Abstract:
:Blood-urea nitrogen, serum creatinine and urine output have long been used as markers of kidney function despite their known limitations. In the past few years, a number of novel biomarkers have been identified in the urine and blood that can detect kidney injury early. Although, to date, none of these biomarkers are in clinical use, many have been validated as reliable and sensitive, allowing detection of kidney injury before serum creatinine levels rise and urine output drops. These markers have been evaluated in great detail in animal models and to a lesser extent in humans in postcardiopulmonary bypass and sepsis. There is relatively scarse data on the use of these biomarkers in the detection of kidney injury associated with the use of pharmacologic agents. The purpose of this article is to summarize these data and highlight the potential utility of these biomarkers in nephropharmacology.
journal_name
Biomark Medjournal_title
Biomarkers in medicineauthors
Khan E,Batuman V,Lertora JJdoi
10.2217/bmm.10.115subject
Has Abstractpub_date
2010-12-01 00:00:00pages
805-14issue
6eissn
1752-0363issn
1752-0371journal_volume
4pub_type
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journal_title:Biomarkers in medicine
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journal_title:Biomarkers in medicine
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journal_title:Biomarkers in medicine
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journal_title:Biomarkers in medicine
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journal_title:Biomarkers in medicine
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journal_title:Biomarkers in medicine
pub_type: 杂志文章
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journal_title:Biomarkers in medicine
pub_type: 杂志文章,meta分析
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journal_title:Biomarkers in medicine
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