Noncovalent liposome linkage and miniaturization of capsosomes for drug delivery.

abstract：:A simple, sequential approach for creation of hydrolytically degradable poly(ethylene glycol) (PEG) hydrogels has been developed and characterized. The chemistry involves an initial step growth polymerization reaction between PEG-diacrylate and dithiothreitol (DTT) to form acrylate-terminated (-PEG-DTT-)n PEG chains, ...

journal_title：Biomacromolecules

authors： Hudalla GA,Eng TS,Murphy WL

更新日期：2008-03-01 00:00:00

abstract：:Enzymatic adsorption and degradation of three types of aliphatic polyester films and two types of polyolefin films by the extracellular PHB depolymerase from Alcaligenes faecalis T1 have been studied by using a quartz crystal microbalance (QCM) technique. Hydrolysis of poly[(R)-3-hydroxybutyrate] was quantitatively fo...

journal_title：Biomacromolecules

authors： Yamashita K,Aoyagi Y,Abe H,Doi Y

更新日期：2001-04-01 00:00:00

abstract：:Monoclonal antibodies (mAb) are a major focus of the pharmaceutical industry, and polyclonal immunoglobulin G (IgG) therapy is used to treat a wide variety of health conditions. As some individuals require mAb/IgG therapy their entire life, there is currently a great desire to formulate antibodies for bolus injection ...

journal_title：Biomacromolecules

authors： Gong Y,Soleymani Abyaneh H,Drossis N,Niederquell A,Kuentz M,Leroux JC,de Haan HW,Gauthier MA

更新日期：2019-09-09 00:00:00

abstract：:We present a synthetic approach toward soft, glycooligomer-functionalized microgel particles mimicking carbohydrate presenting cell surfaces and analyze their specific binding to a model lectin (Concanavalin A, ConA). Focusing on multivalent presentation, a series of sequence-controlled glycooligomers with varying spa...

journal_title：Biomacromolecules

authors： Jacobi F,Camaleño de la Calle A,Boden S,Grafmüller A,Hartmann L,Schmidt S

更新日期：2018-08-13 00:00:00

abstract：:Imbalanced homeostasis and oligomerization of the amyloid-β (Aβ) peptide in the brain are hallmarks of Alzheimer's disease (AD). Microglia and macrophages play a critical role in the etiology of AD either by clearing Aβ from the brain or inducing inflammation. Recent evidence suggests that clearance of Aβ by microglia...

journal_title：Biomacromolecules

authors： Richman M,Perelman A,Gertler A,Rahimipour S

更新日期：2013-01-14 00:00:00

abstract：:Poly(epsilon-caprolactone)/polylactide blend (PCL/PLA) is an interesting biomaterial because PCL and PLA present good complementarity in their physical properties and biodegradability. However, the thermodynamic incompatibility between two component polymers restricts further applications of their blend. In this work,...

journal_title：Biomacromolecules

authors： Wu D,Zhang Y,Zhang M,Yu W

更新日期：2009-02-09 00:00:00

abstract：:Thin films of a biocompatible and nonbiofouling poly(oligo(ethylene glycol) methacrylate) ( pOEGMA) with various thicknesses were formed on gold and Si/SiO 2 substrates by a combination of the formation of self-assembled monolayers (SAMs) terminating in bromoester-an initiator of atom transfer radical polymerization (...

journal_title：Biomacromolecules

authors： Lee BS,Chi YS,Lee KB,Kim YG,Choi IS

更新日期：2007-12-01 00:00:00

abstract：:The synthesis, characterization, and degradation kinetics of three alpha-cyclodextrin (alpha-CD)-poly(ethylene glycol) (PEG) polyrotaxanes with endcaps that were installed using Cu(I)-catalyzed Huisgen cyclization is reported. PEG1500, azidated with azidoacetic acid, was threaded with alpha-CD to form a pseudopolyrota...

journal_title：Biomacromolecules

authors： Loethen S,Ooya T,Choi HS,Yui N,Thompson DH

更新日期：2006-09-01 00:00:00

abstract：:The synthesis of quaternary ammonium (QA)-functionalized silica nanoparticles with and without nitric oxide (NO) release capabilities is described. Glycidyltrialkylammonium chlorides of varied alkyl chain lengths (i.e., methyl, butyl, octyl, and dodecyl) were tethered to the surface of amine-containing silica nanopart...

journal_title：Biomacromolecules

authors： Carpenter AW,Worley BV,Slomberg DL,Schoenfisch MH

更新日期：2012-10-08 00:00:00

abstract：:A series of well-defined thermoresponsive diblock copolymers (PEO45-b-PtNEAn, n=22, 44, 63, 91, 172) were prepared by the atom transfer radical polymerization of trans-N-(2-ethoxy-1,3-dioxan-5-yl) acrylamide (tNEA) using a poly(ethylene oxide) (PEO45) macroinitiator. All copolymers are water-soluble at low temperature...

