Biocompatible micro-gel particles from cross-linked casein micelles.

Abstract:

:The stability of internally cross-linked casein micelles against disruption by urea (which disrupts hydrogen bonds and hydrophobic interactions) and trisodium citrate (which sequesters micellar calcium phosphate) was investigated. Addition of urea (0-6 mol L-1) and/or citrate (0-50 mmol L-1) progressively reduced the turbidity of a suspension of casein micelles cross-linked by transglutaminase and increased particle size (determined by dynamic and static light scattering and small-angle neutron scattering), which was attributed to swelling of the micelles. Furthermore, model calculations, assuming a completely stable casein network, were performed to describe the decreases in turbidity on addition of urea and citrate. Measured and described turbidity values are in agreement, indicating that cross-linking of casein micelles with transglutaminase results in a covalently bound protein network, which is entirely stable to disruption by urea and/or citrate. This may offer potential applications for the use of cross-linked casein micelles as biocompatible protein micro-gel particles.

journal_name

Biomacromolecules

journal_title

Biomacromolecules

authors

Huppertz T,Smiddy MA,de Kruif CG

doi

10.1021/bm061070m

subject

Has Abstract

pub_date

2007-04-01 00:00:00

pages

1300-5

issue

4

eissn

1525-7797

issn

1526-4602

journal_volume

8

pub_type

杂志文章
  • Hydrogels for osteochondral repair based on photocrosslinkable carbamate dendrimers.

    abstract::First generation, photocrosslinkable dendrimers consisting of natural metabolites (i.e., succinic acid, glycerol, and beta-alanine) and nonimmunogenic poly(ethylene glycol) (PEG) were synthesized divergently in high yields using ester and carbamate forming reactions. Aqueous solutions of these dendrimers were photocro...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm800658x

    authors: Degoricija L,Bansal PN,Söntjens SH,Joshi NS,Takahashi M,Snyder B,Grinstaff MW

    更新日期:2008-10-01 00:00:00

  • Peptides are building blocks of heat-induced fibrillar protein aggregates of beta-lactoglobulin formed at pH 2.

    abstract::The proteinaceous material present in beta-lactoglobulin fibrils formed after heating (20 h at 85 degrees C) at pH 2 was identified during this study. Fibrils were separated from the nonaggregated material, and the fibrils were dissociated using 8 M guanidine chloride and 0.1 M 1,4-dithiothreitol (pH 8). Characterizat...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm7014224

    authors: Akkermans C,Venema P,van der Goot AJ,Gruppen H,Bakx EJ,Boom RM,van der Linden E

    更新日期:2008-05-01 00:00:00

  • Novel therapeutic agents for bone resorption. Part 1. Synthesis and protonation thermodynamics of poly(amido-amine)s containing bis-phosphonate residues.

    abstract::Two poly(amido-amine)s (oligoPAM and oligoNER) containing bis-phosphonate residues were obtained by a Michael-type polyaddition of pamidronate and neridronate to 1,4-bis(acryloyl)piperazine. The SEC (size-exclusion chromatography) and the MALDI-TOF (matrix assisted laser desorption ionization) analyses were consistent...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm0607630

    authors: Casolaro M,Casolaro I,Spreafico A,Capperucci C,Frediani B,Marcolongo R,Margiotta N,Ostuni R,Mendichi R,Samperi F,Ishii T,Ito Y

    更新日期:2006-12-01 00:00:00

  • Biodegradable polymers from renewable sources: rheological characterization of hemicellulose-based hydrogels.

    abstract::Hemicellulose-based hydrogels were prepared by radical polymerization of 2-hydroxyethyl methacrylate or poly(ethylene glycol) dimethacrylate with oligomeric hydrosoluble hemicellulose modified with well-defined amounts of methacrylic functions. The polymerization reaction was carried out in water at 40 degrees C using...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm049515z

    authors: Söderqvist Lindblad M,Albertsson AC,Ranucci E,Laus M,Giani E

    更新日期:2005-03-01 00:00:00

  • Analytical model study of dendrimer/DNA complexes.

    abstract::The interaction between positively charged poly(amido amine) (PAMAM) dendrimers of generation 4 and DNA has been investigated for two DNA lengths; 2000 basepairs (bp; L = 680 nm) and 4331 bp (L = 1472.5 nm) using a theoretical model by Schiessel for a semiflexible polyelectrolyte and hard spheres. The model was modifi...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm9000662

    authors: Qamhieh K,Nylander T,Ainalem ML

    更新日期:2009-07-13 00:00:00

  • Physicochemical characterization of bioactive polyacrylic acid organogels as potential antimicrobial implants for the buccal cavity.

