Abstract:
:Superparamagnetic iron oxide nanoparticles are widely used as nanoprobes for magnetic resonance imaging (MRI). Water-soluble iron oxide nanoparticles were synthesized by coating iron oxide nanoparticles with a hydrophilic, biocompatible, biodegradable poly(amino acid) derivative, poly(2-hydroxyethyl aspartamide) graft copolymer for negative contrast enhancement on T2 weighted MRI. HER2/neu antibodies were conjugated on the surface of poly(amino acid) coated iron oxide nanoparticles for the detection of breast cancer. The antibody-grafted iron oxide nanoparticles (PAION-Ab) were about 31.1 nm in diameter. The T2 relaxivity of PAION-Ab was 246 L·mmol(-1)·sec(-1) greater than that of the commercial product such as Feridex. PAION-Ab showed low cytotoxicity even at relatively high concentrations. Furthermore, Prussian blue staining and in vitro MRI study with SKBR-3, breast cancer cells overexpressing HER2/neu receptors indicated that PAION-Ab exhibited excellent cancer cell detection ability and enhanced signal intensities in the T2-weighted image.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Yang HM,Park CW,Woo MA,Kim MI,Jo YM,Park HG,Kim JDdoi
10.1021/bm100560msubject
Has Abstractpub_date
2010-11-08 00:00:00pages
2866-72issue
11eissn
1525-7797issn
1526-4602journal_volume
11pub_type
杂志文章abstract::Electrochemically controlled, reversible assembly of biopolymers into hydrogel structures is a promising technique for on-demand cell or drug encapsulation and release systems. An electrochemically sol-gel transition has been demonstrated in regenerated Bombyx mori silk fibroin, offering a controllable way to generate...
journal_title:Biomacromolecules
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journal_title:Biomacromolecules
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journal_title:Biomacromolecules
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journal_title:Biomacromolecules
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journal_title:Biomacromolecules
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journal_title:Biomacromolecules
pub_type: 杂志文章,评审
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journal_title:Biomacromolecules
pub_type: 杂志文章
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更新日期:2010-10-11 00:00:00
abstract::Herein, we developed a new gene delivery vector by grafting a betaine monomer (N,N-dimethyl(acrylamidopropyl)ammonium propane sulfonate, DMAAPS) onto 25 KDa polyethylenimine (PEI 25K) via the Michael addition reaction. The graft ratio for betaine on PEI polymer could be readily controlled, and in this study three PEI-...
journal_title:Biomacromolecules
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journal_title:Biomacromolecules
pub_type: 杂志文章
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更新日期:2010-01-11 00:00:00
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journal_title:Biomacromolecules
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journal_title:Biomacromolecules
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更新日期:2006-09-01 00:00:00
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journal_title:Biomacromolecules
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更新日期:2019-07-08 00:00:00
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更新日期:2019-03-11 00:00:00
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journal_title:Biomacromolecules
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