Protective effects and mechanisms of G5 PAMAM dendrimers against acute pancreatitis induced by caerulein in mice.


:In this study, generation 5 (G5) polyamidoamine (PAMAM) dendrimers with two different surface groups, G4.5-COOH and G5-OH, were investigated for their protective effects on pancreas injury in a caerulein-induced acute pancreatitis (AP) mouse model. Both dendrimers significantly decreased pathological changes in the pancreas and reduced the inflammatory infiltration of macrophages in pancreatic tissues. In addition, the expression of pro-inflammatory cytokines was significantly inhibited by the two dendrimers, not only in pancreatic tissues from AP mice but also in vitro in mouse peritoneal macrophages with LPS-induced inflammation. G4.5-COOH, which had better in vivo protective effects for AP than G5-OH, led to a significant reduction in the total number of plasma white blood cells (WBCs) and monocytes in AP mice, and its anti-inflammatory mechanism was related to inhibition of the nuclear translocation of NF-κB in macrophages.






Tang Y,Han Y,Liu L,Shen W,Zhang H,Wang Y,Cui X,Wang Y,Liu G,Qi R




Has Abstract


2015-01-12 00:00:00












  • Cyclic Dipeptide-Based Ambidextrous Supergelators: Minimalistic Rational Design, Structure-Gelation Studies, and In Situ Hydrogelation.

    abstract::Ambidextrous supergelators are developed through structure-gelation screening of rationally designed cyclic dipeptides (CDPs). The organo- and hydrogels of CDPs were thoroughly characterized by their minimal gelation concentration (MGC) for organic and aqueous solvents, thermal stability (Tg), and viscoelastic propert...


    pub_type: 杂志文章


    authors: Manchineella S,Murugan NA,Govindaraju T

    更新日期:2017-11-13 00:00:00

  • Enhanced Fluorescence Emission and Singlet Oxygen Generation of Photosensitizers Embedded in Injectable Hydrogels for Imaging-Guided Photodynamic Cancer Therapy.

    abstract::Benefiting from their inherent localized and controlled release properties, hydrogels are ideal delivery systems for therapeutic drugs or nanoparticles. In particular, applications of hydrogels for the delivery and release of photoresponsive drugs or nanoparticles are receiving increasing attention. However, the effec...


    pub_type: 杂志文章


    authors: Xia LY,Zhang X,Cao M,Chen Z,Wu FG

    更新日期:2017-10-09 00:00:00

  • Hydrogels for osteochondral repair based on photocrosslinkable carbamate dendrimers.

    abstract::First generation, photocrosslinkable dendrimers consisting of natural metabolites (i.e., succinic acid, glycerol, and beta-alanine) and nonimmunogenic poly(ethylene glycol) (PEG) were synthesized divergently in high yields using ester and carbamate forming reactions. Aqueous solutions of these dendrimers were photocro...


    pub_type: 杂志文章


    authors: Degoricija L,Bansal PN,Söntjens SH,Joshi NS,Takahashi M,Snyder B,Grinstaff MW

    更新日期:2008-10-01 00:00:00

  • Hepatocyte cocultures with endothelial cells and fibroblasts on micropatterned fibrous mats to promote liver-specific functions and capillary formation capabilities.

    abstract::The maintenance of hepatocyte phenotype and functions remains as a great challenge in the generation of functional liver tissue and in vitro model for drug metabolism studies. The use of hepatocyte coculture systems plays essential roles in the establishment of cell-cell and cell-extracellular matrix communications si...


    pub_type: 杂志文章


    authors: Liu Y,Li H,Yan S,Wei J,Li X

    更新日期:2014-03-10 00:00:00

  • Biocatalytic fabrication of fast-degradable, water-soluble polycarbonate functionalized with tertiary amine groups in backbone.

    abstract::Degradable polymers with specifically designed functionality have wide applications in biomedical fields. We reported herein the synthesis and characterization of a water-soluble and fast-degradable polycarbonate, functionalized with tertiary amine groups in the backbone. A novel cyclic carbonate monomer, namely, 6,14...


    pub_type: 杂志文章


    authors: Wang HF,Su W,Zhang C,Luo XH,Feng J

    更新日期:2010-10-11 00:00:00

  • Bait-and-Switch Supramolecular Strategy To Generate Noncationic RNA-Polymer Complexes for RNA Delivery.

    abstract::RNA interference (RNAi) requires the intracellular delivery of RNA molecules to initiate the neutralization of targeted mRNA molecules, inhibiting the expression or translation of the targeted gene. Current polymers and lipids that are used to deliver RNA molecules are generally required to be positively charged, to a...


