the day after coronary angiography and/or after percutaneous coronary...

journal_title：Biomarkers in medicine

authors： Harutyunyan M,Johansen JS,Mygind ND,Reuter SB,Kastrup J

更新日期：2014-01-01 00:00:00

abstract：:Aim: To investigate and validate predictive value of combination of pretreatment monocyte-to-lymphocyte ratio (MLR) and neutrophil-to-lymphocyte ratio (NLR) for disease free survival (DFS) and overall survival (OS) in nonmuscle invasive bladder cancer after transurethral resection. Materials & methods: Total 358 patie...

journal_title：Biomarkers in medicine

authors： Wang Q,Huang T,Ji J,Wang H,Guo C,Sun X,Zheng K,Dong Z,Cao Y

更新日期：2019-12-01 00:00:00

abstract：:Malignant pleural mesothelioma (MPM) is a highly aggressive and invasive tumor, whose incidence is expected to peak, in many countries, at the end of the present decade, 20-40 years after the peak of asbestos use (asbestos being the most important etiological factor). MPM has a poor prognosis, in part, owing to a diff...

journal_title：Biomarkers in medicine

authors： Cristaudo A,Bonotti A,Simonini S,Bruno R,Foddis R

更新日期：2011-04-01 00:00:00

abstract：:Aim: To evaluate an 8.7-kb mitochondrial DNA (mtDNA) deletion as a potential biomarker of endometriosis. Materials & methods: We tested the diagnostic accuracy of the 8.7-kb deletion real-time PCR assay using 182 prospectively collected blood samples from females presenting with symptoms of endometriosis in a case-con...

journal_title：Biomarkers in medicine

authors： Harbottle A,Maggrah A,Usher R,Desa E,Creed JM

更新日期：2020-02-01 00:00:00

abstract：AIM:The aim of this article was to investigate the performance and predictive value of urinary liver-type FABP (uL-FABP) and urinary NGAL (uNGAL) for renal function and prognosis in obstructive nephropathy (ON). PATIENTS & METHODS:A total of 108 ON patients and urine samples were collected. An ELISA was used to determ...

journal_title：Biomarkers in medicine

authors： Xie Y,Xu W,Wang Q,Shao X,Ni Z,Mou S

更新日期：2014-01-01 00:00:00

abstract：AIM:To establish a database for the associations between idiosyncratic drug reactions (IDRs) and human leukocyte antigens (HLAs) and to systematically assess the characteristics of the drug-HLA associations. MATERIALS & METHODS:Electronic databases were searched to extensively identify drug-HLA association studies fro...

journal_title：Biomarkers in medicine

authors： Du T,Yang L,Luo H,Zhou P,Mei H,Xuan J,Xing Q,Ning B,Mendrick DL,Shi L

更新日期：2015-01-01 00:00:00