TLR9-1486C/T polymorphism is associated with hepatocellular carcinoma recurrence after liver transplantation.

Abstract:

:Aim: To determine whether TLR9 polymorphisms are associated with tumor recurrence after liver transplantation for hepatocellular carcinoma (HCC). Patients & methods: All patients who underwent liver transplantation, and had viable HCC in the explanted liver were included. TLR9-1237C/T and -1486C/T polymorphisms were analyzed by real-time PCR and melting curves analysis. Results: 20 of 159 patients (12.6%) developed post-transplant HCC recurrence. Tumors exceeding Milan criteria, moderately-to-poorly differentiated tumors and microvascular invasion on explants, and pretransplant α-fetoprotein level (all p < 0.01) were associated with an increased risk, while TLR9-1486TT genotype was associated with a decreased risk of HCC recurrence (p = 0.03). Conclusion: TLR9-1486C/T might help to preoperatively identify patients at low risk of post-transplant HCC recurrence.

journal_name

Biomark Med

journal_title

Biomarkers in medicine

authors

de la Fuente S,Citores MJ,Lucena JL,Muñoz P,Cuervas-Mons V

doi

10.2217/bmm-2019-0030

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

995-1004

issue

12

eissn

1752-0363

issn

1752-0371

journal_volume

13

pub_type

杂志文章
  • US FDA draft Guidance Standard for Clinical Trial Imaging Endpoints: more than just imaging?

    abstract::The current cost of developing a successful drug is typically over a billion dollars, with the registration trial(s) determining the success or failure of the entire development program. Often the primary endpoint of these trials is a subjective assessment. For registration trials with subjective endpoints, a regulato...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.12.74

    authors: Walovitch RC,Chokron P,Agarwal S

    更新日期:2012-12-01 00:00:00

  • Parathormone decline levels are better markers of symptomatic hypocalcemia following total thyroidectomy than parathormone alone.

    abstract::Background: We aimed to assess the predictive value of the absolute and relative intact parathormone (iPTH) decline levels as reliable markers of postoperative hypocalcemia. Materials & methods: iPTH levels were measured 4 h after surgery and the following morning after surgery (postoperative day 1). iPTH, absolute iP...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2020-0218

    authors: Rajan S,Ravindhran B,George B,Bantwal G,Vageesh Ayyar,Mohan LN

    更新日期:2020-08-01 00:00:00

  • Biomarkers to optimize the treatment of nicotine dependence.

    abstract::The application of genomic medicine to the treatment of nicotine dependence holds great promise for revitalizing the steady decline in smoking rates witnessed in the USA over the past several decades. This paper examines the current knowledge base concerning the use of biomarkers to guide the selection of nicotine dep...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.11.91

    authors: Schnoll RA,Leone FT

    更新日期:2011-12-01 00:00:00

  • Evaluation of the relation between cardiac biomarkers and thorax computerized tomography findings in COVID-19 patients.

    abstract::Background: Troponin levels may be elevated in COVID-19 infection. The aim of this study was to the explore relation between troponin levels and COVID-19 severity. Materials & methods/Results: One hundred and forty consecutive patients with COVID-19 pneumonia were included. Diagnosis of COVID-19 pneumonia was based on...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2020-0388

    authors: Ileri C,Dogan Z,Ozben B,Karaoglu C,Gunay N,Tigen K,Basat S,Uyan C

    更新日期:2021-01-27 00:00:00

  • Tumor vascularity in prostate cancer: an update on circulating endothelial cells and platelets as noninvasive biomarkers.

    abstract::In order to individually tailor prostate cancer (PCa) treatment, clinicians need better tools to predict prognosis and treatment response. Given the relationship between angiogenesis and cancer progression, circulating endothelial cells (CECs) and their progenitors have logically been proposed as potential biomarkers....

