The application of biomarkers in clinical trials for motor neuron disease.

abstract：:Aim: To develop robust and accurate prognostic biomarkers to help clinicians optimize therapeutic strategies. Materials & methods: Differentially prognosis-related autophagy genes were identified by bioinformatics analysis method. Results: Seven prognosis-related autophagy genes were more significantly related to the ...

journal_title：Biomarkers in medicine

authors： Wang J,Miao Y,Ran J,Yang Y,Guan Q,Mi D

更新日期：2020-09-01 00:00:00

abstract：:In recent years, immune checkpoint inhibitors have rapidly changed treatment paradigms and have been pivotal for the treatment of advanced NSCLC patients. However, many patients don't respond to immunotherapy, and toxicities are a concern. Mounting evidence suggests that PD-L1 expression and tumor mutational burden ar...

journal_title：Biomarkers in medicine

authors： C Guven D,Sahin TK,Dizdar O,Kilickap S

更新日期：2020-10-01 00:00:00

abstract：:Interferons (IFNs) comprise type I, II and III families with multiple subtypes. Via transcription of IFN-stimulated genes (ISGs), IFNs can exert multiple biological effects on the cell. In infectious and chronic inflammatory diseases, the IFNs and their ISG sets can be potentially utilized as biomarkers of disease out...

journal_title：Biomarkers in medicine

authors： Berry CM,Hertzog PJ,Mangan NE

更新日期：2012-04-01 00:00:00

abstract：:Bladder cancer is one of the most prevalent cancers worldwide. Early detection of bladder tumors is critical for improved patient outcomes. The standard method for detection and surveillance of bladder tumors is cystoscopy with urinary cytology. Limitations of cystoscopy and urinary cytology have brought to light the ...

journal_title：Biomarkers in medicine

authors： Rosser CJ,Urquidi V,Goodison S

更新日期：2013-10-01 00:00:00

abstract：:Background: This study aimed to identify glioblastoma prognosis-associated genes with potential diagnosis or prognosis values using integrated bioinformatics analysis. Results: In total, 1831 differentially expressed genes (DEGs) between the glioblastoma and control samples were identified and were clustered into seve...

journal_title：Biomarkers in medicine

authors： Wang D,Liu J,Chen Q,Yang R,Jiang Q

更新日期：2020-11-01 00:00:00

abstract：AIM:Several lines of evidence exist which suggest that changes in the expression of circulating cytokines are linked to the development or reoccurrence of multiple sclerosis (MS). This study aimed to evaluate the serum levels of relevant cytokines after therapy with IFN-β formulations in MS patients. MATERIALS & METHO...

journal_title：Biomarkers in medicine

authors： Arababadi MK,Mosavi R,Khorramdelazad H,Yaghini N,Zarandi ER,Araste M,Pourali R,Nekhei Z,Kennedy D

更新日期：2010-10-01 00:00:00

abstract：AIM:Ankylosing spondylitis (AS) is a chronic systemic inflammatory rheumatic disorder that primarily affects the axial skeleton. To date there is no satisfactory biomarker for diagnosis or prognosis of AS. This study is focused on detection of potential biomarkers for the diagnosis of AS using surface-enhanced laser de...

journal_title：Biomarkers in medicine

authors： Bons JA,van der Heijde D,Bouwman FG,Mariman EC,van Dieijen-Visser MP,Landewé R,van der Linden S,Wodzig WK

更新日期：2008-02-01 00:00:00

abstract：:Alzheimer's disease will reach epidemic proportions within the next 20-30 years if left unchecked. Currently, there are no treatments that prevent or slow Alzheimer's disease but many are being developed. Parallel efforts to develop biomarkers to aid in disease diagnosis and prognosis, and assess disease risk are curr...

journal_title：Biomarkers in medicine

authors： Fagan AM,Holtzman DM

更新日期：2010-02-01 00:00:00

abstract：:Relationships between plasma drug concentrations and clinical outcome have been defined for various chemotherapeutic agents, showing that drug exposure may be a marker of toxicity, mainly hematological and gastrointestinal toxicity, as well as efficacy, expressed as tumor response and survival. Biomarkers provide info...

journal_title：Biomarkers in medicine

authors： Meza-Junco J,Sawyer MB

更新日期：2009-12-01 00:00:00

abstract：:The current cost of developing a successful drug is typically over a billion dollars, with the registration trial(s) determining the success or failure of the entire development program. Often the primary endpoint of these trials is a subjective assessment. For registration trials with subjective endpoints, a regulato...

