Abstract:
:A series of Vitamin E (vitE)-labeled PEIs (PEI-vitEn) were synthesized and showed excellent complexation ability with plasmid DNA (pDNA). The cellular uptake of PEI-vitEn/pDNA complexes was greatly enhanced with the increase of vitE labeling, which is much better than that of control PEI25 in three different cell lines. PEI-vitE6 showed the best performance in gfp pDNA delivery and following GFP expression in HEK-293A cells. In addition, in vivo gene delivery in living mice also confirmed that PEI-vitE6 showed low toxicity and efficiently delivered gfp pDNA to the cells of liver and lung tissues for gene expression.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Liu J,Feng M,Liang D,Yang J,Tang Xdoi
10.1021/acs.biomac.6b00776subject
Has Abstractpub_date
2016-10-10 00:00:00pages
3153-3161issue
10eissn
1525-7797issn
1526-4602journal_volume
17pub_type
杂志文章abstract::In this work, 6-phosphogluconic trisodium salt (6-PG-Na+) is introduced as a new aqueous and nontoxic cross-linking agent to obtain ionic hydrogels. Here, it is shown the formation of hydrogels based on chitosan cross-linked with 6-PG-Na+. This formulation is obtained by ionic interaction of cationic groups of polymer...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.8b00108
更新日期:2018-04-09 00:00:00
abstract::Transparent and bendable regenerated cellulose films prepared from aqueous alkali (NaOH or LiOH)/urea (AU) solutions exhibit high oxygen barrier properties, which are superior to those of conventional cellophane, poly(vinylidene chloride), and poly(vinyl alcohol). Series of AU cellulose films are prepared from differe...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm200766v
更新日期:2011-07-11 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm9000475
更新日期:2009-04-13 00:00:00
abstract::l-Proline is the only, out of 20 essential, amino acid that contains a cyclized substituted α-amino group (is formally an imino acid), which restricts its conformational shape. The synthesis of well-defined homo- and copolymers of l-proline has been plagued either by the low purity of the monomer or the inability of m...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm200495n
更新日期:2011-06-13 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.6b01148
更新日期:2016-11-14 00:00:00
abstract::Inulin, the polydisperse reserve polysaccharide from chicory, has been modified by carbamoylation in organic solvents. The reaction of inulin with a range of alkyl isocyanates resulted, after crystalization, in a variety of carbamoylated inulins from which the interfacial properties were determined. The medium and lon...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm015570l
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journal_title:Biomacromolecules
pub_type: 杂志文章
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.9b01211
更新日期:2019-10-14 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm3002683
更新日期:2012-05-14 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm201012f
更新日期:2011-11-14 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm8008457
更新日期:2008-11-01 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm070352z
更新日期:2007-08-01 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
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更新日期:2009-01-12 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
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更新日期:2010-02-08 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
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更新日期:2019-12-09 00:00:00
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journal_title:Biomacromolecules
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更新日期:2005-11-01 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060432n
更新日期:2006-10-01 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
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journal_title:Biomacromolecules
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journal_title:Biomacromolecules
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journal_title:Biomacromolecules
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journal_title:Biomacromolecules
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更新日期:2014-07-14 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
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更新日期:2008-03-01 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.6b01094
更新日期:2016-11-14 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.8b00088
更新日期:2018-04-09 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm010150h
更新日期:2002-03-01 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
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更新日期:2007-11-01 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm034514c
更新日期:2004-05-01 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.5b00823
更新日期:2015-09-14 00:00:00