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.13.100

    authors: Reeves F,Sapre N,Corcoran N,Hovens C

    更新日期:2013-12-01 00:00:00

  • Changing concept in treatment of asymptomatic severe aortic stenosis and normal ejection fraction: time for biomarkers reappraisal.

    abstract::The uncertainty of whether/how to treat asymptomatic patients with isolated severe aortic stenosis and normal left ventricular ejection fraction is one of the most topical in cardiovascular medicine. Recently, the AVATAR trial: first ever randomized trial in the setting of aortic stenosis has been started in an attemp...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2016-0369

    authors: Banovic MD

    更新日期:2017-04-01 00:00:00

  • Repeated assessment of physical biomeasures or blood biomarkers for the definition of volume status and cardiac loading in LVSD.

    abstract::The application of biomarker technology can be usefully implemented in areas where current techniques are inadequate and where a clinical issue, which affects outcome, can be defined. The definition of the loading status of the heart where there is pre-existent impairment of contractile function is a key target. Heart...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/17520363.1.3.355

    authors: Chuen MJ,Lip GY,MacFadyen RJ

    更新日期:2007-10-01 00:00:00

  • Aptamers generated by Cell SELEX for biomarker discovery.

    abstract::Biomarker discovery is essential to the advancement of our knowledge about diseases and to the development of new strategies for treatment and therapy. Among the newest technologies in this rapidly growing field is a process termed Cell SELEX by which a panel of aptamers can be generated to specifically target disease...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm.09.5

    authors: Kim Y,Liu C,Tan W

    更新日期:2009-04-01 00:00:00

  • Diagnostic value of NKG2D promoter methylation in hepatitis B virus-associated hepatocellular carcinoma.

    abstract::Aim: Natural killer cell receptor group 2D (NKG2D) plays an important role in the immune regulation of tumors. We speculate that DNA methylation are involved in the regulation of NKG2D gene. Methods: We investigated the methylation status of the NKG2D promoter in peripheral blood mononuclear cells of hepatocellular ca...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2019-0102

    authors: Zhao NH,Qian Y,Wu CS,Wang JW,Fang Y,Fan XP,Gao S,Fan YC,Wang K

    更新日期:2019-09-01 00:00:00

  • Biochemical markers of muscle damage and high serum concentration of creatine kinase in patients on statin therapy.

    abstract::Aim: Some patients experience statin-associated muscle symptoms (SAMS) and elevated serum concentrations of CK. The relationship between SAMS and biomarkers of muscle damage was examined. Methods: We analyzed 359 consecutive patients taking statins with high CK values. Muscle-related symptoms and biochemical variables...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2018-0379

    authors: Nogueira AA,Strunz CM,Takada JY,Mansur AP

    更新日期:2019-06-01 00:00:00

  • Novel biomarkers for the prediction of acute kidney injury in patients undergoing liver transplantation.

    abstract:AIM:Because of the delayed rise of serum creatinine concentrations, novel biomarkers such as NGAL, GST and KIM-1 are proposed to detect acute kidney injury (AKI). In this study we evaluated these biomarkers. MATERIALS & METHODS:Twenty-six consecutive adult liver transplantations were evaluated. Markers were measured a...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm.13.91

    authors: Dedeoglu B,de Geus HR,Fortrie G,Betjes MG

    更新日期:2013-12-01 00:00:00

  • Construction prognosis model based on autophagy-related gene signatures in hepatocellular carcinoma.

    abstract::Aim: To develop robust and accurate prognostic biomarkers to help clinicians optimize therapeutic strategies. Materials & methods: Differentially prognosis-related autophagy genes were identified by bioinformatics analysis method. Results: Seven prognosis-related autophagy genes were more significantly related to the ...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2020-0170

    authors: Wang J,Miao Y,Ran J,Yang Y,Guan Q,Mi D

    更新日期:2020-09-01 00:00:00

  • Interferons as biomarkers and effectors: lessons learned from animal models.

    abstract::Interferons (IFNs) comprise type I, II and III families with multiple subtypes. Via transcription of IFN-stimulated genes (ISGs), IFNs can exert multiple biological effects on the cell. In infectious and chronic inflammatory diseases, the IFNs and their ISG sets can be potentially utilized as biomarkers of disease out...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.12.10

    authors: Berry CM,Hertzog PJ,Mangan NE

    更新日期:2012-04-01 00:00:00

  • PON2 and PPARG polymorphisms as biomarkers of risk for coronary heart disease.

    abstract:AIM:Investigate the correlation between paraoxonase 2 (PON2) Ser311Cys polymorphism as well as the peroxisome proliferator-activated receptor gamma (PPARG) His477His polymorphism and the susceptibility to development of coronary heart diseases (CHD) through a meta-analysis. METHODS:Odds ratio and the corresponding 95%...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm-2017-0227

    authors: González-Castro TB,Tovilla-Zárate CA,Juárez-Rojop IE,Hernández-Díaz Y,López-Narváez ML,Rodríguez-Pérez C,González-Hernández YK,Ramos-Méndez MÁ

