B-type natriuretic peptides in heart failure: update on clinical applications and limitations.

Abstract:

:Heart failure remains an important clinical and public health problem with significant mortality, morbidity and economic consequences. The identification of natriuretic peptides and the large number of investigations that followed have led to a better understanding of the neurohormonal pathophysiology of heart failure. The clinical usefulness of natriuretic peptides in heart failure diagnosis, prognosis and treatment guidance remains to be fully clarified but B-type natriuretic peptides and N-terminal pro-BNP appear to have an emerging role. Like any clinical test, the usefulness of natriuretic peptides measurements depends upon appropriate use and recognition of limitations. This review focuses on these issues.

journal_name

Biomark Med

journal_title

Biomarkers in medicine

authors

Miller WL,Targonski PV,Jaffe AS

doi

10.2217/17520363.1.4.503

subject

Has Abstract

pub_date

2007-12-01 00:00:00

pages

503-12

issue

4

eissn

1752-0363

issn

1752-0371

journal_volume

1

pub_type

杂志文章
  • The application of biomarkers in clinical trials for motor neuron disease.

    abstract::The interest and research into disease-related biomarkers has greatly accelerated over the last 10 years. The potential clinical benefits for disease-specific biomarkers include a more rapid and accurate disease diagnosis, and potential reduction in size and duration of clinical drug trials, which would speed up drug ...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.09.71

    authors: Ganesalingam J,Bowser R

    更新日期:2010-04-01 00:00:00

  • The 44th Congress of the International Society of Oncology and Biomarkers: Rio de Janeiro, Brazil, 7-10 September 2017.

    abstract::The 44th Congress of the International Society of Oncology and Biomarkers: Rio de Janeiro, Brazil, 7-10 September 2017 The 44th congress followed the previous one of  International Society of Oncology and Biomarkers (ISOBM) that took place in Chicago (USA) in 2016. The title of the 44th Annual congress was: 'Biomarker...

    journal_title:Biomarkers in medicine

    pub_type:

    doi:10.2217/bmm-2017-0402

    authors: Kinkorová J

    更新日期:2018-02-01 00:00:00

  • In search of epilepsy biomarkers in the immature brain: goals, challenges and strategies.

    abstract::Epilepsy and seizures are very common in the early years of life and are often associated with significant morbidity and mortality. Identification of biomarkers for the early detection of epileptogenicity, epileptogenesis, comorbidities, disease progression and treatment implementation will be very important in implem...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm.11.71

    authors: Galanopoulou AS,Moshé SL

    更新日期:2011-10-01 00:00:00

  • Gamma-glutamyltransferase activity as a surrogate biomarker of metabolic health status in young nondiabetic obese women.

    abstract:AIM:We investigated the association of gamma-glutamyltransferase (GGT) activity with atherogenic risk factors and metabolic health status in young nondiabetic obese women. METHODS & RESULTS:In 140 obese women GGT activity was independently associated with BMI, triglyceride to high-density cholesterol ratio and homeost...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2016-0332

    authors: Mankowska-Cyl A,Krintus M,Rajewski P,Sypniewska G

    更新日期:2017-05-01 00:00:00

  • Problems associated with fluid biomarkers for Parkinson's disease.

    abstract::This article focuses on biochemical markers that may be used in the diagnostics of Parkinson's disease and associated disorders, and to identify early cases and stratify patients into subgroups. We present an updated account of some currently available candidate fluid biomarkers, and discuss their diagnostic performan...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.10.84

    authors: Nyhlén J,Constantinescu R,Zetterberg H

    更新日期:2010-10-01 00:00:00

  • Construction prognosis model based on autophagy-related gene signatures in hepatocellular carcinoma.

    abstract::Aim: To develop robust and accurate prognostic biomarkers to help clinicians optimize therapeutic strategies. Materials & methods: Differentially prognosis-related autophagy genes were identified by bioinformatics analysis method. Results: Seven prognosis-related autophagy genes were more significantly related to the ...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2020-0170

    authors: Wang J,Miao Y,Ran J,Yang Y,Guan Q,Mi D

    更新日期:2020-09-01 00:00:00

  • Cardiotrophin-1 is associated with increased risk of arterial stiffness.