    pub_type: 杂志文章


    authors: Jiang Z,Cui W,Prasad P,Touve MA,Gianneschi NC,Mager J,Thayumanavan S

    更新日期:2019-01-14 00:00:00

  • Cyclodextrin-Functionalized Fiber Yarns Spun from Deep Eutectic Cellulose Solutions for Nonspecific Hormone Capture in Aqueous Matrices.

    abstract::A wood based yarn platform for capturing pharmaceutical molecules from water was developed. Cellulose fiber yarns were modified with cyclodextrins, and the capture of 17α-ethinyl estradiol (EE2), a synthetic estrogen hormone used as contraceptive, from water was tested. The yarns were prepared by spinning a deep eutec...


    pub_type: 杂志文章


    authors: Orelma H,Virtanen T,Spoljaric S,Lehmonen J,Seppälä J,Rojas OJ,Harlin A

    更新日期:2018-02-12 00:00:00

  • Controlled synthesis and inclusion ability of a hyaluronic acid derivative bearing beta-cyclodextrin molecules.

    abstract::A new synthetic route to beta-cyclodextrin-linked hyaluronic acid (HA-CD) was developed. This was based on the preparation of a HA derivative selectively modified with adipic dihydrazide (HA-ADH) and a beta-cyclodextrin derivative possessing an aldehyde function on the primary face, followed by their coupling by a red...


    pub_type: 杂志文章


    authors: Charlot A,Heyraud A,Guenot P,Rinaudo M,Auzély-Velty R

    更新日期:2006-03-01 00:00:00

  • Self-Assembly of Cellulose in Super-Cooled Ionic Liquid under the Impact of Decelerated Antisolvent Infusion: An Approach toward Anisotropic Gels and Aerogels.

    abstract::Assembly of (bio)polymers into long-range anisotropic nanostructured gels and aerogels is of great interest in advanced material engineering since it enables directional tuning of properties, such as diffusivity, light, heat, and sound propagation, cell proliferation, and mechanical properties. Here we present an appr...


    pub_type: 杂志文章


    authors: Plappert SF,Nedelec JM,Rennhofer H,Lichtenegger HC,Bernstorff S,Liebner FW

    更新日期:2018-11-12 00:00:00

  • Combination of Amorphous Silk Fiber Spinning and Postspinning Crystallization for Tough Regenerated Silk Fibers.

    abstract::An artificial spinning system using regenerated silk fibroin solutions is adopted to produce high-performance silk fibers. In previous studies, alcohol-based agents, such as methanol or ethanol, were used to coagulate silk dope solutions, producing silk fiber with poor mechanical properties compared with those of nati...


    pub_type: 杂志文章


    authors: Yazawa K,Malay AD,Ifuku N,Ishii T,Masunaga H,Hikima T,Numata K

    更新日期:2018-06-11 00:00:00

  • Synthesis and characterization of mPEG-PLA prodrug micelles.

    abstract::Polymeric prodrugs of mPEG-PLA-haloperidol (methoxypoly(ethylene glycol)-b-poly(lactic acid)) can self-assemble into nanoscale micelle-like structures in aqueous solutions. mPEG-PLA-haloperidol was prepared and characterized using 1H and 13C NMR. The conjugation efficiency was found to be 64.8 +/- 21%. Micelles that f...


    pub_type: 杂志文章


    authors: Hans M,Shimoni K,Danino D,Siegel SJ,Lowman A

    更新日期:2005-09-01 00:00:00

  • Decomposable hollow biopolymer-based capsules.

    abstract::Decomposable hollow capsules based on deoxyribonucleic acid (DNA) and a low molecular weight organic molecule, a naturally occurring polyamine, spermidine (SP), were formed by applying the layer-by-layer adsorption strategy to colloid particles, viz., assembling DNA/SP multilayers on colloids and subsequently removing...


    pub_type: 杂志文章


    authors: Schüler C,Caruso F

    更新日期:2001-10-01 00:00:00

  • CO2-Responsive Water-Soluble Conjugated Polymers for In Vitro and In Vivo Biological Imaging.

    abstract::Water-soluble conjugated polymers (WCPs) composed of a hydrophobic polythiophene main chain with hydrophilic tertiary amine side-chains can directly self-assemble into sphere-like nano-objects in an aqueous solution due to phase separation between the hydrophilic and hydrophobic segments of the polymeric structure. Du...


    pub_type: 杂志文章


    authors: Cheng CC,Lai YC,Shieh YT,Chang YH,Lee AW,Chen JK,Lee DJ,Lai JY

    更新日期:2020-12-14 00:00:00

  • Efficient Synthesis of Folate-Conjugated Hollow Polymeric Capsules for Accurate Drug Delivery to Cancer Cells.

