Abstract:
AIM:The conflicting relationships of serum omentin with inflammation markers and cardiometabolic disorders were investigated. Results & methods: Unselected 864 population-based middle-aged adults were cross-sectionally studied by sex-specific omentin tertiles. Men in the lowest omentin tertile (T1) had lower systolic blood pressure, HbA1c and glucose values and tended in T3 to higher lipoprotein(a) levels. Logistic regression analysis, adjusted for four covariates, revealed significant independent associations with the presence of hypertension and diabetes only in men. Sex- and age-adjusted odds ratio in gender combined for T2 & T3 versus T1 was 1.34 (95% CI: 1.00-1.79) for metabolic syndrome. DISCUSSION & CONCLUSION:The elicited adverse relationships of omentin-1 support the notion of oxidative stress-induced proinflammatory conversion of omentin, rendering loss of anti-inflammatory properties.
journal_name
Biomark Medjournal_title
Biomarkers in medicineauthors
Onat A,Ademoglu E,Karadeniz Y,Can G,Uzun AO,Simsek B,Kaya Adoi
10.2217/bmm-2017-0197subject
Has Abstractpub_date
2018-02-01 00:00:00pages
141-149issue
2eissn
1752-0363issn
1752-0371journal_volume
12pub_type
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