Emergence of biomarkers in nephropharmacology.

abstract：:The uPA system mainly comprises the urokinase-type plasminogen activator uPA, the cell-surface receptor uPA receptor and the inhibitor PAI-1. Its clinical and prognostic impact especially in breast cancer is well investigated. In this short report, we summarize the published data describing expression of uPA, PAI-1 an...

journal_title：Biomarkers in medicine

authors： Taubert H,Magdolen V,Kotzsch M

更新日期：2013-06-01 00:00:00

abstract：AIM:We aimed to investigate whether baseline monocyte to high-density lipoprotein cholesterol ratio (MHR), an easily available inflammatory and oxidative stress marker, is associated with SYNTAX score. PATIENTS & METHODS:In this cross-sectional study, n = 1229 consecutive patients with coronary artery disease were cla...

journal_title：Biomarkers in medicine

authors： Akboga MK,Balci KG,Maden O,Ertem AG,Kirbas O,Yayla C,Acar B,Aras D,Kisacik H,Aydogdu S

更新日期：2016-01-01 00:00:00

abstract：AIM:Predicting a poor treatment outcome would offer significant benefits for patient care and for new drug development. Materials, methods & results: Urine samples from tuberculosis-positive patients with a successful and unsuccessful treatment outcome were collected at baseline and analyzed. The identified metabolites...

journal_title：Biomarkers in medicine

authors： Luies L,Reenen MV,Ronacher K,Walzl G,Loots DT

更新日期：2017-12-01 00:00:00

abstract：:The aim of this meta-analysis was to review the available evidence regarding the blood concentrations of the oxidative stress marker malondialdehyde (MDA) in chronic obstructive pulmonary disease (COPD) patients in comparison to healthy individuals. 14 studies were included in the meta-analysis (from inception to Octo...

journal_title：Biomarkers in medicine

authors： Paliogiannis P,Fois AG,Sotgia S,Mangoni AA,Zinellu E,Pirina P,Carru C,Zinellu A

更新日期：2018-07-01 00:00:00

abstract：:The application of genomic medicine to the treatment of nicotine dependence holds great promise for revitalizing the steady decline in smoking rates witnessed in the USA over the past several decades. This paper examines the current knowledge base concerning the use of biomarkers to guide the selection of nicotine dep...

journal_title：Biomarkers in medicine

authors： Schnoll RA,Leone FT

更新日期：2011-12-01 00:00:00

abstract：:Increased neurohormonal activation is a key feature of heart failure (HF). Copeptin is a surrogate marker for proarginine vasopressin and the prognostic value of copeptin has been reported for multiple disease states of both nonvascular and cardiovascular etiology. Elevated plasma copeptin in HF has been associated wi...

journal_title：Biomarkers in medicine

authors： Balling L,Gustafsson F

更新日期：2014-01-01 00:00:00

abstract：AIM:The role of octamer-binding transcription factor 4 (Oct4) in gastric cancer (GC) progression is still under debate and reported results are inconsistent. Therefore, we conducted a meta-analysis to evaluate the clinicopathological and prognostic significance of Oct4 expression in patients with GC. MATERIALS & METHO...

journal_title：Biomarkers in medicine

authors： Wei Y,Liu H,Wang C,Zhang W,Wen X,Long H,Xu Z,Guo H,Liu Y,Wei D,Qiu C,Li G,Sun Z

更新日期：2019-02-01 00:00:00

abstract：:It has become increasingly clear that the development of cancer, a multifactorial disease, cannot be explained by a single molecule or gene mutation. As a new discipline, metabolomics focuses on the body's metabolite changes, and attempts to find differences to explain the development of cancer; it has proven to be ef...

journal_title：Biomarkers in medicine

authors： Zhang WT,Zhang ZW,Guo YD,Wang LS,Mao SY,Zhang JF,Liu MN,Yao XD

更新日期：2018-12-01 00:00:00

abstract：:The natriuretic peptide system comprises three structurally related peptides: atrial natriuretic peptide, B-type natriuretic peptide and C-type natriuretic peptide. In circulation, they play an important endocrine role in the regulation of cardiovascular homeostasis by maintaining blood pressure and extracellular flui...

journal_title：Biomarkers in medicine

authors： Lippert S,Goetze JP

更新日期：2010-08-01 00:00:00

abstract：AIM:To determine the performance of plasma calprotectin as a marker of sepsis on intensive care unit (ICU) admission and as a marker of mortality day 30 post-ICU admission. MATERIALS & METHODS:Consecutive ICU patients were allocated to: sepsis (n = 15), postoperative inflammation (n = 23) and intoxication without infl...