journal_title：Biomarkers in medicine

authors： Walovitch RC,Chokron P,Agarwal S

更新日期：2012-12-01 00:00:00

abstract：:Increased neurohormonal activation is a key feature of heart failure (HF). Copeptin is a surrogate marker for proarginine vasopressin and the prognostic value of copeptin has been reported for multiple disease states of both nonvascular and cardiovascular etiology. Elevated plasma copeptin in HF has been associated wi...

journal_title：Biomarkers in medicine

authors： Balling L,Gustafsson F

更新日期：2014-01-01 00:00:00

abstract：AIMS:Progressive vasodegeneration in microvascular beds is the major underlying factor in initiation and progression of diabetic complications. Chemerin shows a strong correlation with various facets of the metabolic syndrome, which is associated with dysregulated angiogenesis. VEGF is shown to have an angiogenic role ...

journal_title：Biomarkers in medicine

authors： Zakareia FA

更新日期：2012-02-01 00:00:00

abstract：:Background: The Tp-e/QT (peak to end of T-wave duration/QT interval) ratio is a promising marker of myocardial repolarization and ventricular arrhythmogenesis. Its elevation is associated with sudden cardiac death in different clinical conditions. This study was designed to assess the possible association between incr...

journal_title：Biomarkers in medicine

authors： Fang J,Su H,Song A,Tong Y,Huang Z,Ding F,Liu Y

更新日期：2020-12-01 00:00:00

abstract：:The 44th Congress of the International Society of Oncology and Biomarkers: Rio de Janeiro, Brazil, 7-10 September 2017 The 44th congress followed the previous one of  International Society of Oncology and Biomarkers (ISOBM) that took place in Chicago (USA) in 2016. The title of the 44th Annual congress was: 'Biomarker...

journal_title：Biomarkers in medicine

authors： Kinkorová J

更新日期：2018-02-01 00:00:00

abstract：:In general, a biomarker has multiple uses such as a diagnostic tool and a method to monitor therapy. The quality of a biomarker depends on how big the difference is between, for example, patients and healthy controls, but also on the capacity of the method used to measure it (the uncertainty in the method should be mu...

journal_title：Biomarkers in medicine

authors： Andreasson U,Vanmechelen E,Shaw LM,Zetterberg H,Vanderstichele H

更新日期：2012-08-01 00:00:00

abstract：AIM:Predicting a poor treatment outcome would offer significant benefits for patient care and for new drug development. Materials, methods & results: Urine samples from tuberculosis-positive patients with a successful and unsuccessful treatment outcome were collected at baseline and analyzed. The identified metabolites...

journal_title：Biomarkers in medicine

authors： Luies L,Reenen MV,Ronacher K,Walzl G,Loots DT

更新日期：2017-12-01 00:00:00

abstract：AIM:To investigate the prognostic performance of complement components in septic patients, complement 3, membrane attack complex (MAC) and mannose-binding lectin were measured and compared among adult patients with sepsis, severe sepsis and septic shock, as well as between in-hospital nonsurvivors and survivors. METHO...

journal_title：Biomarkers in medicine

authors： Zhao X,Chen YX,Li CS

更新日期：2015-01-01 00:00:00

abstract：:Fibrosis is characterized by aberrant myofibroblast accumulation and excessive extracellular matrix deposition, which leads to organ failure and significantly contributes to mortality worldwide. Exosomes, which are extracellular nanovesicles with a diameter of 30-100 nm that are secreted into the extracellular space b...

journal_title：Biomarkers in medicine

authors： Qin XJ,Zhang JX,Wang RL

更新日期：2020-06-01 00:00:00

abstract：:Autophagy is a catabolic process associated with intracellular self-digestion of damaged organelles or redundant proteins enabling maintenance of cell homeostasis. It is accepted that impaired autophagy is closely linked to cancer development and has been extensively studied in a variety of malignancies including colo...

journal_title：Biomarkers in medicine

authors： Gil J,Pesz KA,Sąsiadek MM

更新日期：2016-10-01 00:00:00

abstract：AIM:This study aimed to identify plasma protein changes in a rat model of ischemic stroke using a proteomic approach. MATERIALS & METHODS:Four male Sprague-Dawley rats (3-6 months old) were subjected to 90 min of left middle cerebral artery occlusion under anesthesia with 1.5% isoflurane in O(2)/air followed by 24-h r...

journal_title：Biomarkers in medicine

authors： Chen R,Vendrell I,Chen CP,Cash D,O'Toole KG,Williams SA,Jones C,Preston JE,Wheeler JX

