Evaluation of inflammatory and cardiac-electrophysiological markers in patients undergoing peritoneal dialysis.

Abstract:

:Background: The Tp-e/QT (peak to end of T-wave duration/QT interval) ratio is a promising marker of myocardial repolarization and ventricular arrhythmogenesis. Its elevation is associated with sudden cardiac death in different clinical conditions. This study was designed to assess the possible association between increased Tp-e/QT ratio and clinical factors in peritoneal dialysis patients. Materials & methods: We devised a prospective cross-sectional study, which included 107 patients who were divided into groups according to their Tp-e/QT ratio. The association of an increased Tp-e/QT ratio with related factors was analyzed with multivariate logistic regression. Results: Thirty-one patients, who had an elevated Tp-e/QT ratio, showed higher values of IL-6, left ventricular end-systolic diameter, Tp-e, percentage of diabetes mellitus, coronary artery calcification, and left ventricular ejection fraction. Multivariate analysis revealed that IL-6 was an independent risk factor for a higher Tp-e/QT ratio after adjustments. Conclusion: Our study revealed that a high serum IL-6 level in peritoneal dialysis patients increased the risk of a higher Tp-e/QT ratio, which indicated a potentially hazardous interplay between inflammation and arrhythmogenesis.

journal_name

Biomark Med

journal_title

Biomarkers in medicine

authors

Fang J,Su H,Song A,Tong Y,Huang Z,Ding F,Liu Y

doi

10.2217/bmm-2020-0230

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

1641-1649

issue

17

eissn

1752-0363

issn

1752-0371

journal_volume

14

pub_type

杂志文章
  • Performance of plasma calprotectin as a biomarker of early sepsis: a pilot study.

    abstract:AIM:To determine the performance of plasma calprotectin as a marker of sepsis on intensive care unit (ICU) admission and as a marker of mortality day 30 post-ICU admission. MATERIALS & METHODS:Consecutive ICU patients were allocated to: sepsis (n = 15), postoperative inflammation (n = 23) and intoxication without infl...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2016-0032

    authors: Simm M,Söderberg E,Larsson A,Castegren M,Nilsen T,Eriksson M,Lipcsey M

    更新日期:2016-08-01 00:00:00

  • Biomarkers to optimize the treatment of nicotine dependence.

    abstract::The application of genomic medicine to the treatment of nicotine dependence holds great promise for revitalizing the steady decline in smoking rates witnessed in the USA over the past several decades. This paper examines the current knowledge base concerning the use of biomarkers to guide the selection of nicotine dep...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.11.91

    authors: Schnoll RA,Leone FT

    更新日期:2011-12-01 00:00:00

  • Clinical applications of biomarkers in preeclampsia.

    abstract::Preeclampsia remains a significant cause of maternal morbidity and mortality worldwide. Prediction, diagnosis and management continue to be challenging but advances in the understanding of the pathophysiological processes underlying the disease has enabled identification of multiple biomarkers, some of which aid predi...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.14.19

    authors: Griffin M,Shennan AH

    更新日期:2014-01-01 00:00:00

  • High-sensitivity troponin T is a prognostic marker of hemodynamic instability in patients undergoing valve surgery.

    abstract:AIM:The usefulness of high-sensitivity troponin T (hs-TnT) as a predictor of perioperative hemodynamic instability is currently unknown. METHODS:A prospective study was conducted on a group of 708 consecutive patients with significant valvular heart disease that underwent elective valve surgery. The primary end point ...

    journal_title:Biomarkers in medicine

    pub_type: 临床试验,杂志文章

    doi:10.2217/bmm-2018-0186

    authors: Duchnowski P,Hryniewiecki T,Koźma M,Mariusz K,Piotr S

    更新日期:2018-12-01 00:00:00

  • Proteomic analysis of rat plasma following transient focal cerebral ischemia.

    abstract:AIM:This study aimed to identify plasma protein changes in a rat model of ischemic stroke using a proteomic approach. MATERIALS & METHODS:Four male Sprague-Dawley rats (3-6 months old) were subjected to 90 min of left middle cerebral artery occlusion under anesthesia with 1.5% isoflurane in O(2)/air followed by 24-h r...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm.11.89

    authors: Chen R,Vendrell I,Chen CP,Cash D,O'Toole KG,Williams SA,Jones C,Preston JE,Wheeler JX

    更新日期:2011-12-01 00:00:00

  • Predicting tuberculosis treatment outcome using metabolomics.

