Index of cardiac electrophysiological balance and transmural dispersion of the repolarization index relationships with pericardial fat volume and coronary calcification.

Abstract:

AIM:To assess the possible relationship between coronary atherosclerosis markers, pericardial fat volume (PFV) and coronary artery calcification, with ECG markers of index of the cardiac electrophysiological balance (iCEB) and transmural dispersion of the repolarization in patients with suspected coronary artery disease. METHODOLOGY:One hundred patients who underwent 64-slice multidetector computed tomography angiography were found to be eligible and were enrolled in the study. RESULTS:Patients with high iCEB levels tended to have a higher PFV values compared with patients with low iCEB levels (median [interquartile range]) (152 [29-206] vs 96 [14-177]; p = 0.03). No significant differences in coronary artery calcification values were observed between iCEB and transmural dispersion of the repolarization groups. CONCLUSION:A higher PFV value was observed in patients with high iCEB. Larger prospective studies are required to confirm the results.

journal_name

Biomark Med

journal_title

Biomarkers in medicine

authors

Nafakhi H,Al-Mosawi AA,Alareedh M,Al-Nafakh HA

doi

10.2217/bmm-2017-0187

subject

Has Abstract

pub_date

2018-04-01 00:00:00

pages

321-328

issue

4

eissn

1752-0363

issn

1752-0371

journal_volume

12

pub_type

杂志文章
  • Prognostic utility of the combination of pretreatment monocyte-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in patients with NMIBC after transurethral resection.

    abstract::Aim: To investigate and validate predictive value of combination of pretreatment monocyte-to-lymphocyte ratio (MLR) and neutrophil-to-lymphocyte ratio (NLR) for disease free survival (DFS) and overall survival (OS) in nonmuscle invasive bladder cancer after transurethral resection. Materials & methods: Total 358 patie...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2019-0398

    authors: Wang Q,Huang T,Ji J,Wang H,Guo C,Sun X,Zheng K,Dong Z,Cao Y

    更新日期:2019-12-01 00:00:00

  • Classical and new assays for detecting drug resistance in tuberculosis.

    abstract::Tuberculosis is a public health concern worldwide. Particularly worrying is the emergence of severe forms of drug resistance, such as extensively drug resistant and totally drug resistant tuberculosis, with few treatment options for the afflicted patients. To avoid further spread of drug resistance, its early detectio...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.14.73

    authors: Palomino JC,Vandamme P,Martin A

    更新日期:2014-01-01 00:00:00

  • Endostatin: a promising biomarker in the cardiovascular continuum?

    abstract::The current review article aims to provide an up-to-date summary of previous studies in humans that have reported the association between circulating endostatin levels and different cardiovascular phenotypes. We also aim to provide suggestions for future directions of future research evaluating endostatin as a clinica...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm-2017-0025

    authors: Ruge T,Carlsson AC,Larsson A,Ärnlöv J

    更新日期:2017-10-01 00:00:00

  • Novel biomarkers for cardiovascular risk.

    abstract::Cardiovascular disease refers to different diseases involving the heart and/or the arteries and/or the veins. Cardiovascular disease, overall considered, is a notable source of morbidity and mortality worldwide. Therefore, several research studies are dedicated to explore, by means of biomarkers, the possiblity to cal...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm-2018-0056

    authors: Serra R,Ielapi N,Barbetta A,Andreucci M,de Franciscis S

    更新日期:2018-09-01 00:00:00

  • Early detection of acute coronary syndromes and risk stratification by multimarker analysis.

    abstract::Cardiac troponin is the standard biomarker for the diagnosis of acute myocardial infarction (AMI) and risk stratification for short-term adverse cardiac events (death, AMI or need for revascularization). Unfortunately, the concentration of troponin in blood is normal in AMI patients who present early after the onset o...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/17520363.1.1.45

    authors: Wu AH

    更新日期:2007-06-01 00:00:00

  • Early advances of alpha1-antitrypsin precursor using the proteomic approach in gastric juice.

    abstract::Evaluation of: Hsu PI, Chen CH, Hsieh CS et al.: alpha1-antitrypsin precursor in gastric juice is a novel biomarker for gastric cancer and ulcer. Clin. Cancer Res. 13(3), 876-883 (2007) [1] . The authors have identified the alpha1-antitrypsin precursor as a new protein marker of gastric cancer in gastric juice by 2D e...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/17520363.1.1.209

    authors: Monari M,Foschi J,Serrazanetti GP

    更新日期:2007-06-01 00:00:00

  • Emerging biomarkers in breast cancer care.