journal_title：Biomacromolecules

authors： Qiao ZY,Ji R,Huang XN,Du FS,Zhang R,Liang DH,Li ZC

更新日期：2013-05-13 00:00:00

abstract：:Nanofibrous materials containing the antitumor drug doxorubicin hydrochloride (DOX) were easily prepared using a one-step method by electrospinning of DOX/poly(L-lactide-co-D,L-lactide) (coPLA) and DOX/quaternized chitosan (QCh)/coPLA solutions. The pristine and DOX-containing mats were characterized by ATR-FTIR and X...

journal_title：Biomacromolecules

authors： Ignatova MG,Manolova NE,Toshkova RA,Rashkov IB,Gardeva EG,Yossifova LS,Alexandrov MT

更新日期：2010-06-14 00:00:00

abstract：:The oxidation-responsive behaviors of OEGylated poly-L-cysteine homopolypeptides, that is, poly(L-EG(x)MA-C)n, were investigated. These poly-L-cysteine derivatives adopted mixed conformation in water, in which the β-sheet accounted for a significant proportion. Upon oxidation, the thioethers in polypeptide side chains...

journal_title：Biomacromolecules

authors： Fu X,Ma Y,Shen Y,Fu W,Li Z

更新日期：2014-03-10 00:00:00

abstract：:Presently there is great interest in the construction of nanostructures from DNA fragments. Here we report the preparation of much larger helical textures with different shapes from pure DNA fragments. We have observed them while preparing crystals of the dodecamer d(AAAAAATTTTTT), which only contains adenine and thym...

journal_title：Biomacromolecules

authors： Subirana JA,Creixell M,Baldini R,Campos JL

更新日期：2008-01-01 00:00:00

abstract：:The grafting of thermosensitive amine-terminated statistical polymers onto the surface of cellulose nanocrystals (CNCs) was achieved by a peptidic coupling reaction, leading to unusual properties like colloidal stability at high ionic strength, surface activity, and thermoreversible aggregation. We have used a large v...

journal_title：Biomacromolecules

authors： Azzam F,Heux L,Putaux JL,Jean B

更新日期：2010-12-13 00:00:00

abstract：:The conformational behavior of a long single-chain double-stranded DNA in solutions of free silver ions and silver nanoparticles generated via the reduction of AgNO3 by NaBH4 was monitored by fluorescence and electron microscopies and UV spectroscopy. The interaction of monovalent silver ions with DNA induces shrinkin...

journal_title：Biomacromolecules

authors： Zinchenko AA,Baigl D,Chen N,Pyshkina O,Endo K,Sergeyev VG,Yoshikawa K

更新日期：2008-07-01 00:00:00

abstract：:Ambidextrous supergelators are developed through structure-gelation screening of rationally designed cyclic dipeptides (CDPs). The organo- and hydrogels of CDPs were thoroughly characterized by their minimal gelation concentration (MGC) for organic and aqueous solvents, thermal stability (Tg), and viscoelastic propert...

journal_title：Biomacromolecules

authors： Manchineella S,Murugan NA,Govindaraju T

更新日期：2017-11-13 00:00:00

abstract：:Mutually complementary, self-repulsive oligopeptide pairs were designed to coassemble into viscoelastic hydrogels. Peptide engineering was combined with biophysical techniques to investigate the effects of temperature on the structural and mechanical properties of the resulting hydrogels. Biophysical characterizations...

journal_title：Biomacromolecules

authors： Ramachandran S,Taraban MB,Trewhella J,Gryczynski I,Gryczynski Z,Yu YB

更新日期：2010-06-14 00:00:00

abstract：:Partially benzylamidated, amphipathic poly(gamma-glutamic acid) (BzPGA) was synthesized from poly(gamma-glutamic acid) (PGA) and benzylamine by direct amidation in dimethyl sulfoxide (DMSO). Benzylamine and PGA were heated in DMSO for 1 to 26 h at temperatures between 110 and 130 degrees C, producing derivatives of va...

journal_title：Biomacromolecules

authors： Novak L,Banyai I,Fleischer-Radu JE,Borbély J

更新日期：2007-05-01 00:00:00

abstract：:Biopolymers bearing hydrophobic side-chains, such as hydrophobically modified chitosan (hmC), can connect liposomes into a gel network via hydrophobic interactions. In this paper, we show that such liposome gels possess an attractive combination of properties for certain drug delivery applications. Their shear-thinnin...

journal_title：Biomacromolecules

authors： Lee JH,Oh H,Baxa U,Raghavan SR,Blumenthal R

更新日期：2012-10-08 00:00:00

abstract：:Although composed simply of glucose polymers, the starch granule is a complex, semicrystalline structure. Much of this complexity arises from the fact that the two primary enzymes of synthesis-starch synthase and starch-branching enzyme-exist as multiple isoforms. Each form has distinct properties and plays a unique r...