    abstract:AIM:Predicting a poor treatment outcome would offer significant benefits for patient care and for new drug development. Materials, methods & results: Urine samples from tuberculosis-positive patients with a successful and unsuccessful treatment outcome were collected at baseline and analyzed. The identified metabolites...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2017-0133

    authors: Luies L,Reenen MV,Ronacher K,Walzl G,Loots DT

    更新日期:2017-12-01 00:00:00

  • Biomarker use in tailored combat casualty care.

    abstract::Modern war wounds are complex and primarily involve extremities. They require multiple operative interventions to achieve wound closure and begin rehabilitation. Current assessment of the suitability of surgical wound closure is based upon subjective methods coupled with a semiquantitative determination of the wound b...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm.10.13

    authors: Brown TS,Safford S,Caramanica J,Elster EA

    更新日期:2010-06-01 00:00:00

  • Oxidative stress and SYNTAX score in patients with stable coronary artery disease.

    abstract::Letter in regards to: Akboga MK, Balci KG, Maden O et al. Usefulness of monocyte to HDL-cholesterol ratio to predict high SYNTAX score in patients with stable coronary artery disease. Biomark. Med. 10(4), 375-383 (2016). ...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2016-0326

    authors: Soylemez S

    更新日期:2017-08-01 00:00:00

  • Biochemical markers of muscle damage and high serum concentration of creatine kinase in patients on statin therapy.

    abstract::Aim: Some patients experience statin-associated muscle symptoms (SAMS) and elevated serum concentrations of CK. The relationship between SAMS and biomarkers of muscle damage was examined. Methods: We analyzed 359 consecutive patients taking statins with high CK values. Muscle-related symptoms and biochemical variables...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2018-0379

    authors: Nogueira AA,Strunz CM,Takada JY,Mansur AP

    更新日期:2019-06-01 00:00:00

  • Gelsolin-like actin-capping protein is associated with patient prognosis, cellular apoptosis and proliferation in prostate cancer.

    abstract:AIM:To investigate the role of gelsolin-like actin-capping protein (CapG) in prostate cancer (PCa). MATERIALS & METHODS:CapG expression and its correlation with clinicopathological characters and patient prognosis were analyzed in 76 cases of PCa by immunohistochemistry and qRT-PCR. Then, the influence of CapG downreg...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2016-0186

    authors: Li T,Hong X,Zhao J,Teng Y,Zheng J,Chen H,Chen H,Li H

    更新日期:2016-12-01 00:00:00

  • Circulating malondialdehyde concentrations in patients with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis.

    abstract::The aim of this meta-analysis was to review the available evidence regarding the blood concentrations of the oxidative stress marker malondialdehyde (MDA) in chronic obstructive pulmonary disease (COPD) patients in comparison to healthy individuals. 14 studies were included in the meta-analysis (from inception to Octo...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,meta分析

    doi:10.2217/bmm-2017-0420

    authors: Paliogiannis P,Fois AG,Sotgia S,Mangoni AA,Zinellu E,Pirina P,Carru C,Zinellu A

    更新日期:2018-07-01 00:00:00

  • The prognostic performance of the complement system in septic patients in emergency department: a cohort study.

    abstract:AIM:To investigate the prognostic performance of complement components in septic patients, complement 3, membrane attack complex (MAC) and mannose-binding lectin were measured and compared among adult patients with sepsis, severe sepsis and septic shock, as well as between in-hospital nonsurvivors and survivors. METHO...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm.15.32

    authors: Zhao X,Chen YX,Li CS

    更新日期:2015-01-01 00:00:00

  • Tumor vascularity in prostate cancer: an update on circulating endothelial cells and platelets as noninvasive biomarkers.

    abstract::In order to individually tailor prostate cancer (PCa) treatment, clinicians need better tools to predict prognosis and treatment response. Given the relationship between angiogenesis and cancer progression, circulating endothelial cells (CECs) and their progenitors have logically been proposed as potential biomarkers....

