Proteomic profiling identifies N-acetylmuramoyl-l-alanine amidase as a novel biomarker of sepsis.

abstract：:The interest and research into disease-related biomarkers has greatly accelerated over the last 10 years. The potential clinical benefits for disease-specific biomarkers include a more rapid and accurate disease diagnosis, and potential reduction in size and duration of clinical drug trials, which would speed up drug ...

journal_title：Biomarkers in medicine

authors： Ganesalingam J,Bowser R

更新日期：2010-04-01 00:00:00

abstract：AIM:This study aimed to identify plasma protein changes in a rat model of ischemic stroke using a proteomic approach. MATERIALS & METHODS:Four male Sprague-Dawley rats (3-6 months old) were subjected to 90 min of left middle cerebral artery occlusion under anesthesia with 1.5% isoflurane in O(2)/air followed by 24-h r...

journal_title：Biomarkers in medicine

authors： Chen R,Vendrell I,Chen CP,Cash D,O'Toole KG,Williams SA,Jones C,Preston JE,Wheeler JX

更新日期：2011-12-01 00:00:00

abstract：AIM:We aimed to investigate whether baseline monocyte to high-density lipoprotein cholesterol ratio (MHR), an easily available inflammatory and oxidative stress marker, is associated with SYNTAX score. PATIENTS & METHODS:In this cross-sectional study, n = 1229 consecutive patients with coronary artery disease were cla...

journal_title：Biomarkers in medicine

authors： Akboga MK,Balci KG,Maden O,Ertem AG,Kirbas O,Yayla C,Acar B,Aras D,Kisacik H,Aydogdu S

更新日期：2016-01-01 00:00:00

abstract：AIM:Predicting a poor treatment outcome would offer significant benefits for patient care and for new drug development. Materials, methods & results: Urine samples from tuberculosis-positive patients with a successful and unsuccessful treatment outcome were collected at baseline and analyzed. The identified metabolites...

journal_title：Biomarkers in medicine

authors： Luies L,Reenen MV,Ronacher K,Walzl G,Loots DT

更新日期：2017-12-01 00:00:00

abstract：AIM:This meta-analysis was designed to analyze and evaluate the prognostic role of preoperative or pretreatment platelet-to-lymphocyte ratio (PLR) in patients with colorectal cancer (CRC). METHOD:We searched PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Chinese Biomedical L...

journal_title：Biomarkers in medicine

authors： Min GT,Wang YH,Yao N,Zhao JM,Wang J,Wang HP,Chen W,Deng SJ,Li YM

更新日期：2017-01-01 00:00:00

abstract：:The application of biomarker technology can be usefully implemented in areas where current techniques are inadequate and where a clinical issue, which affects outcome, can be defined. The definition of the loading status of the heart where there is pre-existent impairment of contractile function is a key target. Heart...

journal_title：Biomarkers in medicine

authors： Chuen MJ,Lip GY,MacFadyen RJ

更新日期：2007-10-01 00:00:00

abstract：AIM:To investigate the role of MMP-9 (-1562 C:T) polymorphism as a biomarker for susceptibility to pre-eclampsia. PATIENTS & METHODS:MMP-9 variants were detected in 160 women with mild and severe pre-eclampsia and 112 healthy pregnant women. RESULTS:A significantly higher frequency of MMP-9 CT genotype was observed i...

journal_title：Biomarkers in medicine

authors： Rahimi Z,Rahimi Z,Shahsavandi MO,Bidoki K,Rezaei M

更新日期：2013-02-01 00:00:00

abstract：:Patients with metastatic colorectal cancer have a very poor prognosis. Incorporation of targeted molecular therapies, such as the anti-EGFR receptor monoclonal antibodies cetuximab and panitumumab, into treatment regimens has improved outcomes for patients with wild-type RAS tumors. Yet, response rates remain low and ...

journal_title：Biomarkers in medicine

authors： Caiazza F,Elliott L,Fennelly D,Sheahan K,Doherty GA,Ryan EJ

更新日期：2015-01-01 00:00:00

abstract：:Blood-urea nitrogen, serum creatinine and urine output have long been used as markers of kidney function despite their known limitations. In the past few years, a number of novel biomarkers have been identified in the urine and blood that can detect kidney injury early. Although, to date, none of these biomarkers are ...

journal_title：Biomarkers in medicine

authors： Khan E,Batuman V,Lertora JJ

更新日期：2010-12-01 00:00:00

abstract：AIM:To explore the role of an adipokine-termed fatty acid-binding protein 4 (FABP4) in osteoarthritis (OA). METHODS:Patients with primary knee OA and non-OA controls were included. Paired tissues including plasma, synovial fluid (SF), subcutaneous fat and infrapatellar fat pad (IPFP) were harvested during surgery. FAB...

