Serum YKL-40 for monitoring myocardial ischemia after revascularization in patients with stable coronary artery disease.

Abstract:

AIM:The aim was to investigate the inflammatory biomarker YKL-40 as a monitor of myocardial ischemia in patients with coronary artery disease (CAD). METHODS:A total of 311 patients with stable CAD were included. Blood samples were taken at baseline, the day after coronary angiography and/or after percutaneous coronary intervention and after 6 months. RESULTS:A total of 148 (48%) patients were revascularized and 163 patients underwent only coronary angiography. In the entire population, serum YKL-40 increased significantly from baseline to 6 months (p = 0.05). This tendency was seen in nonrevascularized patients (p = 0.06), but not in revascularized patients (p = 0.46). Serum YKL-40 increased approximately 25% the day after the invasive procedure (p < 0.001) and then decreased significantly to nearly baseline after 6 months (p = 0.002). CONCLUSION:Serum YKL-40 is a potential promising biomarker of disease progression but not of myocardial ischemia in patients with stable CAD.

journal_name

Biomark Med

journal_title

Biomarkers in medicine

authors

Harutyunyan M,Johansen JS,Mygind ND,Reuter SB,Kastrup J

doi

10.2217/bmm.14.20

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

977-87

issue

8

eissn

1752-0363

issn

1752-0371

journal_volume

8

pub_type

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