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.13.100

    authors: Reeves F,Sapre N,Corcoran N,Hovens C

    更新日期:2013-12-01 00:00:00

  • Biomarkers in systemic sclerosis.

    abstract::Systemic sclerosis is an autoimmune inflammatory disorder of unknown etiologycharacterized b y pronounced fibroproliferative alterations in the microvasculature, and frequent cellular and humoral immunity abnormalities, culminating in a severe and often progressive fibrotic process. Numerous biomarkers reflecting the ...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.09.79

    authors: Castro SV,Jimenez SA

    更新日期:2010-02-01 00:00:00

  • Association of IGF-1 with coronary collateral circulation in stable coronary artery disease.

    abstract:AIM:The aim of the present study is to evaluate the relationship between coronary collateral circulation (CCC) grade and serum IGF-1 levels in patients diagnosed with stable coronary artery disease. METHODS:Totally, 190 consecutive patients with stable coronary artery disease who underwent coronary angiography were in...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2016-0354

    authors: Kundi H,Gok M,Kiziltunc E,Cetin M,Ornek E

    更新日期:2017-07-01 00:00:00

  • Human serum proteome analysis: new source of markers in metabolic disorders.

    abstract::The prevalence of metabolic disorders (MDs), especially diabetes, is rapidly increasing worldwide, leading to an increasing risk of cardiovascular and other socially relevant complications. To boost MD biomarker discovery, advanced proteomics can harmonize metabolomics. Indeed, the rapid development of mass spectromet...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.12.92

    authors: Di Girolamo F,Del Chierico F,Caenaro G,Lante I,Muraca M,Putignani L

    更新日期:2012-12-01 00:00:00

  • miRNA panels as biomarkers for bladder cancer.

    abstract:AIM:Specific miRNA profiles have been identified for several samples from patients with bladder cancer. The results are not always congruent and partly contradictory. A comparison of published data was performed to select potential markers. MATERIALS & METHODS:A literature search in PubMed identified 79 articles publi...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.14.26

    authors: Tölle A,Ratert N,Jung K

    更新日期:2014-01-01 00:00:00

  • Biomarkers of inflammation and oxidative stress in atherosclerosis.

    abstract::Increasing evidence has highlighted the roles of oxidative stress and inflammation in the promotion of atherosclerotic cardiovascular disease. Recent pathological studies have elucidated specific mediators that appear to link these pathways to the progression and rupture of atherosclerotic plaque in the artery wall. T...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.10.57

    authors: Uno K,Nicholls SJ

    更新日期:2010-06-01 00:00:00

  • Classical and new assays for detecting drug resistance in tuberculosis.

    abstract::Tuberculosis is a public health concern worldwide. Particularly worrying is the emergence of severe forms of drug resistance, such as extensively drug resistant and totally drug resistant tuberculosis, with few treatment options for the afflicted patients. To avoid further spread of drug resistance, its early detectio...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.14.73

    authors: Palomino JC,Vandamme P,Martin A

    更新日期:2014-01-01 00:00:00

  • Novel biomarkers for cardiovascular risk.

    abstract::Cardiovascular disease refers to different diseases involving the heart and/or the arteries and/or the veins. Cardiovascular disease, overall considered, is a notable source of morbidity and mortality worldwide. Therefore, several research studies are dedicated to explore, by means of biomarkers, the possiblity to cal...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm-2018-0056

    authors: Serra R,Ielapi N,Barbetta A,Andreucci M,de Franciscis S

    更新日期:2018-09-01 00:00:00

  • Urinary biomarkers of bladder cancer: an update and future perspectives.

    abstract::Bladder cancer is one of the most prevalent cancers worldwide. Early detection of bladder tumors is critical for improved patient outcomes. The standard method for detection and surveillance of bladder tumors is cystoscopy with urinary cytology. Limitations of cystoscopy and urinary cytology have brought to light the ...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.13.73

    authors: Rosser CJ,Urquidi V,Goodison S

    更新日期:2013-10-01 00:00:00

  • Usefulness of monocyte to HDL-cholesterol ratio to predict high SYNTAX score in patients with stable coronary artery disease.

    abstract:AIM:We aimed to investigate whether baseline monocyte to high-density lipoprotein cholesterol ratio (MHR), an easily available inflammatory and oxidative stress marker, is associated with SYNTAX score. PATIENTS & METHODS:In this cross-sectional study, n = 1229 consecutive patients with coronary artery disease were cla...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2015-0050

    authors: Akboga MK,Balci KG,Maden O,Ertem AG,Kirbas O,Yayla C,Acar B,Aras D,Kisacik H,Aydogdu S

    更新日期:2016-01-01 00:00:00

  • Charcot-Leyden crystal protein/galectin-10 is a surrogate biomarker of eosinophilic airway inflammation in asthma.

