Abstract:
:We created the dual-responsive nanovehicle that can effectively combine and abundantly utilize magnetic and glutathione (GSH)-reductive triggers to control the drug delivery and achieve more intelligent and powerful targeting. In the nanovehicles, paramagnetic fullerene (C60@CTAF) was prepared via one-step modification of fullerene with magnetic surfactant CTAF by hydrophobic interaction for the first time. The perfect conjugation of C60 and CTAF increased the solubility or dispersity of fullerenes and qualified CTAF with more powerful assembly capability with DNA. DNA molecule in the nanovehicles acted as an electrostatic scaffold to load anticancer drug Dox as well as the important building block for assembly with C60@CTAF into C60@CTAF/DNA. The further combination of deshielding and targeting functions in reduction-responsive disulfide modified HA-SS-COOH coating on C60@CTAF/DNA complexes could reduce the agglomeration and regulate the morphology of C60@CTAF/DNA complexes from irregular microstructures to more uniform ones. More importantly, the introduction of HA-SS-COOH provided a response to a simulating reductive extra-tumoral environment by efficient cleavage of disulfide linkages by GSH and site-specific drug delivery to HepG2 cells. Amazingly, the final nanovehicles presented an increased magnetic susceptibility compared with paramagnetic CTAF, and they "walked" under an applied magnetic field. Because of their facile fabrication, rapid responsiveness to extra tumoral environment, and external automatic controllability by external magnet, the drug delivery nanovehicles constructed by magnetic fullerene-DNA/hyaluronic acid might be of great interest for making new functional nucleic-acid-based drug carriers.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Wang L,Wang Y,Hao J,Dong Sdoi
10.1021/acs.biomac.6b01939subject
Has Abstractpub_date
2017-03-13 00:00:00pages
1029-1038issue
3eissn
1525-7797issn
1526-4602journal_volume
18pub_type
杂志文章abstract::Bioresponsive polymers can enable the development of more effective drug delivery vehicles and medical materials. Acetal-modified polysaccharides allow pH-triggered solubility switching in a versatile and effective manner, but prior work has been limited to a combination of acyclic alkoxyisopropyl and cyclic isopropyl...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.9b00215
更新日期:2019-05-13 00:00:00
abstract::Poly(L-lactide) (PLLA) with various alkyl ester chain end groups were synthesized by ring-opening polymerization of L-lactide in the presence of zinc alkoxide as a catalyst. The structural effect of chain end groups on the rate of enzymatic and nonenzymatic degradations for amorphous films of PLLA were investigated at...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm701259r
更新日期:2008-03-01 00:00:00
abstract::This study shows the application of the electrospinning technique as a viable method for the encapsulation and stabilization of bifidobacterial strains. Poly(vinyl alcohol) (PVOH) was used as the encapsulating material because it is generally recognized as safe (GRAS), has a high oxygen barrier when dry, and is water ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm900660b
更新日期:2009-10-12 00:00:00
abstract::A strategy to light-trigger ionic cross-linking of alginates by incorporating a photosensitive Ca2+ cage (nitr-T) is presented. Upon irradiation, free Ca2+ was released, and this caused gelation of the alginate solution. Addition of Ca2+ "on-demand" allowed us to obtain homogeneous alginate (ALG) gels using concentrat...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm400022h
更新日期:2013-05-13 00:00:00
abstract::A simple, sequential approach for creation of hydrolytically degradable poly(ethylene glycol) (PEG) hydrogels has been developed and characterized. The chemistry involves an initial step growth polymerization reaction between PEG-diacrylate and dithiothreitol (DTT) to form acrylate-terminated (-PEG-DTT-)n PEG chains, ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm701179s
更新日期:2008-03-01 00:00:00
abstract::Chitin nanocrystal aqueous dispersions were prepared by acid hydrolysis of crude chitin from crab shells. The resulting dispersions were studied with small deformation oscillatory experiments and polarized optical microscopy under different conditions of nanocrystal concentration, ionic strength, pH, and temperature. ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm901046c
更新日期:2010-01-11 00:00:00
abstract::Enzymatic hydrolysis of selected copolymers of cellulose diacetate-graft-poly(L-lactide)s (CDA-g-PLLAs) were conducted with proteinase K for film specimens, which were solely quenched from the molten state or, further, annealed at temperatures below or above their glass transition temperatures. The hydrolysis rates de...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm034453i