    abstract::This study describes the formulation and physicochemical characterization of poly(acrylic acid) (PAA) organogels, designed as bioactive implants for improved treatment of infectious diseases of the oral cavity. Organogels were formulated containing a range of concentrations of PAA (3-10% w/w) and metronidazole (2 or 5...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm700597e

    authors: Jones DS,Muldoon BC,Woolfson AD,Andrews GP,Sanderson FD

    更新日期:2008-02-01 00:00:00

  • Optical spectroscopy to investigate the structure of regenerated Bombyx mori silk fibroin in solution.

    abstract::Fluorescence and circular dichroism spectroscopy were used to monitor the conformational transition of regenerated Bombyx mori silk fibroin (RSF) in aqueous solutions under different conditions. According to the analysis of fluorescence spectra using anilinonaphthalene-8-sulfonic acid magnesium salt (ANS) as an extern...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm0343848

    authors: Yang Y,Shao Z,Chen X,Zhou P

    更新日期:2004-05-01 00:00:00

  • Glutathione-Sensitive Hyaluronic Acid-SS-Mertansine Prodrug with a High Drug Content: Facile Synthesis and Targeted Breast Tumor Therapy.

    abstract::Low tolerability and tumor selectivity restricts many potent anticancer drugs including mertansine from wide clinical use. Here, glutathione-activatable hyaluronic acid-SS-mertansine prodrug (HA-SS-DM1) was designed and developed to achieve enhanced tolerability and targeted therapy of CD44+ human breast tumor xenogra...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.6b01094

    authors: Zhong P,Zhang J,Deng C,Cheng R,Meng F,Zhong Z

    更新日期:2016-11-14 00:00:00

  • Structure and Biocompatibility of Bioabsorbable Nanocomposites of Aliphatic-Aromatic Copolyester and Cellulose Nanocrystals.

    abstract::Poly(butylene adipate-co-terephthalate) (PBAT) was first chemically modified via free radical grafting with maleic anhydride (MA) and the MA-g-PBAT graft copolymer was then used as a matrix material to obtain cellulose nanocrystal (CNC)-reinforced MA-g-PBAT bionanocomposites via reactive extrusion process to accelerat...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.7b00578

    authors: Kashani Rahimi S,Aeinehvand R,Kim K,Otaigbe JU

    更新日期:2017-07-10 00:00:00

  • In Situ Synthesis of Magnetic Field-Responsive Hemicellulose Hydrogels for Drug Delivery.

    abstract::A one-pot synthetic methodology for fabricating stimuli-responsive hemicellulose-based hydrogels was developed that consists of the in situ formation of magnetic iron oxide (Fe3O4) nanoparticles during the covalent cross-linking of O-acetyl-galactoglucomannan (AcGGM). The Fe3O4 nanoparticle content controlled the ther...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.5b00801

    authors: Zhao W,Odelius K,Edlund U,Zhao C,Albertsson AC

    更新日期:2015-08-10 00:00:00

  • Self-cross-linking polyelectrolyte complexes for therapeutic cell encapsulation.

    abstract::Self-cross-linking polyelectrolytes are used to strengthen the surface of calcium alginate beads for cell encapsulation. Poly([2-(methacryloyloxy)ethyl]trimethylammonium chloride), containing 30 mol % 2-aminoethyl methacrylate, and poly(sodium methacrylate), containing 30 mol % 2-(methacryloyloxy)ethyl acetoacetate, w...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm800580c

    authors: Mazumder MA,Shen F,Burke NA,Potter MA,Stöver HD

    更新日期:2008-09-01 00:00:00

  • Relationship between length and degree of polymerization of TEMPO-oxidized cellulose nanofibrils.

    abstract::The influence of 2,2,6,6-tetrametylpiperidine-1-oxyl (TEMPO)-mediated oxidation of wood cellulose and the mechanical disintegration of oxidized cellulose in water on degree of polymerization determined by viscosity measurement (DP(v)) and the apparent length of the TEMPO-oxidized cellulose nanofibrils (TOCNs) was inve...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm2017542

    authors: Shinoda R,Saito T,Okita Y,Isogai A

    更新日期:2012-03-12 00:00:00

  • Bait-and-Switch Supramolecular Strategy To Generate Noncationic RNA-Polymer Complexes for RNA Delivery.

    abstract::RNA interference (RNAi) requires the intracellular delivery of RNA molecules to initiate the neutralization of targeted mRNA molecules, inhibiting the expression or translation of the targeted gene. Current polymers and lipids that are used to deliver RNA molecules are generally required to be positively charged, to a...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.8b01321

    authors: Jiang Z,Cui W,Prasad P,Touve MA,Gianneschi NC,Mager J,Thayumanavan S

    更新日期:2019-01-14 00:00:00

  • Giant bent-core mesogens in the thread forming process of marine mussels.

