Diagnostic value of NKG2D promoter methylation in hepatitis B virus-associated hepatocellular carcinoma.

Abstract:

:Aim: Natural killer cell receptor group 2D (NKG2D) plays an important role in the immune regulation of tumors. We speculate that DNA methylation are involved in the regulation of NKG2D gene. Methods: We investigated the methylation status of the NKG2D promoter in peripheral blood mononuclear cells of hepatocellular carcinoma (HCC) patients, chronic hepatitis B patients and healthy controls by methylation-specific PCR and the mRNA expression level was examined by real-time quantitative PCR. Results: The methylation frequency of NKG2D promoter in HCC patients was higher than that of chronic hepatitis B patients and healthy controls. NKG2D promoter methylation has a good predictive value for HCC diagnosis. Conclusion: NKG2D promoter methylation can be used as a noninvasive marker for detecting HCC.

journal_name

Biomark Med

journal_title

Biomarkers in medicine

authors

Zhao NH,Qian Y,Wu CS,Wang JW,Fang Y,Fan XP,Gao S,Fan YC,Wang K

doi

10.2217/bmm-2019-0102

subject

Has Abstract

pub_date

2019-09-01 00:00:00

pages

1093-1105

issue

13

eissn

1752-0363

issn

1752-0371

journal_volume

13

pub_type

杂志文章
  • Biomarkers of inflammation and oxidative stress in atherosclerosis.

    abstract::Increasing evidence has highlighted the roles of oxidative stress and inflammation in the promotion of atherosclerotic cardiovascular disease. Recent pathological studies have elucidated specific mediators that appear to link these pathways to the progression and rupture of atherosclerotic plaque in the artery wall. T...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.10.57

    authors: Uno K,Nicholls SJ

    更新日期:2010-06-01 00:00:00

  • Clinical evaluation of the Heart Check system, a new quantitative measurement of fresh capillary BNP.

    abstract:AIM:We have evaluated here the clinical and analytical performance of the Alere™ Heart Check (AHC) test, a rapid point-of-care immunoassay designed for the measurement of BNP from fresh capillary whole blood. PATIENTS & METHODS:One-hundred-and-sixty-three patients with stable chronic heart failure followed at the card...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm.15.95

    authors: Monfort A,Da Silva K,Vodovar N,Gayat E,Cohen-Solal A,Manivet P

    更新日期:2015-01-01 00:00:00

  • Plasma albumin levels predict risk for nonsurvivors in critically ill patients with COVID-19.

    abstract::Aim: We aimed to explore the biomarkers for disease progression or the risk of nonsurvivors. Materials & methods: This study included 134 hospitalized patients with confirmed COVID-19 infection. The outcome of moderate versus severe versus critically ill patients and survivors versus nonsurvivors were compared. Result...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2020-0254

    authors: Li J,Li M,Zheng S,Li M,Zhang M,Sun M,Li X,Deng A,Cai Y,Zhang H

    更新日期:2020-07-01 00:00:00

  • Seeking an objective diagnosis of depression.

    abstract::Major depressive disorder (MDD: unipolar depression) is widely distributed in the USA and world-wide populations and it is one of the leading causes of disability in both adolescents and adults. Traditional diagnostic approaches for MDD are based on patient interviews, which provide a subjective assessment of clinical...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm-2016-0076

    authors: Bilello JA

    更新日期:2016-08-01 00:00:00

  • Gamma-glutamyltransferase activity as a surrogate biomarker of metabolic health status in young nondiabetic obese women.

    abstract:AIM:We investigated the association of gamma-glutamyltransferase (GGT) activity with atherogenic risk factors and metabolic health status in young nondiabetic obese women. METHODS & RESULTS:In 140 obese women GGT activity was independently associated with BMI, triglyceride to high-density cholesterol ratio and homeost...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2016-0332

    authors: Mankowska-Cyl A,Krintus M,Rajewski P,Sypniewska G

    更新日期:2017-05-01 00:00:00

  • Usefulness of monocyte to HDL-cholesterol ratio to predict high SYNTAX score in patients with stable coronary artery disease.

    abstract:AIM:We aimed to investigate whether baseline monocyte to high-density lipoprotein cholesterol ratio (MHR), an easily available inflammatory and oxidative stress marker, is associated with SYNTAX score. PATIENTS & METHODS:In this cross-sectional study, n = 1229 consecutive patients with coronary artery disease were cla...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2015-0050

    authors: Akboga MK,Balci KG,Maden O,Ertem AG,Kirbas O,Yayla C,Acar B,Aras D,Kisacik H,Aydogdu S

