Emerging biomarkers for PD-1 pathway cancer therapy.

Abstract:

:The field of immuno-oncology has witnessed unprecedented success in recent years, with several PD=1 and PD-L1 inhibitors obtaining US FDA registration and breakthrough drug therapy designation in multiple tumor types. Despite its clear efficacy in certain cancers, treatment with these agents carries a risk of immune-related toxicities and substantial financial burden. It is, therefore, critical to identify patients likely to benefit from such immunotherapies and develop strategies to differentiate responders from nonresponders early during treatment. Here we discuss the development of predictive and treatment response biomarkers for immune checkpoint inhibitors. We first examine the role of PD-L1 expression, the most extensively studied predictive biomarker of response, and further discuss emerging putative predictive biomarkers. We also detail challenges faced in the development of response assessments for immunotherapeutics and propose other biomarkers that may be useful as surrogate intermediate end points of response.

journal_name

Biomark Med

journal_title

Biomarkers in medicine

authors

Lim JS,Sundar R,Chénard-Poirier M,Lopez J,Yap TA

doi

10.2217/bmm-2016-0228

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

53-67

issue

1

eissn

1752-0363

issn

1752-0371

journal_volume

11

pub_type

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