Abstract:
AIM:To investigate the clinical significance of detecting several biomarkers collectively in the diagnosis of rheumatoid arthritis (RA). METHODS:128 RA patients, 174 non-RA patients and 80 healthy controls were enrolled. HLA-DR4 and HLA-DR53 were detected by the PCR-SSP method, 14-3-3η protein, anti-CCP and anti-Sa were detected by ELISA and DD was detected by latex immunoturbidimetric assay. RESULTS:The positive rates of HLA-DR4, HLA-DR53, 14-3-3η protein, anti-CCP and anti-Sa were obviously higher in the RA group (43.8, 38.3, 51.6, 80 and 40.6%, respectively); anti-CCP was of highest sensitivity (79.68%), highest specificity (97.5%) and Youden index (0.77). The AUC of 14-3-3η protein, DD, anti-CCP, anti-Sa were 0.813, 0.859, 0.930, 0.861, respectively. CONCLUSION:All biomarkers were strongly correlated risk factors for RA; the combination of multiple biomarkers might be of help for diagnostic and therapeutic strategies in RA of recent onset.
journal_name
Biomark Medjournal_title
Biomarkers in medicineauthors
Tan L,Wang Q,Zeng T,Long T,Guan X,Wu S,Zheng W,Fu H,Meng Y,Wu Y,Tian Y,Yu J,Chen J,Li H,Cao Ldoi
10.2217/bmm-2017-0371subject
Has Abstractpub_date
2018-07-01 00:00:00pages
697-705issue
7eissn
1752-0363issn
1752-0371journal_volume
12pub_type
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