HLADR: a database system for enhancing the discovery of biomarkers for predicting human leukocyte antigen-mediated idiosyncratic adverse drug reactions.


AIM:To establish a database for the associations between idiosyncratic drug reactions (IDRs) and human leukocyte antigens (HLAs) and to systematically assess the characteristics of the drug-HLA associations. MATERIALS & METHODS:Electronic databases were searched to extensively identify drug-HLA association studies from 1966 to present. RESULTS:A drug-HLA-IDR database, HLADR, was created. The drug-HLA relationship network clearly reflected an ethnicity dependency of the associations. The positive predictive values and the negative predictive values demonstrated that other potential factors may also regulate the occurrence of HLA-specific IDRs. CONCLUSIONS:Constructing studies with samples from homogeneous ethnic groups and identifying cofactors that affect negative predictive values and positive predictive values will become necessary to enhance the predictability of HLA biomarkers for future research on IDRs.


Biomark Med


Biomarkers in medicine


Du T,Yang L,Luo H,Zhou P,Mei H,Xuan J,Xing Q,Ning B,Mendrick DL,Shi L




Has Abstract


2015-01-01 00:00:00












  • Emerging biomarkers for PD-1 pathway cancer therapy.

    abstract::The field of immuno-oncology has witnessed unprecedented success in recent years, with several PD=1 and PD-L1 inhibitors obtaining US FDA registration and breakthrough drug therapy designation in multiple tumor types. Despite its clear efficacy in certain cancers, treatment with these agents carries a risk of immune-r...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审


    authors: Lim JS,Sundar R,Chénard-Poirier M,Lopez J,Yap TA

    更新日期:2017-01-01 00:00:00

  • Serum YKL-40 for monitoring myocardial ischemia after revascularization in patients with stable coronary artery disease.

    abstract:AIM:The aim was to investigate the inflammatory biomarker YKL-40 as a monitor of myocardial ischemia in patients with coronary artery disease (CAD). METHODS:A total of 311 patients with stable CAD were included. Blood samples were taken at baseline, the day after coronary angiography and/or after percutaneous coronary...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Harutyunyan M,Johansen JS,Mygind ND,Reuter SB,Kastrup J

    更新日期:2014-01-01 00:00:00

  • Association between Lp (a) and atherosclerosis in menopausal women without metabolic syndrome.

    abstract:AIM:The association between Lipoprotein (a) (Lp [a]) and common carotid intima media thickness (IMT) has been evaluated in 222 menopausal women. MATERIAL & METHODS:Lp (a) and IMT were measured, carotid ultrasound examination (B-Mode imaging) was performed and mean max IMT was calculated. RESULTS:Lp (a) was significan...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Gentile M,Iannuzzo G,Mattiello A,Marotta G,Iannuzzi A,Panico S,Rubba P

    更新日期:2016-01-01 00:00:00

  • Biomarkers of acute kidney injury in pediatric cardiac patients.

    abstract::Acute kidney injury is a common and significant complication among pediatric patients with congenital heart disease, occurring most commonly after cardiopulmonary bypass. Current laboratory methods of diagnosis are not timely enough to guide management decisions, thus spurring interest in discovering new biomarkers of...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审


    authors: Kwiatkowski DM,Goldstein SL,Krawczeski CD

    更新日期:2012-06-01 00:00:00

  • C-type natriuretic-derived peptides as biomarkers in human disease.

    abstract::The natriuretic peptide system comprises three structurally related peptides: atrial natriuretic peptide, B-type natriuretic peptide and C-type natriuretic peptide. In circulation, they play an important endocrine role in the regulation of cardiovascular homeostasis by maintaining blood pressure and extracellular flui...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Lippert S,Goetze JP

    更新日期:2010-08-01 00:00:00

  • Impact of expression of the uPA system in sarcomas.

    abstract::The uPA system mainly comprises the urokinase-type plasminogen activator uPA, the cell-surface receptor uPA receptor and the inhibitor PAI-1. Its clinical and prognostic impact especially in breast cancer is well investigated. In this short report, we summarize the published data describing expression of uPA, PAI-1 an...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审


    authors: Taubert H,Magdolen V,Kotzsch M

    更新日期:2013-06-01 00:00:00

  • A biomarker of oxidative stress as a nontraditional risk factor in obese subjects.

