C-type natriuretic-derived peptides as biomarkers in human disease.

abstract：AIM:The aim of the present study is to evaluate the relationship between coronary collateral circulation (CCC) grade and serum IGF-1 levels in patients diagnosed with stable coronary artery disease. METHODS:Totally, 190 consecutive patients with stable coronary artery disease who underwent coronary angiography were in...

journal_title：Biomarkers in medicine

authors： Kundi H,Gok M,Kiziltunc E,Cetin M,Ornek E

更新日期：2017-07-01 00:00:00

abstract：:Background: This study aimed to identify glioblastoma prognosis-associated genes with potential diagnosis or prognosis values using integrated bioinformatics analysis. Results: In total, 1831 differentially expressed genes (DEGs) between the glioblastoma and control samples were identified and were clustered into seve...

journal_title：Biomarkers in medicine

authors： Wang D,Liu J,Chen Q,Yang R,Jiang Q

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Circulating tumor cells (CTCs) and tumor-specific alterations in cell-free plasma DNA can both be used as markers of prognosis in breast cancer. To date, there have been no studies that have compared these as markers for subclinical metastases in the follow-up of early breast cancer. In this study, we measur...

journal_title：Biomarkers in medicine

authors： Shaw JA,Brown J,Coombes RC,Jacob J,Payne R,Lee B,Page K,Hava N,Stebbing J

更新日期：2011-02-01 00:00:00

abstract：:Aim: Some patients experience statin-associated muscle symptoms (SAMS) and elevated serum concentrations of CK. The relationship between SAMS and biomarkers of muscle damage was examined. Methods: We analyzed 359 consecutive patients taking statins with high CK values. Muscle-related symptoms and biochemical variables...

journal_title：Biomarkers in medicine

authors： Nogueira AA,Strunz CM,Takada JY,Mansur AP

更新日期：2019-06-01 00:00:00

abstract：AIM:To investigate the role of MMP-9 (-1562 C:T) polymorphism as a biomarker for susceptibility to pre-eclampsia. PATIENTS & METHODS:MMP-9 variants were detected in 160 women with mild and severe pre-eclampsia and 112 healthy pregnant women. RESULTS:A significantly higher frequency of MMP-9 CT genotype was observed i...

journal_title：Biomarkers in medicine

authors： Rahimi Z,Rahimi Z,Shahsavandi MO,Bidoki K,Rezaei M

更新日期：2013-02-01 00:00:00

abstract：AIM:To evaluate the relationship between mean platelet volume (MPV) and red cell distribution width (RDW), and disease activity in rheumatoid arthritis (RA). PATIENTS & METHODS:Hundred RA and 100 controls were included. RESULTS:MPV and RDW were higher in RA (p < 0.0001). The cut-off levels of RDW and MPV were 14.8 an...

journal_title：Biomarkers in medicine

authors： Tecer D,Sezgin M,Kanık A,İncel NA,Çimen ÖB,Biçer A,Şahin G

更新日期：2016-09-01 00:00:00

abstract：:The field of aortopathy, in common with other genomic disorders, is undergoing a revolution. This is largely driven by the implementation of newer forms of genetic sequencing (massively parallel or next-generation sequencing). Advantages conferred by this technology include reduced costs, reduced sequencing time and t...

journal_title：Biomarkers in medicine

authors： Rea G,Stewart FJ

更新日期：2013-08-01 00:00:00

abstract：:Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy and is the fifth leading cause of cancer deaths in women. Developing adjuvant therapy to circumvent drug resistance represents an important aspect of current initiatives to improve survival in women with advanced EOC. A regulatory molecule that ...

journal_title：Biomarkers in medicine

authors： Nagaraj AB,Joseph P,DiFeo A

更新日期：2015-01-01 00:00:00

abstract：AIM:Cardiotrophin-1 null mice presented decreased arterial stiffness. The aim of this study is to investigate the relationship between cardiotrophin-1 and arterial stiffness, assessed by brachial-ankle pulse-wave velocity (baPWV). METHODS:We enrolled 300 subjects, 200 with baPWV >1400 and 100 with baPWV ≤1400 cm/s. R...

journal_title：Biomarkers in medicine

authors： Hung HC,Lu FH,Ou HY,Wu HT,Wu JS,Yang YC,Chang CJ

更新日期：2015-01-01 00:00:00

abstract：:In order to individually tailor prostate cancer (PCa) treatment, clinicians need better tools to predict prognosis and treatment response. Given the relationship between angiogenesis and cancer progression, circulating endothelial cells (CECs) and their progenitors have logically been proposed as potential biomarkers....

