Charcot-Leyden crystal protein/galectin-10 is a surrogate biomarker of eosinophilic airway inflammation in asthma.

abstract：AIM:We investigated the association of gamma-glutamyltransferase (GGT) activity with atherogenic risk factors and metabolic health status in young nondiabetic obese women. METHODS & RESULTS:In 140 obese women GGT activity was independently associated with BMI, triglyceride to high-density cholesterol ratio and homeost...

journal_title：Biomarkers in medicine

authors： Mankowska-Cyl A,Krintus M,Rajewski P,Sypniewska G

更新日期：2017-05-01 00:00:00

abstract：:In general, a biomarker has multiple uses such as a diagnostic tool and a method to monitor therapy. The quality of a biomarker depends on how big the difference is between, for example, patients and healthy controls, but also on the capacity of the method used to measure it (the uncertainty in the method should be mu...

journal_title：Biomarkers in medicine

authors： Andreasson U,Vanmechelen E,Shaw LM,Zetterberg H,Vanderstichele H

更新日期：2012-08-01 00:00:00

abstract：:The uPA system mainly comprises the urokinase-type plasminogen activator uPA, the cell-surface receptor uPA receptor and the inhibitor PAI-1. Its clinical and prognostic impact especially in breast cancer is well investigated. In this short report, we summarize the published data describing expression of uPA, PAI-1 an...

journal_title：Biomarkers in medicine

authors： Taubert H,Magdolen V,Kotzsch M

更新日期：2013-06-01 00:00:00

abstract：AIM:To establish a database for the associations between idiosyncratic drug reactions (IDRs) and human leukocyte antigens (HLAs) and to systematically assess the characteristics of the drug-HLA associations. MATERIALS & METHODS:Electronic databases were searched to extensively identify drug-HLA association studies fro...

journal_title：Biomarkers in medicine

authors： Du T,Yang L,Luo H,Zhou P,Mei H,Xuan J,Xing Q,Ning B,Mendrick DL,Shi L

更新日期：2015-01-01 00:00:00

abstract：:Background: This study aimed to identify glioblastoma prognosis-associated genes with potential diagnosis or prognosis values using integrated bioinformatics analysis. Results: In total, 1831 differentially expressed genes (DEGs) between the glioblastoma and control samples were identified and were clustered into seve...

journal_title：Biomarkers in medicine

authors： Wang D,Liu J,Chen Q,Yang R,Jiang Q

更新日期：2020-11-01 00:00:00

abstract：:Dr Jake Micallef speaks to Hannah L Wilson, Commissioning Editor: Dr Micallef has 20 years of experience in research and development and in the management of early-stage biotechnical companies, including the manufacture of biotechnology products and the establishment of manufacturing operations. Dr Micallef gained thi...

journal_title：Biomarkers in medicine

authors： Micallef J,Wilson HL

更新日期：2014-01-01 00:00:00

abstract：:Major depressive disorder (MDD: unipolar depression) is widely distributed in the USA and world-wide populations and it is one of the leading causes of disability in both adolescents and adults. Traditional diagnostic approaches for MDD are based on patient interviews, which provide a subjective assessment of clinical...

journal_title：Biomarkers in medicine

authors： Bilello JA

更新日期：2016-08-01 00:00:00

abstract：AIM:Because of the delayed rise of serum creatinine concentrations, novel biomarkers such as NGAL, GST and KIM-1 are proposed to detect acute kidney injury (AKI). In this study we evaluated these biomarkers. MATERIALS & METHODS:Twenty-six consecutive adult liver transplantations were evaluated. Markers were measured a...

journal_title：Biomarkers in medicine

authors： Dedeoglu B,de Geus HR,Fortrie G,Betjes MG

更新日期：2013-12-01 00:00:00

abstract：AIM:To investigate the prognostic performance of complement components in septic patients, complement 3, membrane attack complex (MAC) and mannose-binding lectin were measured and compared among adult patients with sepsis, severe sepsis and septic shock, as well as between in-hospital nonsurvivors and survivors. METHO...

journal_title：Biomarkers in medicine

authors： Zhao X,Chen YX,Li CS

更新日期：2015-01-01 00:00:00

abstract：AIM:The role of octamer-binding transcription factor 4 (Oct4) in gastric cancer (GC) progression is still under debate and reported results are inconsistent. Therefore, we conducted a meta-analysis to evaluate the clinicopathological and prognostic significance of Oct4 expression in patients with GC. MATERIALS & METHO...

journal_title：Biomarkers in medicine

authors： Wei Y,Liu H,Wang C,Zhang W,Wen X,Long H,Xu Z,Guo H,Liu Y,Wei D,Qiu C,Li G,Sun Z