    abstract::Aim: Eosinophilic asthma is associated with more exacerbations and differential responses to treatment. The aim of this study was to assess if CLC/Gal-10 and MBP-1 are surrogate biomarkers of eosinophilic inflammation in asthma. Methods & results: Sputum induction was performed in patients with asthma and in healthy c...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2018-0280

    authors: Nyenhuis SM,Alumkal P,Du J,Maybruck BT,Vinicky M,Ackerman SJ

    更新日期:2019-06-01 00:00:00

  • PON2 and PPARG polymorphisms as biomarkers of risk for coronary heart disease.

    abstract:AIM:Investigate the correlation between paraoxonase 2 (PON2) Ser311Cys polymorphism as well as the peroxisome proliferator-activated receptor gamma (PPARG) His477His polymorphism and the susceptibility to development of coronary heart diseases (CHD) through a meta-analysis. METHODS:Odds ratio and the corresponding 95%...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm-2017-0227

    authors: González-Castro TB,Tovilla-Zárate CA,Juárez-Rojop IE,Hernández-Díaz Y,López-Narváez ML,Rodríguez-Pérez C,González-Hernández YK,Ramos-Méndez MÁ

    更新日期:2018-03-01 00:00:00

  • Determination of the severity of ureteropelvic junction obstruction using urinary epidermal growth factor and kidney injury molecule 1 levels.

    abstract:AIM:This study aimed to assess the urinary concentrations of epidermal growth factor (EGF) and kidney injury molecule 1 (KIM-1) in patients with hydronephrosis. METHODS:Neonates with a history of prenatal hydronephrosis were enrolled in three groups. Group 1 included neonates with severe obstruction; group 2 included ...

    journal_title:Biomarkers in medicine

    pub_type: 临床试验,杂志文章

    doi:10.2217/bmm.14.79

    authors: Mohammadjafari H,Rafiei A,Kosaryan M,Yeganeh Y,Hosseinimehr SJ

    更新日期:2014-01-01 00:00:00

  • Genetic biomarkers in aortopathy.

    abstract::The field of aortopathy, in common with other genomic disorders, is undergoing a revolution. This is largely driven by the implementation of newer forms of genetic sequencing (massively parallel or next-generation sequencing). Advantages conferred by this technology include reduced costs, reduced sequencing time and t...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.13.74

    authors: Rea G,Stewart FJ

    更新日期:2013-08-01 00:00:00

  • May autophagy be a novel biomarker and antitumor target in colorectal cancer?

    abstract::Autophagy is a catabolic process associated with intracellular self-digestion of damaged organelles or redundant proteins enabling maintenance of cell homeostasis. It is accepted that impaired autophagy is closely linked to cancer development and has been extensively studied in a variety of malignancies including colo...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm-2016-0083

    authors: Gil J,Pesz KA,Sąsiadek MM

    更新日期:2016-10-01 00:00:00

  • Correlation of peripheral arterial blood flow with plasma chemerin and VEGF in diabetic peripheral vascular disease.

    abstract:AIMS:Progressive vasodegeneration in microvascular beds is the major underlying factor in initiation and progression of diabetic complications. Chemerin shows a strong correlation with various facets of the metabolic syndrome, which is associated with dysregulated angiogenesis. VEGF is shown to have an angiogenic role ...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm.11.85

    authors: Zakareia FA

    更新日期:2012-02-01 00:00:00

  • Repeated assessment of physical biomeasures or blood biomarkers for the definition of volume status and cardiac loading in LVSD.

    abstract::The application of biomarker technology can be usefully implemented in areas where current techniques are inadequate and where a clinical issue, which affects outcome, can be defined. The definition of the loading status of the heart where there is pre-existent impairment of contractile function is a key target. Heart...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/17520363.1.3.355

    authors: Chuen MJ,Lip GY,MacFadyen RJ

    更新日期:2007-10-01 00:00:00

  • Decoding the LncRNA transcriptome of esophageal cancer: identification of clinically relevant LncRNAs.

    abstract:AIM:LncRNAs may act as promising biomarkers in esophageal cancer (EC). Here, we illustrate the LncRNA profile and their clinical relevance in EC. PATIENTS & METHODS:In this study, we utilized the Cancer Genome Atlas RNA-sequencing and clinical data from 186 patients and 13 normal samples. Various statistical and gene ...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2018-0032

    authors: Khadirnaikar S,Narayanan SP,Shukla SK

    更新日期:2018-10-01 00:00:00