Abstract:
:Aim: Natural killer cell receptor group 2D (NKG2D) plays an important role in the immune regulation of tumors. We speculate that DNA methylation are involved in the regulation of NKG2D gene. Methods: We investigated the methylation status of the NKG2D promoter in peripheral blood mononuclear cells of hepatocellular carcinoma (HCC) patients, chronic hepatitis B patients and healthy controls by methylation-specific PCR and the mRNA expression level was examined by real-time quantitative PCR. Results: The methylation frequency of NKG2D promoter in HCC patients was higher than that of chronic hepatitis B patients and healthy controls. NKG2D promoter methylation has a good predictive value for HCC diagnosis. Conclusion: NKG2D promoter methylation can be used as a noninvasive marker for detecting HCC.
journal_name
Biomark Medjournal_title
Biomarkers in medicineauthors
Zhao NH,Qian Y,Wu CS,Wang JW,Fang Y,Fan XP,Gao S,Fan YC,Wang Kdoi
10.2217/bmm-2019-0102subject
Has Abstractpub_date
2019-09-01 00:00:00pages
1093-1105issue
13eissn
1752-0363issn
1752-0371journal_volume
13pub_type
杂志文章abstract::Increasing evidence has highlighted the roles of oxidative stress and inflammation in the promotion of atherosclerotic cardiovascular disease. Recent pathological studies have elucidated specific mediators that appear to link these pathways to the progression and rupture of atherosclerotic plaque in the artery wall. T...
journal_title:Biomarkers in medicine
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journal_title:Biomarkers in medicine
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journal_title:Biomarkers in medicine
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journal_title:Biomarkers in medicine
pub_type: 杂志文章,评审
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journal_title:Biomarkers in medicine
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journal_title:Biomarkers in medicine
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journal_title:Biomarkers in medicine
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journal_title:Biomarkers in medicine
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pub_type: 传,历史文章,面试
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