Abstract：
:Incorporating charged amino acid side chains in polypeptide polymer backbones to improve solubility usually leads to reduced secondary structuring. Here we show that highly water soluble (>15 mg.mL-1) β-sheets can be obtained via nucleotide monophosphate grafting onto simple poly(γ-propargyl- L-glutamate) backbone. This synthetic methodology has been applied to the synthesis of thymidine-based nucleopolypeptides presenting stable β-sheet conformation in aqueous solutions with pH values comprised between 4 and 8. These polymeric analogues of nucleoproteins exhibited selective interaction with simple DNA sequences displaying adenine.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Nguyen M,Stigliani JL,Bijani C,Verhaeghe P,Pratviel G,Bonduelle Cdoi
10.1021/acs.biomac.8b01084subject
Has Abstractpub_date
2018-10-08 00:00:00pages
4068-4074issue
10eissn
1525-7797issn
1526-4602journal_volume
19pub_type
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journal_title：Biomacromolecules
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journal_title：Biomacromolecules
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journal_title：Biomacromolecules
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journal_title：Biomacromolecules
pub_type： 杂志文章
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journal_title：Biomacromolecules
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.6b00906
更新日期：2016-08-08 00:00:00
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