journal_title：Biomarkers in medicine

authors： Reeves F,Sapre N,Corcoran N,Hovens C

更新日期：2013-12-01 00:00:00

abstract：AIM:Investigate the correlation between paraoxonase 2 (PON2) Ser311Cys polymorphism as well as the peroxisome proliferator-activated receptor gamma (PPARG) His477His polymorphism and the susceptibility to development of coronary heart diseases (CHD) through a meta-analysis. METHODS:Odds ratio and the corresponding 95%...

journal_title：Biomarkers in medicine

authors： González-Castro TB,Tovilla-Zárate CA,Juárez-Rojop IE,Hernández-Díaz Y,López-Narváez ML,Rodríguez-Pérez C,González-Hernández YK,Ramos-Méndez MÁ

更新日期：2018-03-01 00:00:00

abstract：:Cardiac troponin is the standard biomarker for the diagnosis of acute myocardial infarction (AMI) and risk stratification for short-term adverse cardiac events (death, AMI or need for revascularization). Unfortunately, the concentration of troponin in blood is normal in AMI patients who present early after the onset o...

journal_title：Biomarkers in medicine

authors： Wu AH

更新日期：2007-06-01 00:00:00

abstract：:Aim: To evaluate an 8.7-kb mitochondrial DNA (mtDNA) deletion as a potential biomarker of endometriosis. Materials & methods: We tested the diagnostic accuracy of the 8.7-kb deletion real-time PCR assay using 182 prospectively collected blood samples from females presenting with symptoms of endometriosis in a case-con...

journal_title：Biomarkers in medicine

authors： Harbottle A,Maggrah A,Usher R,Desa E,Creed JM

更新日期：2020-02-01 00:00:00

abstract：:The aim of this meta-analysis was to review the available evidence regarding the blood concentrations of the oxidative stress marker malondialdehyde (MDA) in chronic obstructive pulmonary disease (COPD) patients in comparison to healthy individuals. 14 studies were included in the meta-analysis (from inception to Octo...

journal_title：Biomarkers in medicine

authors： Paliogiannis P,Fois AG,Sotgia S,Mangoni AA,Zinellu E,Pirina P,Carru C,Zinellu A

更新日期：2018-07-01 00:00:00

abstract：:Cardiovascular disease refers to different diseases involving the heart and/or the arteries and/or the veins. Cardiovascular disease, overall considered, is a notable source of morbidity and mortality worldwide. Therefore, several research studies are dedicated to explore, by means of biomarkers, the possiblity to cal...

journal_title：Biomarkers in medicine

authors： Serra R,Ielapi N,Barbetta A,Andreucci M,de Franciscis S

更新日期：2018-09-01 00:00:00

abstract：:Patients with metastatic colorectal cancer have a very poor prognosis. Incorporation of targeted molecular therapies, such as the anti-EGFR receptor monoclonal antibodies cetuximab and panitumumab, into treatment regimens has improved outcomes for patients with wild-type RAS tumors. Yet, response rates remain low and ...

journal_title：Biomarkers in medicine

authors： Caiazza F,Elliott L,Fennelly D,Sheahan K,Doherty GA,Ryan EJ

更新日期：2015-01-01 00:00:00

abstract：AIM:Because of the delayed rise of serum creatinine concentrations, novel biomarkers such as NGAL, GST and KIM-1 are proposed to detect acute kidney injury (AKI). In this study we evaluated these biomarkers. MATERIALS & METHODS:Twenty-six consecutive adult liver transplantations were evaluated. Markers were measured a...

journal_title：Biomarkers in medicine

authors： Dedeoglu B,de Geus HR,Fortrie G,Betjes MG

更新日期：2013-12-01 00:00:00

abstract：AIM:To explore the role of an adipokine-termed fatty acid-binding protein 4 (FABP4) in osteoarthritis (OA). METHODS:Patients with primary knee OA and non-OA controls were included. Paired tissues including plasma, synovial fluid (SF), subcutaneous fat and infrapatellar fat pad (IPFP) were harvested during surgery. FAB...

journal_title：Biomarkers in medicine

authors： Zhang C,Li T,Chiu KY,Wen C,Xu A,Yan CH

更新日期：2018-02-01 00:00:00

abstract：:The current cost of developing a successful drug is typically over a billion dollars, with the registration trial(s) determining the success or failure of the entire development program. Often the primary endpoint of these trials is a subjective assessment. For registration trials with subjective endpoints, a regulato...

journal_title：Biomarkers in medicine

authors： Walovitch RC,Chokron P,Agarwal S

更新日期：2012-12-01 00:00:00

abstract：AIM:The aim was to investigate the inflammatory biomarker YKL-40 as a monitor of myocardial ischemia in patients with coronary artery disease (CAD). METHODS:A total of 311 patients with stable CAD were included. Blood samples were taken at baseline, the day after coronary angiography and/or after percutaneous coronary...