    abstract:AIM:Cardiotrophin-1 null mice presented decreased arterial stiffness. The aim of this study is to investigate the relationship between cardiotrophin-1 and arterial stiffness, assessed by brachial-ankle pulse-wave velocity (baPWV). METHODS:We enrolled 300 subjects, 200 with baPWV >1400 and 100 with baPWV ≤1400 cm/s. R...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm.14.87

    authors: Hung HC,Lu FH,Ou HY,Wu HT,Wu JS,Yang YC,Chang CJ

    更新日期:2015-01-01 00:00:00

  • Copeptin as a biomarker in heart failure.

    abstract::Increased neurohormonal activation is a key feature of heart failure (HF). Copeptin is a surrogate marker for proarginine vasopressin and the prognostic value of copeptin has been reported for multiple disease states of both nonvascular and cardiovascular etiology. Elevated plasma copeptin in HF has been associated wi...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.14.50

    authors: Balling L,Gustafsson F

    更新日期:2014-01-01 00:00:00

  • How biomarkers can improve pneumonia diagnosis and prognosis: procalcitonin and mid-regional-pro-adrenomedullin.

    abstract::Aim: The diagnostic and prognostic role of procalcitonin (PCT) and mid-regional-pro-adrenomedullin (MR-proADM) were investigated in patients with pneumonia. Material & methods: A total of 168 and 77 patients with pneumonia enrolled in two different hospital settings, an internal medicine unit and an emergency unit wer...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2019-0414

    authors: Spoto S,Legramante JM,Minieri M,Fogolari M,Terrinoni A,Valeriani E,Sebastiano C,Bernardini S,Ciccozzi M,Angeletti PS

    更新日期:2020-05-01 00:00:00

  • Aptamers generated by Cell SELEX for biomarker discovery.

    abstract::Biomarker discovery is essential to the advancement of our knowledge about diseases and to the development of new strategies for treatment and therapy. Among the newest technologies in this rapidly growing field is a process termed Cell SELEX by which a panel of aptamers can be generated to specifically target disease...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm.09.5

    authors: Kim Y,Liu C,Tan W

    更新日期:2009-04-01 00:00:00

  • Galectin-3 and acute heart failure: genetic polymorphisms, plasma level, myocardial fibrosis and 1-year outcomes.

    abstract::Aim: This study sought to investigate the relationship between galectin-3 (Gal-3), myocardial fibrosis (MF) and outcomes in acute heart failure. Materials & methods: The single-nucleotide polymorphisms (SNPs) of LGALS3 at rs4644 and rs4652, plasma Gal-3 level, MF and major adverse events (MAEs) were obtained. Results:...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2020-0269

    authors: Fu H,Nie S,Luo P,Ruan Y,Zhang Z,Miao H,Li X,Wen S,Bai R

    更新日期:2020-07-01 00:00:00

  • Index of cardiac electrophysiological balance and transmural dispersion of the repolarization index relationships with pericardial fat volume and coronary calcification.

    abstract:AIM:To assess the possible relationship between coronary atherosclerosis markers, pericardial fat volume (PFV) and coronary artery calcification, with ECG markers of index of the cardiac electrophysiological balance (iCEB) and transmural dispersion of the repolarization in patients with suspected coronary artery diseas...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2017-0187

    authors: Nafakhi H,Al-Mosawi AA,Alareedh M,Al-Nafakh HA

    更新日期:2018-04-01 00:00:00

  • C-type natriuretic-derived peptides as biomarkers in human disease.

    abstract::The natriuretic peptide system comprises three structurally related peptides: atrial natriuretic peptide, B-type natriuretic peptide and C-type natriuretic peptide. In circulation, they play an important endocrine role in the regulation of cardiovascular homeostasis by maintaining blood pressure and extracellular flui...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm.10.67

    authors: Lippert S,Goetze JP

    更新日期:2010-08-01 00:00:00

  • Clinical significance of detecting HLA-DR, 14-3-3η protein and d-dimer in the diagnosis of rheumatoid arthritis.

    abstract:AIM:To investigate the clinical significance of detecting several biomarkers collectively in the diagnosis of rheumatoid arthritis (RA). METHODS:128 RA patients, 174 non-RA patients and 80 healthy controls were enrolled. HLA-DR4 and HLA-DR53 were detected by the PCR-SSP method, 14-3-3η protein, anti-CCP and anti-Sa we...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2017-0371

    authors: Tan L,Wang Q,Zeng T,Long T,Guan X,Wu S,Zheng W,Fu H,Meng Y,Wu Y,Tian Y,Yu J,Chen J,Li H,Cao L

