Analytical aspects of molecular Alzheimer's disease biomarkers.

abstract：:The natriuretic peptide system comprises three structurally related peptides: atrial natriuretic peptide, B-type natriuretic peptide and C-type natriuretic peptide. In circulation, they play an important endocrine role in the regulation of cardiovascular homeostasis by maintaining blood pressure and extracellular flui...

journal_title：Biomarkers in medicine

authors： Lippert S,Goetze JP

更新日期：2010-08-01 00:00:00

abstract：:Cardiovascular disease refers to different diseases involving the heart and/or the arteries and/or the veins. Cardiovascular disease, overall considered, is a notable source of morbidity and mortality worldwide. Therefore, several research studies are dedicated to explore, by means of biomarkers, the possiblity to cal...

journal_title：Biomarkers in medicine

authors： Serra R,Ielapi N,Barbetta A,Andreucci M,de Franciscis S

更新日期：2018-09-01 00:00:00

abstract：AIM:To assess the possible relationship between coronary atherosclerosis markers, pericardial fat volume (PFV) and coronary artery calcification, with ECG markers of index of the cardiac electrophysiological balance (iCEB) and transmural dispersion of the repolarization in patients with suspected coronary artery diseas...

journal_title：Biomarkers in medicine

authors： Nafakhi H,Al-Mosawi AA,Alareedh M,Al-Nafakh HA

更新日期：2018-04-01 00:00:00

abstract：AIM:To investigate the role of gelsolin-like actin-capping protein (CapG) in prostate cancer (PCa). MATERIALS & METHODS:CapG expression and its correlation with clinicopathological characters and patient prognosis were analyzed in 76 cases of PCa by immunohistochemistry and qRT-PCR. Then, the influence of CapG downreg...

journal_title：Biomarkers in medicine

authors： Li T,Hong X,Zhao J,Teng Y,Zheng J,Chen H,Chen H,Li H

更新日期：2016-12-01 00:00:00

abstract：AIM:This study aimed to assess the urinary concentrations of epidermal growth factor (EGF) and kidney injury molecule 1 (KIM-1) in patients with hydronephrosis. METHODS:Neonates with a history of prenatal hydronephrosis were enrolled in three groups. Group 1 included neonates with severe obstruction; group 2 included ...

journal_title：Biomarkers in medicine

authors： Mohammadjafari H,Rafiei A,Kosaryan M,Yeganeh Y,Hosseinimehr SJ

更新日期：2014-01-01 00:00:00

abstract：AIM:We investigated the association of gamma-glutamyltransferase (GGT) activity with atherogenic risk factors and metabolic health status in young nondiabetic obese women. METHODS & RESULTS:In 140 obese women GGT activity was independently associated with BMI, triglyceride to high-density cholesterol ratio and homeost...

journal_title：Biomarkers in medicine

authors： Mankowska-Cyl A,Krintus M,Rajewski P,Sypniewska G

更新日期：2017-05-01 00:00:00

abstract：:Like all human cancers, colorectal cancer is a complicated disease. While a mature body of research involving colorectal cancer has implicated the putative sequence of genetic alterations that trigger the disease and sustain its progression, there is a surprising paucity of well-validated, clinically useful diagnostic...

journal_title：Biomarkers in medicine

authors： Nibbe RK,Chance MR

更新日期：2009-08-01 00:00:00

abstract：:Clinical proteomics has great promise, but many hurdles. Proteomic approaches may prove to be the answer to decades of frustrating searches for markers that are specific and selective for breast cancer. In order to achieve this goal, the challenge arises that breast cancer is a heterogeneous disease and individual var...

journal_title：Biomarkers in medicine

authors： Ruhlen RL,Sauter ER

更新日期：2007-08-01 00:00:00

abstract：AIM:Childhood cancer remains one of the main cause of death in the pediatric population. Amino acids (AAs) level alterations in plasma are considered to play a role in carcinogenesis and further course of the disease. METHODS:Seventy-seven children with cancer, including 47 with hematological and 30 with solid tumors ...

journal_title：Biomarkers in medicine

authors： Synakiewicz A,Sawicka-Zukowska M,Adrianowska N,Galezowska G,Ratajczyk J,Owczarzak A,Konieczna L,Stachowicz-Stencel T

更新日期：2017-08-01 00:00:00

abstract：AIM:To investigate the clinical significance of detecting several biomarkers collectively in the diagnosis of rheumatoid arthritis (RA). METHODS:128 RA patients, 174 non-RA patients and 80 healthy controls were enrolled. HLA-DR4 and HLA-DR53 were detected by the PCR-SSP method, 14-3-3η protein, anti-CCP and anti-Sa we...

journal_title：Biomarkers in medicine

authors： Tan L,Wang Q,Zeng T,Long T,Guan X,Wu S,Zheng W,Fu H,Meng Y,Wu Y,Tian Y,Yu J,Chen J,Li H,Cao L

