Temperature-induced ultradense PEG polyelectrolyte surface grafting provides effective long-term bioresistance against mammalian cells, serum, and whole blood.

abstract：:The interaction of polysaccharides with water has a critical impact on their biological function as well as their technological applications. We performed ellipsometry experiments at different relative humidities (RH) to measure the equilibrium swelling of ultrathin films of different polysaccharides: native and modif...

journal_title：Biomacromolecules

authors： Grossutti M,Dutcher JR

更新日期：2020-12-14 00:00:00

abstract：:The pressure and temperature dependence of the cloud point transition of an aqueous solution of an elastin-like polypeptide (MGLDGSMG(VPGIG)40VPLE), prepared by bacterial expression of the corresponding artificial gene, was measured. A temperature-pressure diagram was constructed over a wide range of conditions. The (...

journal_title：Biomacromolecules

authors： Tamura T,Yamaoka T,Kunugi S,Panitch A,Tirrell DA

更新日期：2000-01-01 00:00:00

abstract：:In this study, generation 5 (G5) polyamidoamine (PAMAM) dendrimers with two different surface groups, G4.5-COOH and G5-OH, were investigated for their protective effects on pancreas injury in a caerulein-induced acute pancreatitis (AP) mouse model. Both dendrimers significantly decreased pathological changes in the pa...

journal_title：Biomacromolecules

authors： Tang Y,Han Y,Liu L,Shen W,Zhang H,Wang Y,Cui X,Wang Y,Liu G,Qi R

更新日期：2015-01-12 00:00:00

abstract：:Self-assembly in aqueous solution of two oppositely charged globular proteins, hen egg white lysozyme (LYS) and bovine calcium-depleted α-lactalbumin (apo α-LA), was investigated at pH 7.5. The aggregation rate of equimolar mixtures of the two proteins was determined using static and dynamic light scattering as a func...

journal_title：Biomacromolecules

authors： Salvatore D,Croguennec T,Bouhallab S,Forge V,Nicolai T

更新日期：2011-05-09 00:00:00

abstract：:A one-step synthesis of a curcumin-derived hydrogel (curcumin content of 25-75 mol %) is reported. Curcumin is incorporated into the hydrogel backbone and cross-linked through biodegradable carbonate linkages. Curcumin as a part of the polymer backbone is protected from oxidation and degradation, while hydrogel hydrol...

journal_title：Biomacromolecules

authors： Shpaisman N,Sheihet L,Bushman J,Winters J,Kohn J

更新日期：2012-08-13 00:00:00

abstract：:Encapsulation of hydrophilic cancer drugs in polymeric nanocapsules was achieved in a one-pot process via the inverse miniemulsion periphery RAFT polymerization (IMEPP) approach. The chosen guest molecule was gemcitabine hydrochloride, which is used as the first-line treatment of pancreatic cancer. The resulting nanoc...

journal_title：Biomacromolecules

authors： Utama RH,Jiang Y,Zetterlund PB,Stenzel MH

更新日期：2015-07-13 00:00:00

abstract：:Effects of molecular weight (Lc) and field strength (E) on conformation of polymer chains and their density are investigated at the surface and bulk of a driven chain system in three dimensions with a Monte Carlo simulation. As the polymer chains deposit on the surface, a linear density gradient develops in low field....

journal_title：Biomacromolecules

authors： Foo GM,Pandey RB

更新日期：2000-10-01 00:00:00

abstract：:We describe a facile method to amine functionalize and subsequently fluorescently label polymethacrylamides synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. RAFT-generated poly(N-(2-hydroxypropyl) methacrylamide-b-N-[3-(dimethylamino)propyl] methacrylamide) (poly(HPMA-b-DMAPMA)),...

journal_title：Biomacromolecules

authors： York AW,Scales CW,Huang F,McCormick CL

更新日期：2007-08-01 00:00:00

abstract：:Shear flow is indirectly implicated in amyloid formation in vitro. Despite the association between amyloid fibrils and disease, and the prevalence of flow in physiological systems, the effect of this parameter is uncharacterized. We designed a novel Couette cell to quantitatively investigate shear exposure during fibr...

journal_title：Biomacromolecules

authors： Hill EK,Krebs B,Goodall DG,Howlett GJ,Dunstan DE

更新日期：2006-01-01 00:00:00

abstract：:n-Heptyl α-d-mannose (HM) is a nanomolar antagonist of FimH, a virulence factor of E. coli. Herein we report on the construction of multivalent HM-based glycopolymers as potent antiadhesives of type 1 piliated E. coli. We investigate glycopolymer/FimH and glycopolymer/bacteria interactions and show that HM-based glyco...

journal_title：Biomacromolecules

authors： Yan X,Sivignon A,Yamakawa N,Crepet A,Travelet C,Borsali R,Dumych T,Li Z,Bilyy R,Deniaud D,Fleury E,Barnich N,Darfeuille-Michaud A,Gouin SG,Bouckaert J,Bernard J