    更新日期:2018-07-01 00:00:00

  • MMP-9 (-1562 C:T) polymorphism as a biomarker of susceptibility to severe pre-eclampsia.

    abstract:AIM:To investigate the role of MMP-9 (-1562 C:T) polymorphism as a biomarker for susceptibility to pre-eclampsia. PATIENTS & METHODS:MMP-9 variants were detected in 160 women with mild and severe pre-eclampsia and 112 healthy pregnant women. RESULTS:A significantly higher frequency of MMP-9 CT genotype was observed i...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm.12.95

    authors: Rahimi Z,Rahimi Z,Shahsavandi MO,Bidoki K,Rezaei M

    更新日期:2013-02-01 00:00:00

  • Interferons as biomarkers and effectors: lessons learned from animal models.

    abstract::Interferons (IFNs) comprise type I, II and III families with multiple subtypes. Via transcription of IFN-stimulated genes (ISGs), IFNs can exert multiple biological effects on the cell. In infectious and chronic inflammatory diseases, the IFNs and their ISG sets can be potentially utilized as biomarkers of disease out...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.12.10

    authors: Berry CM,Hertzog PJ,Mangan NE

    更新日期:2012-04-01 00:00:00

  • Early advances of alpha1-antitrypsin precursor using the proteomic approach in gastric juice.

    abstract::Evaluation of: Hsu PI, Chen CH, Hsieh CS et al.: alpha1-antitrypsin precursor in gastric juice is a novel biomarker for gastric cancer and ulcer. Clin. Cancer Res. 13(3), 876-883 (2007) [1] . The authors have identified the alpha1-antitrypsin precursor as a new protein marker of gastric cancer in gastric juice by 2D e...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/17520363.1.1.209

    authors: Monari M,Foschi J,Serrazanetti GP

    更新日期:2007-06-01 00:00:00

  • miRNA panels as biomarkers for bladder cancer.

    abstract:AIM:Specific miRNA profiles have been identified for several samples from patients with bladder cancer. The results are not always congruent and partly contradictory. A comparison of published data was performed to select potential markers. MATERIALS & METHODS:A literature search in PubMed identified 79 articles publi...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.14.26

    authors: Tölle A,Ratert N,Jung K

    更新日期:2014-01-01 00:00:00

  • Clinical applications of biomarkers in preeclampsia.

    abstract::Preeclampsia remains a significant cause of maternal morbidity and mortality worldwide. Prediction, diagnosis and management continue to be challenging but advances in the understanding of the pathophysiological processes underlying the disease has enabled identification of multiple biomarkers, some of which aid predi...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.14.19

    authors: Griffin M,Shennan AH

    更新日期:2014-01-01 00:00:00

  • Altered signature of apoptotic endothelial cell-derived microvesicles predicts chronic heart failure phenotypes.

    abstract::Aim: to evaluate the associations between signatures of apoptotic endothelial cell-derived microvesicles (MVs) with phenotypes of chronic heart failure (HF). Methods: The study cohort consisted of 388 prospectively involved subjects with HF patients with predominantly reduced left ventricular ejection fraction (HFrEF)...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2018-0449

    authors: Berezin AE,Kremzer AA,Samura TA,Berezina TA

    更新日期:2019-06-01 00:00:00

  • Soluble markers for diagnosis of malignant pleural mesothelioma.

    abstract::Malignant pleural mesothelioma (MPM) is a highly aggressive and invasive tumor, whose incidence is expected to peak, in many countries, at the end of the present decade, 20-40 years after the peak of asbestos use (asbestos being the most important etiological factor). MPM has a poor prognosis, in part, owing to a diff...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.11.18

    authors: Cristaudo A,Bonotti A,Simonini S,Bruno R,Foddis R

    更新日期:2011-04-01 00:00:00

  • Correlations between lncRNA-SOX2OT polymorphism and susceptibility to breast cancer in a Chinese population.

    abstract:AIM:We evaluated the effect of lncRNA SOX2OT expression and its SNP in tumorigenesis and development of breast cancer (BC) in a case-control study. METHODS:A total of 1106 individuals, 505 newly diagnosed BC patients and 601 age-matched controls (±2 years) were testified. Real-time PCR was adopted for testing tissues'...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2016-0238

    authors: Tang X,Gao Y,Yu L,Lu Y,Zhou G,Cheng L,Sun K,Zhu B,Xu M,Liu J

    更新日期:2017-03-01 00:00:00

  • Usefulness of monocyte to HDL-cholesterol ratio to predict high SYNTAX score in patients with stable coronary artery disease.

