Oxidation-responsive OEGylated poly-L-cysteine and solution properties studies.

Abstract:

:The oxidation-responsive behaviors of OEGylated poly-L-cysteine homopolypeptides, that is, poly(L-EG(x)MA-C)n, were investigated. These poly-L-cysteine derivatives adopted mixed conformation in water, in which the β-sheet accounted for a significant proportion. Upon oxidation, the thioethers in polypeptide side chains were converted to polar sulfone groups, which triggered the secondary structure transition from β-sheet preferred conformation to random coil. Accordingly, the increase of side-chain polarity together with conformation changes increased samples' water solubility and cloud point temperature. Using mPEG45-NH2 as macroinitiator, we synthesized PEG45-b-poly(L-EG2MA-C)22 diblock copolymer via ring-opening polymerization (ROP) of L-EG2MA-C N-carboxyanhydride (NCA). The PEG45-b-poly(L-EG2MA-C)22 was able to self-assemble into spherical micelles in aqueous solution, and the micelles could undergo an oxidation-triggered disassembly due to the oxidation-responsive thioethers. Such a new class of oxidation-responsive polypeptides might provide a promising platform to construct inflammation targeting drug delivery systems.

journal_name

Biomacromolecules

journal_title

Biomacromolecules

authors

Fu X,Ma Y,Shen Y,Fu W,Li Z

doi

10.1021/bm5000554

subject

Has Abstract

pub_date

2014-03-10 00:00:00

pages

1055-61

issue

3

eissn

1525-7797

issn

1526-4602

journal_volume

15

pub_type

杂志文章
  • SEC-MALS-QELS study on the molecular conformation of cellulose in LiCl/amide solutions.

    abstract::The SEC-MALS-QELS (size-exclusion chromatography equipped with multiangle light scattering and quasi-elastic light scattering detectors) method using lithium chloride/N,N-dimethylacetamide (LiCl/DMAc) and LiCl/1,3-dimethyl-2-imidazolidinone (LiCl/DMI) as mobile phases was applied to cellulose and cellulose tricarbanil...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm049386m

    authors: Yanagisawa M,Isogai A

    更新日期:2005-05-01 00:00:00

  • Controlled release and entrapment of enantiomers in self-assembling scaffolds composed of beta-sheet peptides.

    abstract::As a first step toward utilizing self-assembling peptide scaffolds to create tunable matrices for drug delivery, peptide RADAFI and RADAFII, containing the same amino acid composition but different positions of one phenylalanine residue, scaffolds were prepared for controlled release of chiral enantiomers. The release...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm900857j

    authors: Zhao Y,Tanaka M,Kinoshita T,Higuchi M,Tan T

    更新日期:2009-12-14 00:00:00

  • A platelet-mimetic paradigm for metastasis-targeted nanomedicine platforms.

    abstract::There is compelling evidence that, beyond their traditional role in hemostasis and thrombosis, platelets play a significant role in mediating hematologic mechanisms of tumor metastasis by directly and indirectly interacting with pro-metastatic cancer cells. With this rationale, we hypothesized that platelets can be an...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm301996p

    authors: Modery-Pawlowski CL,Master AM,Pan V,Howard GP,Sen Gupta A

    更新日期:2013-03-11 00:00:00

  • Theoretical Rationalization of Self-Assembly of Cellulose Nanocrystals: Effect of Surface Modifications and Counterions.

    abstract::The hierarchical self-assembly of cellulose nanocrystals (CNCs) is an important phenomenon occurring naturally in plant cell walls. Utilization of this assembly for advanced applications requires a fundamental theoretical understanding of interactions between the CNCs, which is still incomplete. Hence, in this work, w...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.0c00469

    authors: Garg M,Linares M,Zozoulenko I

    更新日期:2020-08-10 00:00:00

  • Self-Assembly of Mesoscopic Peptide Surfactant Fibrils Investigated by STORM Super-Resolution Fluorescence Microscopy.

    abstract::Super-resolution fluorescence microscopy, specifically stochastic reconstruction microscopy (STORM), and atomic force microscopy (AFM) were used to image the self-assembly processes of the peptide surfactant I3K. The peptide surfactants self-assembled into giant helical fibrils with diameters between 5 and 10 nm with ...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.7b00465

    authors: Cox H,Georgiades P,Xu H,Waigh TA,Lu JR

    更新日期:2017-11-13 00:00:00

  • Block versus random amphiphilic copolymers as antibacterial agents.