    更新日期:2018-03-01 00:00:00

  • The prognostic role of pretreatment platelet-to-lymphocyte ratio as predictors in patients with colorectal cancer: a meta-analysis.

    abstract:AIM:This meta-analysis was designed to analyze and evaluate the prognostic role of preoperative or pretreatment platelet-to-lymphocyte ratio (PLR) in patients with colorectal cancer (CRC). METHOD:We searched PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Chinese Biomedical L...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,meta分析

    doi:10.2217/bmm-2016-0181

    authors: Min GT,Wang YH,Yao N,Zhao JM,Wang J,Wang HP,Chen W,Deng SJ,Li YM

    更新日期:2017-01-01 00:00:00

  • Index of cardiac electrophysiological balance and transmural dispersion of the repolarization index relationships with pericardial fat volume and coronary calcification.

    abstract:AIM:To assess the possible relationship between coronary atherosclerosis markers, pericardial fat volume (PFV) and coronary artery calcification, with ECG markers of index of the cardiac electrophysiological balance (iCEB) and transmural dispersion of the repolarization in patients with suspected coronary artery diseas...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2017-0187

    authors: Nafakhi H,Al-Mosawi AA,Alareedh M,Al-Nafakh HA

    更新日期:2018-04-01 00:00:00

  • Cytokine patterns after therapy with Avonex®, Rebif®, Betaferon® and CinnoVex™ in relapsing-remitting multiple sclerosis in Iranian patients.

    abstract:AIM:Several lines of evidence exist which suggest that changes in the expression of circulating cytokines are linked to the development or reoccurrence of multiple sclerosis (MS). This study aimed to evaluate the serum levels of relevant cytokines after therapy with IFN-β formulations in MS patients. MATERIALS & METHO...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm.10.81

    authors: Arababadi MK,Mosavi R,Khorramdelazad H,Yaghini N,Zarandi ER,Araste M,Pourali R,Nekhei Z,Kennedy D

    更新日期:2010-10-01 00:00:00

  • Copeptin as a biomarker in heart failure.

    abstract::Increased neurohormonal activation is a key feature of heart failure (HF). Copeptin is a surrogate marker for proarginine vasopressin and the prognostic value of copeptin has been reported for multiple disease states of both nonvascular and cardiovascular etiology. Elevated plasma copeptin in HF has been associated wi...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.14.50

    authors: Balling L,Gustafsson F

    更新日期:2014-01-01 00:00:00

  • FABP4 as a biomarker for knee osteoarthritis.

    abstract:AIM:To explore the role of an adipokine-termed fatty acid-binding protein 4 (FABP4) in osteoarthritis (OA). METHODS:Patients with primary knee OA and non-OA controls were included. Paired tissues including plasma, synovial fluid (SF), subcutaneous fat and infrapatellar fat pad (IPFP) were harvested during surgery. FAB...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2017-0207

    authors: Zhang C,Li T,Chiu KY,Wen C,Xu A,Yan CH

    更新日期:2018-02-01 00:00:00

  • Serum YKL-40 for monitoring myocardial ischemia after revascularization in patients with stable coronary artery disease.

    abstract:AIM:The aim was to investigate the inflammatory biomarker YKL-40 as a monitor of myocardial ischemia in patients with coronary artery disease (CAD). METHODS:A total of 311 patients with stable CAD were included. Blood samples were taken at baseline, the day after coronary angiography and/or after percutaneous coronary...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm.14.20

    authors: Harutyunyan M,Johansen JS,Mygind ND,Reuter SB,Kastrup J

    更新日期:2014-01-01 00:00:00

  • Emerging biomarkers in breast cancer care.

    abstract::Currently, decision-making for breast cancer treatment in the clinical setting is mainly based on clinical data, histomorphological features of the tumor tissue and a few cancer biomarkers such as steroid hormone receptor status (estrogen and progesterone receptors) and oncoprotein HER2 status. Although various therap...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.10.73

    authors: Napieralski R,Brünner N,Mengele K,Schmitt M

    更新日期:2010-08-01 00:00:00

  • Correlations between lncRNA-SOX2OT polymorphism and susceptibility to breast cancer in a Chinese population.

