Structural and Mechanical Roles for the C-Terminal Nonrepetitive Domain Become Apparent in Recombinant Spider Aciniform Silk.

abstract：:We synthesized positively charged biodegradable hydrogels by cross-linking of agmatine-modified poly(ethylene glycol)-tethered fumarate (Agm-PEGF) and poly(propylene fumarate-co-ethylene glycol) (P(PF-co-EG)) to investigate the effect of the guanidino groups of the agmatine on hydrogel swelling behavior and smooth mus...

journal_title：Biomacromolecules

authors： Tanahashi K,Jo S,Mikos AG

更新日期：2002-09-01 00:00:00

abstract：:Optimal curcumin delivery for medicinal applications requires a drug delivery system that both solubilizes curcumin and prevents degradation. To achieve this, curcumin has been encapsulated in submicrometer chitosan/Tween 20 particles via a benchtop spray-drying process. Spray-drying parameters have been optimized usi...

journal_title：Biomacromolecules

authors： O'Toole MG,Henderson RM,Soucy PA,Fasciotto BH,Hoblitzell PJ,Keynton RS,Ehringer WD,Gobin AS

更新日期：2012-08-13 00:00:00

abstract：:We report the engineering of intracellular redox-responsive nanoporous poly(ethylene glycol)-poly(l-lysine) particles (NPEG-PLLs). The obtained particles exhibit no toxicity while maintaining the capability to deliver a small interfering RNA sequence (siRNA) targeting the anti-apoptotic factor, survivin, in prostate c...

journal_title：Biomacromolecules

authors： Cavalieri F,Beretta GL,Cui J,Braunger JA,Yan Y,Richardson JJ,Tinelli S,Folini M,Zaffaroni N,Caruso F

更新日期：2015-07-13 00:00:00

abstract：:An underwater bioadhesive generally comprises a multiprotein complex that provides a molecular basis for self-assembly. We report here a new class of self-assembling peptide inspired by a 20 kDa barnacle cement protein. Studies on the chemically synthesized 24-residue peptide have revealed that (1) it underwent irreve...

journal_title：Biomacromolecules

authors： Nakano M,Shen JR,Kamino K

更新日期：2007-06-01 00:00:00

abstract：:A series of Vitamin E (vitE)-labeled PEIs (PEI-vitEn) were synthesized and showed excellent complexation ability with plasmid DNA (pDNA). The cellular uptake of PEI-vitEn/pDNA complexes was greatly enhanced with the increase of vitE labeling, which is much better than that of control PEI25 in three different cell line...

journal_title：Biomacromolecules

authors： Liu J,Feng M,Liang D,Yang J,Tang X

更新日期：2016-10-10 00:00:00

abstract：:The storage and transport of cells is a fundamental technology which underpins cell biology, biomaterials research, and emerging cell-based therapies. Inspired by antifreeze and ice-binding proteins in extremophiles, macromolecular (polymer) cryoprotectants are emerging as exciting biomaterials to enable the reduction...

journal_title：Biomacromolecules

authors： Murray KA,Gibson MI

更新日期：2020-07-13 00:00:00

abstract：:The development of sustainable materials by employing natural and nontoxic resources has been attracting much attention over the previous years. In this work, we discuss for the first time the chemical combination between resorcinol diglycidyl ether (RDGE), an aromatic biobased thermosetting monomer, and polyhydroxybu...

journal_title：Biomacromolecules

authors： Cantarutti C,Dinu R,Mija A

更新日期：2020-08-10 00:00:00

abstract：:The formation of a microvasculature is regulated in large part by cell-cell interactions. Ephrins and their Eph receptors mediate cell adhesion, repulsion, and migration, all critical processes in angiogenesis. (1) Here we use a covalently immobilized ephrinA1, conjugated to poly(ethylene glycol), to induce vessel for...

journal_title：Biomacromolecules

authors： Saik JE,Gould DJ,Keswani AH,Dickinson ME,West JL

更新日期：2011-07-11 00:00:00

abstract：:To broaden the application scope of lactic acid polymers, a new miniemulsion of poly(alkyl methacrylate-graft-lactic acid)s has been developed. The graft copolymer synthesis was based on a poly(lactic acid) macromonomer having a methacryloyl polymerizable group. The macromonomer and a comonomer of n-butyl methacrylate...

journal_title：Biomacromolecules

authors： Ishimoto K,Arimoto M,Ohara H,Kobayashi S,Ishii M,Morita K,Yamashita H,Yabuuchi N

更新日期：2009-10-12 00:00:00

abstract：:We explore here the possibility that polypeptide chains with directional multiplicity might provide for the control of peptide self-assembly processes. We tested this new possibility using an oppositely directed peptide (ODP) supramolecular system. The ODP could make it possible to form a βαβ motif with antiparallel β...

