Abstract:
:The influence of 2,2,6,6-tetrametylpiperidine-1-oxyl (TEMPO)-mediated oxidation of wood cellulose and the mechanical disintegration of oxidized cellulose in water on degree of polymerization determined by viscosity measurement (DP(v)) and the apparent length of the TEMPO-oxidized cellulose nanofibrils (TOCNs) was investigated. DP(v) values decreased from 1270 to 500-600 with increasing addition of NaClO in the TEMPO-mediated oxidation stage. The DP(v) values were further decreased by mechanical fibrillation in water. There is a linear relationship between the average fibril length and DP(v); the lengths of TOCNs can be approximated from DP(v) using 0.5 M copper ethylenediamine as a solvent of both the cellulose and oxidized celluloses in TOCNs. Based on the cellulose fibril models and TEMPO oxidation mechanism, the depolymerization behavior of TOCNs is tentatively explained in terms of distribution of disordered regions in wood cellulose fibrils and formation of C6-aldehydes in cellulose fibrils during TEMPO-mediated oxidation.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Shinoda R,Saito T,Okita Y,Isogai Adoi
10.1021/bm2017542subject
Has Abstractpub_date
2012-03-12 00:00:00pages
842-9issue
3eissn
1525-7797issn
1526-4602journal_volume
13pub_type
杂志文章abstract::In this paper we report on protein refolding by means of a liquid-liquid transfer technique using a calixarene. We have found that a calix[6]areneacetic acid derivative forms a supramolecular complex with urea-denatured cytochrome c at the oil-water interface, which enables quantitative transfer of the protein from an...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm070418q
更新日期:2007-10-01 00:00:00
abstract::Disulfide bonds stabilize the tertiary- and quaternary structure of proteins. In addition, they can be used to engineer redox-sensitive (bio)materials and drug-delivery systems. Many of these applications require control of the stability of the disulfide bond. It has recently been shown that the charged microenvironme...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm400501c
更新日期:2013-07-08 00:00:00
abstract::Medical glue represents a suitable tool to stop wound bleeding, seal wounds, bond tissues, or implant materials. However, the development of a medical glue for durable underwater bonding remains a challenge. Herein, we developed a hydrophobic hyperbranched polymer-based medical glue with water-resistant bonding abilit...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.0c01302
更新日期:2020-12-14 00:00:00
abstract::Aggregation phenomena in aqueous solutions of purified human tracheobronchial mucin have been studied by rheological methods, steady-state fluorescence, quasielastic light scattering, and spin probe techniques. At temperatures below 30 degrees C and concentrations above 15 mg/mL and in the absence of chaotropic agents...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm005532m
更新日期:2000-10-01 00:00:00
abstract::Peptide ligation is an indispensable step in the chemical synthesis of target peptides and proteins that are difficult to synthesize at once by a solid-phase synthesis. The ligation reaction is generally conducted with two peptide fragments at a high aqueous concentration to increase the reaction rate; however, this o...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.8b01655
更新日期:2019-03-11 00:00:00
abstract::The thermally induced aggregation of bovine β-lactoglobulin in the glass state was studied both as the pure protein and in trehalose mixtures. Calorimetric measurements and size exclusion chromatography were used to characterize the glass state and aggregation, respectively. The initial aggregation rate was characteri...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm100785d
更新日期:2010-11-08 00:00:00
abstract::Spider aciniform (or wrapping) silk is the toughest of the seven types of spider silks/glue due to a combination of high elasticity and strength. Like most spider silk proteins (spidroins), aciniform spidroin (AcSp1) has a large core repetitive domain flanked by relatively short N- and C-terminal nonrepetitive domains...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.7b01057
更新日期:2017-11-13 00:00:00
abstract::A lipid bilayer was deposited on a 3 μm diameter polystyrene (PS) bead via hydrophobic anchoring of bicelles containing oxyamine-bearing cholesteric moieties reacting with the aldehyde functionalized bead surface. Discoidal bicelles were formed by mixing dimyristoylphosphatidylcholine (DMPC), dihexanoylphosphatidylcho...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.5b00042
更新日期:2015-03-09 00:00:00
