TLR9-1486C/T polymorphism is associated with hepatocellular carcinoma recurrence after liver transplantation.


:Aim: To determine whether TLR9 polymorphisms are associated with tumor recurrence after liver transplantation for hepatocellular carcinoma (HCC). Patients & methods: All patients who underwent liver transplantation, and had viable HCC in the explanted liver were included. TLR9-1237C/T and -1486C/T polymorphisms were analyzed by real-time PCR and melting curves analysis. Results: 20 of 159 patients (12.6%) developed post-transplant HCC recurrence. Tumors exceeding Milan criteria, moderately-to-poorly differentiated tumors and microvascular invasion on explants, and pretransplant α-fetoprotein level (all p < 0.01) were associated with an increased risk, while TLR9-1486TT genotype was associated with a decreased risk of HCC recurrence (p = 0.03). Conclusion: TLR9-1486C/T might help to preoperatively identify patients at low risk of post-transplant HCC recurrence.


Biomark Med


Biomarkers in medicine


de la Fuente S,Citores MJ,Lucena JL,Muñoz P,Cuervas-Mons V




Has Abstract


2019-08-01 00:00:00












  • The application of biomarkers in clinical trials for motor neuron disease.

    abstract::The interest and research into disease-related biomarkers has greatly accelerated over the last 10 years. The potential clinical benefits for disease-specific biomarkers include a more rapid and accurate disease diagnosis, and potential reduction in size and duration of clinical drug trials, which would speed up drug ...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审


    authors: Ganesalingam J,Bowser R

    更新日期:2010-04-01 00:00:00

  • Circulating malondialdehyde concentrations in patients with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis.

    abstract::The aim of this meta-analysis was to review the available evidence regarding the blood concentrations of the oxidative stress marker malondialdehyde (MDA) in chronic obstructive pulmonary disease (COPD) patients in comparison to healthy individuals. 14 studies were included in the meta-analysis (from inception to Octo...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,meta分析


    authors: Paliogiannis P,Fois AG,Sotgia S,Mangoni AA,Zinellu E,Pirina P,Carru C,Zinellu A

    更新日期:2018-07-01 00:00:00

  • Galectin-3 and acute heart failure: genetic polymorphisms, plasma level, myocardial fibrosis and 1-year outcomes.

    abstract::Aim: This study sought to investigate the relationship between galectin-3 (Gal-3), myocardial fibrosis (MF) and outcomes in acute heart failure. Materials & methods: The single-nucleotide polymorphisms (SNPs) of LGALS3 at rs4644 and rs4652, plasma Gal-3 level, MF and major adverse events (MAEs) were obtained. Results:...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Fu H,Nie S,Luo P,Ruan Y,Zhang Z,Miao H,Li X,Wen S,Bai R

    更新日期:2020-07-01 00:00:00

  • In search of epilepsy biomarkers in the immature brain: goals, challenges and strategies.

    abstract::Epilepsy and seizures are very common in the early years of life and are often associated with significant morbidity and mortality. Identification of biomarkers for the early detection of epileptogenicity, epileptogenesis, comorbidities, disease progression and treatment implementation will be very important in implem...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Galanopoulou AS,Moshé SL

    更新日期:2011-10-01 00:00:00

  • The association of circulating miR-30a, miR-29 and miR-133 with white-coat hypertension.

    abstract:AIM:The aim of the present study was to investigate the association of circulating miRNAs with white-coat hypertension (WCH) and further analyze whether miRNAs could be as potential biomarkers for WCH. METHOD:Quantitative reverse transcriptase PCR (qRT-PCR) was used to evaluate the expression of selected miRNAs. The a...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Huang YQ,Huang C,Chen JY,Li J,Feng YQ

    更新日期:2016-12-01 00:00:00

  • Biomarker use in tailored combat casualty care.

    abstract::Modern war wounds are complex and primarily involve extremities. They require multiple operative interventions to achieve wound closure and begin rehabilitation. Current assessment of the suitability of surgical wound closure is based upon subjective methods coupled with a semiquantitative determination of the wound b...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Brown TS,Safford S,Caramanica J,Elster EA

    更新日期:2010-06-01 00:00:00

  • A novel 8.7-kb mitochondrial genome deletion accurately detects endometriosis in the plasma of symptomatic women.