更新日期:2004-03-01 00:00:00
abstract::In this paper, we describe the preparation and characterization of Langmuir and Langmuir-Blodgett (LB) monolayers of the enzyme organophosphorus acid anhydrolase (OPAA). Langmuir films of OPAA were characterized on different subphases, such as phosphate, ammonium carbonate, and bis-tris-propane buffers. Monolayers at ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm025775+
更新日期:2003-07-01 00:00:00
abstract::The formation of calcite prism architecture in the prismatic layer of the mollusk shell involves the participation of a number of different proteins. One protein family, Asprich, has been identified as a participant in amorphous calcium carbonate stabilization and calcite architecture in the prismatic layer of the mol...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm100738r
更新日期:2010-10-11 00:00:00
abstract::Recombinant spider silk proteins mimicking the properties of dragline silk proteins represent a class of materials that hold great potential for future high-performance applications. Here we explore the self-assembly behavior of a recombinantly produced spider silk protein based on the dragline silk of the Araneus di...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm300964h
更新日期:2012-10-08 00:00:00
abstract::The production of large quantities of artificial spider silk fibers that match the mechanical properties of the native material has turned out to be challenging. Recent advancements in the field make biomimetic spinning approaches an attractive way forward since they allow the spider silk proteins to assemble into the...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.0c00100
更新日期:2020-06-08 00:00:00
abstract::Angiogenesis has long been a desired therapeutic approach to improve clinical outcomes of conditions typified by ischemia. Vascular endothelial growth factor (VEGF) has demonstrated the ability to generate new blood vessels in vivo, but trials using intravenous delivery have not yet produced clinical success. Localize...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm061211k
更新日期:2007-05-01 00:00:00
abstract::Micellar peroxidase-catalyzed synthesis of chiral polyaniline (PANI) in the presence of dodecylbenzenesulfonic acid (DBSA) was developed. The effect of DBSA concentration on the catalytic efficiency of horseradish and palm tree peroxidases was examined. Favorable conditions for the enzymatic synthesis of chiral PANI, ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm070212p
更新日期:2007-08-01 00:00:00
abstract::The electrospinning of polymer melts can offer an advantage over solution electrospinning, in the development of layered tissue constructs for tissue engineering. Melt electrospinning does not require a solvent, of which many are cytotoxic in nature, and the use of nonwater soluble polymers allows the collection of fi...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm050777q
更新日期:2006-03-01 00:00:00
abstract::We investigated the rheological properties and the penetration of differently sized carboxylated nanoparticles in pig pulmonary mucus, on different distance and time scales. Nanoparticles were either mechanically mixed into the mucus samples or deposited as an aerosol, the latter resembling a more physiologically rele...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.6b00164
更新日期:2016-04-11 00:00:00
abstract::The development and use of synthetic, cross-linked, macromolecular substrates with tunable elasticity has been instrumental in revealing the mechanisms by which cells sense and respond to their mechanical microenvironment. We here describe a hydrogel based on radical-free, cross-linked poly(ethylene glycol) to study t...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm4014827
更新日期:2014-01-13 00:00:00
abstract::The structure of an extracellular polysaccharide (EPS) from Streptococcus thermophilus THS has been determined. A combination of component analysis, methylation analysis and NMR spectroscopy shows that the polysaccharide is composed of pentasaccharide repeating units. Sequential information was obtained by two-dimensi...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0496514
更新日期:2005-01-01 00:00:00
abstract::Two linear alpha-(1,4)-D-glucans substrates, of degrees of polymerization DP approximately 150 and 6000, were exposed to maize starch-branching enzyme IIa (mSBEIIa) in vitro. The resulting branched alpha-glucans and their constituent chains (obtained by debranching) were analyzed by nuclear magnetic resonance (NMR) an...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm701213p
更新日期:2008-03-01 00:00:00