journal_title：Biomarkers in medicine

authors： Simm M,Söderberg E,Larsson A,Castegren M,Nilsen T,Eriksson M,Lipcsey M

更新日期：2016-08-01 00:00:00

abstract：AIM:To investigate the prognostic performance of complement components in septic patients, complement 3, membrane attack complex (MAC) and mannose-binding lectin were measured and compared among adult patients with sepsis, severe sepsis and septic shock, as well as between in-hospital nonsurvivors and survivors. METHO...

journal_title：Biomarkers in medicine

authors： Zhao X,Chen YX,Li CS

更新日期：2015-01-01 00:00:00

abstract：AIM:To establish a database for the associations between idiosyncratic drug reactions (IDRs) and human leukocyte antigens (HLAs) and to systematically assess the characteristics of the drug-HLA associations. MATERIALS & METHODS:Electronic databases were searched to extensively identify drug-HLA association studies fro...

journal_title：Biomarkers in medicine

authors： Du T,Yang L,Luo H,Zhou P,Mei H,Xuan J,Xing Q,Ning B,Mendrick DL,Shi L

更新日期：2015-01-01 00:00:00

abstract：:Modern war wounds are complex and primarily involve extremities. They require multiple operative interventions to achieve wound closure and begin rehabilitation. Current assessment of the suitability of surgical wound closure is based upon subjective methods coupled with a semiquantitative determination of the wound b...

journal_title：Biomarkers in medicine

authors： Brown TS,Safford S,Caramanica J,Elster EA

更新日期：2010-06-01 00:00:00

abstract：:Aim: We aimed to explore the biomarkers for disease progression or the risk of nonsurvivors. Materials & methods: This study included 134 hospitalized patients with confirmed COVID-19 infection. The outcome of moderate versus severe versus critically ill patients and survivors versus nonsurvivors were compared. Result...

journal_title：Biomarkers in medicine

authors： Li J,Li M,Zheng S,Li M,Zhang M,Sun M,Li X,Deng A,Cai Y,Zhang H

更新日期：2020-07-01 00:00:00

abstract：:The prevalence of metabolic disorders (MDs), especially diabetes, is rapidly increasing worldwide, leading to an increasing risk of cardiovascular and other socially relevant complications. To boost MD biomarker discovery, advanced proteomics can harmonize metabolomics. Indeed, the rapid development of mass spectromet...

journal_title：Biomarkers in medicine

authors： Di Girolamo F,Del Chierico F,Caenaro G,Lante I,Muraca M,Putignani L

更新日期：2012-12-01 00:00:00

abstract：:Tuberculosis (TB) and diabetes mellitus Type 2 (DM2) are two diseases as ancient as they are harmful to human health. The outcome for both diseases in part depends on immune and metabolic individual responses. DM2 is increasing yearly, mainly due to environmental, genetic and lifestyle habits. There are multiple evide...

journal_title：Biomarkers in medicine

authors： Salgado-Bustamante M,Rocha-Viggiano AK,Rivas-Santiago C,Magaña-Aquino M,López JA,López-Hernández Y

更新日期：2018-09-01 00:00:00

abstract：:Background: We investigated whether ADAMTS9-AS2 and CADM2 were related to esophageal squamous cell carcinoma (ESCC). Methodology: ESCC microarray datasets and reverse transcriptase qualitative PCR were used to analyze ADAMTS9-AS2 and CADM2 expression. Results: The GSE120356 and GSE33810 datasets identified ADAMTS9-AS2...

journal_title：Biomarkers in medicine

authors： Shen FF,Zhang F,Yang HJ,Li JK,Su JF,Yu PT,Zhou FY,Che GW

更新日期：2020-10-01 00:00:00

abstract：AIM:Because of the delayed rise of serum creatinine concentrations, novel biomarkers such as NGAL, GST and KIM-1 are proposed to detect acute kidney injury (AKI). In this study we evaluated these biomarkers. MATERIALS & METHODS:Twenty-six consecutive adult liver transplantations were evaluated. Markers were measured a...

journal_title：Biomarkers in medicine

authors： Dedeoglu B,de Geus HR,Fortrie G,Betjes MG

更新日期：2013-12-01 00:00:00

abstract：:The field of aortopathy, in common with other genomic disorders, is undergoing a revolution. This is largely driven by the implementation of newer forms of genetic sequencing (massively parallel or next-generation sequencing). Advantages conferred by this technology include reduced costs, reduced sequencing time and t...

journal_title：Biomarkers in medicine

authors： Rea G,Stewart FJ

更新日期：2013-08-01 00:00:00

abstract：:Alzheimer's disease will reach epidemic proportions within the next 20-30 years if left unchecked. Currently, there are no treatments that prevent or slow Alzheimer's disease but many are being developed. Parallel efforts to develop biomarkers to aid in disease diagnosis and prognosis, and assess disease risk are curr...

journal_title：Biomarkers in medicine

authors： Fagan AM,Holtzman DM

更新日期：2010-02-01 00:00:00

abstract：AIM:Childhood cancer remains one of the main cause of death in the pediatric population. Amino acids (AAs) level alterations in plasma are considered to play a role in carcinogenesis and further course of the disease. METHODS:Seventy-seven children with cancer, including 47 with hematological and 30 with solid tumors ...

