Novel biomarkers for the prediction of acute kidney injury in patients undergoing liver transplantation.

Abstract:

AIM:Because of the delayed rise of serum creatinine concentrations, novel biomarkers such as NGAL, GST and KIM-1 are proposed to detect acute kidney injury (AKI). In this study we evaluated these biomarkers. MATERIALS & METHODS:Twenty-six consecutive adult liver transplantations were evaluated. Markers were measured at four different time points during an intensive care unit admission. RESULTS:Plasma NGAL detected AKI with an optimal area under the curve at 8 h after admission (0.86; p = 0.004) and at 4 h after admission for urinary NGAL (0.80; p = 0.012). The other markers failed to detect AKI. CONCLUSION:NGAL is a promising biomarker for detecting AKI in patients after liver transplantation.

journal_name

Biomark Med

journal_title

Biomarkers in medicine

authors

Dedeoglu B,de Geus HR,Fortrie G,Betjes MG

doi

10.2217/bmm.13.91

subject

Has Abstract

pub_date

2013-12-01 00:00:00

pages

947-57

issue

6

eissn

1752-0363

issn

1752-0371

journal_volume

7

pub_type

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