Abstract:
AIM:The aim was to investigate the inflammatory biomarker YKL-40 as a monitor of myocardial ischemia in patients with coronary artery disease (CAD). METHODS:A total of 311 patients with stable CAD were included. Blood samples were taken at baseline, the day after coronary angiography and/or after percutaneous coronary intervention and after 6 months. RESULTS:A total of 148 (48%) patients were revascularized and 163 patients underwent only coronary angiography. In the entire population, serum YKL-40 increased significantly from baseline to 6 months (p = 0.05). This tendency was seen in nonrevascularized patients (p = 0.06), but not in revascularized patients (p = 0.46). Serum YKL-40 increased approximately 25% the day after the invasive procedure (p < 0.001) and then decreased significantly to nearly baseline after 6 months (p = 0.002). CONCLUSION:Serum YKL-40 is a potential promising biomarker of disease progression but not of myocardial ischemia in patients with stable CAD.
journal_name
Biomark Medjournal_title
Biomarkers in medicineauthors
Harutyunyan M,Johansen JS,Mygind ND,Reuter SB,Kastrup Jdoi
10.2217/bmm.14.20subject
Has Abstractpub_date
2014-01-01 00:00:00pages
977-87issue
8eissn
1752-0363issn
1752-0371journal_volume
8pub_type
杂志文章abstract::Generally, obese and overweight individuals display higher free fatty acid levels, which stimulate insulin resistance. The combination of overweight or obesity with insulin resistance can trigger Type 2 diabetes mellitus (T2DM) and are primary contributing factors to the development of uncontrolled T2DM. Genetic polym...
journal_title:Biomarkers in medicine
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pub_type: 临床试验,杂志文章
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