    abstract::Currently, decision-making for breast cancer treatment in the clinical setting is mainly based on clinical data, histomorphological features of the tumor tissue and a few cancer biomarkers such as steroid hormone receptor status (estrogen and progesterone receptors) and oncoprotein HER2 status. Although various therap...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.10.73

    authors: Napieralski R,Brünner N,Mengele K,Schmitt M

    更新日期:2010-08-01 00:00:00

  • Emergence of biomarkers in nephropharmacology.

    abstract::Blood-urea nitrogen, serum creatinine and urine output have long been used as markers of kidney function despite their known limitations. In the past few years, a number of novel biomarkers have been identified in the urine and blood that can detect kidney injury early. Although, to date, none of these biomarkers are ...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.10.115

    authors: Khan E,Batuman V,Lertora JJ

    更新日期:2010-12-01 00:00:00

  • Biomarkers to optimize the treatment of nicotine dependence.

    abstract::The application of genomic medicine to the treatment of nicotine dependence holds great promise for revitalizing the steady decline in smoking rates witnessed in the USA over the past several decades. This paper examines the current knowledge base concerning the use of biomarkers to guide the selection of nicotine dep...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.11.91

    authors: Schnoll RA,Leone FT

    更新日期:2011-12-01 00:00:00

  • A biomarker of oxidative stress as a nontraditional risk factor in obese subjects.

    abstract:BACKGROUND:Oxidative stress has been postulated as an additive factor linking obesity to cardiovascular disease. MATERIALS & METHODS:Derivatives of reactive oxygen species metabolites (d-ROMs) were measured in 136 obese (42 males, 94 females; mean age: 47 ± 12 years; BMI: 36 ± 5 kg/m(2)) and in 306 over- and normal-we...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm.13.49

    authors: Vassalle C,Vigna L,Bianchi S,Maffei S,Novembrino C,De Giuseppe R,de Liso F,Vannucci A,Tirelli S,Maiavacca R,Bamonti F

    更新日期:2013-08-01 00:00:00

  • Urinary biomarkers of bladder cancer: an update and future perspectives.

    abstract::Bladder cancer is one of the most prevalent cancers worldwide. Early detection of bladder tumors is critical for improved patient outcomes. The standard method for detection and surveillance of bladder tumors is cystoscopy with urinary cytology. Limitations of cystoscopy and urinary cytology have brought to light the ...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.13.73

    authors: Rosser CJ,Urquidi V,Goodison S

    更新日期:2013-10-01 00:00:00

  • Proteomic analysis of rat plasma following transient focal cerebral ischemia.

    abstract:AIM:This study aimed to identify plasma protein changes in a rat model of ischemic stroke using a proteomic approach. MATERIALS & METHODS:Four male Sprague-Dawley rats (3-6 months old) were subjected to 90 min of left middle cerebral artery occlusion under anesthesia with 1.5% isoflurane in O(2)/air followed by 24-h r...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm.11.89

    authors: Chen R,Vendrell I,Chen CP,Cash D,O'Toole KG,Williams SA,Jones C,Preston JE,Wheeler JX

    更新日期:2011-12-01 00:00:00

  • Aptamers generated by Cell SELEX for biomarker discovery.

    abstract::Biomarker discovery is essential to the advancement of our knowledge about diseases and to the development of new strategies for treatment and therapy. Among the newest technologies in this rapidly growing field is a process termed Cell SELEX by which a panel of aptamers can be generated to specifically target disease...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm.09.5

    authors: Kim Y,Liu C,Tan W

    更新日期:2009-04-01 00:00:00

  • Circulating malondialdehyde concentrations in patients with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis.

    abstract::The aim of this meta-analysis was to review the available evidence regarding the blood concentrations of the oxidative stress marker malondialdehyde (MDA) in chronic obstructive pulmonary disease (COPD) patients in comparison to healthy individuals. 14 studies were included in the meta-analysis (from inception to Octo...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,meta分析

    doi:10.2217/bmm-2017-0420

    authors: Paliogiannis P,Fois AG,Sotgia S,Mangoni AA,Zinellu E,Pirina P,Carru C,Zinellu A