    abstract:BACKGROUND:Oxidative stress has been postulated as an additive factor linking obesity to cardiovascular disease. MATERIALS & METHODS:Derivatives of reactive oxygen species metabolites (d-ROMs) were measured in 136 obese (42 males, 94 females; mean age: 47 ± 12 years; BMI: 36 ± 5 kg/m(2)) and in 306 over- and normal-we...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Vassalle C,Vigna L,Bianchi S,Maffei S,Novembrino C,De Giuseppe R,de Liso F,Vannucci A,Tirelli S,Maiavacca R,Bamonti F

    更新日期:2013-08-01 00:00:00

  • Circulating malondialdehyde concentrations in patients with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis.

    abstract::The aim of this meta-analysis was to review the available evidence regarding the blood concentrations of the oxidative stress marker malondialdehyde (MDA) in chronic obstructive pulmonary disease (COPD) patients in comparison to healthy individuals. 14 studies were included in the meta-analysis (from inception to Octo...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,meta分析


    authors: Paliogiannis P,Fois AG,Sotgia S,Mangoni AA,Zinellu E,Pirina P,Carru C,Zinellu A

    更新日期:2018-07-01 00:00:00

  • May autophagy be a novel biomarker and antitumor target in colorectal cancer?

    abstract::Autophagy is a catabolic process associated with intracellular self-digestion of damaged organelles or redundant proteins enabling maintenance of cell homeostasis. It is accepted that impaired autophagy is closely linked to cancer development and has been extensively studied in a variety of malignancies including colo...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审


    authors: Gil J,Pesz KA,Sąsiadek MM

    更新日期:2016-10-01 00:00:00

  • G-protein-coupled receptor kinases in cardiovascular conditions: focus on G-protein-coupled receptor kinase 2, a gain in translational medicine.

    abstract::With increasing knowledge of the regulatory mechanisms of G-protein-coupled receptor signaling in heart physiology, many studies have focused on the role of this system in cardiovascular disease. In recent years, scientists have moved their attention from the receptors to their regulatory proteins: the G-protein-coupl...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Campanile A,Iaccarino G

    更新日期:2009-10-01 00:00:00

  • Predictive biomarkers for immunotherapy efficacy in non-small-cell lung cancer: current status and future perspectives.

    abstract::In recent years, immune checkpoint inhibitors have rapidly changed treatment paradigms and have been pivotal for the treatment of advanced NSCLC patients. However, many patients don't respond to immunotherapy, and toxicities are a concern. Mounting evidence suggests that PD-L1 expression and tumor mutational burden ar...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: C Guven D,Sahin TK,Dizdar O,Kilickap S

    更新日期:2020-10-01 00:00:00

  • A novel 8.7-kb mitochondrial genome deletion accurately detects endometriosis in the plasma of symptomatic women.

    abstract::Aim: To evaluate an 8.7-kb mitochondrial DNA (mtDNA) deletion as a potential biomarker of endometriosis. Materials & methods: We tested the diagnostic accuracy of the 8.7-kb deletion real-time PCR assay using 182 prospectively collected blood samples from females presenting with symptoms of endometriosis in a case-con...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Harbottle A,Maggrah A,Usher R,Desa E,Creed JM

    更新日期:2020-02-01 00:00:00

  • Analytical aspects of molecular Alzheimer's disease biomarkers.

    abstract::In general, a biomarker has multiple uses such as a diagnostic tool and a method to monitor therapy. The quality of a biomarker depends on how big the difference is between, for example, patients and healthy controls, but also on the capacity of the method used to measure it (the uncertainty in the method should be mu...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审


    authors: Andreasson U,Vanmechelen E,Shaw LM,Zetterberg H,Vanderstichele H

    更新日期:2012-08-01 00:00:00

  • Biomarkers for predicting postmenopausal coronary heart disease.

    abstract::Coronary heart disease (CHD) is the main cause of death in post-menopausal women (PMW). Beyond the 'traditional' cardiovascular risk factors of CHD, newer biomarkers, reflecting inflammation, endothelial function and oxidative stress, have received growing consideration. We systematically reviewed the literature on th...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,meta分析,评审


    authors: Spoletini I,Vitale C,Rosano GM

    更新日期:2011-08-01 00:00:00

  • Metabolomics applied to the discovery of tuberculosis and diabetes mellitus biomarkers.