journal_title：Biomarkers in medicine

authors： Zhang C,Li T,Chiu KY,Wen C,Xu A,Yan CH

更新日期：2018-02-01 00:00:00

abstract：:Background: The Tp-e/QT (peak to end of T-wave duration/QT interval) ratio is a promising marker of myocardial repolarization and ventricular arrhythmogenesis. Its elevation is associated with sudden cardiac death in different clinical conditions. This study was designed to assess the possible association between incr...

journal_title：Biomarkers in medicine

authors： Fang J,Su H,Song A,Tong Y,Huang Z,Ding F,Liu Y

更新日期：2020-12-01 00:00:00

abstract：:Aim: To determine whether TLR9 polymorphisms are associated with tumor recurrence after liver transplantation for hepatocellular carcinoma (HCC). Patients & methods: All patients who underwent liver transplantation, and had viable HCC in the explanted liver were included. TLR9-1237C/T and -1486C/T polymorphisms were a...

journal_title：Biomarkers in medicine

authors： de la Fuente S,Citores MJ,Lucena JL,Muñoz P,Cuervas-Mons V

更新日期：2019-08-01 00:00:00

abstract：:Background: We aimed to assess the predictive value of the absolute and relative intact parathormone (iPTH) decline levels as reliable markers of postoperative hypocalcemia. Materials & methods: iPTH levels were measured 4 h after surgery and the following morning after surgery (postoperative day 1). iPTH, absolute iP...

journal_title：Biomarkers in medicine

authors： Rajan S,Ravindhran B,George B,Bantwal G,Vageesh Ayyar,Mohan LN

更新日期：2020-08-01 00:00:00

abstract：:Aim: We aimed to explore the biomarkers for disease progression or the risk of nonsurvivors. Materials & methods: This study included 134 hospitalized patients with confirmed COVID-19 infection. The outcome of moderate versus severe versus critically ill patients and survivors versus nonsurvivors were compared. Result...

journal_title：Biomarkers in medicine

authors： Li J,Li M,Zheng S,Li M,Zhang M,Sun M,Li X,Deng A,Cai Y,Zhang H

更新日期：2020-07-01 00:00:00

abstract：:Heart failure remains an important clinical and public health problem with significant mortality, morbidity and economic consequences. The identification of natriuretic peptides and the large number of investigations that followed have led to a better understanding of the neurohormonal pathophysiology of heart failure...

journal_title：Biomarkers in medicine

authors： Miller WL,Targonski PV,Jaffe AS

更新日期：2007-12-01 00:00:00

abstract：:Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy and is the fifth leading cause of cancer deaths in women. Developing adjuvant therapy to circumvent drug resistance represents an important aspect of current initiatives to improve survival in women with advanced EOC. A regulatory molecule that ...

journal_title：Biomarkers in medicine

authors： Nagaraj AB,Joseph P,DiFeo A

更新日期：2015-01-01 00:00:00

abstract：:The current review article aims to provide an up-to-date summary of previous studies in humans that have reported the association between circulating endostatin levels and different cardiovascular phenotypes. We also aim to provide suggestions for future directions of future research evaluating endostatin as a clinica...

journal_title：Biomarkers in medicine

authors： Ruge T,Carlsson AC,Larsson A,Ärnlöv J

更新日期：2017-10-01 00:00:00

abstract：:Evaluation of: Hsu PI, Chen CH, Hsieh CS et al.: alpha1-antitrypsin precursor in gastric juice is a novel biomarker for gastric cancer and ulcer. Clin. Cancer Res. 13(3), 876-883 (2007) [1] . The authors have identified the alpha1-antitrypsin precursor as a new protein marker of gastric cancer in gastric juice by 2D e...

journal_title：Biomarkers in medicine

authors： Monari M,Foschi J,Serrazanetti GP

更新日期：2007-06-01 00:00:00

abstract：AIM:Several lines of evidence exist which suggest that changes in the expression of circulating cytokines are linked to the development or reoccurrence of multiple sclerosis (MS). This study aimed to evaluate the serum levels of relevant cytokines after therapy with IFN-β formulations in MS patients. MATERIALS & METHO...

journal_title：Biomarkers in medicine

authors： Arababadi MK,Mosavi R,Khorramdelazad H,Yaghini N,Zarandi ER,Araste M,Pourali R,Nekhei Z,Kennedy D

更新日期：2010-10-01 00:00:00

abstract：AIM:The purpose of this study was to establish the influence of centrifugation and protease activity on the cerebrospinal fluid (CSF) concentrations of DJ-1 and hemoglobin. MATERIALS & METHODS:The concentrations of DJ-1 and hemoglobin were determined in 12 (DJ-1) and six (hemoglobin) pairs of CSF samples, with one sam...

