HLADR: a database system for enhancing the discovery of biomarkers for predicting human leukocyte antigen-mediated idiosyncratic adverse drug reactions.


AIM:To establish a database for the associations between idiosyncratic drug reactions (IDRs) and human leukocyte antigens (HLAs) and to systematically assess the characteristics of the drug-HLA associations. MATERIALS & METHODS:Electronic databases were searched to extensively identify drug-HLA association studies from 1966 to present. RESULTS:A drug-HLA-IDR database, HLADR, was created. The drug-HLA relationship network clearly reflected an ethnicity dependency of the associations. The positive predictive values and the negative predictive values demonstrated that other potential factors may also regulate the occurrence of HLA-specific IDRs. CONCLUSIONS:Constructing studies with samples from homogeneous ethnic groups and identifying cofactors that affect negative predictive values and positive predictive values will become necessary to enhance the predictability of HLA biomarkers for future research on IDRs.


Biomark Med


Biomarkers in medicine


Du T,Yang L,Luo H,Zhou P,Mei H,Xuan J,Xing Q,Ning B,Mendrick DL,Shi L




Has Abstract


2015-01-01 00:00:00












  • Analytical aspects of molecular Alzheimer's disease biomarkers.

    abstract::In general, a biomarker has multiple uses such as a diagnostic tool and a method to monitor therapy. The quality of a biomarker depends on how big the difference is between, for example, patients and healthy controls, but also on the capacity of the method used to measure it (the uncertainty in the method should be mu...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审


    authors: Andreasson U,Vanmechelen E,Shaw LM,Zetterberg H,Vanderstichele H

    更新日期:2012-08-01 00:00:00

  • C-reactive protein in saliva and dried blood spot as markers of stress reactivity in healthy African-Americans.

    abstract::Aim: Noninvasive assessments of C-reactive protein (CRP) in stress contexts have seldom been compared. This study evaluated CRP response to acute social stress as measured in saliva and dried blood spot (DBS). Materials & methods: African-Americans (N = 118; mean age = 32 years) participated in a laboratory-based soci...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Goetz SM,Lucas T

    更新日期:2020-04-01 00:00:00

  • A novel 8.7-kb mitochondrial genome deletion accurately detects endometriosis in the plasma of symptomatic women.

    abstract::Aim: To evaluate an 8.7-kb mitochondrial DNA (mtDNA) deletion as a potential biomarker of endometriosis. Materials & methods: We tested the diagnostic accuracy of the 8.7-kb deletion real-time PCR assay using 182 prospectively collected blood samples from females presenting with symptoms of endometriosis in a case-con...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Harbottle A,Maggrah A,Usher R,Desa E,Creed JM

    更新日期:2020-02-01 00:00:00

  • Association of IGF-1 with coronary collateral circulation in stable coronary artery disease.

    abstract:AIM:The aim of the present study is to evaluate the relationship between coronary collateral circulation (CCC) grade and serum IGF-1 levels in patients diagnosed with stable coronary artery disease. METHODS:Totally, 190 consecutive patients with stable coronary artery disease who underwent coronary angiography were in...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Kundi H,Gok M,Kiziltunc E,Cetin M,Ornek E

    更新日期:2017-07-01 00:00:00

  • Impact of expression of the uPA system in sarcomas.

    abstract::The uPA system mainly comprises the urokinase-type plasminogen activator uPA, the cell-surface receptor uPA receptor and the inhibitor PAI-1. Its clinical and prognostic impact especially in breast cancer is well investigated. In this short report, we summarize the published data describing expression of uPA, PAI-1 an...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审


    authors: Taubert H,Magdolen V,Kotzsch M

    更新日期:2013-06-01 00:00:00

  • Biomarkers to optimize the treatment of nicotine dependence.

    abstract::The application of genomic medicine to the treatment of nicotine dependence holds great promise for revitalizing the steady decline in smoking rates witnessed in the USA over the past several decades. This paper examines the current knowledge base concerning the use of biomarkers to guide the selection of nicotine dep...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审


    authors: Schnoll RA,Leone FT

    更新日期:2011-12-01 00:00:00

  • Decoding the LncRNA transcriptome of esophageal cancer: identification of clinically relevant LncRNAs.