    abstract::Aim: To evaluate an 8.7-kb mitochondrial DNA (mtDNA) deletion as a potential biomarker of endometriosis. Materials & methods: We tested the diagnostic accuracy of the 8.7-kb deletion real-time PCR assay using 182 prospectively collected blood samples from females presenting with symptoms of endometriosis in a case-con...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Harbottle A,Maggrah A,Usher R,Desa E,Creed JM

    更新日期:2020-02-01 00:00:00

  • The prognostic role of pretreatment platelet-to-lymphocyte ratio as predictors in patients with colorectal cancer: a meta-analysis.

    abstract:AIM:This meta-analysis was designed to analyze and evaluate the prognostic role of preoperative or pretreatment platelet-to-lymphocyte ratio (PLR) in patients with colorectal cancer (CRC). METHOD:We searched PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Chinese Biomedical L...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,meta分析


    authors: Min GT,Wang YH,Yao N,Zhao JM,Wang J,Wang HP,Chen W,Deng SJ,Li YM

    更新日期:2017-01-01 00:00:00

  • A biomarker of oxidative stress as a nontraditional risk factor in obese subjects.

    abstract:BACKGROUND:Oxidative stress has been postulated as an additive factor linking obesity to cardiovascular disease. MATERIALS & METHODS:Derivatives of reactive oxygen species metabolites (d-ROMs) were measured in 136 obese (42 males, 94 females; mean age: 47 ± 12 years; BMI: 36 ± 5 kg/m(2)) and in 306 over- and normal-we...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Vassalle C,Vigna L,Bianchi S,Maffei S,Novembrino C,De Giuseppe R,de Liso F,Vannucci A,Tirelli S,Maiavacca R,Bamonti F

    更新日期:2013-08-01 00:00:00

  • Cytokine patterns after therapy with Avonex®, Rebif®, Betaferon® and CinnoVex™ in relapsing-remitting multiple sclerosis in Iranian patients.

    abstract:AIM:Several lines of evidence exist which suggest that changes in the expression of circulating cytokines are linked to the development or reoccurrence of multiple sclerosis (MS). This study aimed to evaluate the serum levels of relevant cytokines after therapy with IFN-β formulations in MS patients. MATERIALS & METHO...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Arababadi MK,Mosavi R,Khorramdelazad H,Yaghini N,Zarandi ER,Araste M,Pourali R,Nekhei Z,Kennedy D

    更新日期:2010-10-01 00:00:00

  • miRNAs as prognostic and therapeutic tools in epithelial ovarian cancer.

    abstract::Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy and is the fifth leading cause of cancer deaths in women. Developing adjuvant therapy to circumvent drug resistance represents an important aspect of current initiatives to improve survival in women with advanced EOC. A regulatory molecule that ...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审


    authors: Nagaraj AB,Joseph P,DiFeo A

    更新日期:2015-01-01 00:00:00

  • Soluble markers for diagnosis of malignant pleural mesothelioma.

    abstract::Malignant pleural mesothelioma (MPM) is a highly aggressive and invasive tumor, whose incidence is expected to peak, in many countries, at the end of the present decade, 20-40 years after the peak of asbestos use (asbestos being the most important etiological factor). MPM has a poor prognosis, in part, owing to a diff...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审


    authors: Cristaudo A,Bonotti A,Simonini S,Bruno R,Foddis R

    更新日期:2011-04-01 00:00:00

  • Correlations between lncRNA-SOX2OT polymorphism and susceptibility to breast cancer in a Chinese population.

    abstract:AIM:We evaluated the effect of lncRNA SOX2OT expression and its SNP in tumorigenesis and development of breast cancer (BC) in a case-control study. METHODS:A total of 1106 individuals, 505 newly diagnosed BC patients and 601 age-matched controls (±2 years) were testified. Real-time PCR was adopted for testing tissues'...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Tang X,Gao Y,Yu L,Lu Y,Zhou G,Cheng L,Sun K,Zhu B,Xu M,Liu J

    更新日期:2017-03-01 00:00:00

  • May autophagy be a novel biomarker and antitumor target in colorectal cancer?