    更新日期:2016-01-01 00:00:00

  • FABP4 as a biomarker for knee osteoarthritis.

    abstract:AIM:To explore the role of an adipokine-termed fatty acid-binding protein 4 (FABP4) in osteoarthritis (OA). METHODS:Patients with primary knee OA and non-OA controls were included. Paired tissues including plasma, synovial fluid (SF), subcutaneous fat and infrapatellar fat pad (IPFP) were harvested during surgery. FAB...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2017-0207

    authors: Zhang C,Li T,Chiu KY,Wen C,Xu A,Yan CH

    更新日期:2018-02-01 00:00:00

  • Evaluation of the relation between cardiac biomarkers and thorax computerized tomography findings in COVID-19 patients.

    abstract::Background: Troponin levels may be elevated in COVID-19 infection. The aim of this study was to the explore relation between troponin levels and COVID-19 severity. Materials & methods/Results: One hundred and forty consecutive patients with COVID-19 pneumonia were included. Diagnosis of COVID-19 pneumonia was based on...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2020-0388

    authors: Ileri C,Dogan Z,Ozben B,Karaoglu C,Gunay N,Tigen K,Basat S,Uyan C

    更新日期:2021-01-27 00:00:00

  • Genetic biomarkers in aortopathy.

    abstract::The field of aortopathy, in common with other genomic disorders, is undergoing a revolution. This is largely driven by the implementation of newer forms of genetic sequencing (massively parallel or next-generation sequencing). Advantages conferred by this technology include reduced costs, reduced sequencing time and t...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.13.74

    authors: Rea G,Stewart FJ

    更新日期:2013-08-01 00:00:00

  • The prognostic role of pretreatment platelet-to-lymphocyte ratio as predictors in patients with colorectal cancer: a meta-analysis.

    abstract:AIM:This meta-analysis was designed to analyze and evaluate the prognostic role of preoperative or pretreatment platelet-to-lymphocyte ratio (PLR) in patients with colorectal cancer (CRC). METHOD:We searched PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Chinese Biomedical L...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,meta分析

    doi:10.2217/bmm-2016-0181

    authors: Min GT,Wang YH,Yao N,Zhao JM,Wang J,Wang HP,Chen W,Deng SJ,Li YM

    更新日期:2017-01-01 00:00:00

  • Early detection of acute coronary syndromes and risk stratification by multimarker analysis.

    abstract::Cardiac troponin is the standard biomarker for the diagnosis of acute myocardial infarction (AMI) and risk stratification for short-term adverse cardiac events (death, AMI or need for revascularization). Unfortunately, the concentration of troponin in blood is normal in AMI patients who present early after the onset o...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/17520363.1.1.45

    authors: Wu AH

    更新日期:2007-06-01 00:00:00

  • Correlations between lncRNA-SOX2OT polymorphism and susceptibility to breast cancer in a Chinese population.

    abstract:AIM:We evaluated the effect of lncRNA SOX2OT expression and its SNP in tumorigenesis and development of breast cancer (BC) in a case-control study. METHODS:A total of 1106 individuals, 505 newly diagnosed BC patients and 601 age-matched controls (±2 years) were testified. Real-time PCR was adopted for testing tissues'...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2016-0238

    authors: Tang X,Gao Y,Yu L,Lu Y,Zhou G,Cheng L,Sun K,Zhu B,Xu M,Liu J

    更新日期:2017-03-01 00:00:00

  • G-protein-coupled receptor kinases in cardiovascular conditions: focus on G-protein-coupled receptor kinase 2, a gain in translational medicine.

    abstract::With increasing knowledge of the regulatory mechanisms of G-protein-coupled receptor signaling in heart physiology, many studies have focused on the role of this system in cardiovascular disease. In recent years, scientists have moved their attention from the receptors to their regulatory proteins: the G-protein-coupl...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm.09.50

    authors: Campanile A,Iaccarino G

    更新日期:2009-10-01 00:00:00

  • FLNA is a predictor of chemoresistance and poor survival in cervical cancer.

    abstract:AIM:To investigate the expression of FLNA and its potential prognostic significance in cervical cancer. PATIENTS & METHODS:Real-time PCR was performed to evaluate the expression levels of FLNA in 44 pairs of cervical cancer and matched normal adjacent tissues. Kaplan-Meier analysis and Cox proportional hazards model w...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2016-0056

    authors: Jin YZ,Pei CZ,Wen LY

    更新日期:2016-07-01 00:00:00

  • Biomarkers in systemic sclerosis.

