Abstract:
:The uncertainty of whether/how to treat asymptomatic patients with isolated severe aortic stenosis and normal left ventricular ejection fraction is one of the most topical in cardiovascular medicine. Recently, the AVATAR trial: first ever randomized trial in the setting of aortic stenosis has been started in an attempt to adequately address this 'burning issue'. In light of this fact it is important to identify biomarkers which might help in risk stratification of these patients, not only in the referring physician's office during a routine exam, but also for preoperative patients scheduled for surgical replacement/transcatheter aortic valve implantation. This report is focusing on novel laboratory parameters which might be helpful in this risk stratification.
journal_name
Biomark Medjournal_title
Biomarkers in medicineauthors
Banovic MDdoi
10.2217/bmm-2016-0369subject
Has Abstractpub_date
2017-04-01 00:00:00pages
369-376issue
4eissn
1752-0363issn
1752-0371journal_volume
11pub_type
杂志文章abstract::Systemic sclerosis is an autoimmune inflammatory disorder of unknown etiologycharacterized b y pronounced fibroproliferative alterations in the microvasculature, and frequent cellular and humoral immunity abnormalities, culminating in a severe and often progressive fibrotic process. Numerous biomarkers reflecting the ...
journal_title:Biomarkers in medicine
pub_type: 杂志文章,评审
doi:10.2217/bmm.09.79
更新日期:2010-02-01 00:00:00
abstract:AIM:The aim was to investigate the inflammatory biomarker YKL-40 as a monitor of myocardial ischemia in patients with coronary artery disease (CAD). METHODS:A total of 311 patients with stable CAD were included. Blood samples were taken at baseline, the day after coronary angiography and/or after percutaneous coronary...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm.14.20
更新日期:2014-01-01 00:00:00
abstract::Biomarker discovery is essential to the advancement of our knowledge about diseases and to the development of new strategies for treatment and therapy. Among the newest technologies in this rapidly growing field is a process termed Cell SELEX by which a panel of aptamers can be generated to specifically target disease...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm.09.5
更新日期:2009-04-01 00:00:00
abstract::Acute kidney injury is a common and significant complication among pediatric patients with congenital heart disease, occurring most commonly after cardiopulmonary bypass. Current laboratory methods of diagnosis are not timely enough to guide management decisions, thus spurring interest in discovering new biomarkers of...
journal_title:Biomarkers in medicine
pub_type: 杂志文章,评审
doi:10.2217/bmm.12.27
更新日期:2012-06-01 00:00:00
abstract::With the regulatory approvals in Europe and the USA of trastuzumab-based anti-HER2 targeted therapy for upper gastrointestinal cancers in 2010, HER2 testing has now become universal for newly diagnosed cases of both breast cancer and adenocarcinomas of esophagus, stomach and gastroesophageal origin. In the 12 years or...
journal_title:Biomarkers in medicine
pub_type: 杂志文章,评审
doi:10.2217/bmm.11.31
更新日期:2011-06-01 00:00:00
abstract::In this work, we review the main available computational methods of identifying biomarkers of complex diseases from high-throughput data. The emerging omics techniques provide powerful alternatives to measure thousands of molecules in cells in parallel manners. The generated genomic, transcriptomic, proteomic, metabol...
journal_title:Biomarkers in medicine
pub_type: 杂志文章,评审
doi:10.2217/bmm-2015-0035
更新日期:2016-06-01 00:00:00
abstract:AIM:Sepsis is a critical condition that leads to high mortality and is the most common cause of death in intensive care units. Despite exhaustive efforts by the scientific community, a reliable biomarker for diagnosis, evolution and prognosis of sepsis is still lacking. Results & methodology: Here, using high-throughpu...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2016-0184
更新日期:2016-12-01 00:00:00
abstract::Major depressive disorder (MDD: unipolar depression) is widely distributed in the USA and world-wide populations and it is one of the leading causes of disability in both adolescents and adults. Traditional diagnostic approaches for MDD are based on patient interviews, which provide a subjective assessment of clinical...