更新日期：2015-06-08 00:00:00

abstract：:The synthesis and polymerization of six AB(3) tapered self-assembling methacrylate monomers (5a, 5b, 5c,5d, 17a, and 17b) based on first generation alkyl substituted benzyl ether monodendrons (i.e., minidendrons) containing oligooxyethylene units at their focal point and the polymerizable group on their periphery are ...

journal_title：Biomacromolecules

authors： Percec V,Bera TK

更新日期：2002-01-01 00:00:00

abstract：:We prepared statistical copolymers composed of 2-methyl-2-oxazoline (MeOx) in combination with 2-butenyl-2-oxazoline (BuOx) or 2-decenyl-2-oxazoline (DecOx) as a basis for polymer analogous introduction of 1,2-aminothiol moieties at the side chain. MeOx provides hydrophilicity as well as cyto- and hemocompatibility, w...

journal_title：Biomacromolecules

authors： Schmitz M,Kuhlmann M,Reimann O,Hackenberger CP,Groll J

更新日期：2015-04-13 00:00:00

abstract：:Many dental restorative dental composites still utilize 2,2-bis[4-(2-hydroxy-3-methacryloyloxy propoxy) phenyl] propane (Bis-GMA) as base resin. The high viscosity of Bis-GMA necessitates dilution with dimethacrylate ethers of low viscosity such as triethylene glycol dimethacrylate (TEGDMA). However, increased amounts...

journal_title：Biomacromolecules

authors： Kim JW,Kim LU,Kim CK,Cho BH,Kim OY

更新日期：2006-01-01 00:00:00

abstract：:The self-assembly properties of fibrous proteins such as collagen are frequently used to form three-dimensional scaffolds. In this study we investigated the effect of nonuniform alternating and static electric-fields on the self-assembly properties of a dilute solution of vimentin. In the presence of both types of fie...

journal_title：Biomacromolecules

authors： Colbourne TR,Hill IG,Kreplak L

更新日期：2009-07-13 00:00:00

abstract：:Vascular grafts that can support total replacement and maintenance by the body of the injured vessel would improve outcomes of major surgical reconstructions. Building scaffolds using components of the native vessel can encourage biological recognition by native cells as well as mimic mechanical characteristics of the...

journal_title：Biomacromolecules

authors： Bracaglia LG,Messina M,Winston S,Kuo CY,Lerman M,Fisher JP

更新日期：2017-11-13 00:00:00

abstract：:Two poly(amido-amine)s (oligoPAM and oligoNER) containing bis-phosphonate residues were obtained by a Michael-type polyaddition of pamidronate and neridronate to 1,4-bis(acryloyl)piperazine. The SEC (size-exclusion chromatography) and the MALDI-TOF (matrix assisted laser desorption ionization) analyses were consistent...

journal_title：Biomacromolecules

authors： Casolaro M,Casolaro I,Spreafico A,Capperucci C,Frediani B,Marcolongo R,Margiotta N,Ostuni R,Mendichi R,Samperi F,Ishii T,Ito Y

更新日期：2006-12-01 00:00:00

abstract：:Amphiphilic block copolymer self-assembly provides a versatile means to prepare nanoscale micelles in solution. The utilization of these structures as targeted drug delivery vehicles has motivated efforts to prepare bioactive ligand-functionalized polymer micelles. The impact of ligand conjugation on micelle morpholog...

journal_title：Biomacromolecules

authors： Zupancich JA,Bates FS,Hillmyer MA

更新日期：2009-06-08 00:00:00

abstract：:The nature of the hydration of proteins and the subsequent implications for functionality is a matter of importance in both pharmaceutical and food applications. Most published studies rely on the use of one technique and attempt to characterize the system. Few studies have used combinations of techniques. In this pap...

journal_title：Biomacromolecules

authors： Almutawah A,Barker SA,Belton PS

更新日期：2007-05-01 00:00:00

abstract：:A polyethylene glycol (PEG) retinylamine (Ret-NH2) conjugate PEG-GFL-NH-Ret with a glycine-phenylalanine-leucine (GFL) spacer was synthesized for controlled oral delivery of Ret-NH2 to treat retinal degenerative diseases, including Stargardt disease (STGD) and age-related macular degeneration (AMD). The peptide spacer...

journal_title：Biomacromolecules

authors： Yu G,Wu X,Ayat N,Maeda A,Gao SQ,Golczak M,Palczewski K,Lu ZR

更新日期：2014-12-08 00:00:00

abstract：:A novel aptamer modified thermosensitive liposome was designed as an efficient magnetic resonance imaging probe. In this paper, Gd-DTPA was encapsulated into an optimized thermosensitive liposome (TSL) formulation, followed by conjugation with AS1411 for specific targeting against tumor cells that overexpress nucleoli...

