Abstract:
AIM:We investigated the association of gamma-glutamyltransferase (GGT) activity with atherogenic risk factors and metabolic health status in young nondiabetic obese women. METHODS & RESULTS:In 140 obese women GGT activity was independently associated with BMI, triglyceride to high-density cholesterol ratio and homeostasis model assessment. Metabolically healthy but obese women had significantly lower GGT activity, associated with a normal insulin sensitivity, favorable lipid profile and apolipoprotein B to apolipoprotein AI ratio. GGT activity showed good diagnostic accuracy to distinguish between metabolically healthy but obese and obese women at risk (77.8% sensitivity and 60% specificity). GGT activity >17 U/l can predict atherogenic risk and insulin resistance. CONCLUSION:GGT activity may serve as a potential surrogate biomarker of atherogenic risk and metabolic health status.
journal_name
Biomark Medjournal_title
Biomarkers in medicineauthors
Mankowska-Cyl A,Krintus M,Rajewski P,Sypniewska Gdoi
10.2217/bmm-2016-0332subject
Has Abstractpub_date
2017-05-01 00:00:00pages
449-457issue
5eissn
1752-0363issn
1752-0371journal_volume
11pub_type
杂志文章abstract:AIM:We evaluated the effect of lncRNA SOX2OT expression and its SNP in tumorigenesis and development of breast cancer (BC) in a case-control study. METHODS:A total of 1106 individuals, 505 newly diagnosed BC patients and 601 age-matched controls (±2 years) were testified. Real-time PCR was adopted for testing tissues'...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2016-0238
更新日期:2017-03-01 00:00:00
abstract::Clinical proteomics has great promise, but many hurdles. Proteomic approaches may prove to be the answer to decades of frustrating searches for markers that are specific and selective for breast cancer. In order to achieve this goal, the challenge arises that breast cancer is a heterogeneous disease and individual var...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/17520363.1.2.251
更新日期:2007-08-01 00:00:00
abstract::Background: We aimed to assess the predictive value of the absolute and relative intact parathormone (iPTH) decline levels as reliable markers of postoperative hypocalcemia. Materials & methods: iPTH levels were measured 4 h after surgery and the following morning after surgery (postoperative day 1). iPTH, absolute iP...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2020-0218
更新日期:2020-08-01 00:00:00
abstract::In recent years, biobanks of human tissues have evolved from small-scale collections of pathological materials into structured resource centers for acquisition, storage, processing and usage of high-quality biospecimens for research. This evolution goes hand in hand with the development of highly sensitive, high-throu...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm.10.104
更新日期:2010-12-01 00:00:00
abstract::The uPA system mainly comprises the urokinase-type plasminogen activator uPA, the cell-surface receptor uPA receptor and the inhibitor PAI-1. Its clinical and prognostic impact especially in breast cancer is well investigated. In this short report, we summarize the published data describing expression of uPA, PAI-1 an...
journal_title:Biomarkers in medicine
pub_type: 杂志文章,评审
doi:10.2217/bmm.12.105
更新日期:2013-06-01 00:00:00
abstract::Cardiac troponin is the standard biomarker for the diagnosis of acute myocardial infarction (AMI) and risk stratification for short-term adverse cardiac events (death, AMI or need for revascularization). Unfortunately, the concentration of troponin in blood is normal in AMI patients who present early after the onset o...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/17520363.1.1.45
更新日期:2007-06-01 00:00:00
abstract:AIM:To explore the role of an adipokine-termed fatty acid-binding protein 4 (FABP4) in osteoarthritis (OA). METHODS:Patients with primary knee OA and non-OA controls were included. Paired tissues including plasma, synovial fluid (SF), subcutaneous fat and infrapatellar fat pad (IPFP) were harvested during surgery. FAB...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2017-0207
更新日期:2018-02-01 00:00:00
abstract:AIM:To investigate the clinical significance of detecting several biomarkers collectively in the diagnosis of rheumatoid arthritis (RA). METHODS:128 RA patients, 174 non-RA patients and 80 healthy controls were enrolled. HLA-DR4 and HLA-DR53 were detected by the PCR-SSP method, 14-3-3η protein, anti-CCP and anti-Sa we...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2017-0371
更新日期:2018-07-01 00:00:00
abstract:AIM:The usefulness of high-sensitivity troponin T (hs-TnT) as a predictor of perioperative hemodynamic instability is currently unknown. METHODS:A prospective study was conducted on a group of 708 consecutive patients with significant valvular heart disease that underwent elective valve surgery. The primary end point ...