    abstract:AIM:We aimed to investigate whether baseline monocyte to high-density lipoprotein cholesterol ratio (MHR), an easily available inflammatory and oxidative stress marker, is associated with SYNTAX score. PATIENTS & METHODS:In this cross-sectional study, n = 1229 consecutive patients with coronary artery disease were cla...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2015-0050

    authors: Akboga MK,Balci KG,Maden O,Ertem AG,Kirbas O,Yayla C,Acar B,Aras D,Kisacik H,Aydogdu S

    更新日期:2016-01-01 00:00:00

  • Emerging biomarkers for PD-1 pathway cancer therapy.

    abstract::The field of immuno-oncology has witnessed unprecedented success in recent years, with several PD=1 and PD-L1 inhibitors obtaining US FDA registration and breakthrough drug therapy designation in multiple tumor types. Despite its clear efficacy in certain cancers, treatment with these agents carries a risk of immune-r...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm-2016-0228

    authors: Lim JS,Sundar R,Chénard-Poirier M,Lopez J,Yap TA

    更新日期:2017-01-01 00:00:00

  • Association of IGF-1 with coronary collateral circulation in stable coronary artery disease.

    abstract:AIM:The aim of the present study is to evaluate the relationship between coronary collateral circulation (CCC) grade and serum IGF-1 levels in patients diagnosed with stable coronary artery disease. METHODS:Totally, 190 consecutive patients with stable coronary artery disease who underwent coronary angiography were in...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2016-0354

    authors: Kundi H,Gok M,Kiziltunc E,Cetin M,Ornek E

    更新日期:2017-07-01 00:00:00

  • Urinary excretion of liver-type FABP as a new clinical marker for the progression of obstructive nephropathy.

    abstract:AIM:The aim of this article was to investigate the performance and predictive value of urinary liver-type FABP (uL-FABP) and urinary NGAL (uNGAL) for renal function and prognosis in obstructive nephropathy (ON). PATIENTS & METHODS:A total of 108 ON patients and urine samples were collected. An ELISA was used to determ...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm.13.136

    authors: Xie Y,Xu W,Wang Q,Shao X,Ni Z,Mou S

    更新日期:2014-01-01 00:00:00

  • Early detection of acute coronary syndromes and risk stratification by multimarker analysis.

    abstract::Cardiac troponin is the standard biomarker for the diagnosis of acute myocardial infarction (AMI) and risk stratification for short-term adverse cardiac events (death, AMI or need for revascularization). Unfortunately, the concentration of troponin in blood is normal in AMI patients who present early after the onset o...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/17520363.1.1.45

    authors: Wu AH

    更新日期:2007-06-01 00:00:00

  • Emergence of biomarkers in nephropharmacology.

    abstract::Blood-urea nitrogen, serum creatinine and urine output have long been used as markers of kidney function despite their known limitations. In the past few years, a number of novel biomarkers have been identified in the urine and blood that can detect kidney injury early. Although, to date, none of these biomarkers are ...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.10.115

    authors: Khan E,Batuman V,Lertora JJ

    更新日期:2010-12-01 00:00:00

  • Drug exposure: still an excellent biomarker.

    abstract::Relationships between plasma drug concentrations and clinical outcome have been defined for various chemotherapeutic agents, showing that drug exposure may be a marker of toxicity, mainly hematological and gastrointestinal toxicity, as well as efficacy, expressed as tumor response and survival. Biomarkers provide info...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm.09.58

    authors: Meza-Junco J,Sawyer MB

    更新日期:2009-12-01 00:00:00

  • Circulating malondialdehyde concentrations in patients with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis.

    abstract::The aim of this meta-analysis was to review the available evidence regarding the blood concentrations of the oxidative stress marker malondialdehyde (MDA) in chronic obstructive pulmonary disease (COPD) patients in comparison to healthy individuals. 14 studies were included in the meta-analysis (from inception to Octo...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,meta分析

    doi:10.2217/bmm-2017-0420

    authors: Paliogiannis P,Fois AG,Sotgia S,Mangoni AA,Zinellu E,Pirina P,Carru C,Zinellu A

    更新日期:2018-07-01 00:00:00