    更新日期:2018-07-01 00:00:00

  • Proteomic profiling identifies N-acetylmuramoyl-l-alanine amidase as a novel biomarker of sepsis.

    abstract:AIM:Sepsis is a critical condition that leads to high mortality and is the most common cause of death in intensive care units. Despite exhaustive efforts by the scientific community, a reliable biomarker for diagnosis, evolution and prognosis of sepsis is still lacking. Results & methodology: Here, using high-throughpu...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2016-0184

    authors: Pinheiro da Silva F,Cataldi TR,de Lima TM,Starzynski PN,Barbeiro HV,Labate MT,CéMachado MC,de Souza HP,Labate CA

    更新日期:2016-12-01 00:00:00

  • Genetic biomarkers in aortopathy.

    abstract::The field of aortopathy, in common with other genomic disorders, is undergoing a revolution. This is largely driven by the implementation of newer forms of genetic sequencing (massively parallel or next-generation sequencing). Advantages conferred by this technology include reduced costs, reduced sequencing time and t...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.13.74

    authors: Rea G,Stewart FJ

    更新日期:2013-08-01 00:00:00

  • Biomarker use in tailored combat casualty care.

    abstract::Modern war wounds are complex and primarily involve extremities. They require multiple operative interventions to achieve wound closure and begin rehabilitation. Current assessment of the suitability of surgical wound closure is based upon subjective methods coupled with a semiquantitative determination of the wound b...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm.10.13

    authors: Brown TS,Safford S,Caramanica J,Elster EA

    更新日期:2010-06-01 00:00:00

  • Clinical applications of biomarkers in preeclampsia.

    abstract::Preeclampsia remains a significant cause of maternal morbidity and mortality worldwide. Prediction, diagnosis and management continue to be challenging but advances in the understanding of the pathophysiological processes underlying the disease has enabled identification of multiple biomarkers, some of which aid predi...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.14.19

    authors: Griffin M,Shennan AH

    更新日期:2014-01-01 00:00:00

  • Oxidative stress and SYNTAX score in patients with stable coronary artery disease.

    abstract::Letter in regards to: Akboga MK, Balci KG, Maden O et al. Usefulness of monocyte to HDL-cholesterol ratio to predict high SYNTAX score in patients with stable coronary artery disease. Biomark. Med. 10(4), 375-383 (2016). ...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2016-0326

    authors: Soylemez S

    更新日期:2017-08-01 00:00:00

  • Impact of expression of the uPA system in sarcomas.

    abstract::The uPA system mainly comprises the urokinase-type plasminogen activator uPA, the cell-surface receptor uPA receptor and the inhibitor PAI-1. Its clinical and prognostic impact especially in breast cancer is well investigated. In this short report, we summarize the published data describing expression of uPA, PAI-1 an...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.12.105

    authors: Taubert H,Magdolen V,Kotzsch M

    更新日期:2013-06-01 00:00:00

  • HLADR: a database system for enhancing the discovery of biomarkers for predicting human leukocyte antigen-mediated idiosyncratic adverse drug reactions.

    abstract:AIM:To establish a database for the associations between idiosyncratic drug reactions (IDRs) and human leukocyte antigens (HLAs) and to systematically assess the characteristics of the drug-HLA associations. MATERIALS & METHODS:Electronic databases were searched to extensively identify drug-HLA association studies fro...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm.15.98

    authors: Du T,Yang L,Luo H,Zhou P,Mei H,Xuan J,Xing Q,Ning B,Mendrick DL,Shi L

    更新日期:2015-01-01 00:00:00

  • Tumor vascularity in prostate cancer: an update on circulating endothelial cells and platelets as noninvasive biomarkers.

    abstract::In order to individually tailor prostate cancer (PCa) treatment, clinicians need better tools to predict prognosis and treatment response. Given the relationship between angiogenesis and cancer progression, circulating endothelial cells (CECs) and their progenitors have logically been proposed as potential biomarkers....