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    pub_type: 杂志文章


    authors: Song W,Zhang Y,Yu DG,Tran CH,Wang M,Varyambath A,Kim J,Kim I

    更新日期:2020-12-17 00:00:00

  • Affibody-attached hyperbranched conjugated polyelectrolyte for targeted fluorescence imaging of HER2-positive cancer cell.

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    pub_type: 杂志文章


    authors: Pu KY,Shi J,Cai L,Li K,Liu B

    更新日期:2011-08-08 00:00:00

  • Engineering and Characterization of an Enzyme Replacement Therapy for Classical Homocystinuria.

    abstract::Homocystinuria due to loss of cystathionine beta-synthase (CBS) causes accumulation of homocysteine and depletion of cysteine. Current treatments are suboptimal, and thus the development of an enzyme replacement therapy based on PEGylated human truncated CBS (PEG-CBS) has been initiated. Attenuation of potency was obs...


    pub_type: 杂志文章


    authors: Majtan T,Park I,Carrillo RS,Bublil EM,Kraus JP

    更新日期:2017-06-12 00:00:00

  • Cooperative Catechol-Functionalized Polypept(o)ide Brushes and Ag Nanoparticles for Combination of Protein Resistance and Antimicrobial Activity on Metal Oxide Surfaces.

    abstract::Prevention of biofouling and microbial contamination of implanted biomedical devices is essential to maintain their functionality and biocompatibility. For this purpose, polypept(o)ide block copolymers have been developed, in which a protein-resistant polysarcosine (pSar) block is combined with a dopamine-modified pol...


    pub_type: 杂志文章


    authors: Yoo J,Birke A,Kim J,Jang Y,Song SY,Ryu S,Kim BS,Kim BG,Barz M,Char K

    更新日期:2018-05-14 00:00:00

  • Wet-spinning of recombinant silk-elastin-like protein polymer fibers with high tensile strength and high deformability.

    abstract::A recombinant silk-elastin-like protein copolymer SELP-47K containing tandemly repeated amino acid sequence blocks from silk, GAGAGS, and elastin, GVGVP, was fabricated into microdiameter fibers using a wet-spinning technique. Raman spectral analysis revealed the formation of antiparallel beta-sheet crystals of the si...


    pub_type: 杂志文章


    authors: Qiu W,Teng W,Cappello J,Wu X

    更新日期:2009-03-09 00:00:00

  • Self-assembly of elastin-based peptides into the ECM: the importance of integrins and the elastin binding protein in elastic fiber assembly.

    abstract::The formation of a suitable extracellular matrix (ECM) that promotes cell adhesion, organization, and proliferation is essential within biomaterial scaffolds for tissue engineering applications. In this work, short elastin mimetic peptide sequences, EM-19 and EM-23, were engineered to mimic the active motifs of human ...


    pub_type: 杂志文章


    authors: Patel D,Menon R,Taite LJ

    更新日期:2011-02-14 00:00:00

  • Functionalization of poly(oligo(ethylene glycol) methacrylate) films on gold and Si/SiO2 for immobilization of proteins and cells: SPR and QCM studies.

    abstract::Thin films of a biocompatible and nonbiofouling poly(oligo(ethylene glycol) methacrylate) ( pOEGMA) with various thicknesses were formed on gold and Si/SiO 2 substrates by a combination of the formation of self-assembled monolayers (SAMs) terminating in bromoester-an initiator of atom transfer radical polymerization (...


    pub_type: 杂志文章


    authors: Lee BS,Chi YS,Lee KB,Kim YG,Choi IS

    更新日期:2007-12-01 00:00:00

  • Structural and rheological properties of methacrylamide modified gelatin hydrogels.

    abstract::Dynamic shear oscillation measurements at small strain were used to characterize the viscoelastic properties and related differences in the molecular structure of hydrogels based on gelatin methacrylamide. Gelatin was derivatized with methacrylamide side groups and was subsequently cross-linked by radical polymerizati...


    pub_type: 杂志文章


    authors: Van Den Bulcke AI,Bogdanov B,De Rooze N,Schacht EH,Cornelissen M,Berghmans H

    更新日期:2000-04-01 00:00:00

  • Design of Polyphosphate Inhibitors: A Molecular Dynamics Investigation on Polyethylene Glycol-Linked Cationic Binding Groups.

    abstract::Inorganic polyphosphate (polyP) released by human platelets has recently been shown to activate blood clotting and identified as a potential target for the development of novel antithrombotics. Recent studies have shown that polymers with cationic binding groups (CBGs) inhibit polyP and attenuate thrombosis. However, ...


    pub_type: 杂志文章


    authors: Mafi A,Abbina S,Kalathottukaren MT,Morrissey JH,Haynes C,Kizhakkedathu JN,Pfaendtner J,Chou KC