journal_title:Biomarkers in medicine
pub_type: 临床试验,杂志文章
doi:10.2217/bmm-2018-0186
更新日期:2018-12-01 00:00:00
abstract::Background: This study aimed to identify glioblastoma prognosis-associated genes with potential diagnosis or prognosis values using integrated bioinformatics analysis. Results: In total, 1831 differentially expressed genes (DEGs) between the glioblastoma and control samples were identified and were clustered into seve...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2020-0341
更新日期:2020-11-01 00:00:00
abstract::Aim: To evaluate an 8.7-kb mitochondrial DNA (mtDNA) deletion as a potential biomarker of endometriosis. Materials & methods: We tested the diagnostic accuracy of the 8.7-kb deletion real-time PCR assay using 182 prospectively collected blood samples from females presenting with symptoms of endometriosis in a case-con...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2019-0451
更新日期:2020-02-01 00:00:00
abstract::Aim: To determine whether TLR9 polymorphisms are associated with tumor recurrence after liver transplantation for hepatocellular carcinoma (HCC). Patients & methods: All patients who underwent liver transplantation, and had viable HCC in the explanted liver were included. TLR9-1237C/T and -1486C/T polymorphisms were a...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2019-0030
更新日期:2019-08-01 00:00:00
abstract::Letter in regards to: Akboga MK, Balci KG, Maden O et al. Usefulness of monocyte to HDL-cholesterol ratio to predict high SYNTAX score in patients with stable coronary artery disease. Biomark. Med. 10(4), 375-383 (2016). ...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2016-0326
更新日期:2017-08-01 00:00:00
abstract::The uncertainty of whether/how to treat asymptomatic patients with isolated severe aortic stenosis and normal left ventricular ejection fraction is one of the most topical in cardiovascular medicine. Recently, the AVATAR trial: first ever randomized trial in the setting of aortic stenosis has been started in an attemp...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2016-0369
更新日期:2017-04-01 00:00:00
abstract::Like all human cancers, colorectal cancer is a complicated disease. While a mature body of research involving colorectal cancer has implicated the putative sequence of genetic alterations that trigger the disease and sustain its progression, there is a surprising paucity of well-validated, clinically useful diagnostic...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/BMM.09.33
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:Circulating tumor cells (CTCs) and tumor-specific alterations in cell-free plasma DNA can both be used as markers of prognosis in breast cancer. To date, there have been no studies that have compared these as markers for subclinical metastases in the follow-up of early breast cancer. In this study, we measur...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm.10.118
更新日期:2011-02-01 00:00:00
abstract::Increased neurohormonal activation is a key feature of heart failure (HF). Copeptin is a surrogate marker for proarginine vasopressin and the prognostic value of copeptin has been reported for multiple disease states of both nonvascular and cardiovascular etiology. Elevated plasma copeptin in HF has been associated wi...
journal_title:Biomarkers in medicine
pub_type: 杂志文章,评审
doi:10.2217/bmm.14.50
更新日期:2014-01-01 00:00:00
abstract::Aim: We aimed to explore the biomarkers for disease progression or the risk of nonsurvivors. Materials & methods: This study included 134 hospitalized patients with confirmed COVID-19 infection. The outcome of moderate versus severe versus critically ill patients and survivors versus nonsurvivors were compared. Result...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2020-0254
更新日期:2020-07-01 00:00:00
abstract::Epilepsy and seizures are very common in the early years of life and are often associated with significant morbidity and mortality. Identification of biomarkers for the early detection of epileptogenicity, epileptogenesis, comorbidities, disease progression and treatment implementation will be very important in implem...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm.11.71
更新日期:2011-10-01 00:00:00
abstract:AIM:Investigate the correlation between paraoxonase 2 (PON2) Ser311Cys polymorphism as well as the peroxisome proliferator-activated receptor gamma (PPARG) His477His polymorphism and the susceptibility to development of coronary heart diseases (CHD) through a meta-analysis. METHODS:Odds ratio and the corresponding 95%...
