Abstract:
AIM:Cardiotrophin-1 null mice presented decreased arterial stiffness. The aim of this study is to investigate the relationship between cardiotrophin-1 and arterial stiffness, assessed by brachial-ankle pulse-wave velocity (baPWV). METHODS:We enrolled 300 subjects, 200 with baPWV >1400 and 100 with baPWV ≤1400 cm/s. RESULTS:Cardiotrophin-1 levels were significantly higher in subjects with baPWV >1400 than those with baPWV ≤1400 cm/s. The multivariate logistic regression analysis showed that age, prehypertension, hypertension and cardiotrophin-1 were independently associated with baPWV >1400 cm/s after adjusting for gender, obesity, diabetes, homeostasis model assessment-insulin resistance, total cholesterol, high-density lipoprotein cholesterol, triglyceride, high-sensitivity C-reactive protein, creatinine, smoking and habitual exercise. CONCLUSION:Cardiotrophin-1 is positively related to baPWV independent of traditional cardiometabolic risk factors for arterial stiffness.
journal_name
Biomark Medjournal_title
Biomarkers in medicineauthors
Hung HC,Lu FH,Ou HY,Wu HT,Wu JS,Yang YC,Chang CJdoi
10.2217/bmm.14.87subject
Has Abstractpub_date
2015-01-01 00:00:00pages
123-30issue
2eissn
1752-0363issn
1752-0371journal_volume
9pub_type
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journal_title:Biomarkers in medicine
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journal_title:Biomarkers in medicine
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journal_title:Biomarkers in medicine
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journal_title:Biomarkers in medicine
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