    abstract::Autophagy is a catabolic process associated with intracellular self-digestion of damaged organelles or redundant proteins enabling maintenance of cell homeostasis. It is accepted that impaired autophagy is closely linked to cancer development and has been extensively studied in a variety of malignancies including colo...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审


    authors: Gil J,Pesz KA,Sąsiadek MM

    更新日期:2016-10-01 00:00:00

  • MMP-9 (-1562 C:T) polymorphism as a biomarker of susceptibility to severe pre-eclampsia.

    abstract:AIM:To investigate the role of MMP-9 (-1562 C:T) polymorphism as a biomarker for susceptibility to pre-eclampsia. PATIENTS & METHODS:MMP-9 variants were detected in 160 women with mild and severe pre-eclampsia and 112 healthy pregnant women. RESULTS:A significantly higher frequency of MMP-9 CT genotype was observed i...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Rahimi Z,Rahimi Z,Shahsavandi MO,Bidoki K,Rezaei M

    更新日期:2013-02-01 00:00:00

  • Problems associated with fluid biomarkers for Parkinson's disease.

    abstract::This article focuses on biochemical markers that may be used in the diagnostics of Parkinson's disease and associated disorders, and to identify early cases and stratify patients into subgroups. We present an updated account of some currently available candidate fluid biomarkers, and discuss their diagnostic performan...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审


    authors: Nyhlén J,Constantinescu R,Zetterberg H

    更新日期:2010-10-01 00:00:00

  • Gamma-glutamyltransferase activity as a surrogate biomarker of metabolic health status in young nondiabetic obese women.

    abstract:AIM:We investigated the association of gamma-glutamyltransferase (GGT) activity with atherogenic risk factors and metabolic health status in young nondiabetic obese women. METHODS & RESULTS:In 140 obese women GGT activity was independently associated with BMI, triglyceride to high-density cholesterol ratio and homeost...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Mankowska-Cyl A,Krintus M,Rajewski P,Sypniewska G

    更新日期:2017-05-01 00:00:00

  • Correlation of peripheral arterial blood flow with plasma chemerin and VEGF in diabetic peripheral vascular disease.

    abstract:AIMS:Progressive vasodegeneration in microvascular beds is the major underlying factor in initiation and progression of diabetic complications. Chemerin shows a strong correlation with various facets of the metabolic syndrome, which is associated with dysregulated angiogenesis. VEGF is shown to have an angiogenic role ...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Zakareia FA

    更新日期:2012-02-01 00:00:00

  • Newborn screening for autism: in search of candidate biomarkers.

    abstract:BACKGROUND:Autism spectrum disorder (ASD) represents a wide range of neurodevelopmental disorders characterized by impairments in social interaction, language, communication and range of interests. Autism is usually diagnosed in children 3-5 years of age using behavioral characteristics; thus, diagnosis shortly after b...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Mizejewski GJ,Lindau-Shepard B,Pass KA

    更新日期:2013-04-01 00:00:00

  • Performance of plasma calprotectin as a biomarker of early sepsis: a pilot study.

    abstract:AIM:To determine the performance of plasma calprotectin as a marker of sepsis on intensive care unit (ICU) admission and as a marker of mortality day 30 post-ICU admission. MATERIALS & METHODS:Consecutive ICU patients were allocated to: sepsis (n = 15), postoperative inflammation (n = 23) and intoxication without infl...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Simm M,Söderberg E,Larsson A,Castegren M,Nilsen T,Eriksson M,Lipcsey M

    更新日期:2016-08-01 00:00:00

  • FABP4 as a biomarker for knee osteoarthritis.

    abstract:AIM:To explore the role of an adipokine-termed fatty acid-binding protein 4 (FABP4) in osteoarthritis (OA). METHODS:Patients with primary knee OA and non-OA controls were included. Paired tissues including plasma, synovial fluid (SF), subcutaneous fat and infrapatellar fat pad (IPFP) were harvested during surgery. FAB...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Zhang C,Li T,Chiu KY,Wen C,Xu A,Yan CH

    更新日期:2018-02-01 00:00:00

  • Clinical applications of biomarkers in preeclampsia.

    abstract::Preeclampsia remains a significant cause of maternal morbidity and mortality worldwide. Prediction, diagnosis and management continue to be challenging but advances in the understanding of the pathophysiological processes underlying the disease has enabled identification of multiple biomarkers, some of which aid predi...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审


    authors: Griffin M,Shennan AH

    更新日期:2014-01-01 00:00:00

  • Circulating tumor cells and plasma DNA analysis in patients with indeterminate early or metastatic breast cancer.