    abstract:AIM:LncRNAs may act as promising biomarkers in esophageal cancer (EC). Here, we illustrate the LncRNA profile and their clinical relevance in EC. PATIENTS & METHODS:In this study, we utilized the Cancer Genome Atlas RNA-sequencing and clinical data from 186 patients and 13 normal samples. Various statistical and gene ...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Khadirnaikar S,Narayanan SP,Shukla SK

    更新日期:2018-10-01 00:00:00

  • How biomarkers can improve pneumonia diagnosis and prognosis: procalcitonin and mid-regional-pro-adrenomedullin.

    abstract::Aim: The diagnostic and prognostic role of procalcitonin (PCT) and mid-regional-pro-adrenomedullin (MR-proADM) were investigated in patients with pneumonia. Material & methods: A total of 168 and 77 patients with pneumonia enrolled in two different hospital settings, an internal medicine unit and an emergency unit wer...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Spoto S,Legramante JM,Minieri M,Fogolari M,Terrinoni A,Valeriani E,Sebastiano C,Bernardini S,Ciccozzi M,Angeletti PS

    更新日期:2020-05-01 00:00:00

  • Clinicopathological and prognostic significance of octamer-binding transcription factor 4 in patients with gastric cancer: a systematic review and meta-analysis.

    abstract:AIM:The role of octamer-binding transcription factor 4 (Oct4) in gastric cancer (GC) progression is still under debate and reported results are inconsistent. Therefore, we conducted a meta-analysis to evaluate the clinicopathological and prognostic significance of Oct4 expression in patients with GC. MATERIALS & METHO...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,meta分析


    authors: Wei Y,Liu H,Wang C,Zhang W,Wen X,Long H,Xu Z,Guo H,Liu Y,Wei D,Qiu C,Li G,Sun Z

    更新日期:2019-02-01 00:00:00

  • Novel biomarkers for the prediction of acute kidney injury in patients undergoing liver transplantation.

    abstract:AIM:Because of the delayed rise of serum creatinine concentrations, novel biomarkers such as NGAL, GST and KIM-1 are proposed to detect acute kidney injury (AKI). In this study we evaluated these biomarkers. MATERIALS & METHODS:Twenty-six consecutive adult liver transplantations were evaluated. Markers were measured a...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Dedeoglu B,de Geus HR,Fortrie G,Betjes MG

    更新日期:2013-12-01 00:00:00

  • May autophagy be a novel biomarker and antitumor target in colorectal cancer?

    abstract::Autophagy is a catabolic process associated with intracellular self-digestion of damaged organelles or redundant proteins enabling maintenance of cell homeostasis. It is accepted that impaired autophagy is closely linked to cancer development and has been extensively studied in a variety of malignancies including colo...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审


    authors: Gil J,Pesz KA,Sąsiadek MM

    更新日期:2016-10-01 00:00:00

  • Clinical significance of detecting HLA-DR, 14-3-3η protein and d-dimer in the diagnosis of rheumatoid arthritis.

    abstract:AIM:To investigate the clinical significance of detecting several biomarkers collectively in the diagnosis of rheumatoid arthritis (RA). METHODS:128 RA patients, 174 non-RA patients and 80 healthy controls were enrolled. HLA-DR4 and HLA-DR53 were detected by the PCR-SSP method, 14-3-3η protein, anti-CCP and anti-Sa we...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Tan L,Wang Q,Zeng T,Long T,Guan X,Wu S,Zheng W,Fu H,Meng Y,Wu Y,Tian Y,Yu J,Chen J,Li H,Cao L

    更新日期:2018-07-01 00:00:00

  • Oxidative stress and SYNTAX score in patients with stable coronary artery disease.

    abstract::Letter in regards to: Akboga MK, Balci KG, Maden O et al. Usefulness of monocyte to HDL-cholesterol ratio to predict high SYNTAX score in patients with stable coronary artery disease. Biomark. Med. 10(4), 375-383 (2016). ...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Soylemez S

    更新日期:2017-08-01 00:00:00

  • Biomarkers for predicting postmenopausal coronary heart disease.

    abstract::Coronary heart disease (CHD) is the main cause of death in post-menopausal women (PMW). Beyond the 'traditional' cardiovascular risk factors of CHD, newer biomarkers, reflecting inflammation, endothelial function and oxidative stress, have received growing consideration. We systematically reviewed the literature on th...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,meta分析,评审


    authors: Spoletini I,Vitale C,Rosano GM

    更新日期:2011-08-01 00:00:00

  • Clinical applications of biomarkers in preeclampsia.