journal_title：Biomacromolecules

authors： Zhang K,Liu M,Tong X,Sun N,Zhou L,Cao Y,Wang J,Zhang H,Pei R

更新日期：2015-09-14 00:00:00

abstract：:We show the first example of a synergic approach of oxidant (ROS) scavenging carrier and ROS-responsive drug release in the context of a potential therapy against osteoporosis, aiming to inhibit the differentiation of inflammatory cells into osteoclasts. In our "tandem" approach, a branched amphiphilic, PEGylated poly...

journal_title：Biomacromolecules

authors： El Mohtadi F,d'Arcy R,Burke J,Rios De La Rosa JM,Gennari A,Marotta R,Francini N,Donno R,Tirelli N

更新日期：2020-02-10 00:00:00

abstract：:Mutually complementary, self-repulsive oligopeptide pairs were designed to coassemble into viscoelastic hydrogels. Peptide engineering was combined with biophysical techniques to investigate the effects of temperature on the structural and mechanical properties of the resulting hydrogels. Biophysical characterizations...

journal_title：Biomacromolecules

authors： Ramachandran S,Taraban MB,Trewhella J,Gryczynski I,Gryczynski Z,Yu YB

更新日期：2010-06-14 00:00:00

abstract：:Properties of Aloe vera galacturonate hydrogels formed via Ca(2+) crosslinking have been studied in regard to key parameters influencing gel formation including molecular weight, ionic strength, and molar ratio of Ca(2+) to COO(-) functionality. Dynamic oscillatory rheology and pulsed field gradient NMR (PFG-NMR) stud...

journal_title：Biomacromolecules

authors： McConaughy SD,Kirkland SE,Treat NJ,Stroud PA,McCormick CL

更新日期：2008-11-01 00:00:00

abstract：:Biomaterials conceived for vectorization of bioactives are currently considered for biomedical, biological, and environmental applications. We have produced a pH-sensitive biomaterial composed of natural source alginate and chitosan polysaccharides for application as a drug delivery system via oral administration. The...

journal_title：Biomacromolecules

authors： Mathews PD,Fernandes Patta ACM,Gonçalves JV,Gama GDS,Garcia ITS,Mertins O

更新日期：2018-02-12 00:00:00

abstract：:Low tolerability and tumor selectivity restricts many potent anticancer drugs including mertansine from wide clinical use. Here, glutathione-activatable hyaluronic acid-SS-mertansine prodrug (HA-SS-DM1) was designed and developed to achieve enhanced tolerability and targeted therapy of CD44+ human breast tumor xenogra...

journal_title：Biomacromolecules

authors： Zhong P,Zhang J,Deng C,Cheng R,Meng F,Zhong Z

更新日期：2016-11-14 00:00:00

abstract：:On the basis of their versatile structure and chemistry as well as tunable mechanical properties, polymer brushes are well-suited as supports for enzyme immobilization. However, a robust surface design is hindered by an inadequate understanding of the impact on activity from the coupling motif and enzyme distribution ...

journal_title：Biomacromolecules

authors： Lane SM,Kuang Z,Yom J,Arifuzzaman S,Genzer J,Farmer B,Naik R,Vaia RA

更新日期：2011-05-09 00:00:00

abstract：:The oxidation-responsive behaviors of OEGylated poly-L-cysteine homopolypeptides, that is, poly(L-EG(x)MA-C)n, were investigated. These poly-L-cysteine derivatives adopted mixed conformation in water, in which the β-sheet accounted for a significant proportion. Upon oxidation, the thioethers in polypeptide side chains...

journal_title：Biomacromolecules

authors： Fu X,Ma Y,Shen Y,Fu W,Li Z

更新日期：2014-03-10 00:00:00

abstract：:Spider dragline silk exhibits an extraordinary toughness and is typically composed of two types of major ampullate spidroins (MaSp1 and MaSp2), differing in their proline content and hydrophobicity. In this paper, we recombinantly produced an unusual but naturally occurring short major ampullate spidroin (MaSp1s) as a...

journal_title：Biomacromolecules

authors： Thamm C,Scheibel T

更新日期：2017-04-10 00:00:00

abstract：:Polycaprolactone (PCL) was reported a long time ago; however, its biomedical applications has not been extensively investigated in comparison with poly(lactide- co-glycolide) (PLGA) due to its too slow degradation profile. Here, we are reporting an oxalate-connected oligocaprolactone multiblock copolymer (PCL-OX) as a...

journal_title：Biomacromolecules

authors： Chang SH,Lee HJ,Park S,Kim Y,Jeong B

更新日期：2018-06-11 00:00:00

abstract：:Recombinant spider silk proteins mimicking the properties of dragline silk proteins represent a class of materials that hold great potential for future high-performance applications. Here we explore the self-assembly behavior of a recombinantly produced spider silk protein based on the dragline silk of the Araneus di...

journal_title：Biomacromolecules

authors： Young SL,Gupta M,Hanske C,Fery A,Scheibel T,Tsukruk VV

更新日期：2012-10-08 00:00:00