Abstract:
AIM:To investigate the role of gelsolin-like actin-capping protein (CapG) in prostate cancer (PCa). MATERIALS & METHODS:CapG expression and its correlation with clinicopathological characters and patient prognosis were analyzed in 76 cases of PCa by immunohistochemistry and qRT-PCR. Then, the influence of CapG downregulation on cell apoptosis and proliferation were assessed. RESULTS:CapG expression in PCa was significantly higher compared with those in matched adjacent noncancerous prostate tissues, and significantly correlated with clinicopathological characters. Survival analysis indicated that CapG could be an independent prognostic factor in PCa. Moreover, CapG depletion significantly affected cellular proliferation and apoptosis by regulating Caspase 6/Caspase 9/Bcl-2/p-Akt/Akt signaling pathway. CONCLUSION:CapG, as a potential biomarker in PCa, is associated with patient prognosis, cellular apoptosis and proliferation.
journal_name
Biomark Medjournal_title
Biomarkers in medicineauthors
Li T,Hong X,Zhao J,Teng Y,Zheng J,Chen H,Chen H,Li Hdoi
10.2217/bmm-2016-0186subject
Has Abstractpub_date
2016-12-01 00:00:00pages
1251-1260issue
12eissn
1752-0363issn
1752-0371journal_volume
10pub_type
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journal_title:Biomarkers in medicine
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journal_title:Biomarkers in medicine
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