    abstract::Preeclampsia remains a significant cause of maternal morbidity and mortality worldwide. Prediction, diagnosis and management continue to be challenging but advances in the understanding of the pathophysiological processes underlying the disease has enabled identification of multiple biomarkers, some of which aid predi...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审


    authors: Griffin M,Shennan AH

    更新日期:2014-01-01 00:00:00

  • Circulating PV-1 as a marker of celiac disease-associated liver injury.

    abstract::Aim: To investigate the role of endothelial PV-1 in patients with untreated celiac disease (CD)-associated liver injury. Materials & methods: PV-1 and PV-1 mRNA were measured in intestinal biopsies from untreated CD patients with elevated or normal alanine transaminase levels, controls, patients with inflammatory bowe...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: De Leo L,Naviglio S,Vatta S,Benelli E,Stera G,Santon D,Ziberna F,Taddio A,Martelossi S,Giudici F,Giuffrida P,Di Sabatino A,Corazza GR,Ventura A,Not T

    更新日期:2020-12-01 00:00:00

  • Aptamers generated by Cell SELEX for biomarker discovery.

    abstract::Biomarker discovery is essential to the advancement of our knowledge about diseases and to the development of new strategies for treatment and therapy. Among the newest technologies in this rapidly growing field is a process termed Cell SELEX by which a panel of aptamers can be generated to specifically target disease...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Kim Y,Liu C,Tan W

    更新日期:2009-04-01 00:00:00

  • Index of cardiac electrophysiological balance and transmural dispersion of the repolarization index relationships with pericardial fat volume and coronary calcification.

    abstract:AIM:To assess the possible relationship between coronary atherosclerosis markers, pericardial fat volume (PFV) and coronary artery calcification, with ECG markers of index of the cardiac electrophysiological balance (iCEB) and transmural dispersion of the repolarization in patients with suspected coronary artery diseas...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Nafakhi H,Al-Mosawi AA,Alareedh M,Al-Nafakh HA

    更新日期:2018-04-01 00:00:00

  • Plasma albumin levels predict risk for nonsurvivors in critically ill patients with COVID-19.

    abstract::Aim: We aimed to explore the biomarkers for disease progression or the risk of nonsurvivors. Materials & methods: This study included 134 hospitalized patients with confirmed COVID-19 infection. The outcome of moderate versus severe versus critically ill patients and survivors versus nonsurvivors were compared. Result...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Li J,Li M,Zheng S,Li M,Zhang M,Sun M,Li X,Deng A,Cai Y,Zhang H

    更新日期:2020-07-01 00:00:00

  • Population-based serum omentin-1 levels: paradoxical association with cardiometabolic disorders primarily in men.

    abstract:AIM:The conflicting relationships of serum omentin with inflammation markers and cardiometabolic disorders were investigated. Results & methods: Unselected 864 population-based middle-aged adults were cross-sectionally studied by sex-specific omentin tertiles. Men in the lowest omentin tertile (T1) had lower systolic b...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Onat A,Ademoglu E,Karadeniz Y,Can G,Uzun AO,Simsek B,Kaya A

    更新日期:2018-02-01 00:00:00

  • Interferons as biomarkers and effectors: lessons learned from animal models.

    abstract::Interferons (IFNs) comprise type I, II and III families with multiple subtypes. Via transcription of IFN-stimulated genes (ISGs), IFNs can exert multiple biological effects on the cell. In infectious and chronic inflammatory diseases, the IFNs and their ISG sets can be potentially utilized as biomarkers of disease out...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审


    authors: Berry CM,Hertzog PJ,Mangan NE

    更新日期:2012-04-01 00:00:00

  • Identifying network-based biomarkers of complex diseases from high-throughput data.

    abstract::In this work, we review the main available computational methods of identifying biomarkers of complex diseases from high-throughput data. The emerging omics techniques provide powerful alternatives to measure thousands of molecules in cells in parallel manners. The generated genomic, transcriptomic, proteomic, metabol...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审


    authors: Liu ZP

    更新日期:2016-06-01 00:00:00

  • PON2 and PPARG polymorphisms as biomarkers of risk for coronary heart disease.

