A novel 8.7-kb mitochondrial genome deletion accurately detects endometriosis in the plasma of symptomatic women.

abstract：:Aim: Some patients experience statin-associated muscle symptoms (SAMS) and elevated serum concentrations of CK. The relationship between SAMS and biomarkers of muscle damage was examined. Methods: We analyzed 359 consecutive patients taking statins with high CK values. Muscle-related symptoms and biochemical variables...

journal_title：Biomarkers in medicine

authors： Nogueira AA,Strunz CM,Takada JY,Mansur AP

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Autism spectrum disorder (ASD) represents a wide range of neurodevelopmental disorders characterized by impairments in social interaction, language, communication and range of interests. Autism is usually diagnosed in children 3-5 years of age using behavioral characteristics; thus, diagnosis shortly after b...

journal_title：Biomarkers in medicine

authors： Mizejewski GJ,Lindau-Shepard B,Pass KA

更新日期：2013-04-01 00:00:00

abstract：AIM:The conflicting relationships of serum omentin with inflammation markers and cardiometabolic disorders were investigated. Results & methods: Unselected 864 population-based middle-aged adults were cross-sectionally studied by sex-specific omentin tertiles. Men in the lowest omentin tertile (T1) had lower systolic b...

journal_title：Biomarkers in medicine

authors： Onat A,Ademoglu E,Karadeniz Y,Can G,Uzun AO,Simsek B,Kaya A

更新日期：2018-02-01 00:00:00

abstract：:Cardiovascular disease refers to different diseases involving the heart and/or the arteries and/or the veins. Cardiovascular disease, overall considered, is a notable source of morbidity and mortality worldwide. Therefore, several research studies are dedicated to explore, by means of biomarkers, the possiblity to cal...

journal_title：Biomarkers in medicine

authors： Serra R,Ielapi N,Barbetta A,Andreucci M,de Franciscis S

更新日期：2018-09-01 00:00:00

abstract：:Aim: Noninvasive assessments of C-reactive protein (CRP) in stress contexts have seldom been compared. This study evaluated CRP response to acute social stress as measured in saliva and dried blood spot (DBS). Materials & methods: African-Americans (N = 118; mean age = 32 years) participated in a laboratory-based soci...

journal_title：Biomarkers in medicine

authors： Goetz SM,Lucas T

更新日期：2020-04-01 00:00:00

abstract：:Preeclampsia remains a significant cause of maternal morbidity and mortality worldwide. Prediction, diagnosis and management continue to be challenging but advances in the understanding of the pathophysiological processes underlying the disease has enabled identification of multiple biomarkers, some of which aid predi...

journal_title：Biomarkers in medicine

authors： Griffin M,Shennan AH

更新日期：2014-01-01 00:00:00

abstract：AIM:To establish a database for the associations between idiosyncratic drug reactions (IDRs) and human leukocyte antigens (HLAs) and to systematically assess the characteristics of the drug-HLA associations. MATERIALS & METHODS:Electronic databases were searched to extensively identify drug-HLA association studies fro...

journal_title：Biomarkers in medicine

authors： Du T,Yang L,Luo H,Zhou P,Mei H,Xuan J,Xing Q,Ning B,Mendrick DL,Shi L

更新日期：2015-01-01 00:00:00

abstract：:Patients with metastatic colorectal cancer have a very poor prognosis. Incorporation of targeted molecular therapies, such as the anti-EGFR receptor monoclonal antibodies cetuximab and panitumumab, into treatment regimens has improved outcomes for patients with wild-type RAS tumors. Yet, response rates remain low and ...

journal_title：Biomarkers in medicine

authors： Caiazza F,Elliott L,Fennelly D,Sheahan K,Doherty GA,Ryan EJ

更新日期：2015-01-01 00:00:00

abstract：AIM:The usefulness of high-sensitivity troponin T (hs-TnT) as a predictor of perioperative hemodynamic instability is currently unknown. METHODS:A prospective study was conducted on a group of 708 consecutive patients with significant valvular heart disease that underwent elective valve surgery. The primary end point ...

journal_title：Biomarkers in medicine

authors： Duchnowski P,Hryniewiecki T,Koźma M,Mariusz K,Piotr S

更新日期：2018-12-01 00:00:00

abstract：:Aim: This study sought to investigate the relationship between galectin-3 (Gal-3), myocardial fibrosis (MF) and outcomes in acute heart failure. Materials & methods: The single-nucleotide polymorphisms (SNPs) of LGALS3 at rs4644 and rs4652, plasma Gal-3 level, MF and major adverse events (MAEs) were obtained. Results:...