    abstract::We examined the antibacterial and hemolytic activities in a series of amphiphilic block and random copolymers of poly(vinyl ether) derivatives prepared by base-assisting living cationic polymerization. Block and random amphiphilic copolymers with similar monomer compositions showed the same level of activity against ...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm200780r

    authors: Oda Y,Kanaoka S,Sato T,Aoshima S,Kuroda K

    更新日期:2011-10-10 00:00:00

  • Heterostereocomplexes prepared from d-PLA and l-PLA and leuprolide. II. Release of leuprolide.

    abstract::Reversible stereoselective complexes were spontaneously obtained from mixing acetonitrile solutions of enatiomeric d-poly(lactic acid) (d-PLA), l-poly(lactic acid) (l-PLA), and leuprolide, a l-configured nonapeptide LHRH analogue. The complex spontaneously aggregated and precipitated in high yields (>90%) from acetoni...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm0300249

    authors: Slager J,Domb AJ

    更新日期:2003-09-01 00:00:00

  • Effects of emulsion droplet size on the structure of electrospun ultrafine biocomposite fibers with cellulose nanocrystals.

    abstract::Electrospinning of cellulose nanocrystals (CNC)/poly(lactic acid) (PLA) emulsions has been demonstrated to be an effective dispersion and alignment method to control assembly of CNC into continuous composite ultrafine fibers. CNC-PLA nanocomposite random-fiber mats and aligned-fiber yarns were prepared by emulsion ele...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm400540v

    authors: Li Y,Ko FK,Hamad WY

    更新日期:2013-11-11 00:00:00

  • Injectable Polypeptide Hydrogels with Tunable Microenvironment for 3D Spreading and Chondrogenic Differentiation of Bone-Marrow-Derived Mesenchymal Stem Cells.

    abstract::Bone-marrow-derived mesenchymal stem cells (BMSCs) possess vast potential for tissue engineering and regenerative medicine. In this study, an injectable hydrogel comprising poly(l-glutamic acid)-graft-tyramine (PLG-g-TA) with tunable microenvironment was developed via enzyme-catalyzed cross-linking and used as an arti...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.6b00884

    authors: Ren K,Cui H,Xu Q,He C,Li G,Chen X

    更新日期:2016-12-12 00:00:00

  • Injectable and Self-Healing Dynamic Hydrogels Based on Metal(I)-Thiolate/Disulfide Exchange as Biomaterials with Tunable Mechanical Properties.

    abstract::Despite numerous strategies involving dynamic covalent bonds to produce self-healing hydrogels with similar frequency-dependent stiffness to native tissues, it remains challenging to use biologically relevant thiol/disulfide exchange to confer such properties to polymeric networks. Herein, we report a new method based...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.5b00980

    authors: Casuso P,Odriozola I,Pérez-San Vicente A,Loinaz I,Cabañero G,Grande HJ,Dupin D

    更新日期:2015-11-09 00:00:00

  • Horseradish peroxidase-catalyzed polymerization of cardanol in the presence of redox mediators.

    abstract::Horseradish peroxidase-catalyzed polymerization of cardanol in aqueous organic solvent was investigated in the presence of a redox mediator. Cardanol is a phenol derivative from a renewable resource mainly having a C15 unsaturated hydrocarbon chain with mostly 1-3 double bonds at a meta position. Unlike soybean peroxi...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm034325u

    authors: Won K,Kim YH,An ES,Lee YS,Song BK

    更新日期:2004-01-01 00:00:00

  • Sulfated Dendritic Polyglycerol Is a Potent Complement Inhibitor.

    abstract::The complement system is a powerful mechanism of the innate immune defense system. Dysregulation may contribute to several diseases. Heparin is a known regulator of the complement system, but its application is limited due to its anticoagulative activity. A promising alternative is the synthetic analogue dendritic pol...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.9b00889

    authors: Silberreis K,Niesler N,Rades N,Haag R,Dernedde J

    更新日期:2019-10-14 00:00:00

  • Synthesis and characterization of core-shell star copolymers for in vivo PET imaging applications.

    abstract::The synthesis of core-shell star copolymers via living free radical polymerization provides a convenient route to three-dimensional nanostructures having a poly(ethylene glycol) outer shell, a hydrophilic inner shell bearing reactive functional groups, and a central hydrophobic core. By starting with well-defined line...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm7014152

    authors: Fukukawa K,Rossin R,Hagooly A,Pressly ED,Hunt JN,Messmore BW,Wooley KL,Welch MJ,Hawker CJ

    更新日期:2008-04-01 00:00:00

  • Self-Assembled Peptide-Carbon Nitride Hydrogel as a Light-Responsive Scaffold Material.