abstract::Synthetic spider silk holds great potential for use in various applications spanning medical uses to ultra lightweight armor; however, producing synthetic fibers with mechanical properties comparable to natural spider silk has eluded the scientific community. Natural dragline spider silks are commonly made from protei...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm9010672
更新日期:2010-01-11 00:00:00
abstract::High molecular weight trimethylene carbonate (TMC) and epsilon-caprolactone (CL) (co)polymers were synthesized. Melt pressed (co)polymer films were cross-linked by gamma irradiation (25 kGy or 50 kGy) in vacuum, yielding gel fractions of up to 70%. The effects of copolymer composition and irradiation dose on the cytot...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm8007988
更新日期:2008-11-01 00:00:00
abstract::Polymer conjugation increases an enzyme's circulation time and stability for use as a therapeutic agent, but this attachment indubitably affects its properties. Covalent attachment of multiple polyethylene glycol chains with sizes of either 2, 5, 10, or 20 kDa increases the molecular weight and hydrodynamic radius of ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm1006954
更新日期:2010-12-13 00:00:00
abstract::Fibrin sealants are a type of soft tissue adhesive that employs biochemical reactions from the late stages of the blood coagulation cascade. Intrinsic to these adhesives are a structural protein and a transglutaminase crosslinking enzyme. We are investigating an alternative biomimetic adhesive based on gelatin and a c...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm034529a
更新日期:2004-07-01 00:00:00
abstract::This article reports on the successful preparation and characterization of cellulose nanocrystals (CNCs) surface-modified with polylactide (PLA) and poly(butylene succinate) (PBS) binary mixed homopolymer brushes. Their synthesis was designed as a three-step procedure combining polyester synthesis and surface-modifica...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.6b00932
更新日期:2016-09-12 00:00:00
abstract::Bioresponsive poly(amidoamine)s (PAA)s are currently under development as endosomolytic polymers for intracellular delivery of proteins and genes. Here for the first time, small-angle neutron scattering (SANS) is used to systematically investigate the pH-dependent conformational change of an endosomolytic polymer, the...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm049936g
更新日期:2004-07-01 00:00:00
abstract::Hydrophilic copolymers with high refractive index and bactericide properties based on quaternary ammonium salts monomers and methacrylates bearing benzothiazole moieties have been developed for application as foldable intraocular lenses. Composition of the systems was adjusted to get materials with optimized flexibili...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm9006997
更新日期:2009-11-09 00:00:00
abstract::The inferior in vivo stability of micellar drugs has been a prime challenge for their application in targeted drug delivery. Here we report on novel galactose-decorated covalently cross-linked biodegradable micelles based on photo-cross-linkable poly(ethylene glycol)-b-poly(acryloyl carbonate)-b-poly(ε-caprolactone) (...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm2006856
更新日期:2011-08-08 00:00:00
abstract::Detailed structural characterization of protein-polymer conjugates and understanding of the interactions between covalently attached polymers and biomolecules will build a foundation to design and synthesize hybrid biomaterials. Conjugates based on simple protein structures are ideal model system to achieve these ends...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm300561y
更新日期:2012-06-11 00:00:00
abstract::Thanks to chemical stabilization, aldehyde-assisted fractionation (AAF) of lignocellulosic biomass has recently emerged as a powerful tool for the production of largely uncondensed lignin. Depolymerization of AAF lignin via ether cleavage provides aromatic monomers at near theoretical yields based on ether cleavage an...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.0c00927
更新日期:2020-10-12 00:00:00
abstract::Ruthenium(II) tris(bipyridine)-centered poly(ethylenimine) (Ru PEI) was synthesized via acid hydrolysis of Ru tris(bipyridine)-centered poly(2-ethyl-2-oxazoline) (Ru PEOX), and the luminescence, DNA entrapment, and transfection efficiencies were evaluated. Emission maxima for Ru PEI samples are red-shifted compared to...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm700481h
更新日期:2007-09-01 00:00:00
