Biomarkers of acute kidney injury in pediatric cardiac patients.

abstract：:Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy and is the fifth leading cause of cancer deaths in women. Developing adjuvant therapy to circumvent drug resistance represents an important aspect of current initiatives to improve survival in women with advanced EOC. A regulatory molecule that ...

journal_title：Biomarkers in medicine

authors： Nagaraj AB,Joseph P,DiFeo A

更新日期：2015-01-01 00:00:00

abstract：AIMS:Progressive vasodegeneration in microvascular beds is the major underlying factor in initiation and progression of diabetic complications. Chemerin shows a strong correlation with various facets of the metabolic syndrome, which is associated with dysregulated angiogenesis. VEGF is shown to have an angiogenic role ...

journal_title：Biomarkers in medicine

authors： Zakareia FA

更新日期：2012-02-01 00:00:00

abstract：:Aim: Natural killer cell receptor group 2D (NKG2D) plays an important role in the immune regulation of tumors. We speculate that DNA methylation are involved in the regulation of NKG2D gene. Methods: We investigated the methylation status of the NKG2D promoter in peripheral blood mononuclear cells of hepatocellular ca...

journal_title：Biomarkers in medicine

authors： Zhao NH,Qian Y,Wu CS,Wang JW,Fang Y,Fan XP,Gao S,Fan YC,Wang K

更新日期：2019-09-01 00:00:00

abstract：:The current cost of developing a successful drug is typically over a billion dollars, with the registration trial(s) determining the success or failure of the entire development program. Often the primary endpoint of these trials is a subjective assessment. For registration trials with subjective endpoints, a regulato...

journal_title：Biomarkers in medicine

authors： Walovitch RC,Chokron P,Agarwal S

更新日期：2012-12-01 00:00:00

abstract：:In general, a biomarker has multiple uses such as a diagnostic tool and a method to monitor therapy. The quality of a biomarker depends on how big the difference is between, for example, patients and healthy controls, but also on the capacity of the method used to measure it (the uncertainty in the method should be mu...

journal_title：Biomarkers in medicine

authors： Andreasson U,Vanmechelen E,Shaw LM,Zetterberg H,Vanderstichele H

更新日期：2012-08-01 00:00:00

abstract：AIM:This study aimed to assess the urinary concentrations of epidermal growth factor (EGF) and kidney injury molecule 1 (KIM-1) in patients with hydronephrosis. METHODS:Neonates with a history of prenatal hydronephrosis were enrolled in three groups. Group 1 included neonates with severe obstruction; group 2 included ...

journal_title：Biomarkers in medicine

authors： Mohammadjafari H,Rafiei A,Kosaryan M,Yeganeh Y,Hosseinimehr SJ

更新日期：2014-01-01 00:00:00

abstract：AIM:The conflicting relationships of serum omentin with inflammation markers and cardiometabolic disorders were investigated. Results & methods: Unselected 864 population-based middle-aged adults were cross-sectionally studied by sex-specific omentin tertiles. Men in the lowest omentin tertile (T1) had lower systolic b...

journal_title：Biomarkers in medicine

authors： Onat A,Ademoglu E,Karadeniz Y,Can G,Uzun AO,Simsek B,Kaya A

更新日期：2018-02-01 00:00:00

abstract：:Letter in regards to: Akboga MK, Balci KG, Maden O et al. Usefulness of monocyte to HDL-cholesterol ratio to predict high SYNTAX score in patients with stable coronary artery disease. Biomark. Med. 10(4), 375-383 (2016). ...

journal_title：Biomarkers in medicine

authors： Soylemez S

更新日期：2017-08-01 00:00:00

abstract：AIM:This meta-analysis was designed to analyze and evaluate the prognostic role of preoperative or pretreatment platelet-to-lymphocyte ratio (PLR) in patients with colorectal cancer (CRC). METHOD:We searched PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Chinese Biomedical L...

journal_title：Biomarkers in medicine

authors： Min GT,Wang YH,Yao N,Zhao JM,Wang J,Wang HP,Chen W,Deng SJ,Li YM

更新日期：2017-01-01 00:00:00

abstract：:Currently, decision-making for breast cancer treatment in the clinical setting is mainly based on clinical data, histomorphological features of the tumor tissue and a few cancer biomarkers such as steroid hormone receptor status (estrogen and progesterone receptors) and oncoprotein HER2 status. Although various therap...