journal_title:Biomarkers in medicine
pub_type: 杂志文章,评审
doi:10.2217/bmm-2016-0076
更新日期:2016-08-01 00:00:00
abstract:AIM:The conflicting relationships of serum omentin with inflammation markers and cardiometabolic disorders were investigated. Results & methods: Unselected 864 population-based middle-aged adults were cross-sectionally studied by sex-specific omentin tertiles. Men in the lowest omentin tertile (T1) had lower systolic b...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2017-0197
更新日期:2018-02-01 00:00:00
abstract:AIM:To investigate the clinical significance of detecting several biomarkers collectively in the diagnosis of rheumatoid arthritis (RA). METHODS:128 RA patients, 174 non-RA patients and 80 healthy controls were enrolled. HLA-DR4 and HLA-DR53 were detected by the PCR-SSP method, 14-3-3η protein, anti-CCP and anti-Sa we...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2017-0371
更新日期:2018-07-01 00:00:00
abstract:AIM:Ankylosing spondylitis (AS) is a chronic systemic inflammatory rheumatic disorder that primarily affects the axial skeleton. To date there is no satisfactory biomarker for diagnosis or prognosis of AS. This study is focused on detection of potential biomarkers for the diagnosis of AS using surface-enhanced laser de...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/17520363.2.1.23
更新日期:2008-02-01 00:00:00
abstract:AIM:Several lines of evidence exist which suggest that changes in the expression of circulating cytokines are linked to the development or reoccurrence of multiple sclerosis (MS). This study aimed to evaluate the serum levels of relevant cytokines after therapy with IFN-β formulations in MS patients. MATERIALS & METHO...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm.10.81
更新日期:2010-10-01 00:00:00
abstract:AIM:This meta-analysis was designed to analyze and evaluate the prognostic role of preoperative or pretreatment platelet-to-lymphocyte ratio (PLR) in patients with colorectal cancer (CRC). METHOD:We searched PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Chinese Biomedical L...
journal_title:Biomarkers in medicine
pub_type: 杂志文章,meta分析
doi:10.2217/bmm-2016-0181
更新日期:2017-01-01 00:00:00
abstract:AIM:Childhood cancer remains one of the main cause of death in the pediatric population. Amino acids (AAs) level alterations in plasma are considered to play a role in carcinogenesis and further course of the disease. METHODS:Seventy-seven children with cancer, including 47 with hematological and 30 with solid tumors ...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2017-0102
更新日期:2017-08-01 00:00:00
abstract::With increasing knowledge of the regulatory mechanisms of G-protein-coupled receptor signaling in heart physiology, many studies have focused on the role of this system in cardiovascular disease. In recent years, scientists have moved their attention from the receptors to their regulatory proteins: the G-protein-coupl...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm.09.50
更新日期:2009-10-01 00:00:00
abstract::The application of genomic medicine to the treatment of nicotine dependence holds great promise for revitalizing the steady decline in smoking rates witnessed in the USA over the past several decades. This paper examines the current knowledge base concerning the use of biomarkers to guide the selection of nicotine dep...
journal_title:Biomarkers in medicine
pub_type: 杂志文章,评审
doi:10.2217/bmm.11.91
更新日期:2011-12-01 00:00:00
abstract:AIM:The purpose of this study was to establish the influence of centrifugation and protease activity on the cerebrospinal fluid (CSF) concentrations of DJ-1 and hemoglobin. MATERIALS & METHODS:The concentrations of DJ-1 and hemoglobin were determined in 12 (DJ-1) and six (hemoglobin) pairs of CSF samples, with one sam...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm.13.125
更新日期:2014-01-01 00:00:00
abstract:AIM:The association between Lipoprotein (a) (Lp [a]) and common carotid intima media thickness (IMT) has been evaluated in 222 menopausal women. MATERIAL & METHODS:Lp (a) and IMT were measured, carotid ultrasound examination (B-Mode imaging) was performed and mean max IMT was calculated. RESULTS:Lp (a) was significan...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm.16.4
更新日期:2016-01-01 00:00:00
abstract::Aim: To evaluate an 8.7-kb mitochondrial DNA (mtDNA) deletion as a potential biomarker of endometriosis. Materials & methods: We tested the diagnostic accuracy of the 8.7-kb deletion real-time PCR assay using 182 prospectively collected blood samples from females presenting with symptoms of endometriosis in a case-con...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2019-0451
更新日期:2020-02-01 00:00:00
abstract:AIM:Specific miRNA profiles have been identified for several samples from patients with bladder cancer. The results are not always congruent and partly contradictory. A comparison of published data was performed to select potential markers. MATERIALS & METHODS:A literature search in PubMed identified 79 articles publi...