abstract::Functionally designed elastomeric nanofiber fabrics made of the equimolar copolyester, poly(L-lactide-co-epsilon-caprolactone) (PLCL), with type I collagen or the tri-n-butylamine salt of heparin (heparin-TBA) were co-electrospun using 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) as a solvent. The co-electrospun fabrics (...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm050086u
更新日期:2005-07-01 00:00:00
abstract::Recently antifreeze proteins (AFP) have been the subject of many structure-function relationship studies regarding their antifreeze activity. Attempts have been made to elucidate the structure-function relationship by various amino acid substitutions, but to our knowledge there has been no successful from first princi...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm000004w
更新日期:2000-07-01 00:00:00
abstract::Incorporating charged amino acid side chains in polypeptide polymer backbones to improve solubility usually leads to reduced secondary structuring. Here we show that highly water soluble (>15 mg.mL-1) β-sheets can be obtained via nucleotide monophosphate grafting onto simple poly(γ-propargyl- L-glutamate) backbone. Th...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.8b01084
更新日期:2018-10-08 00:00:00
abstract::We have developed herein an engineered polymer-based nanoplatform showing the convergence of two-photon fluorescence imaging and bimodal phototherapeutic activity in a single nanostructure. It was achieved through the appropriate choice of three different components: a β-cyclodextrin-based polymer acting as a suitable...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm500156z
更新日期:2014-05-12 00:00:00
abstract::The C-termini of Spidroins produced in the major and minor ampullate glands of spiders are highly conserved. Despite this conservation, no corresponding peptides have been identified in the spinning dopes or the silk filaments so far. To prove their presence or absence, polyclonal antibodies derived against fusion pro...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm034378b
更新日期:2004-05-01 00:00:00
abstract::As a first step toward utilizing self-assembling peptide scaffolds to create tunable matrices for drug delivery, peptide RADAFI and RADAFII, containing the same amino acid composition but different positions of one phenylalanine residue, scaffolds were prepared for controlled release of chiral enantiomers. The release...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm900857j
更新日期:2009-12-14 00:00:00
abstract::The morphologies of several ionotropic alginate hydrogels and aerogels were investigated by SAXS according to the nature of the divalent metal cation (Mn(2+), Co(2+), Zn(2+), Cu(2+)) and the guluronic fraction of the alginate. All alginate hydrogel and aerogel samples show isotropic small-angle X-ray scattering. Gelat...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm201477g
更新日期:2012-01-09 00:00:00
abstract::Tissue regeneration involves versatile types of cells. The accumulation and disorganized behaviors of undesired cells impair the natural healing process, leading to uncontrolled immune response, restenosis, and/or fibrosis. Cell-selective surfaces and interfaces can have specific and positive effects on desired types ...
journal_title:Biomacromolecules
pub_type: 杂志文章,评审
doi:10.1021/acs.biomac.8b00264
更新日期:2018-06-11 00:00:00
abstract::Dynamic mechanical properties of aqueous solutions of hydroxypropyl methyl cellulose (HPMC) were investigated using oscillatory shear measurements. The structure was investigated with light scattering. A systematic investigation of the frequency dependence of the shear moduli showed that HPMC forms two distinct interp...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm401554s
更新日期:2014-01-13 00:00:00
abstract::Nanoparticles (NPs) composed of chitosan (CS) and poly(gamma-glutamic acid) (gamma-PGA) were prepared by a simple ionic-gelation method for oral insulin delivery. Fourier transform infrared (FT-IR) spectra indicated that CS and gamma-PGA were ionized at pH 2.5-6.6, while X-ray diffractograms demonstrated that the crys...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0607776
更新日期:2007-01-01 00:00:00
abstract::Solid-state NMR is especially useful when the structures of peptides and proteins should be analyzed by taking into account the structural distribution, that is, the distribution of the torsion angle of the individual residue. In this study, two-dimensional spin-diffusion solid-state NMR spectra of 13C-double-labeled ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0600522
更新日期:2006-04-01 00:00:00