    abstract:AIM:We evaluated the effect of lncRNA SOX2OT expression and its SNP in tumorigenesis and development of breast cancer (BC) in a case-control study. METHODS:A total of 1106 individuals, 505 newly diagnosed BC patients and 601 age-matched controls (±2 years) were testified. Real-time PCR was adopted for testing tissues'...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2016-0238

    authors: Tang X,Gao Y,Yu L,Lu Y,Zhou G,Cheng L,Sun K,Zhu B,Xu M,Liu J

    更新日期:2017-03-01 00:00:00

  • Prognostic utility of the combination of pretreatment monocyte-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in patients with NMIBC after transurethral resection.

    abstract::Aim: To investigate and validate predictive value of combination of pretreatment monocyte-to-lymphocyte ratio (MLR) and neutrophil-to-lymphocyte ratio (NLR) for disease free survival (DFS) and overall survival (OS) in nonmuscle invasive bladder cancer after transurethral resection. Materials & methods: Total 358 patie...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2019-0398

    authors: Wang Q,Huang T,Ji J,Wang H,Guo C,Sun X,Zheng K,Dong Z,Cao Y

    更新日期:2019-12-01 00:00:00

  • Endostatin: a promising biomarker in the cardiovascular continuum?

    abstract::The current review article aims to provide an up-to-date summary of previous studies in humans that have reported the association between circulating endostatin levels and different cardiovascular phenotypes. We also aim to provide suggestions for future directions of future research evaluating endostatin as a clinica...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm-2017-0025

    authors: Ruge T,Carlsson AC,Larsson A,Ärnlöv J

    更新日期:2017-10-01 00:00:00

  • Biomarkers in systemic sclerosis.

    abstract::Systemic sclerosis is an autoimmune inflammatory disorder of unknown etiologycharacterized b y pronounced fibroproliferative alterations in the microvasculature, and frequent cellular and humoral immunity abnormalities, culminating in a severe and often progressive fibrotic process. Numerous biomarkers reflecting the ...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.09.79

    authors: Castro SV,Jimenez SA

    更新日期:2010-02-01 00:00:00

  • The 44th Congress of the International Society of Oncology and Biomarkers: Rio de Janeiro, Brazil, 7-10 September 2017.

    abstract::The 44th Congress of the International Society of Oncology and Biomarkers: Rio de Janeiro, Brazil, 7-10 September 2017 The 44th congress followed the previous one of  International Society of Oncology and Biomarkers (ISOBM) that took place in Chicago (USA) in 2016. The title of the 44th Annual congress was: 'Biomarker...

    journal_title:Biomarkers in medicine

    pub_type:

    doi:10.2217/bmm-2017-0402

    authors: Kinkorová J

    更新日期:2018-02-01 00:00:00

  • May autophagy be a novel biomarker and antitumor target in colorectal cancer?

    abstract::Autophagy is a catabolic process associated with intracellular self-digestion of damaged organelles or redundant proteins enabling maintenance of cell homeostasis. It is accepted that impaired autophagy is closely linked to cancer development and has been extensively studied in a variety of malignancies including colo...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm-2016-0083

    authors: Gil J,Pesz KA,Sąsiadek MM

    更新日期:2016-10-01 00:00:00

  • Human serum proteome analysis: new source of markers in metabolic disorders.

    abstract::The prevalence of metabolic disorders (MDs), especially diabetes, is rapidly increasing worldwide, leading to an increasing risk of cardiovascular and other socially relevant complications. To boost MD biomarker discovery, advanced proteomics can harmonize metabolomics. Indeed, the rapid development of mass spectromet...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.12.92

    authors: Di Girolamo F,Del Chierico F,Caenaro G,Lante I,Muraca M,Putignani L

    更新日期:2012-12-01 00:00:00

  • Human tissue biobanks as instruments for drug discovery and development: impact on personalized medicine.

    abstract::In recent years, biobanks of human tissues have evolved from small-scale collections of pathological materials into structured resource centers for acquisition, storage, processing and usage of high-quality biospecimens for research. This evolution goes hand in hand with the development of highly sensitive, high-throu...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm.10.104

    authors: Zatloukal K,Hainaut P

    更新日期:2010-12-01 00:00:00

  • The association of circulating miR-30a, miR-29 and miR-133 with white-coat hypertension.

    abstract:AIM:The aim of the present study was to investigate the association of circulating miRNAs with white-coat hypertension (WCH) and further analyze whether miRNAs could be as potential biomarkers for WCH. METHOD:Quantitative reverse transcriptase PCR (qRT-PCR) was used to evaluate the expression of selected miRNAs. The a...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2016-0215

    authors: Huang YQ,Huang C,Chen JY,Li J,Feng YQ

    更新日期:2016-12-01 00:00:00