更新日期：2019-02-01 00:00:00

abstract：:The uncertainty of whether/how to treat asymptomatic patients with isolated severe aortic stenosis and normal left ventricular ejection fraction is one of the most topical in cardiovascular medicine. Recently, the AVATAR trial: first ever randomized trial in the setting of aortic stenosis has been started in an attemp...

journal_title：Biomarkers in medicine

authors： Banovic MD

更新日期：2017-04-01 00:00:00

abstract：AIM:To explore the role of an adipokine-termed fatty acid-binding protein 4 (FABP4) in osteoarthritis (OA). METHODS:Patients with primary knee OA and non-OA controls were included. Paired tissues including plasma, synovial fluid (SF), subcutaneous fat and infrapatellar fat pad (IPFP) were harvested during surgery. FAB...

journal_title：Biomarkers in medicine

authors： Zhang C,Li T,Chiu KY,Wen C,Xu A,Yan CH

更新日期：2018-02-01 00:00:00

abstract：:Increasing evidence has highlighted the roles of oxidative stress and inflammation in the promotion of atherosclerotic cardiovascular disease. Recent pathological studies have elucidated specific mediators that appear to link these pathways to the progression and rupture of atherosclerotic plaque in the artery wall. T...

journal_title：Biomarkers in medicine

authors： Uno K,Nicholls SJ

更新日期：2010-06-01 00:00:00

abstract：AIM:Investigate the correlation between paraoxonase 2 (PON2) Ser311Cys polymorphism as well as the peroxisome proliferator-activated receptor gamma (PPARG) His477His polymorphism and the susceptibility to development of coronary heart diseases (CHD) through a meta-analysis. METHODS:Odds ratio and the corresponding 95%...

journal_title：Biomarkers in medicine

authors： González-Castro TB,Tovilla-Zárate CA,Juárez-Rojop IE,Hernández-Díaz Y,López-Narváez ML,Rodríguez-Pérez C,González-Hernández YK,Ramos-Méndez MÁ

更新日期：2018-03-01 00:00:00

abstract：:Acute kidney injury is a common and significant complication among pediatric patients with congenital heart disease, occurring most commonly after cardiopulmonary bypass. Current laboratory methods of diagnosis are not timely enough to guide management decisions, thus spurring interest in discovering new biomarkers of...

journal_title：Biomarkers in medicine

authors： Kwiatkowski DM,Goldstein SL,Krawczeski CD

更新日期：2012-06-01 00:00:00

abstract：AIM:Several lines of evidence exist which suggest that changes in the expression of circulating cytokines are linked to the development or reoccurrence of multiple sclerosis (MS). This study aimed to evaluate the serum levels of relevant cytokines after therapy with IFN-β formulations in MS patients. MATERIALS & METHO...

journal_title：Biomarkers in medicine

authors： Arababadi MK,Mosavi R,Khorramdelazad H,Yaghini N,Zarandi ER,Araste M,Pourali R,Nekhei Z,Kennedy D

更新日期：2010-10-01 00:00:00

abstract：:The field of aortopathy, in common with other genomic disorders, is undergoing a revolution. This is largely driven by the implementation of newer forms of genetic sequencing (massively parallel or next-generation sequencing). Advantages conferred by this technology include reduced costs, reduced sequencing time and t...

journal_title：Biomarkers in medicine

authors： Rea G,Stewart FJ

更新日期：2013-08-01 00:00:00

abstract：AIM:Specific miRNA profiles have been identified for several samples from patients with bladder cancer. The results are not always congruent and partly contradictory. A comparison of published data was performed to select potential markers. MATERIALS & METHODS:A literature search in PubMed identified 79 articles publi...

journal_title：Biomarkers in medicine

authors： Tölle A,Ratert N,Jung K

更新日期：2014-01-01 00:00:00

abstract：:Aim: To develop robust and accurate prognostic biomarkers to help clinicians optimize therapeutic strategies. Materials & methods: Differentially prognosis-related autophagy genes were identified by bioinformatics analysis method. Results: Seven prognosis-related autophagy genes were more significantly related to the ...

journal_title：Biomarkers in medicine

authors： Wang J,Miao Y,Ran J,Yang Y,Guan Q,Mi D

更新日期：2020-09-01 00:00:00

abstract：:In recent years, biobanks of human tissues have evolved from small-scale collections of pathological materials into structured resource centers for acquisition, storage, processing and usage of high-quality biospecimens for research. This evolution goes hand in hand with the development of highly sensitive, high-throu...

journal_title：Biomarkers in medicine

authors： Zatloukal K,Hainaut P

更新日期：2010-12-01 00:00:00

abstract：:Podocyturia may be an expression of glomerular disease and is evaluated using urinary podocyte-specific molecules. This article discusses the technical problems of detection and quantification of podocyturia using immunofluorescent staining of specific proteins, urinary podocyte culture, flow cytometry and urinary pod...