journal_title：Biomarkers in medicine

authors： Napieralski R,Brünner N,Mengele K,Schmitt M

更新日期：2010-08-01 00:00:00

abstract：:Patients with metastatic colorectal cancer have a very poor prognosis. Incorporation of targeted molecular therapies, such as the anti-EGFR receptor monoclonal antibodies cetuximab and panitumumab, into treatment regimens has improved outcomes for patients with wild-type RAS tumors. Yet, response rates remain low and ...

journal_title：Biomarkers in medicine

authors： Caiazza F,Elliott L,Fennelly D,Sheahan K,Doherty GA,Ryan EJ

更新日期：2015-01-01 00:00:00

abstract：AIM:To investigate the role of gelsolin-like actin-capping protein (CapG) in prostate cancer (PCa). MATERIALS & METHODS:CapG expression and its correlation with clinicopathological characters and patient prognosis were analyzed in 76 cases of PCa by immunohistochemistry and qRT-PCR. Then, the influence of CapG downreg...

journal_title：Biomarkers in medicine

authors： Li T,Hong X,Zhao J,Teng Y,Zheng J,Chen H,Chen H,Li H

更新日期：2016-12-01 00:00:00

abstract：:In recent years, biobanks of human tissues have evolved from small-scale collections of pathological materials into structured resource centers for acquisition, storage, processing and usage of high-quality biospecimens for research. This evolution goes hand in hand with the development of highly sensitive, high-throu...

journal_title：Biomarkers in medicine

authors： Zatloukal K,Hainaut P

更新日期：2010-12-01 00:00:00

abstract：:Biomarker discovery is essential to the advancement of our knowledge about diseases and to the development of new strategies for treatment and therapy. Among the newest technologies in this rapidly growing field is a process termed Cell SELEX by which a panel of aptamers can be generated to specifically target disease...

journal_title：Biomarkers in medicine

authors： Kim Y,Liu C,Tan W

更新日期：2009-04-01 00:00:00

abstract：:The application of genomic medicine to the treatment of nicotine dependence holds great promise for revitalizing the steady decline in smoking rates witnessed in the USA over the past several decades. This paper examines the current knowledge base concerning the use of biomarkers to guide the selection of nicotine dep...

journal_title：Biomarkers in medicine

authors： Schnoll RA,Leone FT

更新日期：2011-12-01 00:00:00

abstract：:The field of aortopathy, in common with other genomic disorders, is undergoing a revolution. This is largely driven by the implementation of newer forms of genetic sequencing (massively parallel or next-generation sequencing). Advantages conferred by this technology include reduced costs, reduced sequencing time and t...

journal_title：Biomarkers in medicine

authors： Rea G,Stewart FJ

更新日期：2013-08-01 00:00:00

abstract：:The current review article aims to provide an up-to-date summary of previous studies in humans that have reported the association between circulating endostatin levels and different cardiovascular phenotypes. We also aim to provide suggestions for future directions of future research evaluating endostatin as a clinica...

journal_title：Biomarkers in medicine

authors： Ruge T,Carlsson AC,Larsson A,Ärnlöv J

更新日期：2017-10-01 00:00:00

abstract：:Cardiac troponin is the standard biomarker for the diagnosis of acute myocardial infarction (AMI) and risk stratification for short-term adverse cardiac events (death, AMI or need for revascularization). Unfortunately, the concentration of troponin in blood is normal in AMI patients who present early after the onset o...

journal_title：Biomarkers in medicine

authors： Wu AH

更新日期：2007-06-01 00:00:00

abstract：AIM:To determine the performance of plasma calprotectin as a marker of sepsis on intensive care unit (ICU) admission and as a marker of mortality day 30 post-ICU admission. MATERIALS & METHODS:Consecutive ICU patients were allocated to: sepsis (n = 15), postoperative inflammation (n = 23) and intoxication without infl...

journal_title：Biomarkers in medicine

authors： Simm M,Söderberg E,Larsson A,Castegren M,Nilsen T,Eriksson M,Lipcsey M

更新日期：2016-08-01 00:00:00

abstract：:Like all human cancers, colorectal cancer is a complicated disease. While a mature body of research involving colorectal cancer has implicated the putative sequence of genetic alterations that trigger the disease and sustain its progression, there is a surprising paucity of well-validated, clinically useful diagnostic...

journal_title：Biomarkers in medicine

authors： Nibbe RK,Chance MR

更新日期：2009-08-01 00:00:00

abstract：AIM:The aim was to investigate the inflammatory biomarker YKL-40 as a monitor of myocardial ischemia in patients with coronary artery disease (CAD). METHODS:A total of 311 patients with stable CAD were included. Blood samples were taken at baseline, the day after coronary angiography and/or after percutaneous coronary...