    abstract::Systemic sclerosis is an autoimmune inflammatory disorder of unknown etiologycharacterized b y pronounced fibroproliferative alterations in the microvasculature, and frequent cellular and humoral immunity abnormalities, culminating in a severe and often progressive fibrotic process. Numerous biomarkers reflecting the ...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.09.79

    authors: Castro SV,Jimenez SA

    更新日期:2010-02-01 00:00:00

  • Charcot-Leyden crystal protein/galectin-10 is a surrogate biomarker of eosinophilic airway inflammation in asthma.

    abstract::Aim: Eosinophilic asthma is associated with more exacerbations and differential responses to treatment. The aim of this study was to assess if CLC/Gal-10 and MBP-1 are surrogate biomarkers of eosinophilic inflammation in asthma. Methods & results: Sputum induction was performed in patients with asthma and in healthy c...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2018-0280

    authors: Nyenhuis SM,Alumkal P,Du J,Maybruck BT,Vinicky M,Ackerman SJ

    更新日期:2019-06-01 00:00:00

  • Targeting EGFR in metastatic colorectal cancer beyond the limitations of KRAS status: alternative biomarkers and therapeutic strategies.

    abstract::Patients with metastatic colorectal cancer have a very poor prognosis. Incorporation of targeted molecular therapies, such as the anti-EGFR receptor monoclonal antibodies cetuximab and panitumumab, into treatment regimens has improved outcomes for patients with wild-type RAS tumors. Yet, response rates remain low and ...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.15.5

    authors: Caiazza F,Elliott L,Fennelly D,Sheahan K,Doherty GA,Ryan EJ

    更新日期:2015-01-01 00:00:00

  • Biomarkers to optimize the treatment of nicotine dependence.

    abstract::The application of genomic medicine to the treatment of nicotine dependence holds great promise for revitalizing the steady decline in smoking rates witnessed in the USA over the past several decades. This paper examines the current knowledge base concerning the use of biomarkers to guide the selection of nicotine dep...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.11.91

    authors: Schnoll RA,Leone FT

    更新日期:2011-12-01 00:00:00

  • Clinicopathological and prognostic significance of octamer-binding transcription factor 4 in patients with gastric cancer: a systematic review and meta-analysis.

    abstract:AIM:The role of octamer-binding transcription factor 4 (Oct4) in gastric cancer (GC) progression is still under debate and reported results are inconsistent. Therefore, we conducted a meta-analysis to evaluate the clinicopathological and prognostic significance of Oct4 expression in patients with GC. MATERIALS & METHO...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,meta分析

    doi:10.2217/bmm-2018-0086

    authors: Wei Y,Liu H,Wang C,Zhang W,Wen X,Long H,Xu Z,Guo H,Liu Y,Wei D,Qiu C,Li G,Sun Z

    更新日期:2019-02-01 00:00:00

  • The application of biomarkers in clinical trials for motor neuron disease.

    abstract::The interest and research into disease-related biomarkers has greatly accelerated over the last 10 years. The potential clinical benefits for disease-specific biomarkers include a more rapid and accurate disease diagnosis, and potential reduction in size and duration of clinical drug trials, which would speed up drug ...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.09.71

    authors: Ganesalingam J,Bowser R

    更新日期:2010-04-01 00:00:00

  • Circulating malondialdehyde concentrations in patients with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis.

    abstract::The aim of this meta-analysis was to review the available evidence regarding the blood concentrations of the oxidative stress marker malondialdehyde (MDA) in chronic obstructive pulmonary disease (COPD) patients in comparison to healthy individuals. 14 studies were included in the meta-analysis (from inception to Octo...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,meta分析

    doi:10.2217/bmm-2017-0420

    authors: Paliogiannis P,Fois AG,Sotgia S,Mangoni AA,Zinellu E,Pirina P,Carru C,Zinellu A

    更新日期:2018-07-01 00:00:00

  • Evaluation of inflammatory and cardiac-electrophysiological markers in patients undergoing peritoneal dialysis.

    abstract::Background: The Tp-e/QT (peak to end of T-wave duration/QT interval) ratio is a promising marker of myocardial repolarization and ventricular arrhythmogenesis. Its elevation is associated with sudden cardiac death in different clinical conditions. This study was designed to assess the possible association between incr...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2020-0230

    authors: Fang J,Su H,Song A,Tong Y,Huang Z,Ding F,Liu Y

    更新日期:2020-12-01 00:00:00

  • Urinary biomarkers of bladder cancer: an update and future perspectives.