    abstract::Tuberculosis (TB) and diabetes mellitus Type 2 (DM2) are two diseases as ancient as they are harmful to human health. The outcome for both diseases in part depends on immune and metabolic individual responses. DM2 is increasing yearly, mainly due to environmental, genetic and lifestyle habits. There are multiple evide...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审


    authors: Salgado-Bustamante M,Rocha-Viggiano AK,Rivas-Santiago C,Magaña-Aquino M,López JA,López-Hernández Y

    更新日期:2018-09-01 00:00:00

  • Genetic polymorphisms associated with overweight and obesity in uncontrolled Type 2 diabetes mellitus.

    abstract::Generally, obese and overweight individuals display higher free fatty acid levels, which stimulate insulin resistance. The combination of overweight or obesity with insulin resistance can trigger Type 2 diabetes mellitus (T2DM) and are primary contributing factors to the development of uncontrolled T2DM. Genetic polym...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审


    authors: Kasim NB,Huri HZ,Vethakkan SR,Ibrahim L,Abdullah BM

    更新日期:2016-01-01 00:00:00

  • Urinary excretion of liver-type FABP as a new clinical marker for the progression of obstructive nephropathy.

    abstract:AIM:The aim of this article was to investigate the performance and predictive value of urinary liver-type FABP (uL-FABP) and urinary NGAL (uNGAL) for renal function and prognosis in obstructive nephropathy (ON). PATIENTS & METHODS:A total of 108 ON patients and urine samples were collected. An ELISA was used to determ...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Xie Y,Xu W,Wang Q,Shao X,Ni Z,Mou S

    更新日期:2014-01-01 00:00:00

  • Population-based serum omentin-1 levels: paradoxical association with cardiometabolic disorders primarily in men.

    abstract:AIM:The conflicting relationships of serum omentin with inflammation markers and cardiometabolic disorders were investigated. Results & methods: Unselected 864 population-based middle-aged adults were cross-sectionally studied by sex-specific omentin tertiles. Men in the lowest omentin tertile (T1) had lower systolic b...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Onat A,Ademoglu E,Karadeniz Y,Can G,Uzun AO,Simsek B,Kaya A

    更新日期:2018-02-01 00:00:00

  • Proteomic analysis of breast tissue and nipple aspirate fluid for breast cancer detection.

    abstract::Clinical proteomics has great promise, but many hurdles. Proteomic approaches may prove to be the answer to decades of frustrating searches for markers that are specific and selective for breast cancer. In order to achieve this goal, the challenge arises that breast cancer is a heterogeneous disease and individual var...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Ruhlen RL,Sauter ER

    更新日期:2007-08-01 00:00:00

  • Exosomes as mediators and biomarkers in fibrosis.

    abstract::Fibrosis is characterized by aberrant myofibroblast accumulation and excessive extracellular matrix deposition, which leads to organ failure and significantly contributes to mortality worldwide. Exosomes, which are extracellular nanovesicles with a diameter of 30-100 nm that are secreted into the extracellular space b...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Qin XJ,Zhang JX,Wang RL

    更新日期:2020-06-01 00:00:00

  • Biochemical markers of muscle damage and high serum concentration of creatine kinase in patients on statin therapy.

    abstract::Aim: Some patients experience statin-associated muscle symptoms (SAMS) and elevated serum concentrations of CK. The relationship between SAMS and biomarkers of muscle damage was examined. Methods: We analyzed 359 consecutive patients taking statins with high CK values. Muscle-related symptoms and biochemical variables...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Nogueira AA,Strunz CM,Takada JY,Mansur AP

    更新日期:2019-06-01 00:00:00

  • Index of cardiac electrophysiological balance and transmural dispersion of the repolarization index relationships with pericardial fat volume and coronary calcification.

    abstract:AIM:To assess the possible relationship between coronary atherosclerosis markers, pericardial fat volume (PFV) and coronary artery calcification, with ECG markers of index of the cardiac electrophysiological balance (iCEB) and transmural dispersion of the repolarization in patients with suspected coronary artery diseas...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Nafakhi H,Al-Mosawi AA,Alareedh M,Al-Nafakh HA

    更新日期:2018-04-01 00:00:00

  • Circulating PV-1 as a marker of celiac disease-associated liver injury.