abstract::We report the synthesis of poly(methacrylic acid)-co-(oleyl methacrylate) with three different amounts of oleyl methacrylate and compare the ability of these polymers with that of poly(methacrylic acid)-co-(cholesteryl methacrylate) (PMA(c)) to noncovalently anchor liposomes to polymer layers. We subsequently assemble...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm101020e
更新日期:2010-12-13 00:00:00
abstract::A challenge in the development of multifunctional drug delivery systems is to establish a reasonable and effective synthetic route for multifunctional polymer preparation. Herein, we propose a unique protocol to prepare multifunctional micelles by a cross-assembly process using three different functional polyurethanes...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.6b00375
更新日期:2016-06-13 00:00:00
abstract::Images of high methoxyl orange pectin deposited from solution and high methoxyl sugar acid gels (HMSAG) were obtained by atomic force microscopy (AFM) in the tapping mode. For the first time, images of pectin deposited from water revealed that the transition from pectin networks to individual molecules or aggregates t...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0607729
更新日期:2007-02-01 00:00:00
abstract::The stability of internally cross-linked casein micelles against disruption by urea (which disrupts hydrogen bonds and hydrophobic interactions) and trisodium citrate (which sequesters micellar calcium phosphate) was investigated. Addition of urea (0-6 mol L-1) and/or citrate (0-50 mmol L-1) progressively reduced the ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm061070m
更新日期:2007-04-01 00:00:00
abstract::To evaluate the antidiarrheal effect of ginseng, the active principals of ginseng were studied in vitro model of rotavirus infection, the leading cause of severe diarrhea. Two pectic polysaccharides, named as GP50-dHR (56.0 kDa) and GP50-eHR (77.0 kDa), were purified from hot water extract of ginseng by bioassay-linke...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm100397p
更新日期:2010-08-09 00:00:00
abstract::Two poly(amido-amine)s (oligoPAM and oligoNER) containing bis-phosphonate residues were obtained by a Michael-type polyaddition of pamidronate and neridronate to 1,4-bis(acryloyl)piperazine. The SEC (size-exclusion chromatography) and the MALDI-TOF (matrix assisted laser desorption ionization) analyses were consistent...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0607630
更新日期:2006-12-01 00:00:00
abstract::Thymic epithelial cells (TECs) are the main regulators of T lymphocyte development and selection, requiring a three-dimensional (3D) environment to properly perform these biological functions. The aim of this work was to develop a 3D culture substrate that allows the survival and proliferation of TECs. Thus, electrosp...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.0c00933
更新日期:2020-12-14 00:00:00
abstract::The application of nanoparticles comprising amphiphilic block copolymers for the delivery of drugs is a subject of great interest as they hold promise for more effective and selective therapies. In order to achieve this ambition, it is of critical importance to develop our understanding of the self-assembly mechanisms...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.0c00169
更新日期:2020-06-08 00:00:00
abstract::Transparent and bendable regenerated cellulose films prepared from aqueous alkali (NaOH or LiOH)/urea (AU) solutions exhibit high oxygen barrier properties, which are superior to those of conventional cellophane, poly(vinylidene chloride), and poly(vinyl alcohol). Series of AU cellulose films are prepared from differe...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm200766v
更新日期:2011-07-11 00:00:00
abstract::Photo-crosslinkable dendritic macromolecules are attractive materials for the preparation of cartilage tissue engineering scaffolds that may be optimized for in situ formation of hydrated, mechanically stable, and well-integrated hydrogel scaffolds supporting chondrocytes and chondrogenesis. We designed and synthesize...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm050663e
更新日期:2006-01-01 00:00:00
abstract::Hydrophobic methacrylic monomers were polymerized in aqueous media using methylated (1.8)-beta-cyclodextrin (MeCD) additives. Hydrophobic monomers tert-butyl methacrylate (tBuMA), cyclohexyl methacrylate (CMA), and 2-ethylhexyl methacrylate (2EHMA) were each dissolved in chloroform with MeCD. Chloroform was then evapo...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0055706
更新日期:2000-01-01 00:00:00
abstract::A modular approach to engineering cross-linked elastic biomaterials is presented for fine-tuning of material mechanical and biological properties. The three components, soluble elastin, hyaluronic acid, and silk fibroin, contribute with different features to the overall properties of the final material system. The ela...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm1007772
更新日期:2010-09-13 00:00:00