    abstract::In marine mussels (Mytilus), byssal threads are made in minutes from prefabricated smectic polymer liquid crystals by a process resembling reaction injection molding. The mesogens in these arrays are known to be natural block copolymers with rodlike collagen cores. Using atomic force microscopy, it was shown that thes...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm049899t

    authors: Hassenkam T,Gutsmann T,Hansma P,Sagert J,Waite JH

    更新日期:2004-07-01 00:00:00

  • Engineering and Characterization of an Enzyme Replacement Therapy for Classical Homocystinuria.

    abstract::Homocystinuria due to loss of cystathionine beta-synthase (CBS) causes accumulation of homocysteine and depletion of cysteine. Current treatments are suboptimal, and thus the development of an enzyme replacement therapy based on PEGylated human truncated CBS (PEG-CBS) has been initiated. Attenuation of potency was obs...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.7b00154

    authors: Majtan T,Park I,Carrillo RS,Bublil EM,Kraus JP

    更新日期:2017-06-12 00:00:00

  • Polymers and Composites Derived from Castor Oil as Sustainable Materials and Degradable Biomaterials: Current Status and Emerging Trends.

    abstract::Recent years have seen rapid growth in utilizing vegetable oils to derive a wide variety of polymers to replace petroleum-based polymers for minimizing environmental impact. Nonedible castor oil (CO) can be extracted from castor plants that grow easily, even in an arid land. CO is a promising source for developing sev...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.0c01291

    authors: Chakraborty I,Chatterjee K

    更新日期:2020-12-14 00:00:00

  • Polymeric surfactants based on inulin, a polysaccharide extracted from chicory. 1. Synthesis and interfacial properties.

    abstract::Inulin, the polydisperse reserve polysaccharide from chicory, has been modified by carbamoylation in organic solvents. The reaction of inulin with a range of alkyl isocyanates resulted, after crystalization, in a variety of carbamoylated inulins from which the interfacial properties were determined. The medium and lon...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm015570l

    authors: Stevens CV,Meriggi A,Peristeropoulou M,Christov PP,Booten K,Levecke B,Vandamme A,Pittevils N,Tadros TF

    更新日期:2001-01-01 00:00:00

  • Modification of polylactide surfaces with lactide-ethylene oxide functional block copolymers: accessibility of functional groups.

    abstract::Feasibility of using amphiphilic block copolymers composed of polylactide (PLA) and poly(ethylene oxide) (PEO) blocks for biomimetic surface modification of polylactide-based biomaterials for tissue engineering was investigated. PEO-b-PLA copolymers were deposited on the PLA surface from a solution in PEO-selective so...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm900889b

    authors: Tresohlavá E,Popelka S,Machová L,Rypácek F

    更新日期:2010-01-11 00:00:00

  • Affibody-attached hyperbranched conjugated polyelectrolyte for targeted fluorescence imaging of HER2-positive cancer cell.

    abstract::A hyperbranched conjugated polyelectrolyte (HCPE) with a core-shell structure is designed and synthesized via alkyne polycyclotrimerization and click chemistry. The HCPE has an emission maximum at 565 nm with a quantum yield of 12% and a large Stokes shift of 143 nm in water. By virtue of its poly(ethylene glycol) she...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm200563a

    authors: Pu KY,Shi J,Cai L,Li K,Liu B

    更新日期:2011-08-08 00:00:00

  • Noncovalent liposome linkage and miniaturization of capsosomes for drug delivery.

    abstract::We report the synthesis of poly(methacrylic acid)-co-(oleyl methacrylate) with three different amounts of oleyl methacrylate and compare the ability of these polymers with that of poly(methacrylic acid)-co-(cholesteryl methacrylate) (PMA(c)) to noncovalently anchor liposomes to polymer layers. We subsequently assemble...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm101020e

    authors: Hosta-Rigau L,Chandrawati R,Saveriades E,Odermatt PD,Postma A,Ercole F,Breheney K,Wark KL,Städler B,Caruso F

    更新日期:2010-12-13 00:00:00

  • Effect of temperature during assembly on the structure and mechanical properties of peptide-based materials.

    abstract::Mutually complementary, self-repulsive oligopeptide pairs were designed to coassemble into viscoelastic hydrogels. Peptide engineering was combined with biophysical techniques to investigate the effects of temperature on the structural and mechanical properties of the resulting hydrogels. Biophysical characterizations...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm100138m

    authors: Ramachandran S,Taraban MB,Trewhella J,Gryczynski I,Gryczynski Z,Yu YB

    更新日期:2010-06-14 00:00:00

  • Synthesis, characterization, and pH-triggered dethreading of alpha-cyclodextrin-poly(ethylene glycol) polyrotaxanes bearing cleavable endcaps.