更新日期：2018-07-01 00:00:00

abstract：AIM:To establish a database for the associations between idiosyncratic drug reactions (IDRs) and human leukocyte antigens (HLAs) and to systematically assess the characteristics of the drug-HLA associations. MATERIALS & METHODS:Electronic databases were searched to extensively identify drug-HLA association studies fro...

journal_title：Biomarkers in medicine

authors： Du T,Yang L,Luo H,Zhou P,Mei H,Xuan J,Xing Q,Ning B,Mendrick DL,Shi L

更新日期：2015-01-01 00:00:00

abstract：:Currently, decision-making for breast cancer treatment in the clinical setting is mainly based on clinical data, histomorphological features of the tumor tissue and a few cancer biomarkers such as steroid hormone receptor status (estrogen and progesterone receptors) and oncoprotein HER2 status. Although various therap...

journal_title：Biomarkers in medicine

authors： Napieralski R,Brünner N,Mengele K,Schmitt M

更新日期：2010-08-01 00:00:00

abstract：:Background: We aimed to assess the predictive value of the absolute and relative intact parathormone (iPTH) decline levels as reliable markers of postoperative hypocalcemia. Materials & methods: iPTH levels were measured 4 h after surgery and the following morning after surgery (postoperative day 1). iPTH, absolute iP...

journal_title：Biomarkers in medicine

authors： Rajan S,Ravindhran B,George B,Bantwal G,Vageesh Ayyar,Mohan LN

更新日期：2020-08-01 00:00:00

abstract：:Aim: To investigate the role of endothelial PV-1 in patients with untreated celiac disease (CD)-associated liver injury. Materials & methods: PV-1 and PV-1 mRNA were measured in intestinal biopsies from untreated CD patients with elevated or normal alanine transaminase levels, controls, patients with inflammatory bowe...

journal_title：Biomarkers in medicine

authors： De Leo L,Naviglio S,Vatta S,Benelli E,Stera G,Santon D,Ziberna F,Taddio A,Martelossi S,Giudici F,Giuffrida P,Di Sabatino A,Corazza GR,Ventura A,Not T

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Circulating tumor cells (CTCs) and tumor-specific alterations in cell-free plasma DNA can both be used as markers of prognosis in breast cancer. To date, there have been no studies that have compared these as markers for subclinical metastases in the follow-up of early breast cancer. In this study, we measur...

journal_title：Biomarkers in medicine

authors： Shaw JA,Brown J,Coombes RC,Jacob J,Payne R,Lee B,Page K,Hava N,Stebbing J

更新日期：2011-02-01 00:00:00

abstract：:Biomarker discovery is essential to the advancement of our knowledge about diseases and to the development of new strategies for treatment and therapy. Among the newest technologies in this rapidly growing field is a process termed Cell SELEX by which a panel of aptamers can be generated to specifically target disease...

journal_title：Biomarkers in medicine

authors： Kim Y,Liu C,Tan W

更新日期：2009-04-01 00:00:00

abstract：:Patients with metastatic colorectal cancer have a very poor prognosis. Incorporation of targeted molecular therapies, such as the anti-EGFR receptor monoclonal antibodies cetuximab and panitumumab, into treatment regimens has improved outcomes for patients with wild-type RAS tumors. Yet, response rates remain low and ...

journal_title：Biomarkers in medicine

authors： Caiazza F,Elliott L,Fennelly D,Sheahan K,Doherty GA,Ryan EJ

更新日期：2015-01-01 00:00:00

abstract：:Modern war wounds are complex and primarily involve extremities. They require multiple operative interventions to achieve wound closure and begin rehabilitation. Current assessment of the suitability of surgical wound closure is based upon subjective methods coupled with a semiquantitative determination of the wound b...

journal_title：Biomarkers in medicine

authors： Brown TS,Safford S,Caramanica J,Elster EA

更新日期：2010-06-01 00:00:00

abstract：:Aim: to evaluate the associations between signatures of apoptotic endothelial cell-derived microvesicles (MVs) with phenotypes of chronic heart failure (HF). Methods: The study cohort consisted of 388 prospectively involved subjects with HF patients with predominantly reduced left ventricular ejection fraction (HFrEF)...

journal_title：Biomarkers in medicine

authors： Berezin AE,Kremzer AA,Samura TA,Berezina TA

更新日期：2019-06-01 00:00:00

abstract：AIM:This study aimed to identify plasma protein changes in a rat model of ischemic stroke using a proteomic approach. MATERIALS & METHODS:Four male Sprague-Dawley rats (3-6 months old) were subjected to 90 min of left middle cerebral artery occlusion under anesthesia with 1.5% isoflurane in O(2)/air followed by 24-h r...

journal_title：Biomarkers in medicine

authors： Chen R,Vendrell I,Chen CP,Cash D,O'Toole KG,Williams SA,Jones C,Preston JE,Wheeler JX