    abstract::Peptide self-assembly is a facile route to the development of bioorganic hybrid materials that have sophisticated nanostructures toward diverse applications. Here, we report the synthesis of self-assembled peptide (Fmoc-diphenylalanine, Fmoc-FF)/graphitic carbon nitride (g-C3N4) hydrogels for light harvesting and biom...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.7b00889

    authors: Ko JW,Choi WS,Kim J,Kuk SK,Lee SH,Park CB

    更新日期:2017-11-13 00:00:00

  • Does water activity rule P. mirabilis periodic swarming? I. Biochemical and functional properties of the extracellular matrix.

    abstract::The dynamics of bacterial colonies is complex in nature because it correlates the behavior of numerous individual cells in space and time and is characterized by emergent properties such as virulence or antibiotics resistance. Because there is no clear-cut evidence that periodic swarming of P. mirabilis colonies is ru...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm061181l

    authors: Lahaye E,Aubry T,Kervarec N,Douzenel P,Sire O

    更新日期:2007-04-01 00:00:00

  • Laminin-Inspired Cell-Instructive Microenvironments for Neural Stem Cells.

    abstract::Laminin is a heterotrimeric glycoprotein with a key role in the formation and maintenance of the basement membrane architecture and properties, as well as on the modulation of several biological functions, including cell adhesion, migration, differentiation and matrix-mediated signaling. In the central nervous system ...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.9b01319

    authors: Barros D,Amaral IF,Pêgo AP

    更新日期:2020-02-10 00:00:00

  • Dielectric relaxation spectroscopy of hydrated and dehydrated silk fibroin cast from aqueous solution.

    abstract::The dynamics of silk protein in the presence and absence of water has been investigated by dielectric relaxation spectroscopy (DRS). The silk fibroin film cast from its water solution contains 4-7 wt % bound water molecules, which can be removed by dehydration at 165 °C. Temperature and frequency scans were performed ...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm1008316

    authors: Yu L,Hu X,Kaplan D,Cebe P

    更新日期:2010-10-11 00:00:00

  • Improving the properties of chitosan as support for the covalent multipoint immobilization of chymotrypsin.

    abstract::Changing gel structure and immobilization conditions led to a significant improvement in the covalent multipoint attachment of chymotrypsin on chitosan. The use of sodium alginate, gelatin, or kappa-carrageenan, activation with glutaraldehyde, glycidol, or epichlorohydrin, and addition of microorganisms followed by ce...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm8002754

    authors: Adriano WS,Mendonça DB,Rodrigues DS,Mammarella EJ,Giordano RL

    更新日期:2008-08-01 00:00:00

  • Zwitterion Surface-Functionalized Thermoplastic Polyurethane for Antifouling Catheter Applications.

    abstract::Immobilizing zwitterionic molecules on material surfaces has been a promising strategy for creating antifouling surfaces. Herein, we show the ability to surface derivatize an allyl-ether-functionalized thermoplastic polyurethane (TPU) with a zwitterionic thiol in a radically induced thiol-ene reaction. The thermoplast...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.0c00456

    authors: Nikam SP,Chen P,Nettleton K,Hsu YH,Becker ML

    更新日期:2020-07-13 00:00:00

  • Digestive Enzyme Corona Formed in the Gastrointestinal Tract and Its Impact on Epithelial Cell Uptake of Nanoparticles.

    abstract::The fate of intravenously injected nanoparticles (NPs) is significantly affected by nano-protein interaction and corona formation. However, such an interaction between NPs and digestive enzymes occurring in the gastrointestinal tract (GIT) and its impacts on epithelial cell uptake are little known. We synthesized the ...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.9b00175

    authors: Peng Q,Liu J,Zhang T,Zhang TX,Zhang CL,Mu H

    更新日期:2019-04-08 00:00:00

  • Recombinant Production, Characterization, and Fiber Spinning of an Engineered Short Major Ampullate Spidroin (MaSp1s).

    abstract::Spider dragline silk exhibits an extraordinary toughness and is typically composed of two types of major ampullate spidroins (MaSp1 and MaSp2), differing in their proline content and hydrophobicity. In this paper, we recombinantly produced an unusual but naturally occurring short major ampullate spidroin (MaSp1s) as a...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.7b00090

    authors: Thamm C,Scheibel T

    更新日期:2017-04-10 00:00:00

  • Engineering Nonmechanical Protein-Based Hydrogels with Highly Mechanical Properties: Comparison with Natural Muscles.