    abstract::The synthesis, characterization, and degradation kinetics of three alpha-cyclodextrin (alpha-CD)-poly(ethylene glycol) (PEG) polyrotaxanes with endcaps that were installed using Cu(I)-catalyzed Huisgen cyclization is reported. PEG1500, azidated with azidoacetic acid, was threaded with alpha-CD to form a pseudopolyrota...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm0602076

    authors: Loethen S,Ooya T,Choi HS,Yui N,Thompson DH

    更新日期:2006-09-01 00:00:00

  • Typical physicochemical behaviors of chitosan in aqueous solution.

    abstract::Physicochemical properties of a homogeneous series of chitosans with different degrees of acetylation and almost the same degree of polymerization were investigated in an ammonium acetate buffer. Techniques such as interferometry, static light scattering (in batch or coupled on line with a chromatographic system), and...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm025724c

    authors: Schatz C,Viton C,Delair T,Pichot C,Domard A

    更新日期:2003-05-01 00:00:00

  • Changes in glycogen structure over feeding cycle sheds new light on blood-glucose control.

    abstract::Liver glycogen, a highly branched polymer of glucose, is important for maintaining blood-glucose homeostasis. It was recently shown that db/db mice, a model for Type 2 diabetes, are unable to form the large composite glycogen α particles present in normal, healthy mice. In this study, the structure of healthy mouse-li...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm401714v

    authors: Sullivan MA,Aroney ST,Li S,Warren FJ,Joo JS,Mak KS,Stapleton DI,Bell-Anderson KS,Gilbert RG

    更新日期:2014-02-10 00:00:00

  • Photodegradable iron(III) cross-linked alginate gels.

    abstract::Biocompatible photoresponsive materials are of interest for targeted drug delivery, tissue engineering, 2D and 3D protein patterning, and other biomedical applications. We prepared light degradable hydrogels using a natural alginate polysaccharide cross-linked with iron(III) cations. The "hard" iron(III) cations used ...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm300707a

    authors: Narayanan RP,Melman G,Letourneau NJ,Mendelson NL,Melman A

    更新日期:2012-08-13 00:00:00

  • Copolymerization of 2-carboxyisopropylacrylamide with N-isopropylacrylamide accelerates cell detachment from grafted surfaces by reducing temperature.

    abstract::Acrylic acid (AAc) has been utilized to introduce reactive carboxyl groups to a temperature-responsive polymer, poly(N-isopropylacrylamide) (PIPAAm). However, AAc introduction shifts the copolymer phase transition temperatures higher and dampens the steep homopolymer phase transition with increasing AAc content. We pr...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm025692t

    authors: Ebara M,Yamato M,Hirose M,Aoyagi T,Kikuchi A,Sakai K,Okano T

    更新日期:2003-03-01 00:00:00

  • Amino acid grafted chitosan for high performance gene delivery: comparison of amino acid hydrophobicity on vector and polyplex characteristics.

    abstract::To develop a safe, effective, and biocompatible gene delivery vector, a series of hydrophobic amino acid grafted chitosan (AGC) derivatives were synthesized by carbodiimide mediated coupling reaction. Chemical characterization of AGC polymers was performed by NMR and elemental analysis. AGC polymers demonstrated excel...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm301720g

    authors: Layek B,Singh J

    更新日期:2013-02-11 00:00:00

  • Unraveling the Rapid Assembly Process of Stiff Cellulosic Fibers from Mistletoe Berries.

    abstract::The mucilaginous viscin tissue within mistletoe berries possesses an extraordinary ability to be rapidly processed under ambient conditions into stiff cellulosic fibers (>14 GPa) through simple mechanical drawing. This rapid and extreme transformation process is hydration-dependent and involves an astonishing >200-fol...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.9b00648

    authors: Horbelt N,Eder M,Bertinetti L,Fratzl P,Harrington MJ

    更新日期:2019-08-12 00:00:00

  • Crystallite Size Effect on Thermal Conductive Properties of Nonwoven Nanocellulose Sheets.

    abstract::The thermal conductive properties, including the thermal diffusivity and resultant thermal conductivity, of nonwoven nanocellulose sheets were investigated by separately measuring the thermal diffusivity of the sheets in the in-plane and thickness directions with a periodic heating method. The cross-sectional area (or...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.5b00617

    authors: Uetani K,Okada T,Oyama HT

    更新日期:2015-07-13 00:00:00

  • Pretreatment of amphiphilic comb polymer surfaces dramatically affects protein adsorption.

    abstract::New applications in regenerative biotechnology require the ability to understand and control protein-surface interactions on micrometer and submicrometer length scales. Evidence presented here shows that micropatterned amphiphilic comb polymer films exhibit a pretreatment-dependent behavior with respect to protein ads...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm050446d

    authors: Zhang Z,Ma H,Hausner DB,Chilkoti A,Beebe TP Jr

    更新日期:2005-11-01 00:00:00