journal_title：Biomarkers in medicine

authors： Synakiewicz A,Sawicka-Zukowska M,Adrianowska N,Galezowska G,Ratajczyk J,Owczarzak A,Konieczna L,Stachowicz-Stencel T

更新日期：2017-08-01 00:00:00

abstract：:Letter in regards to: Akboga MK, Balci KG, Maden O et al. Usefulness of monocyte to HDL-cholesterol ratio to predict high SYNTAX score in patients with stable coronary artery disease. Biomark. Med. 10(4), 375-383 (2016). ...

journal_title：Biomarkers in medicine

authors： Soylemez S

更新日期：2017-08-01 00:00:00

abstract：:Aim: To develop robust and accurate prognostic biomarkers to help clinicians optimize therapeutic strategies. Materials & methods: Differentially prognosis-related autophagy genes were identified by bioinformatics analysis method. Results: Seven prognosis-related autophagy genes were more significantly related to the ...

journal_title：Biomarkers in medicine

authors： Wang J,Miao Y,Ran J,Yang Y,Guan Q,Mi D

更新日期：2020-09-01 00:00:00

abstract：:Malignant pleural mesothelioma (MPM) is a highly aggressive and invasive tumor, whose incidence is expected to peak, in many countries, at the end of the present decade, 20-40 years after the peak of asbestos use (asbestos being the most important etiological factor). MPM has a poor prognosis, in part, owing to a diff...

journal_title：Biomarkers in medicine

authors： Cristaudo A,Bonotti A,Simonini S,Bruno R,Foddis R

更新日期：2011-04-01 00:00:00

abstract：:Aim: The diagnostic and prognostic role of procalcitonin (PCT) and mid-regional-pro-adrenomedullin (MR-proADM) were investigated in patients with pneumonia. Material & methods: A total of 168 and 77 patients with pneumonia enrolled in two different hospital settings, an internal medicine unit and an emergency unit wer...

journal_title：Biomarkers in medicine

authors： Spoto S,Legramante JM,Minieri M,Fogolari M,Terrinoni A,Valeriani E,Sebastiano C,Bernardini S,Ciccozzi M,Angeletti PS

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Circulating tumor cells (CTCs) and tumor-specific alterations in cell-free plasma DNA can both be used as markers of prognosis in breast cancer. To date, there have been no studies that have compared these as markers for subclinical metastases in the follow-up of early breast cancer. In this study, we measur...

journal_title：Biomarkers in medicine

authors： Shaw JA,Brown J,Coombes RC,Jacob J,Payne R,Lee B,Page K,Hava N,Stebbing J

更新日期：2011-02-01 00:00:00

abstract：AIM:The conflicting relationships of serum omentin with inflammation markers and cardiometabolic disorders were investigated. Results & methods: Unselected 864 population-based middle-aged adults were cross-sectionally studied by sex-specific omentin tertiles. Men in the lowest omentin tertile (T1) had lower systolic b...

journal_title：Biomarkers in medicine

authors： Onat A,Ademoglu E,Karadeniz Y,Can G,Uzun AO,Simsek B,Kaya A

更新日期：2018-02-01 00:00:00

abstract：AIM:We have evaluated here the clinical and analytical performance of the Alere™ Heart Check (AHC) test, a rapid point-of-care immunoassay designed for the measurement of BNP from fresh capillary whole blood. PATIENTS & METHODS:One-hundred-and-sixty-three patients with stable chronic heart failure followed at the card...

journal_title：Biomarkers in medicine

authors： Monfort A,Da Silva K,Vodovar N,Gayat E,Cohen-Solal A,Manivet P

更新日期：2015-01-01 00:00:00

abstract：:With the regulatory approvals in Europe and the USA of trastuzumab-based anti-HER2 targeted therapy for upper gastrointestinal cancers in 2010, HER2 testing has now become universal for newly diagnosed cases of both breast cancer and adenocarcinomas of esophagus, stomach and gastroesophageal origin. In the 12 years or...

journal_title：Biomarkers in medicine

authors： Ross JS

更新日期：2011-06-01 00:00:00

abstract：AIM:Ankylosing spondylitis (AS) is a chronic systemic inflammatory rheumatic disorder that primarily affects the axial skeleton. To date there is no satisfactory biomarker for diagnosis or prognosis of AS. This study is focused on detection of potential biomarkers for the diagnosis of AS using surface-enhanced laser de...

journal_title：Biomarkers in medicine

authors： Bons JA,van der Heijde D,Bouwman FG,Mariman EC,van Dieijen-Visser MP,Landewé R,van der Linden S,Wodzig WK

更新日期：2008-02-01 00:00:00