Lysozyme-lysozyme and lysozyme-salt interactions in the aqueous saline solution: a new square-well potential.

Abstract:

:We investigate lysozyme-lysozyme and lysozyme-salt interactions in electrolyte solutions using a molecular-thermodynamic model. An equation of state based on the statistical mechanical perturbation theory is applied to describe the interactions. The perturbation term includes a new square-well potential of mean force, which implies the information about the lysozyme surface and salt type. The attractive energy of the potential of mean force is correlated with experimental cloud-point temperatures of lysozyme in various solution conditions. The same attractive energy is used to predict osmotic pressure of a given system with no additional parameters. The new potential shows a satisfactory improvement in understanding the interactions between lysozymes in aqueous salt solutions.

journal_name

Biomacromolecules

journal_title

Biomacromolecules

authors

Chang BH,Bae YC

doi

10.1021/bm0300406

keywords:

subject

Has Abstract

pub_date

2003-11-01 00:00:00

pages

1713-8

issue

6

eissn

1525-7797

issn

1526-4602

journal_volume

4

pub_type

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