journal_title：Biomacromolecules

authors： Jeong WJ,Han S,Park H,Jin KS,Lim YB

更新日期：2014-06-09 00:00:00

abstract：:Bone fractures constitute a major cause of morbidity and mortality especially in the elderly. Complications associated with osteoporosis drugs and the age of the patient slow bone turnover and render such fractures difficult to heal. Increasing the speed of fracture repair by administration of a fracture-targeted bone...

journal_title：Biomacromolecules

authors： Low SA,Galliford CV,Yang J,Low PS,Kopeček J

更新日期：2015-10-12 00:00:00

abstract：:To evaluate the antidiarrheal effect of ginseng, the active principals of ginseng were studied in vitro model of rotavirus infection, the leading cause of severe diarrhea. Two pectic polysaccharides, named as GP50-dHR (56.0 kDa) and GP50-eHR (77.0 kDa), were purified from hot water extract of ginseng by bioassay-linke...

journal_title：Biomacromolecules

authors： Baek SH,Lee JG,Park SY,Bae ON,Kim DH,Park JH

更新日期：2010-08-09 00:00:00

abstract：:Biomimetic mineralization of collagen is an advantageous method to obtain resorbable collagen/hydroxy-apatite composites for application in bone regeneration. In this report, established procedures for mineralization of bovine collagen were adapted to a new promising source of collagen from salmon skin challenged by t...

journal_title：Biomacromolecules

authors： Hoyer B,Bernhardt A,Heinemann S,Stachel I,Meyer M,Gelinsky M

更新日期：2012-04-09 00:00:00

abstract：:Self-assembled hydrogen-bonded networks of the polysaccharide pectin, a mechanically functional component of plant cell walls, have been of recent interest as biomimetic exemplars of physical gels, and the microrheological and strain-stiffening behaviors have been previously investigated. Despite this detailed rheolog...

journal_title：Biomacromolecules

authors： Mansel BW,Chu CY,Leis A,Hemar Y,Chen HL,Lundin L,Williams MA

更新日期：2015-10-12 00:00:00

abstract：:Poly(butylene adipate-co-terephthalate) (PBAT) was first chemically modified via free radical grafting with maleic anhydride (MA) and the MA-g-PBAT graft copolymer was then used as a matrix material to obtain cellulose nanocrystal (CNC)-reinforced MA-g-PBAT bionanocomposites via reactive extrusion process to accelerat...

journal_title：Biomacromolecules

authors： Kashani Rahimi S,Aeinehvand R,Kim K,Otaigbe JU

更新日期：2017-07-10 00:00:00

abstract：:Anionic copolymer systems containing sulfated monomers have great potential for delivery of cationic therapeutics, but N-isopropylacrylamide (NIPAm) 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS) copolymer nanoparticles have seen limited characterization to date with regard to physical properties relevant to load...

journal_title：Biomacromolecules

authors： Bartlett RL 2nd,Medow MR,Panitch A,Seal B

更新日期：2012-04-09 00:00:00

abstract：:It was aim of the study to investigate the in vivo potential of a novel insulin-thiomer complex nanoparticulate delivery system. Insulin loaded nanoparticles were obtained by the formation of hydrogen bonds between poly(vinyl pyrrolidone) (PVP) and poly(acrylic acid)-cysteine (PAA-Cys) or poly(acrylic acid) (PAA), res...

journal_title：Biomacromolecules

authors： Deutel B,Greindl M,Thaurer M,Bernkop-Schnürch A

更新日期：2008-01-01 00:00:00

abstract：:Inorganic polyphosphates, linear polymers of orthophosphate, occur naturally throughout biology and have many industrial applications. Their biodegradable nature makes them attractive for a multitude of uses, and it would be important to understand how polyphosphates are turned over enzymatically. Studies of inorganic...

journal_title：Biomacromolecules

authors： Hebbard CF,Wang Y,Baker CJ,Morrissey JH

更新日期：2014-08-11 00:00:00

abstract：:Methylprednisolone steroid esters of hyaluronan differing in degree of functionalization and molecular weight were investigated in aqueous solution. Conformation and aggregation phenomena were elucidated by means of circular dichroism, viscometry, rheology, and nuclear magnetic resonance, mainly by (1)H pulsed field g...

journal_title：Biomacromolecules

authors： Taglienti A,Valentini M,Sequi P,Crescenzi V

更新日期：2005-05-01 00:00:00

abstract：:Dynamic shear oscillation measurements at small strain were used to characterize the viscoelastic properties and related differences in the molecular structure of hydrogels based on gelatin methacrylamide. Gelatin was derivatized with methacrylamide side groups and was subsequently cross-linked by radical polymerizati...

journal_title：Biomacromolecules

authors： Van Den Bulcke AI,Bogdanov B,De Rooze N,Schacht EH,Cornelissen M,Berghmans H

更新日期：2000-04-01 00:00:00

abstract：:Properties of Aloe vera galacturonate hydrogels formed via Ca(2+) crosslinking have been studied in regard to key parameters influencing gel formation including molecular weight, ionic strength, and molar ratio of Ca(2+) to COO(-) functionality. Dynamic oscillatory rheology and pulsed field gradient NMR (PFG-NMR) stud...