journal_title:Biomarkers in medicine
pub_type: 杂志文章,评审
doi:10.2217/bmm-2017-0227
更新日期:2018-03-01 00:00:00
abstract::Fibrosis is characterized by aberrant myofibroblast accumulation and excessive extracellular matrix deposition, which leads to organ failure and significantly contributes to mortality worldwide. Exosomes, which are extracellular nanovesicles with a diameter of 30-100 nm that are secreted into the extracellular space b...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2019-0368
更新日期:2020-06-01 00:00:00
abstract::Heart failure remains an important clinical and public health problem with significant mortality, morbidity and economic consequences. The identification of natriuretic peptides and the large number of investigations that followed have led to a better understanding of the neurohormonal pathophysiology of heart failure...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/17520363.1.4.503
更新日期:2007-12-01 00:00:00
abstract::Aim: To develop robust and accurate prognostic biomarkers to help clinicians optimize therapeutic strategies. Materials & methods: Differentially prognosis-related autophagy genes were identified by bioinformatics analysis method. Results: Seven prognosis-related autophagy genes were more significantly related to the ...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2020-0170
更新日期:2020-09-01 00:00:00
abstract::Preeclampsia remains a significant cause of maternal morbidity and mortality worldwide. Prediction, diagnosis and management continue to be challenging but advances in the understanding of the pathophysiological processes underlying the disease has enabled identification of multiple biomarkers, some of which aid predi...
journal_title:Biomarkers in medicine
pub_type: 杂志文章,评审
doi:10.2217/bmm.14.19
更新日期:2014-01-01 00:00:00
abstract:AIM:The purpose of this study was to establish the influence of centrifugation and protease activity on the cerebrospinal fluid (CSF) concentrations of DJ-1 and hemoglobin. MATERIALS & METHODS:The concentrations of DJ-1 and hemoglobin were determined in 12 (DJ-1) and six (hemoglobin) pairs of CSF samples, with one sam...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm.13.125
更新日期:2014-01-01 00:00:00
abstract::Acute kidney injury is a common and significant complication among pediatric patients with congenital heart disease, occurring most commonly after cardiopulmonary bypass. Current laboratory methods of diagnosis are not timely enough to guide management decisions, thus spurring interest in discovering new biomarkers of...
journal_title:Biomarkers in medicine
pub_type: 杂志文章,评审
doi:10.2217/bmm.12.27
更新日期:2012-06-01 00:00:00
abstract:AIM:To determine the performance of plasma calprotectin as a marker of sepsis on intensive care unit (ICU) admission and as a marker of mortality day 30 post-ICU admission. MATERIALS & METHODS:Consecutive ICU patients were allocated to: sepsis (n = 15), postoperative inflammation (n = 23) and intoxication without infl...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2016-0032
更新日期:2016-08-01 00:00:00
abstract:AIM:The aim of this article was to investigate the performance and predictive value of urinary liver-type FABP (uL-FABP) and urinary NGAL (uNGAL) for renal function and prognosis in obstructive nephropathy (ON). PATIENTS & METHODS:A total of 108 ON patients and urine samples were collected. An ELISA was used to determ...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm.13.136
更新日期:2014-01-01 00:00:00
abstract:AIM:To evaluate the relationship between mean platelet volume (MPV) and red cell distribution width (RDW), and disease activity in rheumatoid arthritis (RA). PATIENTS & METHODS:Hundred RA and 100 controls were included. RESULTS:MPV and RDW were higher in RA (p < 0.0001). The cut-off levels of RDW and MPV were 14.8 an...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2016-0148
更新日期:2016-09-01 00:00:00
abstract::Podocyturia may be an expression of glomerular disease and is evaluated using urinary podocyte-specific molecules. This article discusses the technical problems of detection and quantification of podocyturia using immunofluorescent staining of specific proteins, urinary podocyte culture, flow cytometry and urinary pod...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/17520363.2.6.613
更新日期:2008-12-01 00:00:00