    abstract::Bladder cancer is one of the most prevalent cancers worldwide. Early detection of bladder tumors is critical for improved patient outcomes. The standard method for detection and surveillance of bladder tumors is cystoscopy with urinary cytology. Limitations of cystoscopy and urinary cytology have brought to light the ...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.13.73

    authors: Rosser CJ,Urquidi V,Goodison S

    更新日期:2013-10-01 00:00:00

  • Altered signature of apoptotic endothelial cell-derived microvesicles predicts chronic heart failure phenotypes.

    abstract::Aim: to evaluate the associations between signatures of apoptotic endothelial cell-derived microvesicles (MVs) with phenotypes of chronic heart failure (HF). Methods: The study cohort consisted of 388 prospectively involved subjects with HF patients with predominantly reduced left ventricular ejection fraction (HFrEF)...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2018-0449

    authors: Berezin AE,Kremzer AA,Samura TA,Berezina TA

    更新日期:2019-06-01 00:00:00

  • Biomarkers of immune dysfunction following combination antiretroviral therapy for HIV infection.

    abstract::Combination antiretroviral therapy (cART) has significantly reduced morbidity and mortality of HIV-infected patients, yet their life expectancy remains reduced compared with the general population. Most HIV-infected patients receiving cART have some persistent immune dysfunction characterized by chronic immune activat...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.11.15

    authors: Lichtfuss GF,Hoy J,Rajasuriar R,Kramski M,Crowe SM,Lewin SR

    更新日期:2011-04-01 00:00:00

  • Biomarkers of ocular surface disease using impression cytology.

    abstract::Impression cytology (IC) is a technique which permits the retrieval of the outermost layer of ocular surface cells via the use of various types of filters. It is a minimally invasive method of evaluating human conjunctival epithelial cell morphology in the diagnosis of dry eye disease, a common and distressing disorde...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm-2017-0124

    authors: Hagan S

    更新日期:2017-12-01 00:00:00

  • Proteomic analysis of rat plasma following transient focal cerebral ischemia.

    abstract:AIM:This study aimed to identify plasma protein changes in a rat model of ischemic stroke using a proteomic approach. MATERIALS & METHODS:Four male Sprague-Dawley rats (3-6 months old) were subjected to 90 min of left middle cerebral artery occlusion under anesthesia with 1.5% isoflurane in O(2)/air followed by 24-h r...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm.11.89

    authors: Chen R,Vendrell I,Chen CP,Cash D,O'Toole KG,Williams SA,Jones C,Preston JE,Wheeler JX

    更新日期:2011-12-01 00:00:00

  • Predicting tuberculosis treatment outcome using metabolomics.

    abstract:AIM:Predicting a poor treatment outcome would offer significant benefits for patient care and for new drug development. Materials, methods & results: Urine samples from tuberculosis-positive patients with a successful and unsuccessful treatment outcome were collected at baseline and analyzed. The identified metabolites...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2017-0133

    authors: Luies L,Reenen MV,Ronacher K,Walzl G,Loots DT

    更新日期:2017-12-01 00:00:00

  • Urinary excretion of liver-type FABP as a new clinical marker for the progression of obstructive nephropathy.

    abstract:AIM:The aim of this article was to investigate the performance and predictive value of urinary liver-type FABP (uL-FABP) and urinary NGAL (uNGAL) for renal function and prognosis in obstructive nephropathy (ON). PATIENTS & METHODS:A total of 108 ON patients and urine samples were collected. An ELISA was used to determ...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm.13.136

    authors: Xie Y,Xu W,Wang Q,Shao X,Ni Z,Mou S

    更新日期:2014-01-01 00:00:00

  • Development of NuQ nucleosome blood tests for the detection of colon cancer.

    abstract::Dr Jake Micallef speaks to Hannah L Wilson, Commissioning Editor: Dr Micallef has 20 years of experience in research and development and in the management of early-stage biotechnical companies, including the manufacture of biotechnology products and the establishment of manufacturing operations. Dr Micallef gained thi...

    journal_title:Biomarkers in medicine

    pub_type: 传,历史文章,面试

    doi:10.2217/bmm.14.47

    authors: Micallef J,Wilson HL

    更新日期:2014-01-01 00:00:00