    abstract:BACKGROUND:Circulating tumor cells (CTCs) and tumor-specific alterations in cell-free plasma DNA can both be used as markers of prognosis in breast cancer. To date, there have been no studies that have compared these as markers for subclinical metastases in the follow-up of early breast cancer. In this study, we measur...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Shaw JA,Brown J,Coombes RC,Jacob J,Payne R,Lee B,Page K,Hava N,Stebbing J

    更新日期:2011-02-01 00:00:00

  • Analytical aspects of molecular Alzheimer's disease biomarkers.

    abstract::In general, a biomarker has multiple uses such as a diagnostic tool and a method to monitor therapy. The quality of a biomarker depends on how big the difference is between, for example, patients and healthy controls, but also on the capacity of the method used to measure it (the uncertainty in the method should be mu...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审


    authors: Andreasson U,Vanmechelen E,Shaw LM,Zetterberg H,Vanderstichele H

    更新日期:2012-08-01 00:00:00

  • Predicting tuberculosis treatment outcome using metabolomics.

    abstract:AIM:Predicting a poor treatment outcome would offer significant benefits for patient care and for new drug development. Materials, methods & results: Urine samples from tuberculosis-positive patients with a successful and unsuccessful treatment outcome were collected at baseline and analyzed. The identified metabolites...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Luies L,Reenen MV,Ronacher K,Walzl G,Loots DT

    更新日期:2017-12-01 00:00:00

  • Early advances of alpha1-antitrypsin precursor using the proteomic approach in gastric juice.

    abstract::Evaluation of: Hsu PI, Chen CH, Hsieh CS et al.: alpha1-antitrypsin precursor in gastric juice is a novel biomarker for gastric cancer and ulcer. Clin. Cancer Res. 13(3), 876-883 (2007) [1] . The authors have identified the alpha1-antitrypsin precursor as a new protein marker of gastric cancer in gastric juice by 2D e...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Monari M,Foschi J,Serrazanetti GP

    更新日期:2007-06-01 00:00:00

  • Oxidative stress and SYNTAX score in patients with stable coronary artery disease.

    abstract::Letter in regards to: Akboga MK, Balci KG, Maden O et al. Usefulness of monocyte to HDL-cholesterol ratio to predict high SYNTAX score in patients with stable coronary artery disease. Biomark. Med. 10(4), 375-383 (2016). ...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Soylemez S

    更新日期:2017-08-01 00:00:00

  • Biomarkers of acute kidney injury in pediatric cardiac patients.

    abstract::Acute kidney injury is a common and significant complication among pediatric patients with congenital heart disease, occurring most commonly after cardiopulmonary bypass. Current laboratory methods of diagnosis are not timely enough to guide management decisions, thus spurring interest in discovering new biomarkers of...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审


    authors: Kwiatkowski DM,Goldstein SL,Krawczeski CD

    更新日期:2012-06-01 00:00:00

  • Diagnostic value of NKG2D promoter methylation in hepatitis B virus-associated hepatocellular carcinoma.

    abstract::Aim: Natural killer cell receptor group 2D (NKG2D) plays an important role in the immune regulation of tumors. We speculate that DNA methylation are involved in the regulation of NKG2D gene. Methods: We investigated the methylation status of the NKG2D promoter in peripheral blood mononuclear cells of hepatocellular ca...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Zhao NH,Qian Y,Wu CS,Wang JW,Fang Y,Fan XP,Gao S,Fan YC,Wang K

    更新日期:2019-09-01 00:00:00

  • HLADR: a database system for enhancing the discovery of biomarkers for predicting human leukocyte antigen-mediated idiosyncratic adverse drug reactions.

    abstract:AIM:To establish a database for the associations between idiosyncratic drug reactions (IDRs) and human leukocyte antigens (HLAs) and to systematically assess the characteristics of the drug-HLA associations. MATERIALS & METHODS:Electronic databases were searched to extensively identify drug-HLA association studies fro...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Du T,Yang L,Luo H,Zhou P,Mei H,Xuan J,Xing Q,Ning B,Mendrick DL,Shi L

    更新日期:2015-01-01 00:00:00