更新日期：2011-12-01 00:00:00

abstract：AIM:The purpose of this study was to establish the influence of centrifugation and protease activity on the cerebrospinal fluid (CSF) concentrations of DJ-1 and hemoglobin. MATERIALS & METHODS:The concentrations of DJ-1 and hemoglobin were determined in 12 (DJ-1) and six (hemoglobin) pairs of CSF samples, with one sam...

journal_title：Biomarkers in medicine

authors： Salvesen L,Tanassi JT,Bech S,Pålhagen S,Svenningsson P,Heegaard NH,Winge K

更新日期：2014-01-01 00:00:00

abstract：:Interferons (IFNs) comprise type I, II and III families with multiple subtypes. Via transcription of IFN-stimulated genes (ISGs), IFNs can exert multiple biological effects on the cell. In infectious and chronic inflammatory diseases, the IFNs and their ISG sets can be potentially utilized as biomarkers of disease out...

journal_title：Biomarkers in medicine

authors： Berry CM,Hertzog PJ,Mangan NE

更新日期：2012-04-01 00:00:00

abstract：:Aim: Natural killer cell receptor group 2D (NKG2D) plays an important role in the immune regulation of tumors. We speculate that DNA methylation are involved in the regulation of NKG2D gene. Methods: We investigated the methylation status of the NKG2D promoter in peripheral blood mononuclear cells of hepatocellular ca...

journal_title：Biomarkers in medicine

authors： Zhao NH,Qian Y,Wu CS,Wang JW,Fang Y,Fan XP,Gao S,Fan YC,Wang K

更新日期：2019-09-01 00:00:00

abstract：AIM:Several lines of evidence exist which suggest that changes in the expression of circulating cytokines are linked to the development or reoccurrence of multiple sclerosis (MS). This study aimed to evaluate the serum levels of relevant cytokines after therapy with IFN-β formulations in MS patients. MATERIALS & METHO...

journal_title：Biomarkers in medicine

authors： Arababadi MK,Mosavi R,Khorramdelazad H,Yaghini N,Zarandi ER,Araste M,Pourali R,Nekhei Z,Kennedy D

更新日期：2010-10-01 00:00:00

abstract：AIM:The usefulness of high-sensitivity troponin T (hs-TnT) as a predictor of perioperative hemodynamic instability is currently unknown. METHODS:A prospective study was conducted on a group of 708 consecutive patients with significant valvular heart disease that underwent elective valve surgery. The primary end point ...

journal_title：Biomarkers in medicine

authors： Duchnowski P,Hryniewiecki T,Koźma M,Mariusz K,Piotr S

更新日期：2018-12-01 00:00:00

abstract：AIM:This meta-analysis was designed to analyze and evaluate the prognostic role of preoperative or pretreatment platelet-to-lymphocyte ratio (PLR) in patients with colorectal cancer (CRC). METHOD:We searched PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Chinese Biomedical L...

journal_title：Biomarkers in medicine

authors： Min GT,Wang YH,Yao N,Zhao JM,Wang J,Wang HP,Chen W,Deng SJ,Li YM

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Oxidative stress has been postulated as an additive factor linking obesity to cardiovascular disease. MATERIALS & METHODS:Derivatives of reactive oxygen species metabolites (d-ROMs) were measured in 136 obese (42 males, 94 females; mean age: 47 ± 12 years; BMI: 36 ± 5 kg/m(2)) and in 306 over- and normal-we...

journal_title：Biomarkers in medicine

authors： Vassalle C,Vigna L,Bianchi S,Maffei S,Novembrino C,De Giuseppe R,de Liso F,Vannucci A,Tirelli S,Maiavacca R,Bamonti F

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Autism spectrum disorder (ASD) represents a wide range of neurodevelopmental disorders characterized by impairments in social interaction, language, communication and range of interests. Autism is usually diagnosed in children 3-5 years of age using behavioral characteristics; thus, diagnosis shortly after b...

journal_title：Biomarkers in medicine

authors： Mizejewski GJ,Lindau-Shepard B,Pass KA

更新日期：2013-04-01 00:00:00

abstract：:It has become increasingly clear that the development of cancer, a multifactorial disease, cannot be explained by a single molecule or gene mutation. As a new discipline, metabolomics focuses on the body's metabolite changes, and attempts to find differences to explain the development of cancer; it has proven to be ef...

journal_title：Biomarkers in medicine

authors： Zhang WT,Zhang ZW,Guo YD,Wang LS,Mao SY,Zhang JF,Liu MN,Yao XD

更新日期：2018-12-01 00:00:00

abstract：:With increasing knowledge of the regulatory mechanisms of G-protein-coupled receptor signaling in heart physiology, many studies have focused on the role of this system in cardiovascular disease. In recent years, scientists have moved their attention from the receptors to their regulatory proteins: the G-protein-coupl...

journal_title：Biomarkers in medicine

authors： Campanile A,Iaccarino G

更新日期：2009-10-01 00:00:00