Emergence of biomarkers in nephropharmacology.

Abstract:

:Blood-urea nitrogen, serum creatinine and urine output have long been used as markers of kidney function despite their known limitations. In the past few years, a number of novel biomarkers have been identified in the urine and blood that can detect kidney injury early. Although, to date, none of these biomarkers are in clinical use, many have been validated as reliable and sensitive, allowing detection of kidney injury before serum creatinine levels rise and urine output drops. These markers have been evaluated in great detail in animal models and to a lesser extent in humans in postcardiopulmonary bypass and sepsis. There is relatively scarse data on the use of these biomarkers in the detection of kidney injury associated with the use of pharmacologic agents. The purpose of this article is to summarize these data and highlight the potential utility of these biomarkers in nephropharmacology.

journal_name

Biomark Med

journal_title

Biomarkers in medicine

authors

Khan E,Batuman V,Lertora JJ

doi

10.2217/bmm.10.115

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

805-14

issue

6

eissn

1752-0363

issn

1752-0371

journal_volume

4

pub_type

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