journal_title：Biomacromolecules

authors： McConaughy SD,Kirkland SE,Treat NJ,Stroud PA,McCormick CL

更新日期：2008-11-01 00:00:00

abstract：:Electrospun biopolyelectrolyte nanofibers hold potential for use in a range of biomedical applications, but eliminating toxic chemicals involved in their production remains a key challenge. In this study, we successfully electrospun nanofibers from an aqueous complex coacervate solution composed of chitosan and hyalur...

journal_title：Biomacromolecules

authors： Sun J,Perry SL,Schiffman JD

更新日期：2019-11-11 00:00:00

abstract：:The photoluminescence features of Eu(3+)-, Tb(3+)-, Tb(3+)/Eu(3+)-alginate aerogel (hydrogel and alcogel) and Eu(3+)-alginate xerogel hybrids were investigated. The Eu(3+)-alginate aerogel and alcogel exhibit the highest (5)D0 quantum efficiencies (9.9 and 8.2%, respectively), while the hydrogel and xerogel have lower...

journal_title：Biomacromolecules

authors： Liu F,Carlos LD,Ferreira RA,Rocha J,Gaudino MC,Robitzer M,Quignard F

更新日期：2008-07-01 00:00:00

abstract：:A new family of cationic dendron-bearing lipids (CDLs) with poly(amidoamine) dendrons of first to third generation (named as A1, A2, and A3, respectively) was synthesized through a synthesis approach that permits facile variation of chemical structures. All CDLs could effectively bind small interfering RNA (siRNA) to ...

journal_title：Biomacromolecules

authors： Zhang Y,Chen J,Xiao C,Li M,Tian H,Chen X

更新日期：2013-12-09 00:00:00

abstract：:Superparamagnetic iron oxide nanoparticles are widely used as nanoprobes for magnetic resonance imaging (MRI). Water-soluble iron oxide nanoparticles were synthesized by coating iron oxide nanoparticles with a hydrophilic, biocompatible, biodegradable poly(amino acid) derivative, poly(2-hydroxyethyl aspartamide) graft...

journal_title：Biomacromolecules

authors： Yang HM,Park CW,Woo MA,Kim MI,Jo YM,Park HG,Kim JD

更新日期：2010-11-08 00:00:00

abstract：:Biomimetic nanocomposites and scaffolds hold the key to a wide range of biomedical applications. Here we show, for the first time, a facile scheme of cofibrillizing pathogenic and functional amyloid fibrils via gold nanoparticles (AuNPs) and their applications against amyloidogenesis. This scheme was realized by β-she...

journal_title：Biomacromolecules

authors： Javed I,Sun Y,Adamcik J,Wang B,Kakinen A,Pilkington EH,Ding F,Mezzenga R,Davis TP,Ke PC

更新日期：2017-12-11 00:00:00

abstract：:Single-walled carbon nanotube (SWNT) is a pseudo-one-dimensional nanostructure capable of carrying/displaying a large number of bioactive molecules and species in aqueous solution. In this work, a series of dendritic beta-D-galactopyranosides and alpha-D-mannopyranosides with a terminal amino group were synthesized an...

journal_title：Biomacromolecules

authors： Gu L,Luo PG,Wang H,Meziani MJ,Lin Y,Veca LM,Cao L,Lu F,Wang X,Quinn RA,Wang W,Zhang P,Lacher S,Sun YP

更新日期：2008-09-01 00:00:00

abstract：:Bioresponsive polymers can enable the development of more effective drug delivery vehicles and medical materials. Acetal-modified polysaccharides allow pH-triggered solubility switching in a versatile and effective manner, but prior work has been limited to a combination of acyclic alkoxyisopropyl and cyclic isopropyl...

journal_title：Biomacromolecules

authors： Graham ET,Broaders KE

更新日期：2019-05-13 00:00:00

abstract：:A variety of natural polymers and proteins are considered to be 3D cell culture structures able to mimic the extracellular matrix (ECM) to promote bone tissue regeneration. Pectin, a natural polysaccharide extracted from the plant cell walls and having a chemical structure similar to alginate, provides interesting pro...

journal_title：Biomacromolecules

authors： Munarin F,Guerreiro SG,Grellier MA,Tanzi MC,Barbosa MA,Petrini P,Granja PL

更新日期：2011-03-14 00:00:00

abstract：:Oligonucleotide-spider silk conjugates can be placed on silicon wafers by complementary DNA strands, which are coupled chemically to the surface. Such specific immobilization of spider silk proteins allows the nucleation and guided growth of β-sheet-rich nanofibrils in the presence of phosphate ions on the surface. Ad...

journal_title：Biomacromolecules

authors： Molina A,Scheibel T,Humenik M

更新日期：2019-01-14 00:00:00