Emergence of biomarkers in nephropharmacology.


:Blood-urea nitrogen, serum creatinine and urine output have long been used as markers of kidney function despite their known limitations. In the past few years, a number of novel biomarkers have been identified in the urine and blood that can detect kidney injury early. Although, to date, none of these biomarkers are in clinical use, many have been validated as reliable and sensitive, allowing detection of kidney injury before serum creatinine levels rise and urine output drops. These markers have been evaluated in great detail in animal models and to a lesser extent in humans in postcardiopulmonary bypass and sepsis. There is relatively scarse data on the use of these biomarkers in the detection of kidney injury associated with the use of pharmacologic agents. The purpose of this article is to summarize these data and highlight the potential utility of these biomarkers in nephropharmacology.


Biomark Med


Biomarkers in medicine


Khan E,Batuman V,Lertora JJ




Has Abstract


2010-12-01 00:00:00












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    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审


    authors: Palomino JC,Vandamme P,Martin A

    更新日期:2014-01-01 00:00:00

  • Serum YKL-40 for monitoring myocardial ischemia after revascularization in patients with stable coronary artery disease.

    abstract:AIM:The aim was to investigate the inflammatory biomarker YKL-40 as a monitor of myocardial ischemia in patients with coronary artery disease (CAD). METHODS:A total of 311 patients with stable CAD were included. Blood samples were taken at baseline, the day after coronary angiography and/or after percutaneous coronary...

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    authors: Harutyunyan M,Johansen JS,Mygind ND,Reuter SB,Kastrup J

    更新日期:2014-01-01 00:00:00

  • Discovering biomarkers in bladder cancer by metabolomics.

    abstract::It has become increasingly clear that the development of cancer, a multifactorial disease, cannot be explained by a single molecule or gene mutation. As a new discipline, metabolomics focuses on the body's metabolite changes, and attempts to find differences to explain the development of cancer; it has proven to be ef...

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    authors: Zhang WT,Zhang ZW,Guo YD,Wang LS,Mao SY,Zhang JF,Liu MN,Yao XD

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    pub_type: 杂志文章


    authors: Mankowska-Cyl A,Krintus M,Rajewski P,Sypniewska G

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    abstract::Aim: To develop robust and accurate prognostic biomarkers to help clinicians optimize therapeutic strategies. Materials & methods: Differentially prognosis-related autophagy genes were identified by bioinformatics analysis method. Results: Seven prognosis-related autophagy genes were more significantly related to the ...

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    pub_type: 杂志文章


    authors: Wang J,Miao Y,Ran J,Yang Y,Guan Q,Mi D

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    abstract::Autophagy is a catabolic process associated with intracellular self-digestion of damaged organelles or redundant proteins enabling maintenance of cell homeostasis. It is accepted that impaired autophagy is closely linked to cancer development and has been extensively studied in a variety of malignancies including colo...

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    abstract:AIM:The aim of the present study is to evaluate the relationship between coronary collateral circulation (CCC) grade and serum IGF-1 levels in patients diagnosed with stable coronary artery disease. METHODS:Totally, 190 consecutive patients with stable coronary artery disease who underwent coronary angiography were in...

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    authors: Kundi H,Gok M,Kiziltunc E,Cetin M,Ornek E

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    pub_type: 杂志文章


    authors: Miller WL,Targonski PV,Jaffe AS

    更新日期:2007-12-01 00:00:00

  • A novel 8.7-kb mitochondrial genome deletion accurately detects endometriosis in the plasma of symptomatic women.

    abstract::Aim: To evaluate an 8.7-kb mitochondrial DNA (mtDNA) deletion as a potential biomarker of endometriosis. Materials & methods: We tested the diagnostic accuracy of the 8.7-kb deletion real-time PCR assay using 182 prospectively collected blood samples from females presenting with symptoms of endometriosis in a case-con...

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    pub_type: 杂志文章


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    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Camici M

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    pub_type: 杂志文章,评审


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    abstract::Major depressive disorder (MDD: unipolar depression) is widely distributed in the USA and world-wide populations and it is one of the leading causes of disability in both adolescents and adults. Traditional diagnostic approaches for MDD are based on patient interviews, which provide a subjective assessment of clinical...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


    authors: Kasim NB,Huri HZ,Vethakkan SR,Ibrahim L,Abdullah BM

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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Soylemez S

    更新日期:2017-08-01 00:00:00

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    pub_type: 杂志文章,评审


    authors: Ruge T,Carlsson AC,Larsson A,Ärnlöv J

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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


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    更新日期:2012-04-01 00:00:00

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    abstract:AIM:To assess the possible relationship between coronary atherosclerosis markers, pericardial fat volume (PFV) and coronary artery calcification, with ECG markers of index of the cardiac electrophysiological balance (iCEB) and transmural dispersion of the repolarization in patients with suspected coronary artery diseas...

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    authors: Nafakhi H,Al-Mosawi AA,Alareedh M,Al-Nafakh HA

    更新日期:2018-04-01 00:00:00

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    abstract:AIM:This meta-analysis was designed to analyze and evaluate the prognostic role of preoperative or pretreatment platelet-to-lymphocyte ratio (PLR) in patients with colorectal cancer (CRC). METHOD:We searched PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Chinese Biomedical L...

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    pub_type: 杂志文章,meta分析


    authors: Min GT,Wang YH,Yao N,Zhao JM,Wang J,Wang HP,Chen W,Deng SJ,Li YM

    更新日期:2017-01-01 00:00:00

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    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Khadirnaikar S,Narayanan SP,Shukla SK

    更新日期:2018-10-01 00:00:00

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    abstract:AIM:To investigate the prognostic performance of complement components in septic patients, complement 3, membrane attack complex (MAC) and mannose-binding lectin were measured and compared among adult patients with sepsis, severe sepsis and septic shock, as well as between in-hospital nonsurvivors and survivors. METHO...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


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    更新日期:2015-01-01 00:00:00

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    abstract::Patients with metastatic colorectal cancer have a very poor prognosis. Incorporation of targeted molecular therapies, such as the anti-EGFR receptor monoclonal antibodies cetuximab and panitumumab, into treatment regimens has improved outcomes for patients with wild-type RAS tumors. Yet, response rates remain low and ...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审


    authors: Caiazza F,Elliott L,Fennelly D,Sheahan K,Doherty GA,Ryan EJ

    更新日期:2015-01-01 00:00:00

  • Circulating PV-1 as a marker of celiac disease-associated liver injury.

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    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: De Leo L,Naviglio S,Vatta S,Benelli E,Stera G,Santon D,Ziberna F,Taddio A,Martelossi S,Giudici F,Giuffrida P,Di Sabatino A,Corazza GR,Ventura A,Not T

    更新日期:2020-12-01 00:00:00

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    abstract::Increasing evidence has highlighted the roles of oxidative stress and inflammation in the promotion of atherosclerotic cardiovascular disease. Recent pathological studies have elucidated specific mediators that appear to link these pathways to the progression and rupture of atherosclerotic plaque in the artery wall. T...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审


    authors: Uno K,Nicholls SJ

    更新日期:2010-06-01 00:00:00