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm.13.100

    authors: Reeves F,Sapre N,Corcoran N,Hovens C

    更新日期:2013-12-01 00:00:00

  • Development of NuQ nucleosome blood tests for the detection of colon cancer.

    abstract::Dr Jake Micallef speaks to Hannah L Wilson, Commissioning Editor: Dr Micallef has 20 years of experience in research and development and in the management of early-stage biotechnical companies, including the manufacture of biotechnology products and the establishment of manufacturing operations. Dr Micallef gained thi...

    journal_title:Biomarkers in medicine

    pub_type: 传,历史文章,面试

    doi:10.2217/bmm.14.47

    authors: Micallef J,Wilson HL

    更新日期:2014-01-01 00:00:00

  • Drug exposure: still an excellent biomarker.

    abstract::Relationships between plasma drug concentrations and clinical outcome have been defined for various chemotherapeutic agents, showing that drug exposure may be a marker of toxicity, mainly hematological and gastrointestinal toxicity, as well as efficacy, expressed as tumor response and survival. Biomarkers provide info...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm.09.58

    authors: Meza-Junco J,Sawyer MB

    更新日期:2009-12-01 00:00:00

  • Discovering biomarkers in bladder cancer by metabolomics.

    abstract::It has become increasingly clear that the development of cancer, a multifactorial disease, cannot be explained by a single molecule or gene mutation. As a new discipline, metabolomics focuses on the body's metabolite changes, and attempts to find differences to explain the development of cancer; it has proven to be ef...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审

    doi:10.2217/bmm-2018-0229

    authors: Zhang WT,Zhang ZW,Guo YD,Wang LS,Mao SY,Zhang JF,Liu MN,Yao XD

    更新日期:2018-12-01 00:00:00

  • Biomarkers for predicting postmenopausal coronary heart disease.

    abstract::Coronary heart disease (CHD) is the main cause of death in post-menopausal women (PMW). Beyond the 'traditional' cardiovascular risk factors of CHD, newer biomarkers, reflecting inflammation, endothelial function and oxidative stress, have received growing consideration. We systematically reviewed the literature on th...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.2217/bmm.11.51

    authors: Spoletini I,Vitale C,Rosano GM

    更新日期:2011-08-01 00:00:00

  • Cytokine patterns after therapy with Avonex®, Rebif®, Betaferon® and CinnoVex™ in relapsing-remitting multiple sclerosis in Iranian patients.

    abstract:AIM:Several lines of evidence exist which suggest that changes in the expression of circulating cytokines are linked to the development or reoccurrence of multiple sclerosis (MS). This study aimed to evaluate the serum levels of relevant cytokines after therapy with IFN-β formulations in MS patients. MATERIALS & METHO...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm.10.81

    authors: Arababadi MK,Mosavi R,Khorramdelazad H,Yaghini N,Zarandi ER,Araste M,Pourali R,Nekhei Z,Kennedy D

    更新日期:2010-10-01 00:00:00

  • Decoding the LncRNA transcriptome of esophageal cancer: identification of clinically relevant LncRNAs.

    abstract:AIM:LncRNAs may act as promising biomarkers in esophageal cancer (EC). Here, we illustrate the LncRNA profile and their clinical relevance in EC. PATIENTS & METHODS:In this study, we utilized the Cancer Genome Atlas RNA-sequencing and clinical data from 186 patients and 13 normal samples. Various statistical and gene ...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2018-0032

    authors: Khadirnaikar S,Narayanan SP,Shukla SK

    更新日期:2018-10-01 00:00:00

  • Association between Lp (a) and atherosclerosis in menopausal women without metabolic syndrome.

    abstract:AIM:The association between Lipoprotein (a) (Lp [a]) and common carotid intima media thickness (IMT) has been evaluated in 222 menopausal women. MATERIAL & METHODS:Lp (a) and IMT were measured, carotid ultrasound examination (B-Mode imaging) was performed and mean max IMT was calculated. RESULTS:Lp (a) was significan...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm.16.4

    authors: Gentile M,Iannuzzo G,Mattiello A,Marotta G,Iannuzzi A,Panico S,Rubba P

    更新日期:2016-01-01 00:00:00

  • Plasma albumin levels predict risk for nonsurvivors in critically ill patients with COVID-19.

    abstract::Aim: We aimed to explore the biomarkers for disease progression or the risk of nonsurvivors. Materials & methods: This study included 134 hospitalized patients with confirmed COVID-19 infection. The outcome of moderate versus severe versus critically ill patients and survivors versus nonsurvivors were compared. Result...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章

    doi:10.2217/bmm-2020-0254

    authors: Li J,Li M,Zheng S,Li M,Zhang M,Sun M,Li X,Deng A,Cai Y,Zhang H

    更新日期:2020-07-01 00:00:00