journal_title：Biomarkers in medicine

authors： Fu H,Nie S,Luo P,Ruan Y,Zhang Z,Miao H,Li X,Wen S,Bai R

更新日期：2020-07-01 00:00:00

abstract：:Aim: To investigate and validate predictive value of combination of pretreatment monocyte-to-lymphocyte ratio (MLR) and neutrophil-to-lymphocyte ratio (NLR) for disease free survival (DFS) and overall survival (OS) in nonmuscle invasive bladder cancer after transurethral resection. Materials & methods: Total 358 patie...

journal_title：Biomarkers in medicine

authors： Wang Q,Huang T,Ji J,Wang H,Guo C,Sun X,Zheng K,Dong Z,Cao Y

更新日期：2019-12-01 00:00:00

abstract：AIM:Ankylosing spondylitis (AS) is a chronic systemic inflammatory rheumatic disorder that primarily affects the axial skeleton. To date there is no satisfactory biomarker for diagnosis or prognosis of AS. This study is focused on detection of potential biomarkers for the diagnosis of AS using surface-enhanced laser de...

journal_title：Biomarkers in medicine

authors： Bons JA,van der Heijde D,Bouwman FG,Mariman EC,van Dieijen-Visser MP,Landewé R,van der Linden S,Wodzig WK

更新日期：2008-02-01 00:00:00

abstract：:Aim: To determine whether TLR9 polymorphisms are associated with tumor recurrence after liver transplantation for hepatocellular carcinoma (HCC). Patients & methods: All patients who underwent liver transplantation, and had viable HCC in the explanted liver were included. TLR9-1237C/T and -1486C/T polymorphisms were a...

journal_title：Biomarkers in medicine

authors： de la Fuente S,Citores MJ,Lucena JL,Muñoz P,Cuervas-Mons V

更新日期：2019-08-01 00:00:00

abstract：AIM:The aim of the present study is to evaluate the relationship between coronary collateral circulation (CCC) grade and serum IGF-1 levels in patients diagnosed with stable coronary artery disease. METHODS:Totally, 190 consecutive patients with stable coronary artery disease who underwent coronary angiography were in...

journal_title：Biomarkers in medicine

authors： Kundi H,Gok M,Kiziltunc E,Cetin M,Ornek E

更新日期：2017-07-01 00:00:00

abstract：:Alzheimer's disease will reach epidemic proportions within the next 20-30 years if left unchecked. Currently, there are no treatments that prevent or slow Alzheimer's disease but many are being developed. Parallel efforts to develop biomarkers to aid in disease diagnosis and prognosis, and assess disease risk are curr...

journal_title：Biomarkers in medicine

authors： Fagan AM,Holtzman DM

更新日期：2010-02-01 00:00:00

abstract：:Blood-urea nitrogen, serum creatinine and urine output have long been used as markers of kidney function despite their known limitations. In the past few years, a number of novel biomarkers have been identified in the urine and blood that can detect kidney injury early. Although, to date, none of these biomarkers are ...

journal_title：Biomarkers in medicine

authors： Khan E,Batuman V,Lertora JJ

更新日期：2010-12-01 00:00:00

abstract：AIM:We aimed to investigate whether baseline monocyte to high-density lipoprotein cholesterol ratio (MHR), an easily available inflammatory and oxidative stress marker, is associated with SYNTAX score. PATIENTS & METHODS:In this cross-sectional study, n = 1229 consecutive patients with coronary artery disease were cla...

journal_title：Biomarkers in medicine

authors： Akboga MK,Balci KG,Maden O,Ertem AG,Kirbas O,Yayla C,Acar B,Aras D,Kisacik H,Aydogdu S

更新日期：2016-01-01 00:00:00

abstract：:Relationships between plasma drug concentrations and clinical outcome have been defined for various chemotherapeutic agents, showing that drug exposure may be a marker of toxicity, mainly hematological and gastrointestinal toxicity, as well as efficacy, expressed as tumor response and survival. Biomarkers provide info...

journal_title：Biomarkers in medicine

authors： Meza-Junco J,Sawyer MB

更新日期：2009-12-01 00:00:00

abstract：AIM:To assess the possible relationship between coronary atherosclerosis markers, pericardial fat volume (PFV) and coronary artery calcification, with ECG markers of index of the cardiac electrophysiological balance (iCEB) and transmural dispersion of the repolarization in patients with suspected coronary artery diseas...

journal_title：Biomarkers in medicine

authors： Nafakhi H,Al-Mosawi AA,Alareedh M,Al-Nafakh HA

更新日期：2018-04-01 00:00:00

abstract：:The uncertainty of whether/how to treat asymptomatic patients with isolated severe aortic stenosis and normal left ventricular ejection fraction is one of the most topical in cardiovascular medicine. Recently, the AVATAR trial: first ever randomized trial in the setting of aortic stenosis has been started in an attemp...