    abstract::Aim: To investigate the role of endothelial PV-1 in patients with untreated celiac disease (CD)-associated liver injury. Materials & methods: PV-1 and PV-1 mRNA were measured in intestinal biopsies from untreated CD patients with elevated or normal alanine transaminase levels, controls, patients with inflammatory bowe...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: De Leo L,Naviglio S,Vatta S,Benelli E,Stera G,Santon D,Ziberna F,Taddio A,Martelossi S,Giudici F,Giuffrida P,Di Sabatino A,Corazza GR,Ventura A,Not T

    更新日期:2020-12-01 00:00:00

  • Altered signature of apoptotic endothelial cell-derived microvesicles predicts chronic heart failure phenotypes.

    abstract::Aim: to evaluate the associations between signatures of apoptotic endothelial cell-derived microvesicles (MVs) with phenotypes of chronic heart failure (HF). Methods: The study cohort consisted of 388 prospectively involved subjects with HF patients with predominantly reduced left ventricular ejection fraction (HFrEF)...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Berezin AE,Kremzer AA,Samura TA,Berezina TA

    更新日期:2019-06-01 00:00:00

  • MMP-9 (-1562 C:T) polymorphism as a biomarker of susceptibility to severe pre-eclampsia.

    abstract:AIM:To investigate the role of MMP-9 (-1562 C:T) polymorphism as a biomarker for susceptibility to pre-eclampsia. PATIENTS & METHODS:MMP-9 variants were detected in 160 women with mild and severe pre-eclampsia and 112 healthy pregnant women. RESULTS:A significantly higher frequency of MMP-9 CT genotype was observed i...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Rahimi Z,Rahimi Z,Shahsavandi MO,Bidoki K,Rezaei M

    更新日期:2013-02-01 00:00:00

  • Determination of the severity of ureteropelvic junction obstruction using urinary epidermal growth factor and kidney injury molecule 1 levels.

    abstract:AIM:This study aimed to assess the urinary concentrations of epidermal growth factor (EGF) and kidney injury molecule 1 (KIM-1) in patients with hydronephrosis. METHODS:Neonates with a history of prenatal hydronephrosis were enrolled in three groups. Group 1 included neonates with severe obstruction; group 2 included ...

    journal_title:Biomarkers in medicine

    pub_type: 临床试验,杂志文章


    authors: Mohammadjafari H,Rafiei A,Kosaryan M,Yeganeh Y,Hosseinimehr SJ

    更新日期:2014-01-01 00:00:00

  • TLR9-1486C/T polymorphism is associated with hepatocellular carcinoma recurrence after liver transplantation.

    abstract::Aim: To determine whether TLR9 polymorphisms are associated with tumor recurrence after liver transplantation for hepatocellular carcinoma (HCC). Patients & methods: All patients who underwent liver transplantation, and had viable HCC in the explanted liver were included. TLR9-1237C/T and -1486C/T polymorphisms were a...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: de la Fuente S,Citores MJ,Lucena JL,Muñoz P,Cuervas-Mons V

    更新日期:2019-08-01 00:00:00

  • C-reactive protein in saliva and dried blood spot as markers of stress reactivity in healthy African-Americans.

    abstract::Aim: Noninvasive assessments of C-reactive protein (CRP) in stress contexts have seldom been compared. This study evaluated CRP response to acute social stress as measured in saliva and dried blood spot (DBS). Materials & methods: African-Americans (N = 118; mean age = 32 years) participated in a laboratory-based soci...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Goetz SM,Lucas T

    更新日期:2020-04-01 00:00:00

  • B-type natriuretic peptides in heart failure: update on clinical applications and limitations.

    abstract::Heart failure remains an important clinical and public health problem with significant mortality, morbidity and economic consequences. The identification of natriuretic peptides and the large number of investigations that followed have led to a better understanding of the neurohormonal pathophysiology of heart failure...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Miller WL,Targonski PV,Jaffe AS

    更新日期:2007-12-01 00:00:00

  • Evaluation of the relation between cardiac biomarkers and thorax computerized tomography findings in COVID-19 patients.

    abstract::Background: Troponin levels may be elevated in COVID-19 infection. The aim of this study was to the explore relation between troponin levels and COVID-19 severity. Materials & methods/Results: One hundred and forty consecutive patients with COVID-19 pneumonia were included. Diagnosis of COVID-19 pneumonia was based on...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Ileri C,Dogan Z,Ozben B,Karaoglu C,Gunay N,Tigen K,Basat S,Uyan C

    更新日期:2021-01-27 00:00:00