journal_title：Biomarkers in medicine

authors： Salvesen L,Tanassi JT,Bech S,Pålhagen S,Svenningsson P,Heegaard NH,Winge K

更新日期：2014-01-01 00:00:00

abstract：:Biomarker discovery is essential to the advancement of our knowledge about diseases and to the development of new strategies for treatment and therapy. Among the newest technologies in this rapidly growing field is a process termed Cell SELEX by which a panel of aptamers can be generated to specifically target disease...

journal_title：Biomarkers in medicine

authors： Kim Y,Liu C,Tan W

更新日期：2009-04-01 00:00:00

abstract：AIM:Specific miRNA profiles have been identified for several samples from patients with bladder cancer. The results are not always congruent and partly contradictory. A comparison of published data was performed to select potential markers. MATERIALS & METHODS:A literature search in PubMed identified 79 articles publi...

journal_title：Biomarkers in medicine

authors： Tölle A,Ratert N,Jung K

更新日期：2014-01-01 00:00:00

abstract：AIM:To determine the performance of plasma calprotectin as a marker of sepsis on intensive care unit (ICU) admission and as a marker of mortality day 30 post-ICU admission. MATERIALS & METHODS:Consecutive ICU patients were allocated to: sepsis (n = 15), postoperative inflammation (n = 23) and intoxication without infl...

journal_title：Biomarkers in medicine

authors： Simm M,Söderberg E,Larsson A,Castegren M,Nilsen T,Eriksson M,Lipcsey M

更新日期：2016-08-01 00:00:00

abstract：:Preeclampsia remains a significant cause of maternal morbidity and mortality worldwide. Prediction, diagnosis and management continue to be challenging but advances in the understanding of the pathophysiological processes underlying the disease has enabled identification of multiple biomarkers, some of which aid predi...

journal_title：Biomarkers in medicine

authors： Griffin M,Shennan AH

更新日期：2014-01-01 00:00:00

abstract：:In this work, we review the main available computational methods of identifying biomarkers of complex diseases from high-throughput data. The emerging omics techniques provide powerful alternatives to measure thousands of molecules in cells in parallel manners. The generated genomic, transcriptomic, proteomic, metabol...

journal_title：Biomarkers in medicine

authors： Liu ZP

更新日期：2016-06-01 00:00:00

abstract：:Letter in regards to: Akboga MK, Balci KG, Maden O et al. Usefulness of monocyte to HDL-cholesterol ratio to predict high SYNTAX score in patients with stable coronary artery disease. Biomark. Med. 10(4), 375-383 (2016). ...

journal_title：Biomarkers in medicine

authors： Soylemez S

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Autism spectrum disorder (ASD) represents a wide range of neurodevelopmental disorders characterized by impairments in social interaction, language, communication and range of interests. Autism is usually diagnosed in children 3-5 years of age using behavioral characteristics; thus, diagnosis shortly after b...

journal_title：Biomarkers in medicine

authors： Mizejewski GJ,Lindau-Shepard B,Pass KA

更新日期：2013-04-01 00:00:00

abstract：:Aim: Eosinophilic asthma is associated with more exacerbations and differential responses to treatment. The aim of this study was to assess if CLC/Gal-10 and MBP-1 are surrogate biomarkers of eosinophilic inflammation in asthma. Methods & results: Sputum induction was performed in patients with asthma and in healthy c...

journal_title：Biomarkers in medicine

authors： Nyenhuis SM,Alumkal P,Du J,Maybruck BT,Vinicky M,Ackerman SJ

更新日期：2019-06-01 00:00:00

abstract：AIM:The usefulness of high-sensitivity troponin T (hs-TnT) as a predictor of perioperative hemodynamic instability is currently unknown. METHODS:A prospective study was conducted on a group of 708 consecutive patients with significant valvular heart disease that underwent elective valve surgery. The primary end point ...

journal_title：Biomarkers in medicine

authors： Duchnowski P,Hryniewiecki T,Koźma M,Mariusz K,Piotr S

更新日期：2018-12-01 00:00:00

abstract：AIM:To assess the possible relationship between coronary atherosclerosis markers, pericardial fat volume (PFV) and coronary artery calcification, with ECG markers of index of the cardiac electrophysiological balance (iCEB) and transmural dispersion of the repolarization in patients with suspected coronary artery diseas...

journal_title：Biomarkers in medicine

authors： Nafakhi H,Al-Mosawi AA,Alareedh M,Al-Nafakh HA

更新日期：2018-04-01 00:00:00