Abstract:
AIM:This study aimed to assess the urinary concentrations of epidermal growth factor (EGF) and kidney injury molecule 1 (KIM-1) in patients with hydronephrosis. METHODS:Neonates with a history of prenatal hydronephrosis were enrolled in three groups. Group 1 included neonates with severe obstruction; group 2 included neonates with milder obstruction; and group 3 included neonates with normal findings on postnatal ultrasonography. RESULTS:59 neonates were enrolled. The EGF: Cr and KIM-1: Cr ratios were significantly higher in group 1 than in group 2 (p = 0.016 and 0.015, respectively). The cut-off values were measured as 16.855 (sensitivity 71%, specificity 77%) and 0.4765 (sensitivity 81%, specificity 71%) for EGF:Cr and KIM-1:Cr ratios, respectively. The values were significantly higher in group 1 than in group 2. CONCLUSIONS:Evaluation of the urinary KIM-1:Cr ratio may help identify neonates with severe obstructive hydronephrosis.
journal_name
Biomark Medjournal_title
Biomarkers in medicineauthors
Mohammadjafari H,Rafiei A,Kosaryan M,Yeganeh Y,Hosseinimehr SJdoi
10.2217/bmm.14.79subject
Has Abstractpub_date
2014-01-01 00:00:00pages
1199-206issue
10eissn
1752-0363issn
1752-0371journal_volume
8pub_type
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