journal_title：Biomarkers in medicine

authors： Banovic MD

更新日期：2017-04-01 00:00:00

abstract：:Fibrosis is characterized by aberrant myofibroblast accumulation and excessive extracellular matrix deposition, which leads to organ failure and significantly contributes to mortality worldwide. Exosomes, which are extracellular nanovesicles with a diameter of 30-100 nm that are secreted into the extracellular space b...

journal_title：Biomarkers in medicine

authors： Qin XJ,Zhang JX,Wang RL

更新日期：2020-06-01 00:00:00

abstract：:Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy and is the fifth leading cause of cancer deaths in women. Developing adjuvant therapy to circumvent drug resistance represents an important aspect of current initiatives to improve survival in women with advanced EOC. A regulatory molecule that ...

journal_title：Biomarkers in medicine

authors： Nagaraj AB,Joseph P,DiFeo A

更新日期：2015-01-01 00:00:00

abstract：AIM:This study aimed to identify plasma protein changes in a rat model of ischemic stroke using a proteomic approach. MATERIALS & METHODS:Four male Sprague-Dawley rats (3-6 months old) were subjected to 90 min of left middle cerebral artery occlusion under anesthesia with 1.5% isoflurane in O(2)/air followed by 24-h r...

journal_title：Biomarkers in medicine

authors： Chen R,Vendrell I,Chen CP,Cash D,O'Toole KG,Williams SA,Jones C,Preston JE,Wheeler JX

更新日期：2011-12-01 00:00:00

abstract：:Impression cytology (IC) is a technique which permits the retrieval of the outermost layer of ocular surface cells via the use of various types of filters. It is a minimally invasive method of evaluating human conjunctival epithelial cell morphology in the diagnosis of dry eye disease, a common and distressing disorde...

journal_title：Biomarkers in medicine

authors： Hagan S

更新日期：2017-12-01 00:00:00

abstract：AIM:Because of the delayed rise of serum creatinine concentrations, novel biomarkers such as NGAL, GST and KIM-1 are proposed to detect acute kidney injury (AKI). In this study we evaluated these biomarkers. MATERIALS & METHODS:Twenty-six consecutive adult liver transplantations were evaluated. Markers were measured a...

journal_title：Biomarkers in medicine

authors： Dedeoglu B,de Geus HR,Fortrie G,Betjes MG

更新日期：2013-12-01 00:00:00

abstract：:Increasing evidence has highlighted the roles of oxidative stress and inflammation in the promotion of atherosclerotic cardiovascular disease. Recent pathological studies have elucidated specific mediators that appear to link these pathways to the progression and rupture of atherosclerotic plaque in the artery wall. T...

journal_title：Biomarkers in medicine

authors： Uno K,Nicholls SJ

更新日期：2010-06-01 00:00:00

abstract：AIM:To evaluate the relationship between mean platelet volume (MPV) and red cell distribution width (RDW), and disease activity in rheumatoid arthritis (RA). PATIENTS & METHODS:Hundred RA and 100 controls were included. RESULTS:MPV and RDW were higher in RA (p < 0.0001). The cut-off levels of RDW and MPV were 14.8 an...

journal_title：Biomarkers in medicine

authors： Tecer D,Sezgin M,Kanık A,İncel NA,Çimen ÖB,Biçer A,Şahin G

更新日期：2016-09-01 00:00:00

abstract：:In recent years, biobanks of human tissues have evolved from small-scale collections of pathological materials into structured resource centers for acquisition, storage, processing and usage of high-quality biospecimens for research. This evolution goes hand in hand with the development of highly sensitive, high-throu...

journal_title：Biomarkers in medicine

authors： Zatloukal K,Hainaut P

更新日期：2010-12-01 00:00:00

abstract：:Epilepsy and seizures are very common in the early years of life and are often associated with significant morbidity and mortality. Identification of biomarkers for the early detection of epileptogenicity, epileptogenesis, comorbidities, disease progression and treatment implementation will be very important in implem...

journal_title：Biomarkers in medicine

authors： Galanopoulou AS,Moshé SL

更新日期：2011-10-01 00:00:00

abstract：:Aim: To develop robust and accurate prognostic biomarkers to help clinicians optimize therapeutic strategies. Materials & methods: Differentially prognosis-related autophagy genes were identified by bioinformatics analysis method. Results: Seven prognosis-related autophagy genes were more significantly related to the ...

journal_title：Biomarkers in medicine

authors： Wang J,Miao Y,Ran J,Yang Y,Guan Q,Mi D

更新日期：2020-09-01 00:00:00