更新日期：2011-12-01 00:00:00

abstract：AIM:To investigate the expression of FLNA and its potential prognostic significance in cervical cancer. PATIENTS & METHODS:Real-time PCR was performed to evaluate the expression levels of FLNA in 44 pairs of cervical cancer and matched normal adjacent tissues. Kaplan-Meier analysis and Cox proportional hazards model w...

journal_title：Biomarkers in medicine

authors： Jin YZ,Pei CZ,Wen LY

更新日期：2016-07-01 00:00:00

abstract：:The uncertainty of whether/how to treat asymptomatic patients with isolated severe aortic stenosis and normal left ventricular ejection fraction is one of the most topical in cardiovascular medicine. Recently, the AVATAR trial: first ever randomized trial in the setting of aortic stenosis has been started in an attemp...

journal_title：Biomarkers in medicine

authors： Banovic MD

更新日期：2017-04-01 00:00:00

abstract：:Letter in regards to: Akboga MK, Balci KG, Maden O et al. Usefulness of monocyte to HDL-cholesterol ratio to predict high SYNTAX score in patients with stable coronary artery disease. Biomark. Med. 10(4), 375-383 (2016). ...

journal_title：Biomarkers in medicine

authors： Soylemez S

更新日期：2017-08-01 00:00:00

abstract：:Aim: Noninvasive assessments of C-reactive protein (CRP) in stress contexts have seldom been compared. This study evaluated CRP response to acute social stress as measured in saliva and dried blood spot (DBS). Materials & methods: African-Americans (N = 118; mean age = 32 years) participated in a laboratory-based soci...

journal_title：Biomarkers in medicine

authors： Goetz SM,Lucas T

更新日期：2020-04-01 00:00:00

abstract：AIM:We evaluated the effect of lncRNA SOX2OT expression and its SNP in tumorigenesis and development of breast cancer (BC) in a case-control study. METHODS:A total of 1106 individuals, 505 newly diagnosed BC patients and 601 age-matched controls (±2 years) were testified. Real-time PCR was adopted for testing tissues'...

journal_title：Biomarkers in medicine

authors： Tang X,Gao Y,Yu L,Lu Y,Zhou G,Cheng L,Sun K,Zhu B,Xu M,Liu J

更新日期：2017-03-01 00:00:00

abstract：:Podocyturia may be an expression of glomerular disease and is evaluated using urinary podocyte-specific molecules. This article discusses the technical problems of detection and quantification of podocyturia using immunofluorescent staining of specific proteins, urinary podocyte culture, flow cytometry and urinary pod...

journal_title：Biomarkers in medicine

authors： Camici M

更新日期：2008-12-01 00:00:00

abstract：AIM:This study aimed to assess the urinary concentrations of epidermal growth factor (EGF) and kidney injury molecule 1 (KIM-1) in patients with hydronephrosis. METHODS:Neonates with a history of prenatal hydronephrosis were enrolled in three groups. Group 1 included neonates with severe obstruction; group 2 included ...

journal_title：Biomarkers in medicine

authors： Mohammadjafari H,Rafiei A,Kosaryan M,Yeganeh Y,Hosseinimehr SJ

更新日期：2014-01-01 00:00:00

abstract：AIM:Cardiotrophin-1 null mice presented decreased arterial stiffness. The aim of this study is to investigate the relationship between cardiotrophin-1 and arterial stiffness, assessed by brachial-ankle pulse-wave velocity (baPWV). METHODS:We enrolled 300 subjects, 200 with baPWV >1400 and 100 with baPWV ≤1400 cm/s. R...

journal_title：Biomarkers in medicine

authors： Hung HC,Lu FH,Ou HY,Wu HT,Wu JS,Yang YC,Chang CJ

更新日期：2015-01-01 00:00:00

abstract：:Background: We aimed to assess the predictive value of the absolute and relative intact parathormone (iPTH) decline levels as reliable markers of postoperative hypocalcemia. Materials & methods: iPTH levels were measured 4 h after surgery and the following morning after surgery (postoperative day 1). iPTH, absolute iP...

journal_title：Biomarkers in medicine

authors： Rajan S,Ravindhran B,George B,Bantwal G,Vageesh Ayyar,Mohan LN

更新日期：2020-08-01 00:00:00

abstract：:In this work, we review the main available computational methods of identifying biomarkers of complex diseases from high-throughput data. The emerging omics techniques provide powerful alternatives to measure thousands of molecules in cells in parallel manners. The generated genomic, transcriptomic, proteomic, metabol...

journal_title：Biomarkers in medicine

authors： Liu ZP

更新日期：2016-06-01 00:00:00