journal_title：Biomacromolecules

authors： Smith AM

更新日期：2001-07-01 00:00:00

abstract：:Understanding the self-assembly mechanism of caged proteins provides clues to develop their potential applications in nanotechnology, such as a nanoscale drug delivery system. The E2 protein from Bacillus stearothermophilus , with a virus-like caged structure, has drawn much attention for its potential application as...

journal_title：Biomacromolecules

authors： Peng T,Lee H,Lim S

更新日期：2012-03-12 00:00:00

abstract：:Electrochemically controlled, reversible assembly of biopolymers into hydrogel structures is a promising technique for on-demand cell or drug encapsulation and release systems. An electrochemically sol-gel transition has been demonstrated in regenerated Bombyx mori silk fibroin, offering a controllable way to generate...

journal_title：Biomacromolecules

authors： Lin Y,Xia X,Shang K,Elia R,Huang W,Cebe P,Leisk G,Omenetto F,Kaplan DL

更新日期：2013-08-12 00:00:00

abstract：:The layer-by-layer technique has been used as a powerful method to produce multilayer thin films with tunable properties. When natural polymers are employed, complicated phenomena such as self-aggregation and fibrilogenesis can occur, making it more difficult to obtain and characterize high-quality films. The weak aci...

journal_title：Biomacromolecules

authors： de Moraes MA,Crouzier T,Rubner M,Beppu MM

更新日期：2015-01-12 00:00:00

abstract：:First generation, photocrosslinkable dendrimers consisting of natural metabolites (i.e., succinic acid, glycerol, and beta-alanine) and nonimmunogenic poly(ethylene glycol) (PEG) were synthesized divergently in high yields using ester and carbamate forming reactions. Aqueous solutions of these dendrimers were photocro...

journal_title：Biomacromolecules

authors： Degoricija L,Bansal PN,Söntjens SH,Joshi NS,Takahashi M,Snyder B,Grinstaff MW

更新日期：2008-10-01 00:00:00

abstract：:Tumorigenic cell behaviors can be suppressed or enhanced by their physicochemical environment. As a first step toward developing materials that allow tumorigenic behaviors to be observed and manipulated, we cultured related MCF10 breast cell lines on fibers composed of the Drosophila protein Ultrabithorax (Ubx). These...

journal_title：Biomacromolecules

authors： Hsiao HC,Santos A,Howell DW,Patterson JL,Fuchs-Young RS,Bondos SE

更新日期：2016-11-14 00:00:00

abstract：:Chemotherapy faces challenges, including poor aqueous solubility of the drugs, and cardiotoxicity. Micellar drug delivery systems (DDS) are used to encapsulate anticancer drugs for better therapeutic effects, however, with poor loading content. Herein, we synthesized a micellar DDS using γ-benzyloxy substituted poly(ε...

journal_title：Biomacromolecules

authors： Soltantabar P,Calubaquib EL,Mostafavi E,Biewer MC,Stefan MC

更新日期：2020-04-13 00:00:00

abstract：:Heparin, a sulfated polysaccharide derived from animal sources, is the most commonly used parenteral anticoagulant drug, but it suffers from significant safety and supply issues. Herein, we describe the preparation of heparin mimetic homo- and copolymers via the reversible addition-fragmentation chain transfer (RAFT) ...

journal_title：Biomacromolecules

authors： Nahain AA,Ignjatovic V,Monagle P,Tsanaktsidis J,Vamvounis G,Ferro V

更新日期：2020-02-10 00:00:00

abstract：:Nowadays, active targeting of nanotherapeutics is a challenging issue. Here, we propose a rational design of a ternary nanoassembly (SAP) composed of nonionic amphiphilic β-cyclodextrins (amphiphilic CD) incorporating pheophorbide (Pheo) as a phototherapeutic and an adamantanyl-folic acid conjugate (Ada-FA) to target ...

journal_title：Biomacromolecules

authors： Zagami R,Rapozzi V,Piperno A,Scala A,Triolo C,Trapani M,Xodo LE,Monsù Scolaro L,Mazzaglia A

更新日期：2019-07-08 00:00:00

abstract：:This paper describes the synthesis and characterization of polymer-peptide conjugates to be used as infection-resistant coating for biomaterial implants and devices. Antiadhesive polymer brushes composed of block copolymer Pluronic F-127 (PF127) were functionalized with antimicrobial peptides (AMP), able to kill bacte...

journal_title：Biomacromolecules

authors： Muszanska AK,Rochford ET,Gruszka A,Bastian AA,Busscher HJ,Norde W,van der Mei HC,Herrmann A

更新日期：2014-06-09 00:00:00

abstract：:Cationic spherical polyelectrolyte brushes (SPBs) were synthesized by photoemulsion polymerization, consisting of a polystyrene core with a diameter around 80 nm and a poly(2-aminoethylmethacrylate hydrochloride) (PAEMH) shell with a thickness from 10 to 50 nm densely grafted on the core surface. The binding of variou...

journal_title：Biomacromolecules

authors： Wang S,Chen K,Li L,Guo X

更新日期：2013-03-11 00:00:00