journal_title:Biomarkers in medicine
pub_type: 杂志文章,评审
doi:10.2217/bmm.14.26
更新日期:2014-01-01 00:00:00
abstract::Bladder cancer is one of the most prevalent cancers worldwide. Early detection of bladder tumors is critical for improved patient outcomes. The standard method for detection and surveillance of bladder tumors is cystoscopy with urinary cytology. Limitations of cystoscopy and urinary cytology have brought to light the ...
journal_title:Biomarkers in medicine
pub_type: 杂志文章,评审
doi:10.2217/bmm.13.73
更新日期:2013-10-01 00:00:00
abstract::The uPA system mainly comprises the urokinase-type plasminogen activator uPA, the cell-surface receptor uPA receptor and the inhibitor PAI-1. Its clinical and prognostic impact especially in breast cancer is well investigated. In this short report, we summarize the published data describing expression of uPA, PAI-1 an...
journal_title:Biomarkers in medicine
pub_type: 杂志文章,评审
doi:10.2217/bmm.12.105
更新日期:2013-06-01 00:00:00
abstract::Aim: Noninvasive assessments of C-reactive protein (CRP) in stress contexts have seldom been compared. This study evaluated CRP response to acute social stress as measured in saliva and dried blood spot (DBS). Materials & methods: African-Americans (N = 118; mean age = 32 years) participated in a laboratory-based soci...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2019-0391
更新日期:2020-04-01 00:00:00
abstract:AIM:To assess the possible relationship between coronary atherosclerosis markers, pericardial fat volume (PFV) and coronary artery calcification, with ECG markers of index of the cardiac electrophysiological balance (iCEB) and transmural dispersion of the repolarization in patients with suspected coronary artery diseas...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2017-0187
更新日期:2018-04-01 00:00:00
abstract::Like all human cancers, colorectal cancer is a complicated disease. While a mature body of research involving colorectal cancer has implicated the putative sequence of genetic alterations that trigger the disease and sustain its progression, there is a surprising paucity of well-validated, clinically useful diagnostic...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/BMM.09.33
更新日期:2009-08-01 00:00:00
abstract::Aim: To investigate and validate predictive value of combination of pretreatment monocyte-to-lymphocyte ratio (MLR) and neutrophil-to-lymphocyte ratio (NLR) for disease free survival (DFS) and overall survival (OS) in nonmuscle invasive bladder cancer after transurethral resection. Materials & methods: Total 358 patie...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2019-0398
更新日期:2019-12-01 00:00:00
abstract::The prevalence of metabolic disorders (MDs), especially diabetes, is rapidly increasing worldwide, leading to an increasing risk of cardiovascular and other socially relevant complications. To boost MD biomarker discovery, advanced proteomics can harmonize metabolomics. Indeed, the rapid development of mass spectromet...
journal_title:Biomarkers in medicine
pub_type: 杂志文章,评审
doi:10.2217/bmm.12.92
更新日期:2012-12-01 00:00:00
abstract::It has become increasingly clear that the development of cancer, a multifactorial disease, cannot be explained by a single molecule or gene mutation. As a new discipline, metabolomics focuses on the body's metabolite changes, and attempts to find differences to explain the development of cancer; it has proven to be ef...
journal_title:Biomarkers in medicine
pub_type: 杂志文章,评审
doi:10.2217/bmm-2018-0229
更新日期:2018-12-01 00:00:00
abstract::Letter in regards to: Akboga MK, Balci KG, Maden O et al. Usefulness of monocyte to HDL-cholesterol ratio to predict high SYNTAX score in patients with stable coronary artery disease. Biomark. Med. 10(4), 375-383 (2016). ...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2016-0326
更新日期:2017-08-01 00:00:00
abstract::Combination antiretroviral therapy (cART) has significantly reduced morbidity and mortality of HIV-infected patients, yet their life expectancy remains reduced compared with the general population. Most HIV-infected patients receiving cART have some persistent immune dysfunction characterized by chronic immune activat...
journal_title:Biomarkers in medicine
pub_type: 杂志文章,评审
doi:10.2217/bmm.11.15
更新日期:2011-04-01 00:00:00