    更新日期:2018-04-09 00:00:00

  • Synthesis of multifunctional cellulose nanocrystals for lectin recognition and bacterial imaging.

    abstract::Multifunctional cellulose nanocrystals have been synthesized and applied as a new type of glyconanomaterial in lectin binding and bacterial imaging. The cellulose nanocrystals were prepared by TEMPO-mediated oxidation and acidic hydrolysis, followed by functionalization with a quinolone fluorophore and carbohydrate li...


    pub_type: 杂志文章


    authors: Zhou J,Butchosa N,Jayawardena HS,Park J,Zhou Q,Yan M,Ramström O

    更新日期:2015-04-13 00:00:00

  • Polymerization of polyfunctional macromolecules: synthesis of a new class of high molecular weight poly(amino acid)s by oxidative coupling of phenol-containing precursor polymers.

    abstract::Oxidative coupling of phenol-containing precursor poly(amino acid)s, poly(alpha-glutamine), poly(alpha/beta-asparagine), and poly(gamma-glutamine) derivatives, has been examined to produce a new class of soluble poly(amino acid)s. Under appropriate reaction conditions, the Fe-salen and HRP catalysts efficiently induce...


    pub_type: 杂志文章


    authors: Fukuoka T,Uyama H,Kobayashi S

    更新日期:2004-05-01 00:00:00

  • Modular elastic patches: mechanical and biological effects.

    abstract::A modular approach to engineering cross-linked elastic biomaterials is presented for fine-tuning of material mechanical and biological properties. The three components, soluble elastin, hyaluronic acid, and silk fibroin, contribute with different features to the overall properties of the final material system. The ela...


    pub_type: 杂志文章


    authors: Serban MA,Kluge JA,Laha MM,Kaplan DL

    更新日期:2010-09-13 00:00:00

  • Long-circulating near-infrared fluorescence core-cross-linked polymeric micelles: synthesis, characterization, and dual nuclear/optical imaging.

    abstract::We report the synthesis of PEG-coated, core-cross-linked polymeric micelles (CCPMs) derived from an amine-terminated amphiphilic block copolymer, poly(PEG-methacrylate)-b-poly(triethoxysilyl propylmethacrylate). The block copolymer self-assembled to form micellar nanoparticles, and a Cy-7-like near-infrared fluorescen...


    pub_type: 杂志文章


    authors: Yang Z,Zheng S,Harrison WJ,Harder J,Wen X,Gelovani JG,Qiao A,Li C

    更新日期:2007-11-01 00:00:00

  • Smart PEGylation of trypsin.

    abstract::Thermoresponsive oligo(ethylene glycol)-based copolymers were investigated for trypsin conjugation. These copolymers have been synthesized by atom transfer radical polymerization of 2-(2-methoxyethoxy)ethyl methacrylate (MEO(2)MA) with oligo(ethylene glycol) methyl ether methacrylate (OEGMA(475), M(n) = 475 g.mol(-1))...


    pub_type: 杂志文章


    authors: Zarafshani Z,Obata T,Lutz JF

    更新日期:2010-08-09 00:00:00

  • Pretreatment of amphiphilic comb polymer surfaces dramatically affects protein adsorption.

    abstract::New applications in regenerative biotechnology require the ability to understand and control protein-surface interactions on micrometer and submicrometer length scales. Evidence presented here shows that micropatterned amphiphilic comb polymer films exhibit a pretreatment-dependent behavior with respect to protein ads...


    pub_type: 杂志文章


    authors: Zhang Z,Ma H,Hausner DB,Chilkoti A,Beebe TP Jr

    更新日期:2005-11-01 00:00:00

  • Nanogel formation consisting of DNA and poly(amido amine) dendrimer studied by static light scattering and atomic force microscopy.

    abstract::Binding of a poly(amido amine) dendrimer with salmon testes DNA in an aqueous solution of 0.01 M NaCl at pH 6.5 has been investigated. It was shown from the physicochemical experiments of static light scattering and ultra-violet and circular dichroism spectroscopy that at a 0.2 mixing ratio of dendrimer/DNA (number ra...


    pub_type: 杂志文章


    authors: Mitra A,Imae T

    更新日期:2004-01-01 00:00:00

  • Thermoresponsive Self-Immolative Polyglyoxylamides.

    abstract::Thermoresponsive polymers with lower critical solution temperatures (LCSTs) are of significant interest for a wide range of applications from sensors to drug delivery vehicles. However, the most widely investigated LCST polymers have nondegradable backbones, limiting their applications in vivo or in the environment. D...


    pub_type: 杂志文章


    authors: Rabiee Kenaree A,Sirianni QEA,Classen K,Gillies ER

    更新日期:2020-09-14 00:00:00