journal_title：Biomarkers in medicine

authors： Harutyunyan M,Johansen JS,Mygind ND,Reuter SB,Kastrup J

更新日期：2014-01-01 00:00:00

abstract：:Major depressive disorder (MDD: unipolar depression) is widely distributed in the USA and world-wide populations and it is one of the leading causes of disability in both adolescents and adults. Traditional diagnostic approaches for MDD are based on patient interviews, which provide a subjective assessment of clinical...

journal_title：Biomarkers in medicine

authors： Bilello JA

更新日期：2016-08-01 00:00:00

abstract：:Biomarker discovery is essential to the advancement of our knowledge about diseases and to the development of new strategies for treatment and therapy. Among the newest technologies in this rapidly growing field is a process termed Cell SELEX by which a panel of aptamers can be generated to specifically target disease...

journal_title：Biomarkers in medicine

authors： Kim Y,Liu C,Tan W

更新日期：2009-04-01 00:00:00

abstract：:Dr Jake Micallef speaks to Hannah L Wilson, Commissioning Editor: Dr Micallef has 20 years of experience in research and development and in the management of early-stage biotechnical companies, including the manufacture of biotechnology products and the establishment of manufacturing operations. Dr Micallef gained thi...

journal_title：Biomarkers in medicine

authors： Micallef J,Wilson HL

更新日期：2014-01-01 00:00:00

abstract：AIM:Childhood cancer remains one of the main cause of death in the pediatric population. Amino acids (AAs) level alterations in plasma are considered to play a role in carcinogenesis and further course of the disease. METHODS:Seventy-seven children with cancer, including 47 with hematological and 30 with solid tumors ...

journal_title：Biomarkers in medicine

authors： Synakiewicz A,Sawicka-Zukowska M,Adrianowska N,Galezowska G,Ratajczyk J,Owczarzak A,Konieczna L,Stachowicz-Stencel T

更新日期：2017-08-01 00:00:00

abstract：:In recent years, immune checkpoint inhibitors have rapidly changed treatment paradigms and have been pivotal for the treatment of advanced NSCLC patients. However, many patients don't respond to immunotherapy, and toxicities are a concern. Mounting evidence suggests that PD-L1 expression and tumor mutational burden ar...

journal_title：Biomarkers in medicine

authors： C Guven D,Sahin TK,Dizdar O,Kilickap S

更新日期：2020-10-01 00:00:00

abstract：:The 44th Congress of the International Society of Oncology and Biomarkers: Rio de Janeiro, Brazil, 7-10 September 2017 The 44th congress followed the previous one of  International Society of Oncology and Biomarkers (ISOBM) that took place in Chicago (USA) in 2016. The title of the 44th Annual congress was: 'Biomarker...

journal_title：Biomarkers in medicine

authors： Kinkorová J

更新日期：2018-02-01 00:00:00

abstract：AIM:To investigate the expression of FLNA and its potential prognostic significance in cervical cancer. PATIENTS & METHODS:Real-time PCR was performed to evaluate the expression levels of FLNA in 44 pairs of cervical cancer and matched normal adjacent tissues. Kaplan-Meier analysis and Cox proportional hazards model w...

journal_title：Biomarkers in medicine

authors： Jin YZ,Pei CZ,Wen LY

更新日期：2016-07-01 00:00:00

abstract：:The prevalence of metabolic disorders (MDs), especially diabetes, is rapidly increasing worldwide, leading to an increasing risk of cardiovascular and other socially relevant complications. To boost MD biomarker discovery, advanced proteomics can harmonize metabolomics. Indeed, the rapid development of mass spectromet...

journal_title：Biomarkers in medicine

authors： Di Girolamo F,Del Chierico F,Caenaro G,Lante I,Muraca M,Putignani L

更新日期：2012-12-01 00:00:00

abstract：AIM:Predicting a poor treatment outcome would offer significant benefits for patient care and for new drug development. Materials, methods & results: Urine samples from tuberculosis-positive patients with a successful and unsuccessful treatment outcome were collected at baseline and analyzed. The identified metabolites...

journal_title：Biomarkers in medicine

authors： Luies L,Reenen MV,Ronacher K,Walzl G,Loots DT

更新日期：2017-12-01 00:00:00

abstract：:Tuberculosis is a public health concern worldwide. Particularly worrying is the emergence of severe forms of drug resistance, such as extensively drug resistant and totally drug resistant tuberculosis, with few treatment options for the afflicted patients. To avoid further spread of drug resistance, its early detectio...

journal_title：Biomarkers in medicine

authors： Palomino JC,Vandamme P,Martin A

更新日期：2014-01-01 00:00:00