    abstract:AIM:Investigate the correlation between paraoxonase 2 (PON2) Ser311Cys polymorphism as well as the peroxisome proliferator-activated receptor gamma (PPARG) His477His polymorphism and the susceptibility to development of coronary heart diseases (CHD) through a meta-analysis. METHODS:Odds ratio and the corresponding 95%...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审


    authors: González-Castro TB,Tovilla-Zárate CA,Juárez-Rojop IE,Hernández-Díaz Y,López-Narváez ML,Rodríguez-Pérez C,González-Hernández YK,Ramos-Méndez MÁ

    更新日期:2018-03-01 00:00:00

  • Usefulness of monocyte to HDL-cholesterol ratio to predict high SYNTAX score in patients with stable coronary artery disease.

    abstract:AIM:We aimed to investigate whether baseline monocyte to high-density lipoprotein cholesterol ratio (MHR), an easily available inflammatory and oxidative stress marker, is associated with SYNTAX score. PATIENTS & METHODS:In this cross-sectional study, n = 1229 consecutive patients with coronary artery disease were cla...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Akboga MK,Balci KG,Maden O,Ertem AG,Kirbas O,Yayla C,Acar B,Aras D,Kisacik H,Aydogdu S

    更新日期:2016-01-01 00:00:00

  • Copeptin as a biomarker in heart failure.

    abstract::Increased neurohormonal activation is a key feature of heart failure (HF). Copeptin is a surrogate marker for proarginine vasopressin and the prognostic value of copeptin has been reported for multiple disease states of both nonvascular and cardiovascular etiology. Elevated plasma copeptin in HF has been associated wi...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审


    authors: Balling L,Gustafsson F

    更新日期:2014-01-01 00:00:00

  • Biomarkers of immune dysfunction following combination antiretroviral therapy for HIV infection.

    abstract::Combination antiretroviral therapy (cART) has significantly reduced morbidity and mortality of HIV-infected patients, yet their life expectancy remains reduced compared with the general population. Most HIV-infected patients receiving cART have some persistent immune dysfunction characterized by chronic immune activat...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章,评审


    authors: Lichtfuss GF,Hoy J,Rajasuriar R,Kramski M,Crowe SM,Lewin SR

    更新日期:2011-04-01 00:00:00

  • TLR9-1486C/T polymorphism is associated with hepatocellular carcinoma recurrence after liver transplantation.

    abstract::Aim: To determine whether TLR9 polymorphisms are associated with tumor recurrence after liver transplantation for hepatocellular carcinoma (HCC). Patients & methods: All patients who underwent liver transplantation, and had viable HCC in the explanted liver were included. TLR9-1237C/T and -1486C/T polymorphisms were a...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: de la Fuente S,Citores MJ,Lucena JL,Muñoz P,Cuervas-Mons V

    更新日期:2019-08-01 00:00:00

  • Development of NuQ nucleosome blood tests for the detection of colon cancer.

    abstract::Dr Jake Micallef speaks to Hannah L Wilson, Commissioning Editor: Dr Micallef has 20 years of experience in research and development and in the management of early-stage biotechnical companies, including the manufacture of biotechnology products and the establishment of manufacturing operations. Dr Micallef gained thi...

    journal_title:Biomarkers in medicine

    pub_type: 传,历史文章,面试


    authors: Micallef J,Wilson HL

    更新日期:2014-01-01 00:00:00

  • Serum YKL-40 for monitoring myocardial ischemia after revascularization in patients with stable coronary artery disease.

    abstract:AIM:The aim was to investigate the inflammatory biomarker YKL-40 as a monitor of myocardial ischemia in patients with coronary artery disease (CAD). METHODS:A total of 311 patients with stable CAD were included. Blood samples were taken at baseline, the day after coronary angiography and/or after percutaneous coronary...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Harutyunyan M,Johansen JS,Mygind ND,Reuter SB,Kastrup J

    更新日期:2014-01-01 00:00:00

  • Proteomic analysis of rat plasma following transient focal cerebral ischemia.

    abstract:AIM:This study aimed to identify plasma protein changes in a rat model of ischemic stroke using a proteomic approach. MATERIALS & METHODS:Four male Sprague-Dawley rats (3-6 months old) were subjected to 90 min of left middle cerebral artery occlusion under anesthesia with 1.5% isoflurane in O(2)/air followed by 24-h r...

    journal_title:Biomarkers in medicine

    pub_type: 杂志文章


    authors: Chen R,Vendrell I,Chen CP,Cash D,O'Toole KG,Williams SA,Jones C,Preston JE,Wheeler JX

    更新日期:2011-12-01 00:00:00