journal_title：Biomarkers in medicine

authors： Harutyunyan M,Johansen JS,Mygind ND,Reuter SB,Kastrup J

更新日期：2014-01-01 00:00:00

abstract：AIM:We have evaluated here the clinical and analytical performance of the Alere™ Heart Check (AHC) test, a rapid point-of-care immunoassay designed for the measurement of BNP from fresh capillary whole blood. PATIENTS & METHODS:One-hundred-and-sixty-three patients with stable chronic heart failure followed at the card...

journal_title：Biomarkers in medicine

authors： Monfort A,Da Silva K,Vodovar N,Gayat E,Cohen-Solal A,Manivet P

更新日期：2015-01-01 00:00:00

abstract：:Increasing evidence has highlighted the roles of oxidative stress and inflammation in the promotion of atherosclerotic cardiovascular disease. Recent pathological studies have elucidated specific mediators that appear to link these pathways to the progression and rupture of atherosclerotic plaque in the artery wall. T...

journal_title：Biomarkers in medicine

authors： Uno K,Nicholls SJ

更新日期：2010-06-01 00:00:00

abstract：AIM:The role of octamer-binding transcription factor 4 (Oct4) in gastric cancer (GC) progression is still under debate and reported results are inconsistent. Therefore, we conducted a meta-analysis to evaluate the clinicopathological and prognostic significance of Oct4 expression in patients with GC. MATERIALS & METHO...

journal_title：Biomarkers in medicine

authors： Wei Y,Liu H,Wang C,Zhang W,Wen X,Long H,Xu Z,Guo H,Liu Y,Wei D,Qiu C,Li G,Sun Z

更新日期：2019-02-01 00:00:00

abstract：:Aim: To evaluate an 8.7-kb mitochondrial DNA (mtDNA) deletion as a potential biomarker of endometriosis. Materials & methods: We tested the diagnostic accuracy of the 8.7-kb deletion real-time PCR assay using 182 prospectively collected blood samples from females presenting with symptoms of endometriosis in a case-con...

journal_title：Biomarkers in medicine

authors： Harbottle A,Maggrah A,Usher R,Desa E,Creed JM

更新日期：2020-02-01 00:00:00

abstract：:Autophagy is a catabolic process associated with intracellular self-digestion of damaged organelles or redundant proteins enabling maintenance of cell homeostasis. It is accepted that impaired autophagy is closely linked to cancer development and has been extensively studied in a variety of malignancies including colo...

journal_title：Biomarkers in medicine

authors： Gil J,Pesz KA,Sąsiadek MM

更新日期：2016-10-01 00:00:00

abstract：:Systemic sclerosis is an autoimmune inflammatory disorder of unknown etiologycharacterized b y pronounced fibroproliferative alterations in the microvasculature, and frequent cellular and humoral immunity abnormalities, culminating in a severe and often progressive fibrotic process. Numerous biomarkers reflecting the ...

journal_title：Biomarkers in medicine

authors： Castro SV,Jimenez SA

更新日期：2010-02-01 00:00:00

abstract：AIM:To explore the role of an adipokine-termed fatty acid-binding protein 4 (FABP4) in osteoarthritis (OA). METHODS:Patients with primary knee OA and non-OA controls were included. Paired tissues including plasma, synovial fluid (SF), subcutaneous fat and infrapatellar fat pad (IPFP) were harvested during surgery. FAB...

journal_title：Biomarkers in medicine

authors： Zhang C,Li T,Chiu KY,Wen C,Xu A,Yan CH

更新日期：2018-02-01 00:00:00

abstract：AIM:The aim of this article was to investigate the performance and predictive value of urinary liver-type FABP (uL-FABP) and urinary NGAL (uNGAL) for renal function and prognosis in obstructive nephropathy (ON). PATIENTS & METHODS:A total of 108 ON patients and urine samples were collected. An ELISA was used to determ...

journal_title：Biomarkers in medicine

authors： Xie Y,Xu W,Wang Q,Shao X,Ni Z,Mou S

更新日期：2014-01-01 00:00:00

abstract：:Aim: Noninvasive assessments of C-reactive protein (CRP) in stress contexts have seldom been compared. This study evaluated CRP response to acute social stress as measured in saliva and dried blood spot (DBS). Materials & methods: African-Americans (N = 118; mean age = 32 years) participated in a laboratory-based soci...

journal_title：Biomarkers in medicine

authors： Goetz SM,Lucas T

更新日期：2020-04-01 00:00:00