Abstract:
AIM:Investigate the correlation between paraoxonase 2 (PON2) Ser311Cys polymorphism as well as the peroxisome proliferator-activated receptor gamma (PPARG) His477His polymorphism and the susceptibility to development of coronary heart diseases (CHD) through a meta-analysis. METHODS:Odds ratio and the corresponding 95% CI were used to assess the results. We included 7476 CHD patients and 8504 healthy controls. All the statistical analyses were performed by Comprehensive Meta-Analysis software (CMA, version 2.0). RESULTS:The Ser311Cys polymorphism decreased susceptibility in the overall population and Asian population to CHD. The His477His polymorphism has a protective role in the overall population; however, the subgroup analysis by ethnicity suggested that in Asian population, His477His might increase the risk of CHD. CONCLUSION:These polymorphisms constitute important predictive indicators of CHD susceptibility.
journal_name
Biomark Medjournal_title
Biomarkers in medicineauthors
González-Castro TB,Tovilla-Zárate CA,Juárez-Rojop IE,Hernández-Díaz Y,López-Narváez ML,Rodríguez-Pérez C,González-Hernández YK,Ramos-Méndez MÁdoi
10.2217/bmm-2017-0227subject
Has Abstractpub_date
2018-03-01 00:00:00pages
287-297issue
3eissn
1752-0363issn
1752-0371journal_volume
12pub_type
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