journal_title：Biomarkers in medicine

authors： Camici M

更新日期：2008-12-01 00:00:00

abstract：:Aim: This study sought to investigate the relationship between galectin-3 (Gal-3), myocardial fibrosis (MF) and outcomes in acute heart failure. Materials & methods: The single-nucleotide polymorphisms (SNPs) of LGALS3 at rs4644 and rs4652, plasma Gal-3 level, MF and major adverse events (MAEs) were obtained. Results:...

journal_title：Biomarkers in medicine

authors： Fu H,Nie S,Luo P,Ruan Y,Zhang Z,Miao H,Li X,Wen S,Bai R

更新日期：2020-07-01 00:00:00

abstract：:Fibrosis is characterized by aberrant myofibroblast accumulation and excessive extracellular matrix deposition, which leads to organ failure and significantly contributes to mortality worldwide. Exosomes, which are extracellular nanovesicles with a diameter of 30-100 nm that are secreted into the extracellular space b...

journal_title：Biomarkers in medicine

authors： Qin XJ,Zhang JX,Wang RL

更新日期：2020-06-01 00:00:00

abstract：AIM:The aim was to investigate the inflammatory biomarker YKL-40 as a monitor of myocardial ischemia in patients with coronary artery disease (CAD). METHODS:A total of 311 patients with stable CAD were included. Blood samples were taken at baseline, the day after coronary angiography and/or after percutaneous coronary...

journal_title：Biomarkers in medicine

authors： Harutyunyan M,Johansen JS,Mygind ND,Reuter SB,Kastrup J

更新日期：2014-01-01 00:00:00

abstract：:Aim: To investigate the role of endothelial PV-1 in patients with untreated celiac disease (CD)-associated liver injury. Materials & methods: PV-1 and PV-1 mRNA were measured in intestinal biopsies from untreated CD patients with elevated or normal alanine transaminase levels, controls, patients with inflammatory bowe...

journal_title：Biomarkers in medicine

authors： De Leo L,Naviglio S,Vatta S,Benelli E,Stera G,Santon D,Ziberna F,Taddio A,Martelossi S,Giudici F,Giuffrida P,Di Sabatino A,Corazza GR,Ventura A,Not T

更新日期：2020-12-01 00:00:00

abstract：AIM:To investigate the role of MMP-9 (-1562 C:T) polymorphism as a biomarker for susceptibility to pre-eclampsia. PATIENTS & METHODS:MMP-9 variants were detected in 160 women with mild and severe pre-eclampsia and 112 healthy pregnant women. RESULTS:A significantly higher frequency of MMP-9 CT genotype was observed i...

journal_title：Biomarkers in medicine

authors： Rahimi Z,Rahimi Z,Shahsavandi MO,Bidoki K,Rezaei M

更新日期：2013-02-01 00:00:00

abstract：:Interferons (IFNs) comprise type I, II and III families with multiple subtypes. Via transcription of IFN-stimulated genes (ISGs), IFNs can exert multiple biological effects on the cell. In infectious and chronic inflammatory diseases, the IFNs and their ISG sets can be potentially utilized as biomarkers of disease out...

journal_title：Biomarkers in medicine

authors： Berry CM,Hertzog PJ,Mangan NE

更新日期：2012-04-01 00:00:00

abstract：AIM:Predicting a poor treatment outcome would offer significant benefits for patient care and for new drug development. Materials, methods & results: Urine samples from tuberculosis-positive patients with a successful and unsuccessful treatment outcome were collected at baseline and analyzed. The identified metabolites...

journal_title：Biomarkers in medicine

authors： Luies L,Reenen MV,Ronacher K,Walzl G,Loots DT

更新日期：2017-12-01 00:00:00

abstract：:Aim: Some patients experience statin-associated muscle symptoms (SAMS) and elevated serum concentrations of CK. The relationship between SAMS and biomarkers of muscle damage was examined. Methods: We analyzed 359 consecutive patients taking statins with high CK values. Muscle-related symptoms and biochemical variables...

journal_title：Biomarkers in medicine

authors： Nogueira AA,Strunz CM,Takada JY,Mansur AP

更新日期：2019-06-01 00:00:00

abstract：:Preeclampsia remains a significant cause of maternal morbidity and mortality worldwide. Prediction, diagnosis and management continue to be challenging but advances in the understanding of the pathophysiological processes underlying the disease has enabled identification of multiple biomarkers, some of which aid predi...

journal_title：Biomarkers in medicine

authors： Griffin M,Shennan AH

更新日期：2014-01-01 00:00:00