    abstract::The elegant elasticity and toughness of muscles that are controlled by myofilament sliding, highly elastic springlike properties of titin, and Ca2+-induced conformational change of the troponin complex have been a source of inspiration to develop advanced materials for simulating elastic muscle motion. Herein, a highl...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.0c01002

    authors: Zhao L,Zhang X,Luo Q,Hou C,Xu J,Liu J

    更新日期:2020-10-12 00:00:00

  • Locally controlled release of basic fibroblast growth factor from multilayered capsules.

    abstract::Biodegradable multilayered capsules encapsulating basic fibroblast growth factor (bFGF) were developed as a cytokine release carrier for drug delivery systems. The multilayered hollow capsules were fabricated via the layer-by-layer (LbL) assembly of chitosan (CT) and dextran sulfate (Dex). The bFGF was encapsulated in...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm800321w

    authors: Itoh Y,Matsusaki M,Kida T,Akashi M

    更新日期:2008-08-01 00:00:00

  • Characterization of methylprednisolone esters of hyaluronan in aqueous solution: conformation and aggregation behavior.

    abstract::Methylprednisolone steroid esters of hyaluronan differing in degree of functionalization and molecular weight were investigated in aqueous solution. Conformation and aggregation phenomena were elucidated by means of circular dichroism, viscometry, rheology, and nuclear magnetic resonance, mainly by (1)H pulsed field g...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm049221d

    authors: Taglienti A,Valentini M,Sequi P,Crescenzi V

    更新日期:2005-05-01 00:00:00

  • Molecular Orientation Enhancement of Silk by the Hot-Stretching-Induced Transition from α-Helix-HFIP Complex to β-Sheet.

    abstract::Enhancing the molecular orientation of the regenerated silk fibroin (RF) up to a level comparable to the native silk is highly challenging. Our novel and promising strategy for the poststretching process is (1) creating at first an α-helix-HFIP complex with a hexagonal packing as an intermediate state and then (2) str...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.6b00043

    authors: Yoshioka T,Tashiro K,Ohta N

    更新日期:2016-04-11 00:00:00

  • Collagen fibril structure is affected by collagen concentration and decorin.

    abstract::Collagen fibrils were obtained in vitro by aggregation from acid-soluble type I collagen at different initial concentrations and with the addition of decorin core or intact decorin. All specimens were observed by scanning electron microscopy and atomic force microscopy. In line with the findings of other authors, lack...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm070091t

    authors: Raspanti M,Viola M,Sonaggere M,Tira ME,Tenni R

    更新日期:2007-07-01 00:00:00

  • Lysozyme-lysozyme and lysozyme-salt interactions in the aqueous saline solution: a new square-well potential.

    abstract::We investigate lysozyme-lysozyme and lysozyme-salt interactions in electrolyte solutions using a molecular-thermodynamic model. An equation of state based on the statistical mechanical perturbation theory is applied to describe the interactions. The perturbation term includes a new square-well potential of mean force,...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm0300406

    authors: Chang BH,Bae YC

    更新日期:2003-11-01 00:00:00

  • Formulation and drying of alginate beads for controlled release and stabilization of invertase.

    abstract::Several alternatives to the conventional alginate beads formulation were studied for encapsulation of invertase. Pectin was added to the alginate/enzyme solution while trehalose and β-cyclodextrin were added to the calcium gelation media. The effect of composition changes, freezing, drying methods (freeze, vacuum, or ...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm2009075

    authors: Santagapita PR,Mazzobre MF,Buera MP

    更新日期:2011-09-12 00:00:00

  • Glyco-nanoparticles with sheddable saccharide shells: a unique and potent platform for hepatoma-targeting delivery of anticancer drugs.

    abstract::Reduction-sensitive shell-sheddable glyco-nanoparticles were designed and developed based on poly(ε-caprolactone)-graft-SS-lactobionic acid (PCL-g-SS-LBA) copolymer for efficient hepatoma-targeting delivery of doxorubicin (DOX). PCL-g-SS-LBA was prepared by ring-opening copolymerization of ε-caprolactone and pyridyl d...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm401749t

    authors: Chen W,Zou Y,Meng F,Cheng R,Deng C,Feijen J,Zhong Z

    更新日期:2014-03-10 00:00:00

  • Completely monodisperse, highly repetitive proteins for bioconjugate capillary electrophoresis: development and characterization.

    abstract::Protein-based polymers are increasingly being used in biomaterial applications because of their ease of customization and potential monodispersity. These advantages make protein polymers excellent candidates for bioanalytical applications. Here we describe improved methods for producing drag-tags for free-solution con...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm200358r

    authors: Lin JS,Albrecht JC,Meagher RJ,Wang X,Barron AE

    更新日期:2011-06-13 00:00:00