Predictive biomarkers for immunotherapy efficacy in non-small-cell lung cancer: current status and future perspectives.

Abstract:

:In recent years, immune checkpoint inhibitors have rapidly changed treatment paradigms and have been pivotal for the treatment of advanced NSCLC patients. However, many patients don't respond to immunotherapy, and toxicities are a concern. Mounting evidence suggests that PD-L1 expression and tumor mutational burden are useful biomarkers in NSCLC and widely used in clinical practice. Given various limitations of PD-L1 and tumor mutational burden, many candidate biomarkers have emerged. From these biomarkers, peripheral blood-based biomarkers are promising options for the prediction of immunotherapy efficacy with ease of access, repeatability and low cost. This review provides an overview of recent developments on the biomarkers in immunotherapy efficacy together with comments on future perspectives.

journal_name

Biomark Med

journal_title

Biomarkers in medicine

authors

C Guven D,Sahin TK,Dizdar O,Kilickap S

doi

10.2217/bmm-2020-0310

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

1383-1392

issue

14

eissn

1752-0363

issn

1752-0371

journal_volume

14

pub_type

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